谷氨酸脱氢酶与几种肿瘤的关系
|
摘要
大多数生物体中都含有谷氨酸脱氢酶(Glutamate dehydrogenase, GDH)(E.C. 1.4.1.2–1.4.1.4)。在真核生物中,该酶主要存在于线粒体中,并在氮和碳的代谢以及信号通路中起着至关重要的作用。研究发现谷氨酸脱氢酶与肿瘤发生及发展有一定的关系,对于肿瘤研究具有一定意义,但是关于其与人类肿瘤的关系方面的综述很少见。文中对谷氨酸脱氢酶与乳腺癌、胶质瘤、结直肠癌以及卵巢癌等的关系进行了归纳和总结,希望可以为相关研究提供帮助。
Most organisms contain glutamate dehydrogenase(E.C. 1.4.1.2–1.4.1.4). In eukaryotes, the enzyme is mainly present in mitochondria. This enzyme plays a vital role in the metabolism of nitrogen and carbon and the signaling pathway.Studies have found that glutamate dehydrogenase has a certain relationship with the occurrence and development of tumors,which is significant for tumor research, but reviews on its relationship with human tumors are rare. This review summarized the relationship between glutamate dehydrogenase and breast cancer, glioma, colorectal cancer and ovarian cancer, etc, thus providing assistance for related research.
Most organisms contain glutamate dehydrogenase(E.C. 1.4.1.2–1.4.1.4). In eukaryotes, the enzyme is mainly present in mitochondria. This enzyme plays a vital role in the metabolism of nitrogen and carbon and the signaling pathway.Studies have found that glutamate dehydrogenase has a certain relationship with the occurrence and development of tumors,which is significant for tumor research, but reviews on its relationship with human tumors are rare. This review summarized the relationship between glutamate dehydrogenase and breast cancer, glioma, colorectal cancer and ovarian cancer, etc, thus providing assistance for related research.
引文
[1]Oliveira T,Panjikar S,Carrigan JB,et al.Crystal structure of NAD+-dependent Peptoniphilus asaccharolyticus glutamate dehydrogenase reveals determinants of cofactor specificity.J Struct Biol,2012,177(2):543-552.
[2]Huang GC,Tian B.The physiological role of glutamate dehydrogenase in higher plants.Chin Bull Botany,2001,18(4):396-401(in Chinese).黄国存,田波.高等植物中的谷氨酸脱氢酶及其生理作用.植物学通报,2001,18(4):396-401.
[3]Britton KL,Baker PJ,Engel PC,et al.Evolution of substrate diversity in the superfamily of amino acid dehydrogenases:prospects for rational chiral synthesis.J Mol Biol,1993,234(4):938-945.
[4]Peterson PE,Smith TJ.The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery.Structure,1999,7(7):769-782.
[5]Maechler P,Carobbio S,Rubi B.In beta-cells,mitochondria integrate and generate metabolic signals controlling insulin secretion.Int J Biochem Cell Biol,2006,38(5/6):696-709.
[6]Wullschleger S,Loewith R,Hall MN.TOR signaling in growth and metabolism.Cell,2006,124(3):471-484.
[7]George A,Bell JE.Effects of adenosine5?-diphosphate on bovine glutamate dehydrogenase:diethyl pyrocarbonate modification.Biochemistry,1980,19(26):6057-6061.
[8]Britton KL,Baker PJ,Rice DW,et al.Structural relationship between the hexameric and tetrameric family of glutamate dehydrogenases.Eur J Biochem,1992,209(3):851-859.
[9]Austen BM,Haberland ME,Nyc JF,et al.Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora.IV.The COOH-terminal 669 residues of the peptide chain;Comparison with other glutamate dehydrogenases.JBiol Chem,1977,252(22):8142-8149.
[10]Werner C,Stubbs MT,Krauth-Siegel RL,et al.The crystal structure of Plasmodium falciparum glutamate dehydrogenase,a putative target for novel antimalarial drugs.J Mol Biol,2005,349(3):597-607.
[11]Hanahan D,Weinberg RA.Hallmarks of cancer:the next generation.Cell,2011,144(5):646-674.
[12]Wise DR,Thompson CB.Glutamine addiction:a new therapeutic target in cancer.Trends Biochem Sci,2010,35(8):427-433.
[13]Yuneva M,Zamboni N,Oefner P,et al.Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.J Cell Biol,2007,178(1):93-105.
[14]Yang LF,Moss T,Mangala LS,et al.Metabolic shifts toward glutamine regulate tumor growth,invasion and bioenergetics in ovarian cancer.Mol Syst Biol,2014,10(5):728-750.
