微小RNA-214在宫颈癌中的研究进展
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摘要
微小RNA(miRNA)可在转录后水平调控肿瘤相关基因的表达,从而在肿瘤发生发展等过程中发挥重要作用。研究显示,miR-214在宫颈癌细胞中表达异常,并可通过与多种宫颈癌相关基因(包括Plexin-B1、GALNT7以及TFAM等)的相互作用抑制宫颈癌细胞的增殖、迁移、侵袭能力,促进宫颈癌细胞的凋亡。文中就近年来有关miR-214在宫颈癌中的研究进展进行综述,以期探索miR-214与宫颈癌发生发展之间的关系,并为宫颈癌的临床诊断和治疗提供新的思路。
MicroRNAs( miRNAs) play important roles in the processes of the occurrence and development of cancers,through regulating tumor related gene expression at post-transcription. It has shown that the expression of miR-214 is aberrant in cervical cancer. Also,miR-214 could affect the proliferation,migration,invasion and apoptosis of tumor cells by targeting various genes. This article focuses on the studies of miR-214 function in cervical cancer,and will provide a novel approach for the clinical diagnosis and the treatment of cervical cancer.
MicroRNAs( miRNAs) play important roles in the processes of the occurrence and development of cancers,through regulating tumor related gene expression at post-transcription. It has shown that the expression of miR-214 is aberrant in cervical cancer. Also,miR-214 could affect the proliferation,migration,invasion and apoptosis of tumor cells by targeting various genes. This article focuses on the studies of miR-214 function in cervical cancer,and will provide a novel approach for the clinical diagnosis and the treatment of cervical cancer.
引文
[1]Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.
[2]Campos-Viguri GE,Jimenez-Wences H,Peralta-Zaragoza O,et al.miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer[J].Infect Agent Cancer,2015,10:42.
[3]Peralta-Zaragoza O,Deas J,Meneses-Acosta A,et al.Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells[J].BMC Cancer,2016,16(1):215.
[4]Pillai RS,Bhattacharyya SN,Filipowicz W,et al.Repression of protein synthesis by miRNAs:how many mechanisms?[J]Trends Cell Biol,2007,17(3):118-126.
[5]Wu L,Fan J,Belasco JG,et al.MicroRNAs direct rapid deadenylation of mRNA[J].Proc Natl Acad Sci USA,2006,103(11):4034-4039.
[6]Zhou H,Yang YH,Basile JR,et al.The Semaphorin 4D-Plexin-B1-Rho A signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4[J].Angiogenesis,2014,17(1):1-14.
[7]Peng RQ,Wan HY,Li HF,et al.MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7[J].J Biol Chem,2012,287(17):14301-14309.
[8]Ding X,Qiu L,Zhang L,et al.The role of semaphorin 4D as a potential biomarker for antiangiogenic therapy in colorectal cancer[J].Onco Targets Ther,2016,9:1189-1204.
[9]Hofmann BT,Schlüter L,Lange P,et al.COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer[J].Mol Cancer,2015,14(1):1-15.
[10]Nie GH,Luo L,Duan HF,et al.GALNT7,a target of miR-494,participates in the oncogenesis of nasopharyngeal carcinoma[J].Tumour Biol,2016,37(4):1-9.
[11]Xie D,Wu X,Lan L,et al.Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics[J].Oncotarget,2016,7(10):11609-11624.
[12]Tie J,Desai J.Antiangiogenic therapies targeting the vascular endothelia growth factor signaling system[J].Crit Rev Oncog,2012,17(1):51-67.
[13]Basile JR,Barac A,Zhu T,et al.Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B[J].Cancer Res,2004,64(15):5212-5224.
[14]Qiang R,Wang F,Shi LY,et al.Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of He La cells[J].Int J Biochem Cell Biol,2011(43):632-641.
[15]Hua S,Saunders M,Dimapasoc LM,et al.Differentiation of cancer cell origin and molecular subtype by plasma membrane N-glycan profiling[J].J Proteome Res,2014,13(2):961-968.
[16]Casey RC,Oegema TR,Jr,Skubitz KM,et al.Cell membrane glycosylation mediates the adhesion,migration,and invasion of ovarian carcinoma cells[J].Clin Exp Metastasis,2003,20(2):143-152.
[17]Vojta A,Samarzija I,Bockor L,et al.Glyco-genes change expression in cancer through aberrant methylation[J].Biochim Biophys Acta,2016,1860(8):1776-1785.
[18]Garstka HL,Schmitt WE,Schultz J,et al.Import of mitochondrial transcription factor A(TFAM)into rat liver mitochondria stimulates transcription of mitochondrial DNA[J].Nucleic Acids Res,2003,31(17):5039-5047.
[19]李海霞,鲁艳明,温冬雪,等.凋亡诱导因子在宫颈癌组织中的表达及意义[J].中国医科大学学报,2009,38(4):268-273.
[20]Wen Z,Lei Z,Jin-An M,et al.The inhibitory role of miR-214in cervical cancer cells through directly targeting mitochondrial transcription factor A(TFAM)[J].Eur J Gynaecol Oncol,2014,35(6):676-682.
[21]朱玲,王祥喜,李雪梅.TRAIL诱导肿瘤细胞凋亡的分子机制及其在肿瘤生物治疗中的应用前景[J].生物物理学报,2012,28(6):448-456.
