穗花牡荆文献研究及药性探讨
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摘要
目的:基于外来植物药穗花牡荆(Vitex agnus castus L)的科学研究文献,结合中医药理论探讨穗花牡荆的中药药性,为穗花牡荆在我国的研究、配伍及临床应用提供理论基础。方法:选取中国知网、Web of Science(Wo S)核心合集(SCI)和Pub Med文献数据库并查阅穗花牡荆相关文献,筛选设计合理、信度较高、结论可靠的科学研究文献,以46篇临床研究文献为依据,126篇化学成分、药理研究文献为佐证,结合中医理论探讨穗花牡荆的中药药性。结果:初步推断穗花牡荆的中药药性为辛、甘,微寒,归肝、肾经;功能主治为疏肝解郁、填精益髓、强筋健骨,用于经前期综合征之烦躁易怒、乳房胀痛、头痛等,预防骨质疏松、促进骨折愈合。结论:概括归纳穗花牡荆的性味归经、功能主治及用法用量,赋予穗花牡荆明确的中药药性,为穗花牡荆与中药的配伍及临床应用奠定理论基础。
Objective: To provide the theoretical basis for the research,compatibility and clinical application of Vitex agnus-castus L. in China based on the scientific literature of Vitex agnus-castus L. and traditional Chinese medicine theory to explore the medicinal properties of it. Methods: After checking the related documents in CNKI,Web of science and Pubmed databases,the irrelevant and duplicate documents,accept documents which has rational design,high reliability,and reliable conclusions were selected out.The medicinal properties of Vitex agnus-castus L were studied combining its' clinical trials,chemical constituents researches,pharmacological researches and traditional Chinese medicine theory. Results: The preliminary inference of the traditional Chinese medicinal properties of Vitex agnus-castus L. were as follows: the property and flavor were pungent,sweet,slightly cold and belonging to liver and kidney; the function was soothing the liver to remove stagnancy of liver-qi,filling essence,strong sinews and bones. It could be used for the treatment of premenstrual syndrome irritability,emotional restlessness,breast tenderness,headache,etc.,and to prevent osteoporosis and promote fracture healing. Conclusion: Summarizing the characteristics of natures,tastes,guiding,function indications,usage and dosage,it will lay a theoretical foundation for the compatibility and clinical application of Vitex agnuscastus L..
Objective: To provide the theoretical basis for the research,compatibility and clinical application of Vitex agnus-castus L. in China based on the scientific literature of Vitex agnus-castus L. and traditional Chinese medicine theory to explore the medicinal properties of it. Methods: After checking the related documents in CNKI,Web of science and Pubmed databases,the irrelevant and duplicate documents,accept documents which has rational design,high reliability,and reliable conclusions were selected out.The medicinal properties of Vitex agnus-castus L were studied combining its' clinical trials,chemical constituents researches,pharmacological researches and traditional Chinese medicine theory. Results: The preliminary inference of the traditional Chinese medicinal properties of Vitex agnus-castus L. were as follows: the property and flavor were pungent,sweet,slightly cold and belonging to liver and kidney; the function was soothing the liver to remove stagnancy of liver-qi,filling essence,strong sinews and bones. It could be used for the treatment of premenstrual syndrome irritability,emotional restlessness,breast tenderness,headache,etc.,and to prevent osteoporosis and promote fracture healing. Conclusion: Summarizing the characteristics of natures,tastes,guiding,function indications,usage and dosage,it will lay a theoretical foundation for the compatibility and clinical application of Vitex agnuscastus L..
引文
[1]张建军,王淳,费文婷,等.外来药物“中药化”的研究思路与策略[J].中华中医药杂志,2017,32(4):1425-1430.
[2]Bulut G,Tuzlaci E.An ethnobotanical study of medicinal plants in Turgutlu(Manisa-Turkey)[J].J Ethnopharmacol,2013,149(3):633-647.
[3]孟李,魏铁花.185穗花牡荆的药理活性与临床应用[J].国外医药(植物药分册),2005,20(4):145-149.
[4]Zhelev I,Batsalova T,Georgieva L,et al.CHEMICAL COMPOSI-TION,CYTOTOXICITY AND ANTIOXIDANT ACTIVITY OF ESSEN-TIAL OIL FROM Vitex agnus-castus FRUITS,GROWING IN BUL-GARIA[J].OXIDATION COMMUNICATIONS,2016.39(1).145-156.
[5]Lederle F,Kaldun C,Namyslo JC,et al.3D-Printing inside the Glovebox:A Versatile Tool for Inert-Gas Chemistry Combined with Spectroscopy[J].Helv Chim Acta,2016,99(4):255-266.
[6]Momoeda M,Sasaki H,Tagashira E,et al.Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients:a prospective,open-label study[J].Adv Ther,2014,31(3):362-373.
