PET-CT联合血清肿瘤标志物在肺癌中的诊断价值分析
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摘要
目的探讨正电子发射计算机断层显像(PET-CT)联合血清肿瘤标志物检测在肺癌中的诊断价值。方法回顾性分析2016-01~2018-03该院收治的56例肺癌患者,探讨PET-CT、血清肿瘤标志物、PET-CT联合血清肿瘤标志物检测肺癌诊断的准确度、特异度、敏感度情况。结果 PET-CT的准确度、特异度、敏感度分别为76. 79%、69. 23%、79. 07%,血清肿瘤标志物的准确度、特异度、敏感度分别为69. 64%、53. 85%、74. 42%,而联合检测的准确度、特异度、敏感度分别为85. 71%、53. 85%、95. 35%,联合检测可以提高肺癌诊断的准确度与敏感度,差异有统计学意义(P <0. 05)。结论 PET-CT联合血清肿瘤标志物检测能够提高肺癌诊断的准确度及敏感度,值得临床应用与推广。
Objective To investigate the diagnostic value of positron emission tomography-computed tomography( PET-CT) combined with serum tumor markers in lung cancer. Methods The data of 56 hospitalized patients with lung cancer in our hospital from January 2016 to March 2018 were retrospectively analyzed. The accuracy,specificity and sensitivity of PET-CT,serum tumor markers and PET-CT combined with serum tumor markers were analyzed for the diagnosis of lung cancer. Results The accuracy,specificity and sensitivity were 76. 79%,69. 23% and79. 07% in PET-CT method,and 69. 64%,53. 85% and 74. 42% in serum tumor markers detection method,85. 71%,53. 85% and 95. 35% in PET-CT combined with serum tumor markers detection method. The combined examination method can improve the diagnostic accuracy and sensitivity of lung cancer,with significant differences among the three methods( P < 0. 05). Conclusion PET-CT combined with serum tumor markers detection can improve the diagnostic accuracy and sensitivity of lung cancer,and is suitable for clinical application.
Objective To investigate the diagnostic value of positron emission tomography-computed tomography( PET-CT) combined with serum tumor markers in lung cancer. Methods The data of 56 hospitalized patients with lung cancer in our hospital from January 2016 to March 2018 were retrospectively analyzed. The accuracy,specificity and sensitivity of PET-CT,serum tumor markers and PET-CT combined with serum tumor markers were analyzed for the diagnosis of lung cancer. Results The accuracy,specificity and sensitivity were 76. 79%,69. 23% and79. 07% in PET-CT method,and 69. 64%,53. 85% and 74. 42% in serum tumor markers detection method,85. 71%,53. 85% and 95. 35% in PET-CT combined with serum tumor markers detection method. The combined examination method can improve the diagnostic accuracy and sensitivity of lung cancer,with significant differences among the three methods( P < 0. 05). Conclusion PET-CT combined with serum tumor markers detection can improve the diagnostic accuracy and sensitivity of lung cancer,and is suitable for clinical application.
引文
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11高世乐,董六一,王崇,等.全身PET/CT断层显像联合肿瘤标志物检测在肺癌诊断及鉴别诊断中的临床意义[J].安徽医药,2015,19(4):702-705.
2 Lou E,Johnson ML,Sima C,et al.Analysis of a panel of serum biomarkers in patients with metastatic lung cancer[J].J Clin Oncol,2010,28(15 supple):e18080.
3 Olsen JR,Dehdashti F,Siegel BA,et al.Prognostic utility of squamous cell carcinoma antigen in carcinoma of the cervix:association with pre-and posttreatment FDG-PET[J].Int J Radiat Oncol Biol Phys,2011,81(3):772-777.
4 Pavic'evic'R,Bubanovic'G,Franjevic'A,et al.CYFRA21-1 in nonsmall cell lung cancer---standardisation and application during diagnosis[J].Coll Antropol,2008,32(2):485-498.
5方艳,吴宁,梁颖,等.18F-FDG PET/CT在宫颈癌治疗后鳞状细胞癌抗原再次升高患者中的应用[J].中国医学影像技术,2016,32(1):91-94.
6王绍波,吴湖炳,季云海,等.18F-FDG PET/CT在同时性多原发食管癌中的应用[J].中国医学影像学杂志,2016,24(1):1-3,7.
7 Schmidt-Hansen M,Baldwin DR,Zamora J.FDG-PET/CT imaging for mediastinal staging in patients with potentially resectable non-small cell lung cancer[J].JAMA,2015,313(14):1465-1466.
8 Sahiner I,Vural GU.Positron emission tomography/computerized tomography in lung cancer[J].Quant Imaging Med Surg,2014,4(3):195-206.
9王荣福.PET/CT分子影像新技术在肿瘤中的应用[J].肿瘤学,2011,17(10):727-729.
10 Garcia-Velloso MJ,Bastarrika G,de-Torres JP,et al.Assessment of indeterminate pulmonary nodules detected in lung cancer screening:Diagnostic accuracy of FDG PET/CT[J].Lung Cancer,2016,97:81-86.
11高世乐,董六一,王崇,等.全身PET/CT断层显像联合肿瘤标志物检测在肺癌诊断及鉴别诊断中的临床意义[J].安徽医药,2015,19(4):702-705.