湖北长盛川青砖茶对2型糖尿病合并血脂异常患者胰岛素抵抗、血脂的影响
摘要
目的观察湖北长盛川青砖茶对2型糖尿病(T2DM)患者胰岛素抵抗、血脂的影响。方法选择40例健康人为对照组。77例T2DM合并血脂异常患者随机分为饮用青砖茶组39例、基础治疗组38例。观察饮长盛川青砖茶前后稳态模型胰岛素抵抗指数(HOMA-IR)、空腹胰岛素(FIns)、白细胞介素(IL)-6、超氧化物歧化酶(SOD)、对氧磷酶(pon)3、鸢尾素(Irisin)、胰岛素用量(insulin dosage)的变化。结果青砖茶组、基础治疗组HOMA-IR、FIns、IL-6、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平显著高于对照组(P<0.05,P<0.01),pon3、Irisin、SOD、高密度脂蛋白胆固醇(HDL)-C显著低于对照组(P<0.05,P<0.01);血清pon3、Irisin、SOD水平与HOMA-IR呈负相关(P<0.05,P<0.01),空腹血糖(FPG)、糖化血红蛋白(HbA1c)、FIns、IL-6与HOMA-IR正相关(P<0.05,P<0.01);回归分析显示:pon3、Irisin、IL-6是HOMA-IR的独立影响因素。青砖茶组饮长盛川青砖茶后pon3、Irisin、SOD水平显著上升,insulin dosage、IL-6、HOMA-IR、TG显著下降(P<0.05)。结论长盛川青砖茶改善了T2DM患者的胰岛素抵抗、脂代谢,减少了胰岛素用量。
引文
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17 刘云涛,董国锋,潘敬芳.对氧磷酶3在糖尿病大鼠脂肪组织的表达及二甲双胍的干预研究[J].解放军药学学报,2017;33(6):532-4.
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2 Tehrani HG,Allahdadian,Zarre F,et al.Effect of green tea on metabolic and hormonal aspect of polycystic ovarian syndrome in overweight and obese women suffering from polycystic ovarian syndrome:a clinical trial[J].J Educ Health Promot,2017;5:36.
3 Kafeshani M,Entezari MH,Karimian J,et al.A comparative study of the effect of green tea and sour tea on blood pressure and lipid profile in healthy adult men[J].ARYA Atheroscler,2017;13(3):109-16.
4 Yang Z,Chen X,Chen Y,et al.Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice[J].Int J Clin Exp Pathol,2015;8(6):6490-7.
5 Liu BW,Yin FZ,Qi XM,et al.The levels of serum irisin as a predictor of insulin resistance in han chinese adults with metabolically healthy obesity[J].Clin Lab,2017;63(5):881-6.
6 Lee HJ,Lee JO,Kim N,et al.Irisin,a novel myokine,regulates glucose uptake in skeletal muscle cells via AMPK[J].Mol Endocrinol,2015;29(6):873-81.
7 Assyov Y,Gateva A,Tsakova A,et al.Irisin in the glucose continuum[J].Exp Clin Endocrinol Diabetes,2016;124(1):22-7.
8 Choi YK,Kim MK,Bae KH,et al.Serum irisin levels in new-onset type 2 diabetes[J].Diabetes Res Clin Pract,2013;100(1):96-101.
9 刘云涛,简磊,潘敬芳.血清鸢尾素与2型糖尿病颈动脉粥样硬化的相关性[J].上海医学,2017;40(8):470-4.
10 Park MJ,Kim DI,Choi JH,et al.New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro[J].Cell Signal,2015;27(9):1831-9.
11 Xin C,Liu J,Zhang J,et al.Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway [J].Int J Obes (Lond),2016;40(3):443-51.
12 Duran ID,Gül?elik NE,ünal M.Irisin levels inthe progression of diabetes in sedentary women[J].Clin Biochem,2015;48(18):1268-72.
13 Jensen GS,Beaman JL,He Y,et al.Reduction of body fat and improved lipid profile associated with daily consumption of a Puer tea extract in a hyperlipidemic population:a randomized placebo-controlled trial[J].Clin Interv Aging,2016;11:367-76.
14 Rull A,García R,Fernández-Sender L,et al.Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease [J].Atherosclerosis,2012;22(2):545-51.
15 刘云涛,简磊,李建伟,等.新诊断2型糖尿病患者血清对氧磷酶3水平与颈动脉粥样硬化的相关性[J].中国糖尿病杂志,2014;22(1):47-50.
16 刘云涛,简磊,李建伟.阿托伐他汀对2型糖尿病颈动脉粥样硬化患者血清对氧磷酶3影响的临床观察[J].中国糖尿病杂志,2014;22(11):979-83.
17 刘云涛,董国锋,潘敬芳.对氧磷酶3在糖尿病大鼠脂肪组织的表达及二甲双胍的干预研究[J].解放军药学学报,2017;33(6):532-4.
18 Zhu L,Shen Y,Sun W.Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oralsquamous cell carcinoma[J].Biomed Pharmacother,2017;85:712-7.
19 Li S,Chen H,Wang J,et al.Involvement of the PI3K/Akt signal pathway in the hypoglycemic effects of tea polysaccharides on diabetic mice[J].Int J Biol Macromol,2015;81:967-74.
20 Shih DM,Yu JM,Vergnes L,et al.PON3 knockout mice are susceptible to obesity,gallstone formation,and atherosclerosis[J].FASEB J,2015;29(4):1185-97.