超敏C反应蛋白和胱抑素C与冠心病的关联性研究
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摘要
目的分析超敏C反应蛋白(hs-CRP)和胱抑素C(Cys-C)与冠心病的关联性。方法选取2017-08~2018-01收治的冠心病患者218例作为冠心病组,再根据Gensini评分结果分为三组:≤30分为轻度病变组77例,30~48分为中度病变组69例,≥48分为重度病变组72例,另外选取同时期健康体检者48名作为对照组。hs-CRP浓度和Cys-C浓度均采用免疫透射比浊法测定。结果冠心病组hs-CRP和Cys-C均高于对照组(P<0.05)。与轻度病变和中度病变组比较,重度病变组hs-CRP和Cys-C均显著升高(P<0.05)。与轻度病变组比较,中度病变组hs-CRP和Cys-C均显著升高(P<0.05)。结论 hs-CRP和Cys-C与冠心病的严重程度存在关联性。
Objective To study the correlation between hypersensitive C reactive protein(hs-CRP) and cystatin C(Cys-C) in coronary heart disease.Methods Two hundred and eighteen patients with coronary heart disease were collected as coronary heart disease group from August 2017 to January 2018.The patients in the coronary heart disease group were divided into three subgroups according to Gensini scores:mild lesion group(Gensini scores≤30 points,n=77),moderate lesion group(Gensini scores=30 ~ 48 points,n=69) and severe lesion group(Gensini scores≥48 points,n=72).48 healthy subjects during the same period were selected as control group.hs-CRP and Cys-C were determined by immunoturbidimetry.Results The levels of hs-CRP and Cys-C in the coronary heart disease group were significantly higher than those in the control group(P<0.05).Compared with those in the mild lesion group and the moderate lesion group,the levels of hs-CRP and Cys-C in the severe lesion group were significantly evelated(P<0.05).Compared with those in the mild lesion group,the levels of hs-CRP and Cys-C in the moderate lesion group were significantly elevated(P<0.05).Conclusion hs-CRP and Cys-C are significantly correlated with the severity of coronary heart disease.
Objective To study the correlation between hypersensitive C reactive protein(hs-CRP) and cystatin C(Cys-C) in coronary heart disease.Methods Two hundred and eighteen patients with coronary heart disease were collected as coronary heart disease group from August 2017 to January 2018.The patients in the coronary heart disease group were divided into three subgroups according to Gensini scores:mild lesion group(Gensini scores≤30 points,n=77),moderate lesion group(Gensini scores=30 ~ 48 points,n=69) and severe lesion group(Gensini scores≥48 points,n=72).48 healthy subjects during the same period were selected as control group.hs-CRP and Cys-C were determined by immunoturbidimetry.Results The levels of hs-CRP and Cys-C in the coronary heart disease group were significantly higher than those in the control group(P<0.05).Compared with those in the mild lesion group and the moderate lesion group,the levels of hs-CRP and Cys-C in the severe lesion group were significantly evelated(P<0.05).Compared with those in the mild lesion group,the levels of hs-CRP and Cys-C in the moderate lesion group were significantly elevated(P<0.05).Conclusion hs-CRP and Cys-C are significantly correlated with the severity of coronary heart disease.
引文
1刘子铭,赵菲菲,李凯勇,等.中性粒细胞与淋巴细胞比值和冠心病关系的探讨[J].武汉大学学报(医学版),2018,39(1):114-119.
2齐宏,黄珊,马祥生,等.同型半胱氨酸、高敏C反应蛋白及胱抑素C和脂蛋白相关磷脂酶A2与冠心病的相关性[J].广东医学,2014,35(14):2253-2256.
3谭小林,熊文娟,杜东平.胱抑素C、同型半胱氨酸、超敏C反应蛋白、总胆固醇、低密度脂蛋白胆固醇与急性脑梗死的关系[J].西南军医,2014,16(4):385-387.
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6邰胜,王翎,钱惠英.高龄老年高血压患者高敏C反应蛋白与血压节律的关系[J].临床心血管病杂志,2018,34(6):559-562.
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8杨淑珍,孙宇.血清胱抑素C和尿酸水平对冠心病病变程度的预测价值[J].中国实验诊断学,2014,18(2):265-266.
9杨曙光,汤学超.血清胱抑素C水平与冠心病严重程度的关系[J].中国动脉硬化杂志,2014,22(12):1247-1250.
10刘卫华,庞振瑶.冠心病介入治疗前后心功能与胱抑素C的对比观察[J].中国临床新医学,2010,3(1):38-40.
11郭守玉,龙明智.冠心病患者胱抑素C水平与冠状动脉造影Gensini评分的相关性[J].检验医学与临床,2012,9(4):385-386,388.
12陈湘桂,仇昌智,刘醒存.冠心病患者不同胱抑素C和同型半胱氨酸水平与冠状动脉病变的相关性[J].临床心血管病杂志,2009,25(8):609-611.
2齐宏,黄珊,马祥生,等.同型半胱氨酸、高敏C反应蛋白及胱抑素C和脂蛋白相关磷脂酶A2与冠心病的相关性[J].广东医学,2014,35(14):2253-2256.
3谭小林,熊文娟,杜东平.胱抑素C、同型半胱氨酸、超敏C反应蛋白、总胆固醇、低密度脂蛋白胆固醇与急性脑梗死的关系[J].西南军医,2014,16(4):385-387.
4凌琳,承艳,康丽娜,等.冠心病患者血清高敏C反应蛋白和Periostin蛋白与冠状动脉病变严重程度的相关性[J].中国动脉硬化杂志,2013,21(5):440-444.
5钟雷,苏德淳,丛涛,等.白细胞计数和中性粒/淋巴比值与冠心病斑块负荷的关系研究[J].大连医科大学学报,2014,36(4):367-371.
6邰胜,王翎,钱惠英.高龄老年高血压患者高敏C反应蛋白与血压节律的关系[J].临床心血管病杂志,2018,34(6):559-562.
7童海,涂玉林.高敏C反应蛋白与动脉粥样硬化[J].中国动脉硬化杂志,2010,18(9):746-750.
8杨淑珍,孙宇.血清胱抑素C和尿酸水平对冠心病病变程度的预测价值[J].中国实验诊断学,2014,18(2):265-266.
9杨曙光,汤学超.血清胱抑素C水平与冠心病严重程度的关系[J].中国动脉硬化杂志,2014,22(12):1247-1250.
10刘卫华,庞振瑶.冠心病介入治疗前后心功能与胱抑素C的对比观察[J].中国临床新医学,2010,3(1):38-40.
11郭守玉,龙明智.冠心病患者胱抑素C水平与冠状动脉造影Gensini评分的相关性[J].检验医学与临床,2012,9(4):385-386,388.
12陈湘桂,仇昌智,刘醒存.冠心病患者不同胱抑素C和同型半胱氨酸水平与冠状动脉病变的相关性[J].临床心血管病杂志,2009,25(8):609-611.