[15]Timmerman LA,Holton T,Yuneva M,et al.Glutamine sensitivity analysis identifies the xCTantiporter as a common triple-negative breast tumor therapeutic target.Cancer Cell,2013,24(4):450-465.
[16]DeBerardinis RJ,Cheng T.Q’s next:the diverse functions of glutamine in metabolism,cell biology and cancer.Oncogene,2010,29(3):313-324.
[17]McGuirk S,Gravel SP,Deblois G,et al.PGC-1αsupports glutamine metabolism in breast cancer.Cancer Metabol,2013,1(1):22-32.
[18]Takeuchi Y,Nakayama Y,Fukusaki E,et al.Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion.Biochem Biophys Res Commun,2018,495(1):761-767.
[19]Shashidharan P,Plaitakis A.The discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and disease.Neurochel Res,2014,39(3):460-470.
[20]Spanaki C,Kotzamani D,Plaitakis A.Widening spectrum of cellular and subcellular expression of human GLUD1 and GLUD2 glutamate dehydrogenases suggests novel functions.Neurochem Res,2017,42(1):92-107.
[21]Jin LT,Li D,Alesi GN,et al.Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.Cancer Cell,2015,27(2):257-270.
[22]DeSantis CE,Fedewa SA,Goding Sauer A,et al.Breast cancer statistics,2015:convergence of incidence rates between black and white women.CA-Cancer J Clin,2016,66(1):31-42.
[23]Ryu JE,Park HK,Choi HJ,et al.Expression of the glutamine metabolism-related proteins glutaminase 1and glutamate dehydrogenase in canine mammary tumours.Vet Comp Oncol,2018,16(2):239-245.
[24]Spinelli JB,Yoon H,Ringel AE,et al.Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.Science,2017,358(6365):941-946.
[25]Ostrom QT,Bauchet L,Davis FG,et al.The epidemiology of glioma in adults:a“state of the science”review.Neuro Oncol,2014,16(7):896-913.
[26]Cuddapah VA,Robel S,Watkins S,et al.Aneurocentric perspective on glioma invasion.Nat Rev Neurosci,2014,15(7):455-465.
[27]de Groot J,Sontheimer H.Glutamate and the biology of gliomas.Glia,2011,59(8):1181-1189.
[28]Campbell SL,Buckingham SC,Sontheimer H.Human glioma cells induce hyperexcitability in cortical networks.Epilepsia,2012,53(8):1360-1370.
[29]Yang CD,Sudderth J,Dang TY,et al.Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.Cancer Res,2009,69(20):7986-7993.
[30]Chen RH,Nishimura MC,Kharbanda S,et al.Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma.Proc Natl Acad Sci USA,2014,111(39):14217-14222.
[31]Siegel RL,Miller KD,Jemal A.Cancer statistics,2015.CA-Cancer J Clin,2015,65(1):5-29.
[32]Richter JM,Campbell EJ,Chung DC.Interval colorectal cancer after colonoscopy.Clin Colorectal Cancer,2015,14(1):46-51.
[33]Liu GJ,Zhu J,Yu ML,et al.Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients.JTransl Med,2015,13:144.
[34]Siegel R,Ma JM,Zou ZH,et al.Cancer statistics,2014.CA-Cancer J Clin,2014,64(1):9-29.
[35]Sung PL,Chang YH,Chao KC,et al.Global distribution pattern of histological subtypes of epithelial ovarian cancer:a database analysis and systematic review.Gynecol Oncol,2014,133(2):147-154.
[36]Yuan LQ,Sheng XG,Willson AK,et al.Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway.Endoc-Relat Cancer,2015,22(4):577-591.
[37]Forner A,Llovet JM,Bruix DJ.Hepatocellular carcinoma.Lancet,2012,379(9822):1245-1255.
[38]Glazer RI,Vogel CL,Patel IR,et al.Glutamate dehydrogenase activity related to histopathological grade of hepatocellular carcinoma in man.Cancer Res,1974,34(11):2975-2978.
[39]Ye XH,Huai JP,Ding J,et al.Smoking,alcohol consumption,and the risk of extrahepatic cholangiocarcinoma:a meta-analysis.World JGastroenterol,2013,19(46):8780-8788.
[40]Tyson GL,El-Serag HB.Risk factors for cholangiocarcinoma.Hepatology,2011,54(1):173-184.
[41]Yang HX,Zhou JP,Wei X,et al.Survival outcomes and progonostic factors of extrahepatic cholangiocarcinoma patients following surgical resection:adjuvant therapy is a favorable prognostic factor.Mol Clin Oncol,2014,2(6):1069-1075.
