芒果叶提取物芒果苷保护心脑肾及血管药效的研究进展
|
摘要
综述了芒果苷对心、脑、肾及血管损伤方面的保护药效研究进展;芒果苷具有酚羟基结构和肾上腺糖皮质激素样作用,有抗炎、抗氧化等药理活性,具有抗心肌炎症,抗心肌氧化,抗心肌缺血,抗脑炎症,抗脑氧化,抗脑缺血,抗肾脏炎症,抗肾脏氧化,抗肾脏缺血以及保护血管等作用。
The article reviewed the research progress of mangiferin in the protection of the heart, brain,kidney and blood vessel injury. Mangiferin had phenolic hydroxyl structure and adrenocorticosteroid-like effect,which had anti-inflammatory, anti-oxidation and other pharmacological activities, and also can be used for antimyocardial inflammation, anti-myocardial oxidation, anti-myocardial ischemia, anti-brain inflammation, anti-brain oxidation, anti-ischemia, anti kidney inflammation, anti renal oxidation, anti renal ischemia and vascular protection.
The article reviewed the research progress of mangiferin in the protection of the heart, brain,kidney and blood vessel injury. Mangiferin had phenolic hydroxyl structure and adrenocorticosteroid-like effect,which had anti-inflammatory, anti-oxidation and other pharmacological activities, and also can be used for antimyocardial inflammation, anti-myocardial oxidation, anti-myocardial ischemia, anti-brain inflammation, anti-brain oxidation, anti-ischemia, anti kidney inflammation, anti renal oxidation, anti renal ischemia and vascular protection.
引文
[1]杨海光,方莲花,杜冠华.芒果苷的药理作用研究进展[J].中国药理学通报,2016,32(1):5-8.
[2]徐丽,张元媛,曹军平.芒果苷对大鼠心肌缺血再灌注损伤的保护作用及其机制研究[J].药物评价研究,2016,39(2):198-201.
[3]桂俊.黄芪治疗病毒性心肌炎的分子机制[D].上海:复旦大学,2013.
[4]胡小勤,邓家刚,杜正彩,等.芒果苷联合葛根素对自发性高血压大鼠心脏炎性损伤的协同保护作用[J].中国实验方剂学杂志,2017,23(9):146-151.
[5]Hou J,Zheng D,Fung G,et al.Mangiferin suppressed advanced glycation end products(AGEs)through NF-κB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats[J].Canadian Journal of Physiology and Pharmacology,2016,94(3):332-340.
[6]刘桑.心肌酶在重症肺炎的临床应用[J].临床肺科杂志,2013,18(8):1385-1386.
[7]张善辉,闾爱斌,王平平,等.血清心肌酶检测对成人重症肺炎的临床意义[J].中国卫生检验杂志,2014,24(24):3556-3558.
[8]Agustini FD,Arozal W,Louisa M,et al.Cardioprotection mechanism of mangiferin on doxorubicin-induced rats:Focus on intracellular calcium regulation[J].Pharm Biol,2016,54(7):1289-1297.
[9]S Prabhu,Shoba Narayan,CS shyamala Devi.Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction[J].Phytother Res,2009,23(6):756-760.
[10]张华,彭军良,姚向阳.敛痔散促进低位单纯性肛瘘术后创面愈合临床研究[J].中医学报,2014,29(3):431-432.
[11]周方平,王业皇.功能性肛门直肠疼痛的中医药治疗[J].中医学报,2014,9(1):1427-1428.
[12]Zhang C,Kong X,Zhou H,et al.An Experimental Novel Study:Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Ratsvia Downregulation of Hydroxyproline,IL-6,and TGF-β1[J].Evid Based Complement Alternat Med,2013,29(8):291814.
[13]杨雪梅,杨海红,杨春霞,等.当归活性成分提取及其复合物栓剂抗炎活性研究[J].西北师范大学学报(自然科学版),2012,48(4):71-75.
[14]史才兴,李晓琎,袁丽丽,等.芒果苷对H2O2诱导的BRL细胞氧化损伤的保护作用[J].解剖学研究,2017,39(2):110-114.
[15]张翠,张根葆,王继胜,等.芒果苷对糖尿病大鼠心肌的保护作用[J].中国临床药理学与治疗学,2016,21(8):859-862.
[16]Suchal K,Malik S,Gamad N,et al.Mangiferin protect myocardial insults hrough modulation of MAPK/TGF-βpathways[J].Eur J pharmacol,2016(776):34-43.
[17]Quan W,Yin Y,Xi M,et al.Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardialischemia/reperfusion injury in vivo and in vitro[J].J Tradit Chin Med,2013,33(1):85-91.
[18]郑德志.大鼠心肌缺血再灌注损伤心室重构及芒果苷对其作用和机制的研究[D].重庆:第三军医大学,2012.
[19]王超,王国贤.芒果苷对大鼠心肌缺血再灌注损伤的保护作用[J].中国动脉硬化杂志,2008,94(9):697-700.
[20]范睿.琼玉膏干预衰老大鼠下丘脑炎症通路相关蛋白延缓衰老的研究[D].广州:广州中医药大学,2016.
