火针联合异维A酸红霉素凝胶治疗泛发性扁平疣临床疗效及机制
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摘要
目的:探讨火针联合异维A酸红霉素凝胶治疗泛发性扁平疣患者临床效果。方法:选择泛发性扁平疣患者共78例,按照随机数字的方法分为两组,对照组和观察组,每组39例患者,对照组患者给予异维A酸红霉素凝胶治疗,观察组患者在对照组基础上联合火针治疗,对治疗的效果进行分析。结果:经过治疗后,对照组患者的白细胞介素-2,白细胞介素-10,干扰素-γ,皮损计分分别从(17.72±6.25)ng/L,(10.35±2.26)ng/L,(22.71±5.61)ng/L,(7.41±2.05)分,变化为(24.21±4.27)ng/L,(8.02±2.00)ng/L,(25.61±4.58)ng/L,(4.91±1.51)分,观察组患者的白细胞介素-2,白细胞介素-10,干扰素-γ,皮损计分分别从(17.56±5.81)ng/L,(10.43±2.18)ng/L,(22.98±6.47)ng/L,(7.45±2.28)分,变化为(29.15±3.66)ng/L,(6.61±1.81)ng/L,(33.25±5.12)ng/L,(3.31±1.41)分,观察组患者改善的程度高于对照组患者,数据差异均具有统计学意义(t=-5.486,3.264,-6.945,4.836,P<0.05),观察组患者的治疗效果优于对照组患者,数据差异具有统计学意义(z=-6.555,P<0.05),两组患者在治疗过程中所出现的各项不良反应发生率的数据差异均不具有统计学意义(χ~2=0.214,0.157,0.126,0.347,2.053,P>0.05),对照组患者复发率为12.82%(5/39),观察组患者复发率为0.05%(2/39),数据差异具有统计学意义(χ~2=5.342,P<0.05)。结论:使用火针联合异维A酸红霉素凝胶治疗扁平疣患者,可以改善免疫因子,提升治疗效果,安全性良好。
Objective:To investigate the clinical effect of fire needle combined with isotretinoin erythromycin gel in the treatment of generalized flat wart. Methods:A total of 78 patients with generalized verruca were selected. According to the random number method, the patients were divided into the control group and the observation group, with 39 patients in each group. The patients in the control group were treated with erythromycin isovitamin A acid gel, and the observation group was treated with fire needle on the basis of the control group, and the effect of the treatment was analyzed. Results:After treatment, the control group's interleukin-2, interleukin-10, interferon-γ and skin lesion scores from(17.72±6.25)ng/L,(10.35±2.26)ng/L,(22.71±5.61)ng/L and(7.41±2.05)points respectively changed to(24.21±4.27)ng/L,(8.02±2.00)ng/L,(25.61±4.58)ng/L and(4.91±1.51)points. The interleukin-2, interleukin-10, interferon-γ and skin lesion scores of the observation group changed from(17.56±5.81)ng/L,(10.43±2.18)ng/L,(22.98±6.47)ng/L and(7.45±2.28)points to(29.15±3.66)ng/L,(6.61±1.81)ng/L,(33.25±5.12) ng/L and(3.31±1.41)points. The improvement of patients in the observation group was higher than that of the control group, and the data was statistically significant(t=-5.486, 3.264,-6.945, 4.836, P<0.05). The treatment effect of the observation group was better than that of the control group, and the data was statistically significant(z=-6.555, P<0.05). There were no statistically significant differences in the incidence of adverse events between the two groups(χ~2=0.214, 0.157, 0.126, 0.347, 2.053, P>0.05). The recurrence rate was 12.82%(5/39) in the control group and 0.05%(2/39) in the observation group. The difference was statistically significant(χ~2=5.342, P<0.05). Conclusion:The use of fire needle combined with isotretinoin erythromycin gel in the treatment of patients with flat warts can improve immune factors, the treatment effect and has good safety.
