动物FABP基因家族研究进展及育种应用探讨
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摘要
脂肪酸结合蛋白家族(FABPs)是脂质结合蛋白超家族成员,它们广泛存在于哺乳动物的小肠、肝、心、脑、骨骼肌等多种细胞内。在调节细胞内长链脂肪酸(LCFA)的摄取、转运和代谢等生理活动发挥着重要的作用。本研究对几种常见的脂肪酸结合蛋白,如心脏型脂肪酸结合蛋白(H-FABP)、脂肪细胞型脂肪酸结合蛋白(A-FABP)、肠型脂肪酸结合蛋白(I-FABP)基因的基因多态性、在动物育种上的应用等相关研究进展进行了阐述,为利用FABPs基因改良和提高畜产品品质提供参考。
Fatty acid binding proteins are members of superfamily of lipid-binding proteins, which are widespread exist in the cells of small intestine, liver, heart, brain, skeletal muscle and so on of mammalian. They play important roles in absorption, transportation of LCFA in cell and metabolic regulation. In this article, several common fatty acid binding proteins, such as H-FABP, A-FABP, I-FABP were elaborated, which could provide reference for improving and enhancing the quality of animal product by using FABPs gene.
Fatty acid binding proteins are members of superfamily of lipid-binding proteins, which are widespread exist in the cells of small intestine, liver, heart, brain, skeletal muscle and so on of mammalian. They play important roles in absorption, transportation of LCFA in cell and metabolic regulation. In this article, several common fatty acid binding proteins, such as H-FABP, A-FABP, I-FABP were elaborated, which could provide reference for improving and enhancing the quality of animal product by using FABPs gene.
引文
Bemlohr D.A.,Simpson M.A.,and Hertzel A.V.,1997,Intracellular lipid-binding proteins and their genes,Annu.Rev.Nutr.,17(7):277-303
Cameron N.D.,and Enser M.B.,1991,Fatty acid composition of lipid in longissimus dorsi muscle of Duroc and British Landrance pigs and its relationship with eating quality,Mea Sci.,29:295-307
Cao H.H.,Li H.B.,and Wang L.X.,1999,Review on FABPs gene as candidate gene for intramuscular fat content in pig Guowai Xumu Keji(Animal Science Abroad),26(6):31-33(曹红鹤,李宏滨,王立贤,1999,FABPs作为猪肌内脂肪性状候选基因的研究进展,国外畜牧科技,26(6):31-33)
Chang X.T.,Hou X.P.,Wang Z.H.,Song G.Q.,Dong M.G.,Hou X.P.,Wang J.,and Zhou J.G.,2007,Association of A54Tsingle nucleotide polymorphism of IFABP gene with serum lipid levels in type 2 diabetes mellitus,Zhongguo Tangniaobing Zazhi(Department of Biochemistry),(5):285-288(常晓彤,侯丽娟,王振辉,宋桂芹,董明纲,侯小平,李桂喜,王健,周建光,2007,IFABP基因单核苷酸多态性与2型糖尿病患者血清脂质水平的关系,中国糖尿病杂志(5):285-288)
Chen C.H.,He P.J.,Lei Z.M.,Zhao S.G.,Cheng S.R.,and Wu JP.,2013,Polymorphisms of M-calpain and H-FABP genes in Longdong local cattle and simmental crossbred beef and its relationship with meat quality trait,Sichuan Nongye Daxue Xuebao(Journal of Sichuan Agricultural University),31(2):198-202(陈春华,贺鹏迦,雷赵民,赵生国,成述儒,吴建平,2013,陇东地方牛和西杂肉牛M-calpain和H-FABP基因多态性及其与肉质性状的相关性分析,四川农业大学学报,31(2):198-202)
Chu L.L.,Wang Q.G.,Guan T.Z.,and Li H.,2008,Association analyses between SNPs in the flanking region of I-FABPgene and growth and carcass composition traits,Dongbe Nongye Daxue Xuebao(Journal of Northeast Agricultural University),39(9):70-74(初丽丽,王启贵,关天竹,李辉2008,I-FABP基因侧翼区多态性与鸡生长和胴体组成性状的相关研究,东北农业大学学报,39(9):70-74)
