健康体检人群血同型半胱氨酸与血尿酸水平分析
|
摘要
目的:通过对健康体检人群血浆同型半胱氨酸(Hcy)与血尿酸(UA)水平的调查,评估常见慢性病(高血压、糖尿病、脑卒中、冠心病、血脂异常等)的高危因素,为慢性病的防控提供理论依据。方法:选取2014-06-2016-03重庆市涪陵区健康体检人群11 166例,其中男6 995例,女4 171例。取禁食12h以上静脉血,检测血浆Hcy、UA、血糖、肝功能指标及肾功能指标等。分析不同性别、年龄人群Hcy与UA水平与变化趋势,以及Hcy与UA的关系。结果:不同年龄段男性Hcy与UA水平均高于女性。男性Hcy水平随着年龄增长呈"U"型曲线变化;女性Hcy水平从40～49岁年龄段开始,随年龄增长逐渐升高。男性UA水平随年龄增长呈"杓"形曲线变化,19～29岁年龄段UA水平最高,之后随年龄增长逐渐下降,至60～69岁UA水平最低,70岁以上年龄段UA水平再次逐渐升高;女性UA整体水平随年龄增长而增长。高Hcy组人群UA水平较正常Hcy组明显增高。结论:健康体检人群血Hcy、UA水平男性高于女性。高Hcy者血UA水平较Hcy正常者明显升高。不同年龄段Hcy与UA水平分布不同。应结合高发年龄段给予其重点指导干预,以达到节约成本、预防疾病的目的。
Objective:To investigate levels of plasma homocysteine(Hcy)and blood uric acid(UA)in healthy people,and provide the heoretical basis for the prevention and control of chronic diseases(hypertension,diabetes,stroke,coronary heart disease,dyslipidemia and so on).Method:A total of 11 166 cases who undertook physical examination from June 2014 to March 2016 were included,including 6 995 males and 4 171 females.Hcy,UA,blood glucose,liver function,renal function and other biochemical indexes(more than 12 hours of fasting venous blood)were measured.Differences and trends of Hcy and UA levels in different gender and age groups were compared,and the relationship between HCY and UA was analyzed.Result:Hcy and UA levels of men were higher than those of women in different age groups.The level of male Hcy was a " U" curve with age,and the level of female Hcy began to rise from the age of 40-49.The level of male UA showed a " dipper" curve,with the highest level of UA appeared in 19-29 years old,then gradually decreased with age,and the lowest level of UA appeared at the age of 60-69,then gradually increased again in the age of 70.The overall level of female UA raised with the increase of age.Serum UA level in the high Hcy group was significantly higher than that in the normal Hcy group.Conclusion:Levels of Hcy and UA in healthy men are higher than those in women.The UA level in the high Hcy group is significantly higher than that in the normal Hcy group.The distribution of Hcy and UA in different age groups is different.In order to save costs and prevent diseases,we should give high-risk populations guidances and interventions.
Objective:To investigate levels of plasma homocysteine(Hcy)and blood uric acid(UA)in healthy people,and provide the heoretical basis for the prevention and control of chronic diseases(hypertension,diabetes,stroke,coronary heart disease,dyslipidemia and so on).Method:A total of 11 166 cases who undertook physical examination from June 2014 to March 2016 were included,including 6 995 males and 4 171 females.Hcy,UA,blood glucose,liver function,renal function and other biochemical indexes(more than 12 hours of fasting venous blood)were measured.Differences and trends of Hcy and UA levels in different gender and age groups were compared,and the relationship between HCY and UA was analyzed.Result:Hcy and UA levels of men were higher than those of women in different age groups.The level of male Hcy was a " U" curve with age,and the level of female Hcy began to rise from the age of 40-49.The level of male UA showed a " dipper" curve,with the highest level of UA appeared in 19-29 years old,then gradually decreased with age,and the lowest level of UA appeared at the age of 60-69,then gradually increased again in the age of 70.The overall level of female UA raised with the increase of age.Serum UA level in the high Hcy group was significantly higher than that in the normal Hcy group.Conclusion:Levels of Hcy and UA in healthy men are higher than those in women.The UA level in the high Hcy group is significantly higher than that in the normal Hcy group.The distribution of Hcy and UA in different age groups is different.In order to save costs and prevent diseases,we should give high-risk populations guidances and interventions.
引文
[1]杨英,杨俊.同型半胱氨酸与心血管疾病关系的研究进展[J].临床心血管病杂志,2017,33(2):106-109.
[2]Perticone F,Maio R,Tassone JE,et al.Interaction between uric acid and endothelial dysfunction predicts new onset of diabetes in hypertensive patients[J].Int J Cardiol,2013,167(1):232-236.
[3]刘梅,施有为.高尿酸血症与临床相关疾病的关系及治疗[J].广东医学,2012,33(13):2023-2026.
[4]刘梅林,梁文奕,朱馨媛.尿酸对动脉粥样硬化的影响及相关机制[J].临床心血管病杂志,2013,29(1):3-6.
[5]常颂桔,黄伟.高尿酸血症与高血压及糖尿病相关性研究进展[J].中国医疗前沿,2012,7(23):11-13.
[6]修岩.高尿酸血症与血栓形成的关系[J].医学信息,2010,23(5):1471-1472.
