ER阴性乳腺癌钼靶X线征象与PR、C-erbB-2和P53表达的相关性
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摘要
目的 探讨雌激素受体(ER)阴性乳腺癌的钼靶X线征象与孕激素受体(PR)、C-erbB-2、P53表达的相关性。方法 回顾性分析35例具有乳腺钼靶并经病理证实为ER阴性乳腺癌的患者资料,记录各病变免疫组化指标及其X线钼靶表现。分析癌组织中PR、C-erbB-2、P53的表达与病变大小、恶性钙化、毛刺征以及淋巴结转移的关系。结果 35例阴性乳腺癌中,PR均为阴性。病变组织学类型仅与P53的表达具有相关性(P<0.05),而与c-erbB-2的表达无显著相关性。病变的大小、毛刺征象、恶性钙化及淋巴结转移情况与c-erbB-2、P53的表达无显著相关性。结论 ER阴性乳腺癌的钼靶X线征象与PR、C-erbB-2和P53表达无显著相关性,尚不能作为ER阴性乳腺癌PR、C-erbB-2和P53表达的预测指标。
Objective To investigate the molybdenum target mammographic manifestations and its correlation with the expressions of progesterone receptor(PR),C-erbB-2,P53 in patients with negative ER breast cancer.Methods The clinical data about 35 patients with negative ER breast cancer who were diagnosed by mammary gland molybdenum target and pathological examinatin in our hospital were retrospectivly analyzed. The correlation between the expressions of PR,C-erbB-2,P53 and lesion size, malignant calcifications,spiculation,lymph node metastasis was analyzed.Results In the 35 patients with negative ER breast cancer, the histological types of lesions were correlated with P53 expression only(P<0.05),however, which were not correlated with c-erbB-2 expression.Moreover there was no significant correlation between the lesion size,malignant calcifications,spiculation,lymph node metastasis and the expressions of c-erbB-2, P53.Conclusion There is no significant correlation between the molybdenum target mammographic manifestations and the expressions of PR,C-erbB-2,P53 in patients with negative ER breast cancer,therefor,which can not be regarded as the indexes yet to predict the expressions of PR,C-erbB-2 and P53.
Objective To investigate the molybdenum target mammographic manifestations and its correlation with the expressions of progesterone receptor(PR),C-erbB-2,P53 in patients with negative ER breast cancer.Methods The clinical data about 35 patients with negative ER breast cancer who were diagnosed by mammary gland molybdenum target and pathological examinatin in our hospital were retrospectivly analyzed. The correlation between the expressions of PR,C-erbB-2,P53 and lesion size, malignant calcifications,spiculation,lymph node metastasis was analyzed.Results In the 35 patients with negative ER breast cancer, the histological types of lesions were correlated with P53 expression only(P<0.05),however, which were not correlated with c-erbB-2 expression.Moreover there was no significant correlation between the lesion size,malignant calcifications,spiculation,lymph node metastasis and the expressions of c-erbB-2, P53.Conclusion There is no significant correlation between the molybdenum target mammographic manifestations and the expressions of PR,C-erbB-2,P53 in patients with negative ER breast cancer,therefor,which can not be regarded as the indexes yet to predict the expressions of PR,C-erbB-2 and P53.
引文
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3 Putti TC,El-Rehim DM,Rakha EA,et al.Estrogen receptor-negative breast carcinomas:a review of morphology and immunophenotypical analysis.Mod Pathol,2005,18:26-35.
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5 张颖,阮祥燕,米鑫,等.孕激素受体膜组分1(PGRMC1) 对预测乳腺癌预后作用的研究.首都医科大学学报,2015.36:548-552.
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7 American college of Radiology(ACR).Breast imaning reporting and data system (BI-RADS).4th ed.Reston:Amcollege Radiol,2003.1-259.
8 刘瑞磊,陈晓萍,龙梅珺,等.乳腺癌发生发展与雌激素受体β 的表达的关系.中华实验外科杂志,2015,32:2517-2519.
9 Ellis IO,Galea M,Broughton N,et al.Pathological prognostic factors in breast cancer.II.Histological type.Relationship with survival in a large study with long-term follow-up.Histopathology,1992,20:479-489.