Corsico B.,Cistola D.P.,Frieden C.,and Storch J.,1995,The helical domain of intestinal fatty acid binding protein is critical for collisional transfer of fatty acids to phospholipid membranes,Proceedings of the National Academy of Sciences of the United States of America,95(21):12174-12178
Cui L.,Chen X.,Zhou Y.,and Zhang S.J.,2016,Research progress on FABPs family genes,Xumu Yu Shouyi(Anima Husbandry&Veterinary Medicine),48(7):128-131(崔璐陈星,周颖,张淑君,2016,FABPs家族基因的研究进展畜牧与兽医,48(7):128-131)
Frans G.,Günther R.,Johannes A.L.,Jacques H.V.,and Marinus F.W.,1997,Characterization chromosomal localization and genetic variation of the porcine heart fatty acid-binding protein gene,Mamm.Genome,8(5):328-332
Hertzel A.V.,Bennaars-Eiden A.,and Bernlohr D.A.,2002,Increased lipolysis in transgenic animals over expressing the epithelial fatty acid binding protein in adipose cells,Journal of Lipid Research,43:2105-2111
Jiang Y.Z.,Li X.W.,and Yang G.X.,2006,Sequence characterization,tissue-specific expression and polymorphism of the porcine(Sus scrofa)liver-type fatty acid binding protein gene,Yichuan Xuebao(Acta Genetica Sinica),33(7):598-606(姜延志,李学伟,杨光希,2006,猪L-FABP基因的克隆、表达特征及遗传多态性研究,遗传学报,33(7):598-606)
Kuang L.D.,Lin Y.Q.,Xu Y.O.,Li Y.P.,Jiang Z.R.,and Zheng Y.C.,2010,Cloning and expression profiling of adipocyte fatty acid-binding protein gene(A-FABP)of Jiulong Yak,Nongye Shnegwu Jishu(Journal of Agricultural Biotechnology),18(6):1098-1102(邝良德,林亚秋,徐亚欧,李玉萍,蒋忠荣,郑玉才,2010,九龙牦牛脂肪细胞型脂肪酸结合蛋白基因(A-FABP)的克隆及其表达谱,农业生物技术学报,18(6):1098-1102)
Li W.F.,Xu S.Z.,Cao H.H.,and Li H.B.,2004,Genetic variation in Intron2 of H-FABP gene in three bovine hybrids and the relationships with meat quality traits,Xumu Shouyi Xuebao(Acta Vet et Zootech Sin),35(3):252-255(李武峰,许尚忠,曹红鹤,李宏滨,2004,3个杂交牛种H-FABP基因第二内含子的遗传变异与肉品质性状的相关分析,畜牧兽医学报,35(3):252-255)
Liao X.D.,Ren L.M.,Wang G.Y.,Li A.,and Huang Y.H.,2012,Polymorphism of FABP2 gene and its association with body size and carcass traits in Peking duck,Zhongguo Jiaqin(China Poultry),34(17):23-30(廖秀冬,任立明,王光瑛,李昂,黄银花,2012,北京鸭FABP2基因多态性与体尺和屠体性状的相关性研究,中国家禽,34(17):23-30)
Liu Y.Y.,Zan L.S.,Wang H.B.,Ji S.H.,and Fan Y.Y.,2010,Genetic polymorphisms within 5'flanking region of bovine A-FABP gene and its relationships with beef performance traits in Qinchuan cattle,Xumu Shouyi Xuebao(Acta Veterinaria et Zootechnica Sinica),41(6):44-650(刘艳妍,昝林森,王洪宝,季舒涵,樊月圆,2010,A-FABP基因5'侧翼区多态性及其与秦川牛肉用性状的关联分析,畜牧兽医学报,41(6):644-650)
Pang W.J.,and Yang G.S.,2005,Relationship between molecular marker of eight pig and one wild pig H-FABP gene and IMFcontent,Nongye Shengwu Jishu Xueao(Journal of Agricultural Biotechnology),2005(6):733-738(庞卫军,杨公社,2005,8个猪种和野猪H-FABP基因分子标记与IMF含量的关系,农业生物技术学报,2005(6):733-738)