[7]He Z,Chen R,Zhou Y,et al.Treatment for premenstrual syndrome with Vitex agnus castus:A prospective,randomized,multi-center placebo controlled study in China[J].Maturitas,2009,63(1):99-103.
[8]Mirghafourvand M,Mohammad-Alizadeh-Charandabi S,Ahmadpour P,et al.Effects of Vitex agnus and Flaxseed on cyclic mastalgia:Arandomized controlled trial[J].Complement Ther Med,2016,24:90-95.
[9]Eftekhari MH,Rostami ZH,Emami MJ,et al.Effects of“vitex agnus castus”extract and magnesium supplementation,alone and in combination,on osteogenic and angiogenic factors and fracture healing in women with long bone fracture[J].J Res Med Sci,2014,19(1):1-7.
[10]Ahangarpour A,Najimi SA,Farbood Y.Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model[J].JOURNAL OF THE CHINESEMEDICAL ASSOCIATION.2016,79(11):589-596.
[11]Moreno FN,Campos-Shimada LB,da CSC,et al.Vitex agnus-castus L.(Verbenaceae)Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats[J].Evid Based Complement Alternat Med,2015,2015:212378.
[12]Aslanturk OS,Celik TA.Antioxidant activity and anticancer effect of Vitex agnus-castus L.(Verbenaceae)seed extracts on MCF-7 breast cancer cells[J].CARYOLOGIA,2013,66(3):257-267.
[13]Aˇgalar HG,ift9i GA,Yιldιrιm SU,et al.The LC/ESI-MSMS Profiles and Biological Potentials of Vitex agnus castus Extracts[J].Nat Prod Commun,2016,11(11):1655-1660.
[14]Kikuchi H,Yuan B,Nishimura Y,et al.Cytotoxicity of Vitex agnuscastus fruit extract and its major component,casticin,correlates with differentiation status in leukemia cell lines[J].Int J Oncol,2013,43(6):1976-1984.
[15]Kikuchi H,Yuan B,Yuhara E,et al.Involvement of histone H3phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract[J].Int J Oncol,2014,45(2):843-852.
[16]Ahmad B,Hafeez N,Ara G,et al.Antibacterial activity of crude methanolic extract and various fractions of Vitex agnus castus and Myrsine africana against clinical isolates of Methicillin Resistant Staphylococcus aureus[J].Pak J Pharm Sci,2016,29(6):1977-1983.
[17]Eryigit T,Ccedillg A,Okut N.Evaluation of Chemical Composition and Antimicrobial Activity of Vitex agnus castus L.Fruits'Essential Oils from West Anatolia,Turkey[J].JOURNAL OF ESSENTIAL OILBEARING PLANTS,2015,18(1):208-214.
[18]Azizuddin,Mahmood Iffat,Choudhary Muhammad Iqbal,et al.Antifungal,Antibacterial,Phytotoxic and Cytotoxic Potential of Casticin I-solated from Vitex agnus-castus[J].JOURNAL OF THE CHEMICALSOCIETY OF PAKISTAN,2012,34(5):1286-1289.
[19]Stojkovic Dejan,Sokovic Marina,Glamoclija Jasmina,et al.Chemical Composition and Antimicrobial Activity of Vitex agnus-castus L.Fruits and Leaves Essential Oils[J].FOOD CHEMISTRY,2011,128(4):1017-1022.
[20]Neves RC,Camara CA.Chemical composition and acaricidal activity of the essential oils from Vitex agnus-castus L.(Verbenaceae)and selected monoterpenes[J].An Acad Bras Cienc,2016,88(3):1221-1233.
[21]o2i'c-Jurjevi'c B,Ajd6anovi'c V,Filipovi'c B,et al.Functional morphology of pituitary-thyroid and-adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil[J].Acta Histochem,2016,118(7):736-745.
[22]Ignjatovic D,Tovilovic Gordana,Sosic-Jurjevic Branka.et al,BIOAC-TIVITY OF THE ESSENTIAL OIL FROM BERRIES OF VITEX AG-NUS CASTUS IN MIDDLE AGED MALE RATS[J].DIGEST JOUR-NAL OF NANOMATERIALS AND BIOSTRUCTURES,2012,7(4):1727-1734.
[23]Ibrahim NA,Shalaby AS,Farag RS,et al.Gynecological efficacy and chemical investigation of Vitex agnus-castus L.fruits growing in E-gypt[J].Nat Prod Res,2008,22(6):537-546.
[24]Li Ye,Shen Yan.Casticin attenuates rheumatoid arthritis through PKC-NF-kappa B signaling in vitro and in vivo[J].INTERNATION-AL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLO-GY,2016,9(3):2879-2887.
[25]Lee H,Jung KH,Lee H,et al.Casticin,an active compound isolated from Vitex Fructus,ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model[J].Int Immunopharmacol,2015,28(2):1097-1101.