[42]Ramírez-Merino N,Aix SP,Cortés-Funes H.Chemotherapy for cholangiocarcinoma:an update.World J Gastrointest Oncol,2013,5(7):171-176.
[43]Su Z,Liu GJ,Fang TF,et al.Expression and prognostic value of glutamate dehydrogenase in extrahepatic cholangiocarcinoma patients.Am JTransl Res,2017,9(5):2106-2118.
[44]Knight SB,Crosbie PA,Balata H,et al.Progress and prospects of early detection in lung cancer.Open Biol,2017,7(9):170070.
[45]Michalak S,Rybacka-Mossakowska J,Ambrosius W,et al.The markers of glutamate metabolism in peripheral blood mononuclear cells and neurological complications in lung cancer patients.Dis Markers,2016,2016:2895972.
[46]Csibi A,Fendt SM,Li CG,et al.The mTORC1pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.Cell,2013,153(4):840-854.
[47]Spanaki C,Zaganas I,Kounoupa Z,et al.The complex regulation of human glud1 and glud2glutamate dehydrogenases and its implications in nerve tissue biology.Neurochem Int,2012,61(4):470-481.
[2]Huang GC,Tian B.The physiological role of glutamate dehydrogenase in higher plants.Chin Bull Botany,2001,18(4):396-401(in Chinese).黄国存,田波.高等植物中的谷氨酸脱氢酶及其生理作用.植物学通报,2001,18(4):396-401.
[3]Britton KL,Baker PJ,Engel PC,et al.Evolution of substrate diversity in the superfamily of amino acid dehydrogenases:prospects for rational chiral synthesis.J Mol Biol,1993,234(4):938-945.
[4]Peterson PE,Smith TJ.The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery.Structure,1999,7(7):769-782.
[5]Maechler P,Carobbio S,Rubi B.In beta-cells,mitochondria integrate and generate metabolic signals controlling insulin secretion.Int J Biochem Cell Biol,2006,38(5/6):696-709.
[6]Wullschleger S,Loewith R,Hall MN.TOR signaling in growth and metabolism.Cell,2006,124(3):471-484.
[7]George A,Bell JE.Effects of adenosine5?-diphosphate on bovine glutamate dehydrogenase:diethyl pyrocarbonate modification.Biochemistry,1980,19(26):6057-6061.
[8]Britton KL,Baker PJ,Rice DW,et al.Structural relationship between the hexameric and tetrameric family of glutamate dehydrogenases.Eur J Biochem,1992,209(3):851-859.
[9]Austen BM,Haberland ME,Nyc JF,et al.Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora.IV.The COOH-terminal 669 residues of the peptide chain;Comparison with other glutamate dehydrogenases.JBiol Chem,1977,252(22):8142-8149.
[10]Werner C,Stubbs MT,Krauth-Siegel RL,et al.The crystal structure of Plasmodium falciparum glutamate dehydrogenase,a putative target for novel antimalarial drugs.J Mol Biol,2005,349(3):597-607.
[11]Hanahan D,Weinberg RA.Hallmarks of cancer:the next generation.Cell,2011,144(5):646-674.
[12]Wise DR,Thompson CB.Glutamine addiction:a new therapeutic target in cancer.Trends Biochem Sci,2010,35(8):427-433.
[13]Yuneva M,Zamboni N,Oefner P,et al.Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.J Cell Biol,2007,178(1):93-105.
[14]Yang LF,Moss T,Mangala LS,et al.Metabolic shifts toward glutamine regulate tumor growth,invasion and bioenergetics in ovarian cancer.Mol Syst Biol,2014,10(5):728-750.
[15]Timmerman LA,Holton T,Yuneva M,et al.Glutamine sensitivity analysis identifies the xCTantiporter as a common triple-negative breast tumor therapeutic target.Cancer Cell,2013,24(4):450-465.
[16]DeBerardinis RJ,Cheng T.Q’s next:the diverse functions of glutamine in metabolism,cell biology and cancer.Oncogene,2010,29(3):313-324.
[17]McGuirk S,Gravel SP,Deblois G,et al.PGC-1αsupports glutamine metabolism in breast cancer.Cancer Metabol,2013,1(1):22-32.
[18]Takeuchi Y,Nakayama Y,Fukusaki E,et al.Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion.Biochem Biophys Res Commun,2018,495(1):761-767.
[19]Shashidharan P,Plaitakis A.The discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and disease.Neurochel Res,2014,39(3):460-470.
[20]Spanaki C,Kotzamani D,Plaitakis A.Widening spectrum of cellular and subcellular expression of human GLUD1 and GLUD2 glutamate dehydrogenases suggests novel functions.Neurochem Res,2017,42(1):92-107.
