儿童及青少年精神分裂症患者血清同型半胱氨酸、叶酸水平与PANSS评分的关系研究
|
摘要
目的探讨儿童及青少年精神分裂症患者血清同型半胱氨酸(homocysteine,Hcy)、叶酸水平与阳性和阴性症状量表(positive and negative symptoms scale,PANSS)评分的相关性。方法采用病例-对照的研究方法。选取西安市精神卫生中心儿少心理科2017年4月～2018年7月期间的100例精神分裂症患者作为病例组,同时选取口腔医院120例健康体检患者作为对照组。分析两组患者的血清同型半胱氨酸(Hcy)、叶酸水平,并采用阳性和阴性症状量表(positive and nega-tive symptoms scales,PANSS)评定患者病情的严重程度。结果①病例组的叶酸水平为7.98±6.39ng/ml,Hcy水平为28.47±23.41μmol/L,对照组的叶酸水平为11.14±4.52ng/ml,Hcy水平为14.57±4.27μmol/L。病例组的叶酸水平明显低于对照组,Hcy水平明显高于对照组,差异均具有统计学意义(t=2.433,P<0.05;t=3.459,P<0.01);②病例组患者的PANSS评分与Hcy水平呈正相关(r=0.440,P<0.01),PANSS阴性评分与叶酸水平呈负相关(r=-0.346,P<0.05),Hcy水平与叶酸水平呈负相关(r=-0.497,P<0.01)。结论儿童及青少年精神分裂症患者血清Hcy,叶酸水平和PANSS评分有密切的关系。
Objective To observe the correlation between serum homocysteine(Hcy),folic acid levels and positive and negative symptoms scale(PANSS)score in children and adolescents patients with schizophrenia.Methods The case-control method was used in this study.100 patients with schizophrenia in the Department of Children and Adolescents Psychology in Xi'an Mental Health Center were selected as the case group from April 2017 to July 2018,and 120 healthy people in the Oral Hospital were selected as the control group.The levels of serum Hcy,folic acid were analyzed and the patients of case group were assessed using positive and negative symptoms scales(PANSS).Results ①The levels of serum folic acid and Hcy for case group were 7.98±6.39 ng/ml and 28.47±23.41μmol/L,and the levels of serum folic acid and Hcy for control group were 11.14±4.52 ng/ml and 14.57±4.27μmol/L.The levels of serum folic acid were significantly lower and the levels of serum Hcy were significantly higher in case group compare with contorol group,the difference was statistically significant(t=2.433,P<0.05;t=3.459,P<0.01).②A positive correlation existed between PANSS scores and Hcy levels(r=0.440,P<0.01),and a negative correlation existed between negative symptoms scores and folic acid levels(r=-0.346,P<0.05),and a negative correlation existed between serum Hcy and folic acid levels(r=-0.497,P<0.01).Conclusion There was a relationship between serum Hcy,folic acid levels and PANSS score in children and adolescents patients with schizophrenia.
Objective To observe the correlation between serum homocysteine(Hcy),folic acid levels and positive and negative symptoms scale(PANSS)score in children and adolescents patients with schizophrenia.Methods The case-control method was used in this study.100 patients with schizophrenia in the Department of Children and Adolescents Psychology in Xi'an Mental Health Center were selected as the case group from April 2017 to July 2018,and 120 healthy people in the Oral Hospital were selected as the control group.The levels of serum Hcy,folic acid were analyzed and the patients of case group were assessed using positive and negative symptoms scales(PANSS).Results ①The levels of serum folic acid and Hcy for case group were 7.98±6.39 ng/ml and 28.47±23.41μmol/L,and the levels of serum folic acid and Hcy for control group were 11.14±4.52 ng/ml and 14.57±4.27μmol/L.The levels of serum folic acid were significantly lower and the levels of serum Hcy were significantly higher in case group compare with contorol group,the difference was statistically significant(t=2.433,P<0.05;t=3.459,P<0.01).②A positive correlation existed between PANSS scores and Hcy levels(r=0.440,P<0.01),and a negative correlation existed between negative symptoms scores and folic acid levels(r=-0.346,P<0.05),and a negative correlation existed between serum Hcy and folic acid levels(r=-0.497,P<0.01).Conclusion There was a relationship between serum Hcy,folic acid levels and PANSS score in children and adolescents patients with schizophrenia.