Wang J.H.,Wen S.P.,Rao H.,Jia J.J.,Li Q.H.,Ge C.R.,and Cao Z.H.,2008,Key genes influencing beef quality,Yunnan Nongye Daxue Xuebao(Journal of Yunnan Agricultural U-niversity),23(5):693-696(王金浩,文生萍,饶华,贾俊静,李琦华,葛长荣,曹振辉,2008,影响牛肉品质的主效基因,云南农业大学学报,23(5):693-696)
Wen L.Z.,Zhao Y.M.,Zhang G.L.,Jiang H.,Wang C.M.,Zhao Z.H.,Zhang J.B.,Yuan B.,and Gao Y.,2008,Single nucleltide polymorphism of H-FABP gene and effect with mea quality in red steppe,Zhongguo Nongxue Tongbao(Chinese Agricultural Science Bulletin),24(5):17-21(文力正,赵玉民,张国梁,姜昊,王聪明,赵志辉,张嘉保,袁宝,高妍2008,草原红牛H-FABP基因单核苷酸多态性及其对肉质的影响,中国农学通报,24(5):17-21)
Wu Z.L.,Zhao Z.H.,Li S.F.,Huang H.Y.,Li C.M.,Wang Q.B.and Xue L.G.,2015,Growth curve fitting correlation analysis of body weight and body measurement in quality chicken,Zhongguo Jiaqin(China Poultry),37(8):16-18(吴兆林赵振华,黎寿丰,黄华云,李春苗,王钱保,薛龙岗,2015优质肉鸡体重优质肉鸡体重、体尺生长曲线拟合与相关性分析,中国家禽,37(8):16-18)
Wulf D.M.,Taturm J.D.,Green R.D.,Morgan J.B.,Golden B.L.and Smith G.C.,1996,Genetic influences on beef longissimus palatability in Charolais-sired and Limousin sired steers and heifers,Journal of Animal Science,74:2394-2405
Xu S.S.,An R.R.,Chen Y.F.,Cheng M.,Li H.,and Wang S.Z.2016,Association of haplotypes of FABP2 gene with growth and body composition traits in chickens,Zhongguo Jiaqin(China Poultry),38(8):5-9(徐松松,安荣荣,陈耀峰,程敏,李辉,王守志,2016,鸡FABP2基因单倍型与生长和体组成性状的相关分析,中国家禽,38(8):5-9)
You X.Y.,Yang F.Y.,and Xie Y.W.,2010,Research progress on the roles of H-FABP gene in the fatty deposition,Zhongguo Xumu Shouyi(Chinese Animal Husbandry and Veterinary),37(11):115-118(游小燕,杨飞云,谢跃伟,2010,H-FABP基因在脂肪沉积中作用的研究进展,中国畜牧兽医,37(11):115-118)
Zhao S.G.,Tang H.J.,Jiao T.,Liu L.S.,Zhou R.,and Xu Z.F.,2015,Correlation analysis between SNPs of A-FABPgene and characteristics of carcass and meat quality in Zaosheng Cattle,Caoye Kexue(Pratacultural Science),32(7):1150-1155(赵生国,唐红杰,焦婷,刘立山,周瑞,徐振飞,2015,早胜牛A-FABP基因SNPs与胴体品质和肉质性状的关系,草业科学,32(7):1150-1155)
Zhou G.L.,Zhu Q.,Guo S.L.,and Wu Y.H.,2005,Analysis on polymorphism of H-FABP gene in Luxi cattle and the relationships with meat quality traits,Xibei Nongye Xuebao(Acta Agriculture Boreali-occidentalis Sinica),14(3):5-7(周国利,朱奇,郭善利,吴玉厚,2005,鲁西黄牛H-FABP基因的多态性及其与肉质性状关系的分析,西北农业学报,14(3):5-7)
Cameron N.D.,and Enser M.B.,1991,Fatty acid composition of lipid in longissimus dorsi muscle of Duroc and British Landrance pigs and its relationship with eating quality,Mea Sci.,29:295-307
Cao H.H.,Li H.B.,and Wang L.X.,1999,Review on FABPs gene as candidate gene for intramuscular fat content in pig Guowai Xumu Keji(Animal Science Abroad),26(6):31-33(曹红鹤,李宏滨,王立贤,1999,FABPs作为猪肌内脂肪性状候选基因的研究进展,国外畜牧科技,26(6):31-33)
Chang X.T.,Hou X.P.,Wang Z.H.,Song G.Q.,Dong M.G.,Hou X.P.,Wang J.,and Zhou J.G.,2007,Association of A54Tsingle nucleotide polymorphism of IFABP gene with serum lipid levels in type 2 diabetes mellitus,Zhongguo Tangniaobing Zazhi(Department of Biochemistry),(5):285-288(常晓彤,侯丽娟,王振辉,宋桂芹,董明纲,侯小平,李桂喜,王健,周建光,2007,IFABP基因单核苷酸多态性与2型糖尿病患者血清脂质水平的关系,中国糖尿病杂志(5):285-288)