[26]Pantelic J,Filipovic B,Sosic-Jurjevic B,et al.VITEX AGNUS-CAS-TUS ESSENTIAL OIL AFFECTS THYROID C CELLS AND BONEMETABOLISM IN MIDDLE-AGED MALE RATS[J].ACTA VET-ERINARIA-BEOGRAD,2013,63(1):23-35.
[27]Sehmisch S,Boeckhoff J,Wille J,et al.Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation[J].Phytother Res,2009,23(6):851-858.
[28]Oztürk A,Ilman AA,Saˇglam H,et al.The effects of phytoestrogens on fracture healing:experimental research in New Zealand white rabbits[J].Ulus Travma Acil Cerrahi Derg,2008,14(1):21-27.
[29]Oroojan AA,Ahangarpour A,Khorsandi L,et al.Effects of hydro-alcoholic extract of Vitex agnus-castus fruit on kidney of D-galactoseinduced aging model in female mice[J].Iran J Vet Res,2016,17(3):203-206.
[30]van Die MD,Bone KM,Burger HG,et al.Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women:findings from a subpopulation analysis[J].J Altern Complement Med,2009,15(9):1045-1048.
[31]Schellenberg R,Zimmermann C,Drewe J,et al.Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome[J].Phytomedicine,2012,19(14):1325-1331.
[32]Ma L,Lin S,Chen R,et al.Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus(BNO 1095)in Chinese women[J].Aust N Z J Obstet Gynaecol,2010,50(2):189-193.
[33]王淳,张建军,王佳,等.玛咖的临床文献研究及其中药性能探讨[J].中华中医药杂志,2017,32(12):5569-5573.
[34]张建军,陈绍红,朱映黎,等.南美草药阿萨伊的中药性能与功用探析[J].中国中药杂志,2015,40(11):2258-2264.
[2]Bulut G,Tuzlaci E.An ethnobotanical study of medicinal plants in Turgutlu(Manisa-Turkey)[J].J Ethnopharmacol,2013,149(3):633-647.
[3]孟李,魏铁花.185穗花牡荆的药理活性与临床应用[J].国外医药(植物药分册),2005,20(4):145-149.
[4]Zhelev I,Batsalova T,Georgieva L,et al.CHEMICAL COMPOSI-TION,CYTOTOXICITY AND ANTIOXIDANT ACTIVITY OF ESSEN-TIAL OIL FROM Vitex agnus-castus FRUITS,GROWING IN BUL-GARIA[J].OXIDATION COMMUNICATIONS,2016.39(1).145-156.
[5]Lederle F,Kaldun C,Namyslo JC,et al.3D-Printing inside the Glovebox:A Versatile Tool for Inert-Gas Chemistry Combined with Spectroscopy[J].Helv Chim Acta,2016,99(4):255-266.
[6]Momoeda M,Sasaki H,Tagashira E,et al.Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients:a prospective,open-label study[J].Adv Ther,2014,31(3):362-373.
[7]He Z,Chen R,Zhou Y,et al.Treatment for premenstrual syndrome with Vitex agnus castus:A prospective,randomized,multi-center placebo controlled study in China[J].Maturitas,2009,63(1):99-103.
[8]Mirghafourvand M,Mohammad-Alizadeh-Charandabi S,Ahmadpour P,et al.Effects of Vitex agnus and Flaxseed on cyclic mastalgia:Arandomized controlled trial[J].Complement Ther Med,2016,24:90-95.
[9]Eftekhari MH,Rostami ZH,Emami MJ,et al.Effects of“vitex agnus castus”extract and magnesium supplementation,alone and in combination,on osteogenic and angiogenic factors and fracture healing in women with long bone fracture[J].J Res Med Sci,2014,19(1):1-7.
[10]Ahangarpour A,Najimi SA,Farbood Y.Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model[J].JOURNAL OF THE CHINESEMEDICAL ASSOCIATION.2016,79(11):589-596.
[11]Moreno FN,Campos-Shimada LB,da CSC,et al.Vitex agnus-castus L.(Verbenaceae)Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats[J].Evid Based Complement Alternat Med,2015,2015:212378.
[12]Aslanturk OS,Celik TA.Antioxidant activity and anticancer effect of Vitex agnus-castus L.(Verbenaceae)seed extracts on MCF-7 breast cancer cells[J].CARYOLOGIA,2013,66(3):257-267.
[13]Aˇgalar HG,ift9i GA,Yιldιrιm SU,et al.The LC/ESI-MSMS Profiles and Biological Potentials of Vitex agnus castus Extracts[J].Nat Prod Commun,2016,11(11):1655-1660.
[14]Kikuchi H,Yuan B,Nishimura Y,et al.Cytotoxicity of Vitex agnuscastus fruit extract and its major component,casticin,correlates with differentiation status in leukemia cell lines[J].Int J Oncol,2013,43(6):1976-1984.