10 李魏玮.雌激素受体β对乳腺癌细胞耐药及增殖凋亡作用的研究济南:山东大学学报,2014.
11 姚永忠,王雪晨,张丽华.乳腺癌C-erbB-2、PCNA的表达及其与ER、PR的相关性研究.实用医学杂志,2005,2l:136-138.
12 夏琛,吴义启.ER、PR、HER-2、P53和KI67在四种乳腺癌中表达。湖北科技学院学报,2017,8:280-282.
13 杨玉华,娄丹,吕小梅,等.乳腺癌中雌激素受体GPR30与ER、PR及HER2的相关性.实用医学杂志,2015,31:2854-2856.
14 Enache DE,Georgescu CV.Ptran Negative estrogen-receptor invasive breast carcinoma:mammographic aspects,correlations with HER2/neuoncoprotein status.Rom J Morphol Embryol,2012,53:755-762.
15 丁茹,朱昭.环乳腺浸润性导管癌X线表现与ER、PR、Her-2、Ki-67、P53表达的相关性研究.临床和实验医学杂志,2016,14:1390-1394.
16 宋士群,黎庶.乳腺癌的X线征象与免疫组化标记物相关性研究.中国CT和MRI杂志,2008,6:25-28.
2 Zhang Q,Liu LY,Wallg F.The challges in female physical and childbearing characteristics in China and potential association with risk of breast ca.BMC Public Health,2012,12:368.
3 Putti TC,El-Rehim DM,Rakha EA,et al.Estrogen receptor-negative breast carcinomas:a review of morphology and immunophenotypical analysis.Mod Pathol,2005,18:26-35.
4 Carey LA,Dees EC,Sawyer L,et al.The triple negative paradox:primary tumor chemosensitivity of breast cancer subtypes.Clin Cancer Res,2007,13:2329-2334.
5 张颖,阮祥燕,米鑫,等.孕激素受体膜组分1(PGRMC1) 对预测乳腺癌预后作用的研究.首都医科大学学报,2015.36:548-552.
6 Sahab ZJ,Man YG,Semaan SM,et al.Alteration in protein expression in estrogen receptor alpha-negative human breast cancer tissues indicates amalignant and metastatic phenotype.Clin Exp etastasis,2010,27:493-503.
7 American college of Radiology(ACR).Breast imaning reporting and data system (BI-RADS).4th ed.Reston:Amcollege Radiol,2003.1-259.
8 刘瑞磊,陈晓萍,龙梅珺,等.乳腺癌发生发展与雌激素受体β 的表达的关系.中华实验外科杂志,2015,32:2517-2519.
9 Ellis IO,Galea M,Broughton N,et al.Pathological prognostic factors in breast cancer.II.Histological type.Relationship with survival in a large study with long-term follow-up.Histopathology,1992,20:479-489.
10 李魏玮.雌激素受体β对乳腺癌细胞耐药及增殖凋亡作用的研究济南:山东大学学报,2014.
11 姚永忠,王雪晨,张丽华.乳腺癌C-erbB-2、PCNA的表达及其与ER、PR的相关性研究.实用医学杂志,2005,2l:136-138.
12 夏琛,吴义启.ER、PR、HER-2、P53和KI67在四种乳腺癌中表达。湖北科技学院学报,2017,8:280-282.
13 杨玉华,娄丹,吕小梅,等.乳腺癌中雌激素受体GPR30与ER、PR及HER2的相关性.实用医学杂志,2015,31:2854-2856.
14 Enache DE,Georgescu CV.Ptran Negative estrogen-receptor invasive breast carcinoma:mammographic aspects,correlations with HER2/neuoncoprotein status.Rom J Morphol Embryol,2012,53:755-762.
15 丁茹,朱昭.环乳腺浸润性导管癌X线表现与ER、PR、Her-2、Ki-67、P53表达的相关性研究.临床和实验医学杂志,2016,14:1390-1394.
16 宋士群,黎庶.乳腺癌的X线征象与免疫组化标记物相关性研究.中国CT和MRI杂志,2008,6:25-28.