[7]郑学军,李林臣,王晓霞,等.高尿酸血症干预方法研究进展[J].河北北方学院学报(自然科学版),2016,32(2):36-38.
[8]朱小莉,刘芳,王晓峰.同型半胱氨酸及雌激素对老年女性冠状动脉病变的影响[J].中国老年学杂志,2015,35(21):6083-6085.
[9]李开军,吴聪聪,向贻佳,等.绝经后女性冠心病患者雌激素水平与血同型半胱氨酸、血脂等关系的分析[J].心脑血管病防治,2014,14(3):222-224.
[10]华文娟,李雪峰,朱福海,等.体检人群血清同型半胱氨酸水平升高的影响因素分析[J].中国慢性病预防与控制,2017,25(11):824-827.
[11]雷艳梅,刘集鸿.高尿酸血症患病率及其与雌二醇水平相关性分析[J].广州医药,2018,49(3):37-39.
[12]张雅莉,谢亮,赵荣芳.强化膳食纤维饮食干预对肥胖合并高尿酸血症患者的影响[J].中国老年学杂志,2018,38(12):2817-2819.
[13]董燕燕,陈光亮.高同型半胱氨酸血症危害及致病机制研究进展[J].中国药理学通报,2014,30(9):1205-1208.
[14]乔云飞,李允模.同型半胱氨酸在呼吸系统疾病中的研究进展[J].医学综述,2016,22(6):1077-1080.
[15]李建成.同型半胱氨酸与心血管疾病[J].临床医学,2012,32(1):114-116.
[16]常颂桔,杨波,王洪雄,等.尿酸干预对老年高血压合并糖尿病患者缺血性脑卒中的影响[J].实用老年医学,2013,27(8):637-639.
[17]靖涛,宋志军,孙雯雯,等.高尿酸血症与非胰岛素依赖型糖尿病慢性并发症的关系[J].中国医学装备,2014,11(B12):80-80.
[18]赵鑫,陈章荣,吴新华,等.云南地区慢性心力衰竭患者血尿酸变化特点[J].临床心血管病杂志,2016,32(12):1232-1234.
[19]Malinow MR,Levenson J,Giral P,et al.Role of blood pressure,uric acid,and hemorheological parameters on plasma homocysline concentration[J].Atherosclerosis,1995,114(2):175-183.
[2]Perticone F,Maio R,Tassone JE,et al.Interaction between uric acid and endothelial dysfunction predicts new onset of diabetes in hypertensive patients[J].Int J Cardiol,2013,167(1):232-236.
[3]刘梅,施有为.高尿酸血症与临床相关疾病的关系及治疗[J].广东医学,2012,33(13):2023-2026.
[4]刘梅林,梁文奕,朱馨媛.尿酸对动脉粥样硬化的影响及相关机制[J].临床心血管病杂志,2013,29(1):3-6.
[5]常颂桔,黄伟.高尿酸血症与高血压及糖尿病相关性研究进展[J].中国医疗前沿,2012,7(23):11-13.
[6]修岩.高尿酸血症与血栓形成的关系[J].医学信息,2010,23(5):1471-1472.
[7]郑学军,李林臣,王晓霞,等.高尿酸血症干预方法研究进展[J].河北北方学院学报(自然科学版),2016,32(2):36-38.
[8]朱小莉,刘芳,王晓峰.同型半胱氨酸及雌激素对老年女性冠状动脉病变的影响[J].中国老年学杂志,2015,35(21):6083-6085.
[9]李开军,吴聪聪,向贻佳,等.绝经后女性冠心病患者雌激素水平与血同型半胱氨酸、血脂等关系的分析[J].心脑血管病防治,2014,14(3):222-224.
[10]华文娟,李雪峰,朱福海,等.体检人群血清同型半胱氨酸水平升高的影响因素分析[J].中国慢性病预防与控制,2017,25(11):824-827.
[11]雷艳梅,刘集鸿.高尿酸血症患病率及其与雌二醇水平相关性分析[J].广州医药,2018,49(3):37-39.
[12]张雅莉,谢亮,赵荣芳.强化膳食纤维饮食干预对肥胖合并高尿酸血症患者的影响[J].中国老年学杂志,2018,38(12):2817-2819.
[13]董燕燕,陈光亮.高同型半胱氨酸血症危害及致病机制研究进展[J].中国药理学通报,2014,30(9):1205-1208.
[14]乔云飞,李允模.同型半胱氨酸在呼吸系统疾病中的研究进展[J].医学综述,2016,22(6):1077-1080.
[15]李建成.同型半胱氨酸与心血管疾病[J].临床医学,2012,32(1):114-116.
[16]常颂桔,杨波,王洪雄,等.尿酸干预对老年高血压合并糖尿病患者缺血性脑卒中的影响[J].实用老年医学,2013,27(8):637-639.
[17]靖涛,宋志军,孙雯雯,等.高尿酸血症与非胰岛素依赖型糖尿病慢性并发症的关系[J].中国医学装备,2014,11(B12):80-80.
[18]赵鑫,陈章荣,吴新华,等.云南地区慢性心力衰竭患者血尿酸变化特点[J].临床心血管病杂志,2016,32(12):1232-1234.
[19]Malinow MR,Levenson J,Giral P,et al.Role of blood pressure,uric acid,and hemorheological parameters on plasma homocysline concentration[J].Atherosclerosis,1995,114(2):175-183.