[15]Kikuchi H,Yuan B,Yuhara E,et al.Involvement of histone H3phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract[J].Int J Oncol,2014,45(2):843-852.
[16]Ahmad B,Hafeez N,Ara G,et al.Antibacterial activity of crude methanolic extract and various fractions of Vitex agnus castus and Myrsine africana against clinical isolates of Methicillin Resistant Staphylococcus aureus[J].Pak J Pharm Sci,2016,29(6):1977-1983.
[17]Eryigit T,Ccedillg A,Okut N.Evaluation of Chemical Composition and Antimicrobial Activity of Vitex agnus castus L.Fruits'Essential Oils from West Anatolia,Turkey[J].JOURNAL OF ESSENTIAL OILBEARING PLANTS,2015,18(1):208-214.
[18]Azizuddin,Mahmood Iffat,Choudhary Muhammad Iqbal,et al.Antifungal,Antibacterial,Phytotoxic and Cytotoxic Potential of Casticin I-solated from Vitex agnus-castus[J].JOURNAL OF THE CHEMICALSOCIETY OF PAKISTAN,2012,34(5):1286-1289.
[19]Stojkovic Dejan,Sokovic Marina,Glamoclija Jasmina,et al.Chemical Composition and Antimicrobial Activity of Vitex agnus-castus L.Fruits and Leaves Essential Oils[J].FOOD CHEMISTRY,2011,128(4):1017-1022.
[20]Neves RC,Camara CA.Chemical composition and acaricidal activity of the essential oils from Vitex agnus-castus L.(Verbenaceae)and selected monoterpenes[J].An Acad Bras Cienc,2016,88(3):1221-1233.
[21]o2i'c-Jurjevi'c B,Ajd6anovi'c V,Filipovi'c B,et al.Functional morphology of pituitary-thyroid and-adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil[J].Acta Histochem,2016,118(7):736-745.
[22]Ignjatovic D,Tovilovic Gordana,Sosic-Jurjevic Branka.et al,BIOAC-TIVITY OF THE ESSENTIAL OIL FROM BERRIES OF VITEX AG-NUS CASTUS IN MIDDLE AGED MALE RATS[J].DIGEST JOUR-NAL OF NANOMATERIALS AND BIOSTRUCTURES,2012,7(4):1727-1734.
[23]Ibrahim NA,Shalaby AS,Farag RS,et al.Gynecological efficacy and chemical investigation of Vitex agnus-castus L.fruits growing in E-gypt[J].Nat Prod Res,2008,22(6):537-546.
[24]Li Ye,Shen Yan.Casticin attenuates rheumatoid arthritis through PKC-NF-kappa B signaling in vitro and in vivo[J].INTERNATION-AL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLO-GY,2016,9(3):2879-2887.
[25]Lee H,Jung KH,Lee H,et al.Casticin,an active compound isolated from Vitex Fructus,ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model[J].Int Immunopharmacol,2015,28(2):1097-1101.
[26]Pantelic J,Filipovic B,Sosic-Jurjevic B,et al.VITEX AGNUS-CAS-TUS ESSENTIAL OIL AFFECTS THYROID C CELLS AND BONEMETABOLISM IN MIDDLE-AGED MALE RATS[J].ACTA VET-ERINARIA-BEOGRAD,2013,63(1):23-35.
[27]Sehmisch S,Boeckhoff J,Wille J,et al.Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation[J].Phytother Res,2009,23(6):851-858.
[28]Oztürk A,Ilman AA,Saˇglam H,et al.The effects of phytoestrogens on fracture healing:experimental research in New Zealand white rabbits[J].Ulus Travma Acil Cerrahi Derg,2008,14(1):21-27.
[29]Oroojan AA,Ahangarpour A,Khorsandi L,et al.Effects of hydro-alcoholic extract of Vitex agnus-castus fruit on kidney of D-galactoseinduced aging model in female mice[J].Iran J Vet Res,2016,17(3):203-206.
[30]van Die MD,Bone KM,Burger HG,et al.Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women:findings from a subpopulation analysis[J].J Altern Complement Med,2009,15(9):1045-1048.
[31]Schellenberg R,Zimmermann C,Drewe J,et al.Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome[J].Phytomedicine,2012,19(14):1325-1331.
[32]Ma L,Lin S,Chen R,et al.Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus(BNO 1095)in Chinese women[J].Aust N Z J Obstet Gynaecol,2010,50(2):189-193.
[33]王淳,张建军,王佳,等.玛咖的临床文献研究及其中药性能探讨[J].中华中医药杂志,2017,32(12):5569-5573.
[34]张建军,陈绍红,朱映黎,等.南美草药阿萨伊的中药性能与功用探析[J].中国中药杂志,2015,40(11):2258-2264.