[21]Marquez L,García-Bueno B,Madrigal JL,et al.Mangiferin decreases inflammation and oxidative damage in rat brain after stress[J].Eur J Nutr,2012,56(6):729-739.
[22]Yan-Yan Fu,Fang Zhang,Lei Zhang,et al.Mangiferin Regulates Interleukin-6 and Cystathionine-b-Synthase in Lipopolysaccharide-Induced Brain Injury[J].Cellular and Molecular Neurobiology,2014,34(5):651-657.
[23]Kasbe P,Jangra A,Lahkar M.Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress,proinflammatory cytokines and acetylcholinesterase level[J].Pharmacology,2015(31):107-112.
[24]谭安雄,朱耀斌,李小云.芒果苷对大鼠脑缺血再灌注损伤的保护作用[J].中国医院药学杂志,2011,31(23):1928-1930.
[25]Biradar SM,Joshi H,Chheda TK.Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease[J].Eur J Pharmacol,2012,683(1/3):140-147.
[26]谭安雄,钱凤,朱耀斌.芒果苷对易卒中型自发性高血压大鼠脑缺血再灌注后炎性因子的影响[J].中华高血压志,2010,18(4):380-384.
[27]李雪.芒果苷对脑缺血再灌注损伤的保护作用及其机制研究[D].广州:南方医科大学,2014.
[28]Zhang Yang,Chen Weian,Huang Susu,et al.Protective effects of mangiferin on cerebral ischemia–reperfusion injury and its mechanisms[J].Eur J Pharmacol,2016,15(771):145-151.
[29]陈凌,甘华.炎症小体及其与肾脏疾病的关系[J].当代医学,2012,18(3):31-33.
[30]Rajendran P,Rengarajan T,Nishigaki Y,et al.In vitro studies on mangiferin protection against cadmiuminduced human renal endothelial damage and cell death via the MAP kinase and NF-κB pathways[J].JRecept Signal Transduct Res,2016,36(1):57-66.
[31]胡小勤,杜正彩,李琦,等.芒果苷联合葛根素对自发性高血压大鼠肾脏炎性损伤的协同保护作用[J].科学技术与工程,2016,16(32):196-204.
[32]司立宁,甘桂芬,刘慧琴,等.枸杞多糖对力竭运动致大鼠肾脏氧化损伤的保护作用[J].时珍国医国药,2016,27(9):2068-2070.
[33]邱水晶,刘义,杜红禹.芒果苷对糖尿病大鼠肾脏的保护作用及机制[J].中国动脉硬化杂志,2010,18(12):956-960.
[34]Wang B,Wan J,Gong X,et al.Mangiferin attenuates renal ischemia-reperfusion injury by inhibiting inflammation and inducing adenosine production[J].Int Immunopharmacol,2015,25(1):148-154.
[35]周建军,严犇,黄芳.芒果苷抑制糖基化产物的生成及对血管内皮保护作用[J].中国生化药物杂志,2012,33(3):283-285.
[36]王阳阳,于惠玲,陈岩,等.芒果苷对血管内皮细胞中组织因子的影响及其机制[J].中国药理学通报,2017,33(7):961-965.
[37]Daud NH,Aung CS,Hewavitharana AK,et al.Mango extracts and the mango component mangiferin promote endothelial cell migration[J].J Agric Food Chem,2010,58(8):5181-5186.
[2]徐丽,张元媛,曹军平.芒果苷对大鼠心肌缺血再灌注损伤的保护作用及其机制研究[J].药物评价研究,2016,39(2):198-201.
[3]桂俊.黄芪治疗病毒性心肌炎的分子机制[D].上海:复旦大学,2013.
[4]胡小勤,邓家刚,杜正彩,等.芒果苷联合葛根素对自发性高血压大鼠心脏炎性损伤的协同保护作用[J].中国实验方剂学杂志,2017,23(9):146-151.
[5]Hou J,Zheng D,Fung G,et al.Mangiferin suppressed advanced glycation end products(AGEs)through NF-κB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats[J].Canadian Journal of Physiology and Pharmacology,2016,94(3):332-340.
[6]刘桑.心肌酶在重症肺炎的临床应用[J].临床肺科杂志,2013,18(8):1385-1386.
[7]张善辉,闾爱斌,王平平,等.血清心肌酶检测对成人重症肺炎的临床意义[J].中国卫生检验杂志,2014,24(24):3556-3558.
[8]Agustini FD,Arozal W,Louisa M,et al.Cardioprotection mechanism of mangiferin on doxorubicin-induced rats:Focus on intracellular calcium regulation[J].Pharm Biol,2016,54(7):1289-1297.
[9]S Prabhu,Shoba Narayan,CS shyamala Devi.Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction[J].Phytother Res,2009,23(6):756-760.
[10]张华,彭军良,姚向阳.敛痔散促进低位单纯性肛瘘术后创面愈合临床研究[J].中医学报,2014,29(3):431-432.
[11]周方平,王业皇.功能性肛门直肠疼痛的中医药治疗[J].中医学报,2014,9(1):1427-1428.