Objective:To investigate the clinical effect of fire needle combined with isotretinoin erythromycin gel in the treatment of generalized flat wart. Methods:A total of 78 patients with generalized verruca were selected. According to the random number method, the patients were divided into the control group and the observation group, with 39 patients in each group. The patients in the control group were treated with erythromycin isovitamin A acid gel, and the observation group was treated with fire needle on the basis of the control group, and the effect of the treatment was analyzed. Results:After treatment, the control group's interleukin-2, interleukin-10, interferon-γ and skin lesion scores from(17.72±6.25)ng/L,(10.35±2.26)ng/L,(22.71±5.61)ng/L and(7.41±2.05)points respectively changed to(24.21±4.27)ng/L,(8.02±2.00)ng/L,(25.61±4.58)ng/L and(4.91±1.51)points. The interleukin-2, interleukin-10, interferon-γ and skin lesion scores of the observation group changed from(17.56±5.81)ng/L,(10.43±2.18)ng/L,(22.98±6.47)ng/L and(7.45±2.28)points to(29.15±3.66)ng/L,(6.61±1.81)ng/L,(33.25±5.12) ng/L and(3.31±1.41)points. The improvement of patients in the observation group was higher than that of the control group, and the data was statistically significant(t=-5.486, 3.264,-6.945, 4.836, P<0.05). The treatment effect of the observation group was better than that of the control group, and the data was statistically significant(z=-6.555, P<0.05). There were no statistically significant differences in the incidence of adverse events between the two groups(χ~2=0.214, 0.157, 0.126, 0.347, 2.053, P>0.05). The recurrence rate was 12.82%(5/39) in the control group and 0.05%(2/39) in the observation group. The difference was statistically significant(χ~2=5.342, P<0.05). Conclusion:The use of fire needle combined with isotretinoin erythromycin gel in the treatment of patients with flat warts can improve immune factors, the treatment effect and has good safety.
引文
[1] 夏登梅,李红林,詹凌,等.调Q开关532nm Nd:YAG激光联合重组人干扰素ɑ-2b乳膏治疗面部扁平疣疗效分析[J].中国美容医学,2018,27(2):76-78.
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[10] 曾芬,曹志翔.玉屏风滴丸联合聚肌胞皮损内注射治疗扁平疣的疗效观察[J].实用临床医药杂志,2017,21(21):194,196.
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[12] 童辉,石年,龚玲珍,等.金叶败毒颗粒联合火针治疗扁平疣的临床观察[J].中国中西医结合皮肤性病学杂志,2017,16(5):425-426.
[13] 赵欣,王建修,刘春雷,等.活血补肾法结合火针治疗白癜风临床效果观察[J].临床合理用药杂志,2018,11(5):113-114.
[14] 《针灸技术操作规范第12 部分:火针》项目组.中华人民共和国国家标准(GB/T20709.2-2008)针灸技术操作规范第12部分:火针[S].中国针灸,2009(12):1004-1007.
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[16] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,2002:300.
[17] 蒋存火,程孝顶,曲善忠,等.火针+甘露聚糖肽胶囊治疗面部难治性扁平疣60例疗效观察[J].中国医药导刊,2017,19(6):606-607.
[18] 李金勇,周洪文,封常霞,等.香蓝驱毒颗粒治疗扁平疣临床疗效及对IL-10、IFN-γ的影响[J].中国中西医结合皮肤性病学杂志,2017,16(3):206-208.
[19] 阮仁杰.自制中药倒膜联合火针治疗面部扁平疣60例疗效观察[J].中国中西医结合皮肤性病学杂志,2017,16(3):245-246.
[20] 葛海燕,吴瑾,王纯,等.卡介菌多糖核酸联合伊可尔治疗面部扁平疣的疗效分析[J].东南国防医药,2017,19(3):309-310.
[21] 刘煜,杨海平.调Q激光与自体疣植入治疗扁平疣的疗效比较[J].皮肤病与性病,2017,39(3):210-212.
[22] 孙永新.卡介苗多糖核酸注射液与异维A酸红霉素凝胶联合治疗扁平疣[J].中国冶金工业医学杂志,2014,31(1):20.
[23] 冯红梅,周佩,王灵姣,等.火针治疗扁平疣的研究进展[J].湖南中医杂志,2017,33(10):205-206.