[22]Wang F,Liu M,Li X,et al.MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells[J].FEBS Lett,2013,587(5):488-495.
[23]Yang Z,Chen S,Luan X,et al.MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of He La cells[J].IUBMB Life,2009,61(11):1075-1082.
[24]Ranjan K,Pathak C.Expression of c FLIP Determines the Basal Interaction of Bcl-2 with Beclin-1 and Regulates p53 Dependent Ubiquitination of Beclin-1 During Autophagic Stress[J].J Cell Biochem,2016,117(8):1757-1768.
[25]Srinivas KP,Viji R,Dan VM,et al.DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by upregulating p38 MAP kinase[J].Oncotarget,2016,7(17):24154-24171.
[26]张有为,王锐,宋海珠.非小细胞肺癌相关抑癌基因甲基化谱的研究[J].医学研究生学报,2010,23(7):713-720.
[2]Campos-Viguri GE,Jimenez-Wences H,Peralta-Zaragoza O,et al.miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer[J].Infect Agent Cancer,2015,10:42.
[3]Peralta-Zaragoza O,Deas J,Meneses-Acosta A,et al.Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells[J].BMC Cancer,2016,16(1):215.
[4]Pillai RS,Bhattacharyya SN,Filipowicz W,et al.Repression of protein synthesis by miRNAs:how many mechanisms?[J]Trends Cell Biol,2007,17(3):118-126.
[5]Wu L,Fan J,Belasco JG,et al.MicroRNAs direct rapid deadenylation of mRNA[J].Proc Natl Acad Sci USA,2006,103(11):4034-4039.
[6]Zhou H,Yang YH,Basile JR,et al.The Semaphorin 4D-Plexin-B1-Rho A signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4[J].Angiogenesis,2014,17(1):1-14.
[7]Peng RQ,Wan HY,Li HF,et al.MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7[J].J Biol Chem,2012,287(17):14301-14309.
[8]Ding X,Qiu L,Zhang L,et al.The role of semaphorin 4D as a potential biomarker for antiangiogenic therapy in colorectal cancer[J].Onco Targets Ther,2016,9:1189-1204.
[9]Hofmann BT,Schlüter L,Lange P,et al.COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer[J].Mol Cancer,2015,14(1):1-15.
[10]Nie GH,Luo L,Duan HF,et al.GALNT7,a target of miR-494,participates in the oncogenesis of nasopharyngeal carcinoma[J].Tumour Biol,2016,37(4):1-9.
[11]Xie D,Wu X,Lan L,et al.Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics[J].Oncotarget,2016,7(10):11609-11624.
[12]Tie J,Desai J.Antiangiogenic therapies targeting the vascular endothelia growth factor signaling system[J].Crit Rev Oncog,2012,17(1):51-67.
[13]Basile JR,Barac A,Zhu T,et al.Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B[J].Cancer Res,2004,64(15):5212-5224.
[14]Qiang R,Wang F,Shi LY,et al.Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of He La cells[J].Int J Biochem Cell Biol,2011(43):632-641.
[15]Hua S,Saunders M,Dimapasoc LM,et al.Differentiation of cancer cell origin and molecular subtype by plasma membrane N-glycan profiling[J].J Proteome Res,2014,13(2):961-968.
[16]Casey RC,Oegema TR,Jr,Skubitz KM,et al.Cell membrane glycosylation mediates the adhesion,migration,and invasion of ovarian carcinoma cells[J].Clin Exp Metastasis,2003,20(2):143-152.
[17]Vojta A,Samarzija I,Bockor L,et al.Glyco-genes change expression in cancer through aberrant methylation[J].Biochim Biophys Acta,2016,1860(8):1776-1785.
[18]Garstka HL,Schmitt WE,Schultz J,et al.Import of mitochondrial transcription factor A(TFAM)into rat liver mitochondria stimulates transcription of mitochondrial DNA[J].Nucleic Acids Res,2003,31(17):5039-5047.
[19]李海霞,鲁艳明,温冬雪,等.凋亡诱导因子在宫颈癌组织中的表达及意义[J].中国医科大学学报,2009,38(4):268-273.
[20]Wen Z,Lei Z,Jin-An M,et al.The inhibitory role of miR-214in cervical cancer cells through directly targeting mitochondrial transcription factor A(TFAM)[J].Eur J Gynaecol Oncol,2014,35(6):676-682.
[21]朱玲,王祥喜,李雪梅.TRAIL诱导肿瘤细胞凋亡的分子机制及其在肿瘤生物治疗中的应用前景[J].生物物理学报,2012,28(6):448-456.
[22]Wang F,Liu M,Li X,et al.MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells[J].FEBS Lett,2013,587(5):488-495.
[23]Yang Z,Chen S,Luan X,et al.MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of He La cells[J].IUBMB Life,2009,61(11):1075-1082.
[24]Ranjan K,Pathak C.Expression of c FLIP Determines the Basal Interaction of Bcl-2 with Beclin-1 and Regulates p53 Dependent Ubiquitination of Beclin-1 During Autophagic Stress[J].J Cell Biochem,2016,117(8):1757-1768.
[25]Srinivas KP,Viji R,Dan VM,et al.DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by upregulating p38 MAP kinase[J].Oncotarget,2016,7(17):24154-24171.
[26]张有为,王锐,宋海珠.非小细胞肺癌相关抑癌基因甲基化谱的研究[J].医学研究生学报,2010,23(7):713-720.