[12]Zhang C,Kong X,Zhou H,et al.An Experimental Novel Study:Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Ratsvia Downregulation of Hydroxyproline,IL-6,and TGF-β1[J].Evid Based Complement Alternat Med,2013,29(8):291814.
[13]杨雪梅,杨海红,杨春霞,等.当归活性成分提取及其复合物栓剂抗炎活性研究[J].西北师范大学学报(自然科学版),2012,48(4):71-75.
[14]史才兴,李晓琎,袁丽丽,等.芒果苷对H2O2诱导的BRL细胞氧化损伤的保护作用[J].解剖学研究,2017,39(2):110-114.
[15]张翠,张根葆,王继胜,等.芒果苷对糖尿病大鼠心肌的保护作用[J].中国临床药理学与治疗学,2016,21(8):859-862.
[16]Suchal K,Malik S,Gamad N,et al.Mangiferin protect myocardial insults hrough modulation of MAPK/TGF-βpathways[J].Eur J pharmacol,2016(776):34-43.
[17]Quan W,Yin Y,Xi M,et al.Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardialischemia/reperfusion injury in vivo and in vitro[J].J Tradit Chin Med,2013,33(1):85-91.
[18]郑德志.大鼠心肌缺血再灌注损伤心室重构及芒果苷对其作用和机制的研究[D].重庆:第三军医大学,2012.
[19]王超,王国贤.芒果苷对大鼠心肌缺血再灌注损伤的保护作用[J].中国动脉硬化杂志,2008,94(9):697-700.
[20]范睿.琼玉膏干预衰老大鼠下丘脑炎症通路相关蛋白延缓衰老的研究[D].广州:广州中医药大学,2016.
[21]Marquez L,García-Bueno B,Madrigal JL,et al.Mangiferin decreases inflammation and oxidative damage in rat brain after stress[J].Eur J Nutr,2012,56(6):729-739.
[22]Yan-Yan Fu,Fang Zhang,Lei Zhang,et al.Mangiferin Regulates Interleukin-6 and Cystathionine-b-Synthase in Lipopolysaccharide-Induced Brain Injury[J].Cellular and Molecular Neurobiology,2014,34(5):651-657.
[23]Kasbe P,Jangra A,Lahkar M.Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress,proinflammatory cytokines and acetylcholinesterase level[J].Pharmacology,2015(31):107-112.
[24]谭安雄,朱耀斌,李小云.芒果苷对大鼠脑缺血再灌注损伤的保护作用[J].中国医院药学杂志,2011,31(23):1928-1930.
[25]Biradar SM,Joshi H,Chheda TK.Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease[J].Eur J Pharmacol,2012,683(1/3):140-147.
[26]谭安雄,钱凤,朱耀斌.芒果苷对易卒中型自发性高血压大鼠脑缺血再灌注后炎性因子的影响[J].中华高血压志,2010,18(4):380-384.
[27]李雪.芒果苷对脑缺血再灌注损伤的保护作用及其机制研究[D].广州:南方医科大学,2014.
[28]Zhang Yang,Chen Weian,Huang Susu,et al.Protective effects of mangiferin on cerebral ischemia–reperfusion injury and its mechanisms[J].Eur J Pharmacol,2016,15(771):145-151.
[29]陈凌,甘华.炎症小体及其与肾脏疾病的关系[J].当代医学,2012,18(3):31-33.
[30]Rajendran P,Rengarajan T,Nishigaki Y,et al.In vitro studies on mangiferin protection against cadmiuminduced human renal endothelial damage and cell death via the MAP kinase and NF-κB pathways[J].JRecept Signal Transduct Res,2016,36(1):57-66.
[31]胡小勤,杜正彩,李琦,等.芒果苷联合葛根素对自发性高血压大鼠肾脏炎性损伤的协同保护作用[J].科学技术与工程,2016,16(32):196-204.
[32]司立宁,甘桂芬,刘慧琴,等.枸杞多糖对力竭运动致大鼠肾脏氧化损伤的保护作用[J].时珍国医国药,2016,27(9):2068-2070.
[33]邱水晶,刘义,杜红禹.芒果苷对糖尿病大鼠肾脏的保护作用及机制[J].中国动脉硬化杂志,2010,18(12):956-960.
[34]Wang B,Wan J,Gong X,et al.Mangiferin attenuates renal ischemia-reperfusion injury by inhibiting inflammation and inducing adenosine production[J].Int Immunopharmacol,2015,25(1):148-154.
[35]周建军,严犇,黄芳.芒果苷抑制糖基化产物的生成及对血管内皮保护作用[J].中国生化药物杂志,2012,33(3):283-285.
[36]王阳阳,于惠玲,陈岩,等.芒果苷对血管内皮细胞中组织因子的影响及其机制[J].中国药理学通报,2017,33(7):961-965.
[37]Daud NH,Aung CS,Hewavitharana AK,et al.Mango extracts and the mango component mangiferin promote endothelial cell migration[J].J Agric Food Chem,2010,58(8):5181-5186.