引文
[1]NUMATA S,KINOSHITA M,TAJIMA A,et al.E-valuation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis[J].BMC Medical Genetics,2015,16(1):54.
[2]赵佳,姚创利,左林,等.冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响[J].现代检验医学杂志,2015,30(5):44-45,49.ZHAO Jia,YAO Chuangli,ZUO Lin,et al.Effects of homocysteine on blood lipid and manganese superoxide dismutase in patients with coronary heart disease[J].Journal of Modern Laboratory Medicine,2015,30(5):44-45,49.
[3]王禺,李秀娥,赵曼,等.急性脑梗死患者的NT-proB-NP和Hcy及部分凝血纤溶指标变化的临床意义[J].现代检验医学杂志,2017,32(3):89-91.WANG Yu,LI Xiue,ZHAO Man,et al.Clinical significance of changes in NT-proBNP,Hcy and partial coagulation-fibrinolytic indexes with acute cerebral infarction[J].Journal of Modern Laboratory Medicine,2017,32(3):89-91.
[4]MINAGAWA H,WATANABE A,AKATSU H,et al.Homocysteine,another risk factor for Alzheimer disease,impairs apolipoprotein E3function[J].J Biol Chem,2010,285(49):38382-38388.
[5]王晓燕,王伟灵.高同型半胱氨酸血症的神经毒性机制研究进展[J].检验医学,2014,29(12):1263-1267.WANG Xiaoyan,WANG Weiling.Research advance on mechanisms of hyperhomocysteinemia neurotoxicity[J].Laboratory Medicine,2014,29(12):1263-1267.
[6]张晓鸣,陈景旭,李娟,等.精神分裂症患者血清同型半胱氨酸水平及其影响因素[J].中国健康心理学杂志,2018,26(4):481-484.ZHANG Xiaoming,CHEN Jingxu,LI Juan,et al.Serum concentrations of homocysteine and related factors in the patients with schizophrenia[J].China Journal of Health Psychology,2018,26(4):481-484.
[7]李桂民,朱相华,张媛,等.精神分裂症与抑郁症患者血清同型半胱氨酸的水平研究[J].国际检验医学杂志,2011,32(6):689-690.LI Guimin,ZHU Xianghua,ZHANG Yuan,et al.Study on the level of serum homocysteine in patients with schizophrenia and depression[J].International Journal of Laboratory Medicine,2011,32(6):689-690.
[8]BORBA C,FEKADU A,TEFERRA S,et al.A placebo-controlled trial of folate with B12in patients with schizophrenia with residual symptoms in Ethiopia using a sequential parallel comparison design[J].British Journal of Medicine&Medical Research,2014,4(23):4090.
[9]DESERNO L,HEINZ A,SCHLAGENHAUF F.Computational approaches to schizophrenia:A perspective on negative symptoms[J].Schizophr Res,2017,186:46-54.
[10]陈旭梅.首发精神分裂症患者皮质厚度的改变及其与叶酸、HCY和BDNF水平的相关性研究[D].郑州:郑州大学,2014.CHEN Xumei.Changes of cortical thickness in drug naive first episode schizophrenia and their correlations with serum folate,homocysteine,BDNF levels[D].Zhengzhou:Zhengzhou University,2014.
[11]左林,赵佳,姜小建,等.缺血性脑血管病患者血清同型半胱氨酸、叶酸和维生素B12水平与头颈部血管狭窄的相关性研究[J].现代检验医学杂志,2017,32(2):23-25,29.ZUO Lin,ZHAO Jia,JIANG Xiaojian,et al.Correlation study between serum homocysteine,folate,Vitamin B12levels and head and neck vascular stenosis in patients with ischemic cerebro vascular disease[J].Journal of Modern Laboratory Medicine,2017,32(2):23-25,29.
[12]易峰,毛静宇,张洋洋,等.精神分裂症患者血浆同型半胱氨酸水平的Meta分析[J].中国神经精神疾病杂志,2013,39(8):463-468.YI Feng,MAO Jingyu,ZHANG Yangyang,et al.Plasma homocysteine level in schizophrenia:a metaanalysis[J].Chinese Journal of Nervous and Mental Diseases,2013,39(8):463-468.