[21]Jin LT,Li D,Alesi GN,et al.Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.Cancer Cell,2015,27(2):257-270.
[22]DeSantis CE,Fedewa SA,Goding Sauer A,et al.Breast cancer statistics,2015:convergence of incidence rates between black and white women.CA-Cancer J Clin,2016,66(1):31-42.
[23]Ryu JE,Park HK,Choi HJ,et al.Expression of the glutamine metabolism-related proteins glutaminase 1and glutamate dehydrogenase in canine mammary tumours.Vet Comp Oncol,2018,16(2):239-245.
[24]Spinelli JB,Yoon H,Ringel AE,et al.Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.Science,2017,358(6365):941-946.
[25]Ostrom QT,Bauchet L,Davis FG,et al.The epidemiology of glioma in adults:a“state of the science”review.Neuro Oncol,2014,16(7):896-913.
[26]Cuddapah VA,Robel S,Watkins S,et al.Aneurocentric perspective on glioma invasion.Nat Rev Neurosci,2014,15(7):455-465.
[27]de Groot J,Sontheimer H.Glutamate and the biology of gliomas.Glia,2011,59(8):1181-1189.
[28]Campbell SL,Buckingham SC,Sontheimer H.Human glioma cells induce hyperexcitability in cortical networks.Epilepsia,2012,53(8):1360-1370.
[29]Yang CD,Sudderth J,Dang TY,et al.Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.Cancer Res,2009,69(20):7986-7993.
[30]Chen RH,Nishimura MC,Kharbanda S,et al.Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma.Proc Natl Acad Sci USA,2014,111(39):14217-14222.
[31]Siegel RL,Miller KD,Jemal A.Cancer statistics,2015.CA-Cancer J Clin,2015,65(1):5-29.
[32]Richter JM,Campbell EJ,Chung DC.Interval colorectal cancer after colonoscopy.Clin Colorectal Cancer,2015,14(1):46-51.
[33]Liu GJ,Zhu J,Yu ML,et al.Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients.JTransl Med,2015,13:144.
[34]Siegel R,Ma JM,Zou ZH,et al.Cancer statistics,2014.CA-Cancer J Clin,2014,64(1):9-29.
[35]Sung PL,Chang YH,Chao KC,et al.Global distribution pattern of histological subtypes of epithelial ovarian cancer:a database analysis and systematic review.Gynecol Oncol,2014,133(2):147-154.
[36]Yuan LQ,Sheng XG,Willson AK,et al.Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway.Endoc-Relat Cancer,2015,22(4):577-591.
[37]Forner A,Llovet JM,Bruix DJ.Hepatocellular carcinoma.Lancet,2012,379(9822):1245-1255.
[38]Glazer RI,Vogel CL,Patel IR,et al.Glutamate dehydrogenase activity related to histopathological grade of hepatocellular carcinoma in man.Cancer Res,1974,34(11):2975-2978.
[39]Ye XH,Huai JP,Ding J,et al.Smoking,alcohol consumption,and the risk of extrahepatic cholangiocarcinoma:a meta-analysis.World JGastroenterol,2013,19(46):8780-8788.
[40]Tyson GL,El-Serag HB.Risk factors for cholangiocarcinoma.Hepatology,2011,54(1):173-184.
[41]Yang HX,Zhou JP,Wei X,et al.Survival outcomes and progonostic factors of extrahepatic cholangiocarcinoma patients following surgical resection:adjuvant therapy is a favorable prognostic factor.Mol Clin Oncol,2014,2(6):1069-1075.
[42]Ramírez-Merino N,Aix SP,Cortés-Funes H.Chemotherapy for cholangiocarcinoma:an update.World J Gastrointest Oncol,2013,5(7):171-176.
[43]Su Z,Liu GJ,Fang TF,et al.Expression and prognostic value of glutamate dehydrogenase in extrahepatic cholangiocarcinoma patients.Am JTransl Res,2017,9(5):2106-2118.
[44]Knight SB,Crosbie PA,Balata H,et al.Progress and prospects of early detection in lung cancer.Open Biol,2017,7(9):170070.
[45]Michalak S,Rybacka-Mossakowska J,Ambrosius W,et al.The markers of glutamate metabolism in peripheral blood mononuclear cells and neurological complications in lung cancer patients.Dis Markers,2016,2016:2895972.
[46]Csibi A,Fendt SM,Li CG,et al.The mTORC1pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.Cell,2013,153(4):840-854.
[47]Spanaki C,Zaganas I,Kounoupa Z,et al.The complex regulation of human glud1 and glud2glutamate dehydrogenases and its implications in nerve tissue biology.Neurochem Int,2012,61(4):470-481.