摘要
朗格汉斯细胞(LC)是表皮中重要的抗原递呈细胞,其特异性表达的CD207蛋白对于细胞发挥抗原免疫清除和免疫调节等功能有重要作用。CD207在皮肤病毒感染(人类免疫缺陷病毒(HIV)、麻疹、人乳头瘤病毒(HPV))、细菌感染(麻风分枝杆菌、表皮葡萄球菌)、真菌感染(念珠菌、马拉色菌及酵母菌属)、过敏性皮肤病、皮肤肿瘤等皮肤疾病的免疫调节机制中发挥重要作用。该文就CD207与皮肤疾病相关的研究进展进行综述。
引文
[1] Valladeau J,Ravel O,Dezutter-Dambuyant C,et al.Langerin,a novel C-type lectin specific to Langerhans cells,is an endocytic receptor that induces the formation of Birbeck granules[J].Immunity,2000,12(1):71-81.
[2] Takahara K,Omatsu Y,Yashima Y,et al.Identification and expression of mouse Langerin (CD207) in dendritic cells[J].Int Immunol,2002,14(5):433-44.
[3] van den Berg L M,Ribeiro C M,Zijlstra-Willems E M,et al.Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells[J].Retrovirology,2014,11:123.
[4] Hunger R E,Sieling P A,Ochoa M T,et al.Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells[J].J Clin Invest,2004,113(5):701-8.
[5] de Witte L,Nabatov A,Pion M,et al.Langerin is a natural barrier to HIV-1 transmission by Langerhans cells[J].Nat Medi,2007,13(3):367-71.
[6] de Jong M A,de Witte L,Oudhoff M J,et al.TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo[J].J Clin Invest,2008,118(10):3440-52.
[7] van der Vlist M,de Witte L,de Vries R D,et al.Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4(+) T cells but are incapable of cross-presentation[J].Eur J Immunol,2011,41(9):2619-31.
[8] Bousarghin L,Hubert P,Franzen E,et al.Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells[J].J Gene Virol,2005,86(Pt 5):1297-305.
[9] 冯进云,饶国洲,刘玉萍,等.尖锐湿疣表皮CD1a和CD207的表达[J].细胞与分子免疫学杂志,2009,25(5):420-2.
[10] Kim H J,Brennan P J,Heaslip D,et al.Carbohydrate-dependent binding of langerin to SodC,a cell wall glycoprotein of Mycobacterium leprae[J].J Bacteriol,2015,197(3):615-25.
[11] Miranda A,Amadeu T P,Schueler G,et al.Increased Langerhans cell accumulation after mycobacterial stimuli[J].Histopathology,2007,51(5):649-56.
[12] Naik S,Bouladoux N,Wilhelm C,et al.Compartmentalized control of skin immunity by resident commensals[J].Science,2012,337(6098):1115-9.
[13] 张月强.CD207在Langerhans细胞介导对皮肤菌群免疫应答中的作用及机制[D].第四军医大学,2017.
[14] 俞先水,张小宁,陈婷,等.C型凝集素受体CD207对表皮葡萄球菌的结合[J].中国皮肤性病学杂志,2015,29(5):451-4.
[15] 张月强,陈婷,陈长城,等.朗格汉斯细胞通过CD207参与皮肤对表皮葡萄球菌的免疫应答[J].中国皮肤性病学杂志,2017,31(5):490-3.
[16] de Jong M A,Vriend L E,Theelen B,et al.C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi[J].Mol Immunol,2010,47(6):1216-25.
[17] Barboza T C,Quaresma J A,de Brito A C,et al.Jorge Lobo's disease:immunohistochemical characterization of dendritic cells in cutaneous lesions[J].Mycopathologia,2015,179(3-4):269-74.
[18] Wang L,Bursch L S,Kissenpfennig A,et al.Langerin expressing cells promote skin immune responses under defined conditions[J].J Immunol,2008,180(7):4722-7.
[19] Lee J H,Tsai M R,Sun C K,et al.Evaluation of the role of CD207 on Langerhans cells in a murine model of atopic dermatitis by in situ imaging using Cr:forsterite laser-based multimodality nonlinear microscopy[J].J Biomed Opt,2012,17(11):116007.
[20] Dubrac S,Schmuth M,Ebner S.Atopic dermatitis:the role of Langerhans cells in disease pathogenesis[J].Immunol Cell Biol,2010,88(4):400-9.
[21] Cai X Y,Zheng X D,Fang L,et al.A variant on chromosome 2p13.3 is associated with atopic dermatitis in Chinese Han population[J].Gene,2017,628:281-5.
[22] Shevchuk Z,Filip A,Shevchuk V,et al.Number of Langerhans cells is decreased in premalignant keratosis and skin cancers[J].Exp Oncol,2014,36(1):34-7.
[23] Gerber A L,Munst A,Schlapbach C,et al.High expression of FOXP3 in primary melanoma is associated with tumour progression[J].Br J Dermatol,2014,170(1):103-9.
[24] Tan S K,Chieng L O,Madhavan K,et al.Indeterminate dendritic cell tumor in thoracic spine:a case report[J].World Neurosurg,2017,108:543-7.
[25] Glitzner E,Korosec A,Brunner P M,et al.Specific roles for dendritic cell subsets during initiation and progression of psoriasis[J].EMBO Mol Med,2014,6(10):1312-27.