[2] 孙瑜,张峻岭,刘栋,等.47例扁平疣的皮肤镜特征分析[J].中国中西医结合皮肤性病学杂志,2018,17(1):6-8.
[3] 许岳亭,魏跃钢.中西医结合治疗颜面部扁平疣34例临床观察[J].江苏中医药,2018,50(2):37-39.
[4] 周艳娣.卡介菌多糖核酸联合维A酸乳膏治疗扁平疣患者的临床观察[J].中外医学研究,2018,16(4):37-38.
[5] 韩春玉,王琪,夏秀娟,等.火针联合重组人干扰素α-2b凝胶治疗扁平疣疗效分析[J].中国保健营养,2018,28(1):322-323.
[6] 唐莉,林琳,肖艳,等.Er∶YAG点阵激光联合10%5-氨基酮戊酸光动力治疗顽固性扁平疣的疗效[J].中华医学美学美容杂志,2017,23(6):393-395.
[7] 毕兴杰,范崇帅,高峰,等.达表去毒汤联合α-2b干扰素软膏治疗扁平疣的临床研究[J].中国麻风皮肤病杂志,2017,33(11):679-680.
[8] 李明鑫,李波.扁平疣的治疗新进展[J].中国现代医生,2017,55(33):165-168.
[9] 唐艳.维A酸乳膏联合重组人干扰素α-2b凝胶治疗扁平疣疗效的影响[J].中国微生态学杂志,2018,30(2):197-199.
[10] 曾芬,曹志翔.玉屏风滴丸联合聚肌胞皮损内注射治疗扁平疣的疗效观察[J].实用临床医药杂志,2017,21(21):194,196.
[11] 陈俊杰,黄玉成,李天举,等.耳穴刺络放血联合改良疣体包埋术治疗扁平疣疗效观察[J].中国中西医结合皮肤性病学杂志,2017,16(5):417-418.
[12] 童辉,石年,龚玲珍,等.金叶败毒颗粒联合火针治疗扁平疣的临床观察[J].中国中西医结合皮肤性病学杂志,2017,16(5):425-426.
[13] 赵欣,王建修,刘春雷,等.活血补肾法结合火针治疗白癜风临床效果观察[J].临床合理用药杂志,2018,11(5):113-114.
[14] 《针灸技术操作规范第12 部分:火针》项目组.中华人民共和国国家标准(GB/T20709.2-2008)针灸技术操作规范第12部分:火针[S].中国针灸,2009(12):1004-1007.
[15] Yang YL,Sang J,Liao NX,et al.Off-label photodynamic therapy for recalcitrant facial flat warts using topical 5-aminolevulinic acid[J].Lasers Med Sci,2016,31(5):929-936.
[16] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,2002:300.
[17] 蒋存火,程孝顶,曲善忠,等.火针+甘露聚糖肽胶囊治疗面部难治性扁平疣60例疗效观察[J].中国医药导刊,2017,19(6):606-607.
[18] 李金勇,周洪文,封常霞,等.香蓝驱毒颗粒治疗扁平疣临床疗效及对IL-10、IFN-γ的影响[J].中国中西医结合皮肤性病学杂志,2017,16(3):206-208.
[19] 阮仁杰.自制中药倒膜联合火针治疗面部扁平疣60例疗效观察[J].中国中西医结合皮肤性病学杂志,2017,16(3):245-246.
[20] 葛海燕,吴瑾,王纯,等.卡介菌多糖核酸联合伊可尔治疗面部扁平疣的疗效分析[J].东南国防医药,2017,19(3):309-310.
[21] 刘煜,杨海平.调Q激光与自体疣植入治疗扁平疣的疗效比较[J].皮肤病与性病,2017,39(3):210-212.
[22] 孙永新.卡介苗多糖核酸注射液与异维A酸红霉素凝胶联合治疗扁平疣[J].中国冶金工业医学杂志,2014,31(1):20.
[23] 冯红梅,周佩,王灵姣,等.火针治疗扁平疣的研究进展[J].湖南中医杂志,2017,33(10):205-206.