Chen C.H.,He P.J.,Lei Z.M.,Zhao S.G.,Cheng S.R.,and Wu JP.,2013,Polymorphisms of M-calpain and H-FABP genes in Longdong local cattle and simmental crossbred beef and its relationship with meat quality trait,Sichuan Nongye Daxue Xuebao(Journal of Sichuan Agricultural University),31(2):198-202(陈春华,贺鹏迦,雷赵民,赵生国,成述儒,吴建平,2013,陇东地方牛和西杂肉牛M-calpain和H-FABP基因多态性及其与肉质性状的相关性分析,四川农业大学学报,31(2):198-202)
Chu L.L.,Wang Q.G.,Guan T.Z.,and Li H.,2008,Association analyses between SNPs in the flanking region of I-FABPgene and growth and carcass composition traits,Dongbe Nongye Daxue Xuebao(Journal of Northeast Agricultural University),39(9):70-74(初丽丽,王启贵,关天竹,李辉2008,I-FABP基因侧翼区多态性与鸡生长和胴体组成性状的相关研究,东北农业大学学报,39(9):70-74)
Corsico B.,Cistola D.P.,Frieden C.,and Storch J.,1995,The helical domain of intestinal fatty acid binding protein is critical for collisional transfer of fatty acids to phospholipid membranes,Proceedings of the National Academy of Sciences of the United States of America,95(21):12174-12178
Cui L.,Chen X.,Zhou Y.,and Zhang S.J.,2016,Research progress on FABPs family genes,Xumu Yu Shouyi(Anima Husbandry&Veterinary Medicine),48(7):128-131(崔璐陈星,周颖,张淑君,2016,FABPs家族基因的研究进展畜牧与兽医,48(7):128-131)
Frans G.,Günther R.,Johannes A.L.,Jacques H.V.,and Marinus F.W.,1997,Characterization chromosomal localization and genetic variation of the porcine heart fatty acid-binding protein gene,Mamm.Genome,8(5):328-332
Hertzel A.V.,Bennaars-Eiden A.,and Bernlohr D.A.,2002,Increased lipolysis in transgenic animals over expressing the epithelial fatty acid binding protein in adipose cells,Journal of Lipid Research,43:2105-2111
Jiang Y.Z.,Li X.W.,and Yang G.X.,2006,Sequence characterization,tissue-specific expression and polymorphism of the porcine(Sus scrofa)liver-type fatty acid binding protein gene,Yichuan Xuebao(Acta Genetica Sinica),33(7):598-606(姜延志,李学伟,杨光希,2006,猪L-FABP基因的克隆、表达特征及遗传多态性研究,遗传学报,33(7):598-606)
Kuang L.D.,Lin Y.Q.,Xu Y.O.,Li Y.P.,Jiang Z.R.,and Zheng Y.C.,2010,Cloning and expression profiling of adipocyte fatty acid-binding protein gene(A-FABP)of Jiulong Yak,Nongye Shnegwu Jishu(Journal of Agricultural Biotechnology),18(6):1098-1102(邝良德,林亚秋,徐亚欧,李玉萍,蒋忠荣,郑玉才,2010,九龙牦牛脂肪细胞型脂肪酸结合蛋白基因(A-FABP)的克隆及其表达谱,农业生物技术学报,18(6):1098-1102)
Li W.F.,Xu S.Z.,Cao H.H.,and Li H.B.,2004,Genetic variation in Intron2 of H-FABP gene in three bovine hybrids and the relationships with meat quality traits,Xumu Shouyi Xuebao(Acta Vet et Zootech Sin),35(3):252-255(李武峰,许尚忠,曹红鹤,李宏滨,2004,3个杂交牛种H-FABP基因第二内含子的遗传变异与肉品质性状的相关分析,畜牧兽医学报,35(3):252-255)
Liao X.D.,Ren L.M.,Wang G.Y.,Li A.,and Huang Y.H.,2012,Polymorphism of FABP2 gene and its association with body size and carcass traits in Peking duck,Zhongguo Jiaqin(China Poultry),34(17):23-30(廖秀冬,任立明,王光瑛,李昂,黄银花,2012,北京鸭FABP2基因多态性与体尺和屠体性状的相关性研究,中国家禽,34(17):23-30)