[2]赵佳,姚创利,左林,等.冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响[J].现代检验医学杂志,2015,30(5):44-45,49.ZHAO Jia,YAO Chuangli,ZUO Lin,et al.Effects of homocysteine on blood lipid and manganese superoxide dismutase in patients with coronary heart disease[J].Journal of Modern Laboratory Medicine,2015,30(5):44-45,49.
[3]王禺,李秀娥,赵曼,等.急性脑梗死患者的NT-proB-NP和Hcy及部分凝血纤溶指标变化的临床意义[J].现代检验医学杂志,2017,32(3):89-91.WANG Yu,LI Xiue,ZHAO Man,et al.Clinical significance of changes in NT-proBNP,Hcy and partial coagulation-fibrinolytic indexes with acute cerebral infarction[J].Journal of Modern Laboratory Medicine,2017,32(3):89-91.
[4]MINAGAWA H,WATANABE A,AKATSU H,et al.Homocysteine,another risk factor for Alzheimer disease,impairs apolipoprotein E3function[J].J Biol Chem,2010,285(49):38382-38388.
[5]王晓燕,王伟灵.高同型半胱氨酸血症的神经毒性机制研究进展[J].检验医学,2014,29(12):1263-1267.WANG Xiaoyan,WANG Weiling.Research advance on mechanisms of hyperhomocysteinemia neurotoxicity[J].Laboratory Medicine,2014,29(12):1263-1267.
[6]张晓鸣,陈景旭,李娟,等.精神分裂症患者血清同型半胱氨酸水平及其影响因素[J].中国健康心理学杂志,2018,26(4):481-484.ZHANG Xiaoming,CHEN Jingxu,LI Juan,et al.Serum concentrations of homocysteine and related factors in the patients with schizophrenia[J].China Journal of Health Psychology,2018,26(4):481-484.
[7]李桂民,朱相华,张媛,等.精神分裂症与抑郁症患者血清同型半胱氨酸的水平研究[J].国际检验医学杂志,2011,32(6):689-690.LI Guimin,ZHU Xianghua,ZHANG Yuan,et al.Study on the level of serum homocysteine in patients with schizophrenia and depression[J].International Journal of Laboratory Medicine,2011,32(6):689-690.
[8]BORBA C,FEKADU A,TEFERRA S,et al.A placebo-controlled trial of folate with B12in patients with schizophrenia with residual symptoms in Ethiopia using a sequential parallel comparison design[J].British Journal of Medicine&Medical Research,2014,4(23):4090.
[9]DESERNO L,HEINZ A,SCHLAGENHAUF F.Computational approaches to schizophrenia:A perspective on negative symptoms[J].Schizophr Res,2017,186:46-54.
[10]陈旭梅.首发精神分裂症患者皮质厚度的改变及其与叶酸、HCY和BDNF水平的相关性研究[D].郑州:郑州大学,2014.CHEN Xumei.Changes of cortical thickness in drug naive first episode schizophrenia and their correlations with serum folate,homocysteine,BDNF levels[D].Zhengzhou:Zhengzhou University,2014.
[11]左林,赵佳,姜小建,等.缺血性脑血管病患者血清同型半胱氨酸、叶酸和维生素B12水平与头颈部血管狭窄的相关性研究[J].现代检验医学杂志,2017,32(2):23-25,29.ZUO Lin,ZHAO Jia,JIANG Xiaojian,et al.Correlation study between serum homocysteine,folate,Vitamin B12levels and head and neck vascular stenosis in patients with ischemic cerebro vascular disease[J].Journal of Modern Laboratory Medicine,2017,32(2):23-25,29.
[12]易峰,毛静宇,张洋洋,等.精神分裂症患者血浆同型半胱氨酸水平的Meta分析[J].中国神经精神疾病杂志,2013,39(8):463-468.YI Feng,MAO Jingyu,ZHANG Yangyang,et al.Plasma homocysteine level in schizophrenia:a metaanalysis[J].Chinese Journal of Nervous and Mental Diseases,2013,39(8):463-468.