Liu Y.Y.,Zan L.S.,Wang H.B.,Ji S.H.,and Fan Y.Y.,2010,Genetic polymorphisms within 5'flanking region of bovine A-FABP gene and its relationships with beef performance traits in Qinchuan cattle,Xumu Shouyi Xuebao(Acta Veterinaria et Zootechnica Sinica),41(6):44-650(刘艳妍,昝林森,王洪宝,季舒涵,樊月圆,2010,A-FABP基因5'侧翼区多态性及其与秦川牛肉用性状的关联分析,畜牧兽医学报,41(6):644-650)
Pang W.J.,and Yang G.S.,2005,Relationship between molecular marker of eight pig and one wild pig H-FABP gene and IMFcontent,Nongye Shengwu Jishu Xueao(Journal of Agricultural Biotechnology),2005(6):733-738(庞卫军,杨公社,2005,8个猪种和野猪H-FABP基因分子标记与IMF含量的关系,农业生物技术学报,2005(6):733-738)
Wang J.H.,Wen S.P.,Rao H.,Jia J.J.,Li Q.H.,Ge C.R.,and Cao Z.H.,2008,Key genes influencing beef quality,Yunnan Nongye Daxue Xuebao(Journal of Yunnan Agricultural U-niversity),23(5):693-696(王金浩,文生萍,饶华,贾俊静,李琦华,葛长荣,曹振辉,2008,影响牛肉品质的主效基因,云南农业大学学报,23(5):693-696)
Wen L.Z.,Zhao Y.M.,Zhang G.L.,Jiang H.,Wang C.M.,Zhao Z.H.,Zhang J.B.,Yuan B.,and Gao Y.,2008,Single nucleltide polymorphism of H-FABP gene and effect with mea quality in red steppe,Zhongguo Nongxue Tongbao(Chinese Agricultural Science Bulletin),24(5):17-21(文力正,赵玉民,张国梁,姜昊,王聪明,赵志辉,张嘉保,袁宝,高妍2008,草原红牛H-FABP基因单核苷酸多态性及其对肉质的影响,中国农学通报,24(5):17-21)
Wu Z.L.,Zhao Z.H.,Li S.F.,Huang H.Y.,Li C.M.,Wang Q.B.and Xue L.G.,2015,Growth curve fitting correlation analysis of body weight and body measurement in quality chicken,Zhongguo Jiaqin(China Poultry),37(8):16-18(吴兆林赵振华,黎寿丰,黄华云,李春苗,王钱保,薛龙岗,2015优质肉鸡体重优质肉鸡体重、体尺生长曲线拟合与相关性分析,中国家禽,37(8):16-18)
Wulf D.M.,Taturm J.D.,Green R.D.,Morgan J.B.,Golden B.L.and Smith G.C.,1996,Genetic influences on beef longissimus palatability in Charolais-sired and Limousin sired steers and heifers,Journal of Animal Science,74:2394-2405
Xu S.S.,An R.R.,Chen Y.F.,Cheng M.,Li H.,and Wang S.Z.2016,Association of haplotypes of FABP2 gene with growth and body composition traits in chickens,Zhongguo Jiaqin(China Poultry),38(8):5-9(徐松松,安荣荣,陈耀峰,程敏,李辉,王守志,2016,鸡FABP2基因单倍型与生长和体组成性状的相关分析,中国家禽,38(8):5-9)
You X.Y.,Yang F.Y.,and Xie Y.W.,2010,Research progress on the roles of H-FABP gene in the fatty deposition,Zhongguo Xumu Shouyi(Chinese Animal Husbandry and Veterinary),37(11):115-118(游小燕,杨飞云,谢跃伟,2010,H-FABP基因在脂肪沉积中作用的研究进展,中国畜牧兽医,37(11):115-118)
Zhao S.G.,Tang H.J.,Jiao T.,Liu L.S.,Zhou R.,and Xu Z.F.,2015,Correlation analysis between SNPs of A-FABPgene and characteristics of carcass and meat quality in Zaosheng Cattle,Caoye Kexue(Pratacultural Science),32(7):1150-1155(赵生国,唐红杰,焦婷,刘立山,周瑞,徐振飞,2015,早胜牛A-FABP基因SNPs与胴体品质和肉质性状的关系,草业科学,32(7):1150-1155)
Zhou G.L.,Zhu Q.,Guo S.L.,and Wu Y.H.,2005,Analysis on polymorphism of H-FABP gene in Luxi cattle and the relationships with meat quality traits,Xibei Nongye Xuebao(Acta Agriculture Boreali-occidentalis Sinica),14(3):5-7(周国利,朱奇,郭善利,吴玉厚,2005,鲁西黄牛H-FABP基因的多态性及其与肉质性状关系的分析,西北农业学报,14(3):5-7)