Neuregulin-1及其受体ErbB在中枢神经系统损伤修复中作用的研究进展
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摘要
神经调节蛋白-1(NRG-1)是一类包含表皮生长因子样结构域,在神经组织中发挥着多种生物学效应的营养因子。在神经损伤时,NRG-1的作用涉及神经元迁移、轴突生长、髓鞘和突触的形成,以及促进神经再生,近年来受到越来越多的关注,文中将对NRG-1及其Erb B受体的特性及其在中枢神经损伤修复中的作用进行综述。
引文
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[20]Chen PS,Peng GS,Li G,et al. Valproate protects dopa-minergic neurons in midbra-in neuron/gl-ia cultures by stimulating the release of neurotrophic factors from astrocytees[J]. Mol Psychiatry,2006,11(12):1116-1125. DOI:10. 1038/sj. mp. 4001893.
[21]Saito H,Sato T,Kaba H,et al. Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain[J]. Glia,2009,57(4):362-379. DOI:10. 1002/glia.20762.
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[23]孙娇丽.神经调节蛋白1介导星形胶质细胞活化在慢性神经病理性疼痛发生发展中的作用研究[D].华中科技大学,2013.
[24]Xu J,Hu C,Chen S,et al. Neuregulin-1 protects mouse cerebellum against oxidative stress and neuroinflammation[J]. Brain Res,2017,1670(1):32-43. DOI:10. 1016/j. brainres. 2017. 06.012.
[25]Zhao X,Liao Y,Morgan S,et al. Noninflammatory changes of microglia are sufficient to cause epilepsy[J]. Cell Rep,2018,22(8):2080-2093. DOI:10. 1016/j. celrep. 2018. 02. 004.
[26]Xiang Y,Liu T,Yang H,et al. NRG-1‐ErbB signalling promotes microglia activation contributing to incision‐induced mechanical allodynia[J]. Eur J Pain,2015,19(5):686-694.DOI:10. 1002/ejp. 590.
[27]Calvo M,Zhu N,Tsantoulas C,et al. Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury[J]. J Neurosci,2010,30(15):5437-5450. DOI:10. 1523/JNEUROSCI. 5169-09. 2010.
[28]Ikawa D,Makinodan M,Iwata K,et al. Microglia-derived neuregulin expression in psychiatric disorders[J]. Brain Behav Immun,2017,61:375-385. DOI:10. 1016/j. bbi. 2017. 01. 003.
[29]Alizadeh A,Santhosh KT,Kataria H,et al. Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury[J]. J Neuroinflammation,2018,15(1):53. DOI:10. 1186/s12974-018-1093-9.
[30]Lok J,Zhao S,Leung W,et al. Neuregulin-1 effects on endothelial and blood-brain barrier perme-ability after experimental injury[J].Transl Stroke Res,2012,3(suppl 1):S119-124. DOI:10.1007/s12975-012-0157-x.
[31]Liu M,Solomon W,Cespedes JC,et al. Neuregulin-1 attenuates experimental cerebral malaria(ECM)pathogenesis by regulating ErbB4/AKT/STAT3 signaling[J]. J Neuroinflammation,2018,15(1):104. DOI:10. 1186/s12974-018-1147-z.
[32]Bartus K,Galino J,James ND,et al. Neuregulin-1 controls an endogenous repair mechanism aft-er spinal cord injury[J]. Brain,2016,139(Pt):1394-1416. DOI:10. 1093/brain/aww039.
[33] Alizadeh A,Dyck SM,Kataria H,et al. Neuregulin-1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury[J]. Glia,2017,65(7):1152-1175. DOI:10. 1002/glia. 23150.
[34]Puntambekar SS,Hinton DR,Yin X,et al. Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination[J]. Glia,2015,63(11):2106-2120.DOI:10. 1002/glia. 22880.
[35]Santhosh KT,Alizadeh A,Karimi-Abdolrezaee S. Design and optimization of PLGA microparticle-s for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury[J]. J Control Release,2017,261:147-162. DOI:10. 1016/j. jconrel. 2017. 06.030.
[36]Guan YF,Wu CY,Fang YY,et al. Neuregulin1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission[J]. Neuroscience,2015,307:151-159. DOI:10. 1016/j. neuroscience. 2015. 08. 047.
[37]Wang S,Li Y,Paudyal R,et al. Evaluation of neuregulin-1’s neuroprotection against ischemic injury in rats using diffusion tensor imaging[J]. Magn Reson Imaging,2018,53(1):63-70. DOI:10. 1016/j. mri. 2018. 07. 002.
[38]Surles-zeigler MC,Li Y,Distel TJ,et al. Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites:A role for the ETS-1 transcription factor[J]. PLo S One,2018,13(6):e0197092.DOI:10. 1371/journal. pone. 0197092.
[39]Li Q,Zhang R,Ge YL,et al. Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat[J]. J Mol Neurosci,2009,38(2):207-215. DOI:10. 1007/s12031-008-9150-y.
[40]Gu N,Ge K,Hao C,et al. Neuregulin1βeffects on brain tissue via ERK5-dependent MAPK pathway in a rat model of cerebral ischemia-reperfusion injury[J]. J Mol Neurosci,2017,61(4):607-616. DOI:10. 1007/s12031-017-0902-4.
[41] Ji Y,Teng L,Zhang R,et al. NRG-1βexerts neuroprotective effects against ischemia reperfusion-induced injury in rats through the JNK signaling pathway[J]. Neuroscience,2017,362(1):13-24. DOI:10. 1016/j. neuroscience. 2017. 08. 032.
[2]Mei L,Nave KA. Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases[J]. Neuron,2014,83(1):27-49. DOI:10. 1016/j. neuron. 2014. 06. 007.
[3]Law AJ,Lipska BK,Weickert CS,et al. Neuregulin1 transcripts are differentially expressed in schizophrenia and regulated by 5’SNPs associated with the disease[J]. Proc Natl Acad Sci USA,2006,103(13):6747-6752. DOI:10. 1073/pnas. 0602002103.
[4]Rosen KM,Ford BD,Querfurth HW. Downregulation and increased turnover ofβ-amyloid precursor protein in skeletal muscle cultures by neuregulin-1[J]. Exp Neurol,2003,181(2):170-180.
[5]Chen YJ,Zhang M,Yin DM,et al. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation[J]. Proc Natl Acad Sci USA,2010,107(50):21818-21823. DOI:10. 1073/pnas. 1010669107.
[6] Mei L,Xiong WC. Neuregulin1 in neural development,synaptic plasticity and schizophrenia[J]. Nat Rev Neurosci,2008,9(6):437-452. DOI:10. 1038/nrn2392.
[7] Iwakura Y,Wang R,Inamura N,et al. Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons[J]. PLo S One,2017,12(3):e0174780. DOI:10. 1371/journal. pone. 0174780.
[8]Fornasari BE,El Soury M,De Marchis S,et al. Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4[J].Mol Cell Neurosci,2016,77:87-94. DOI:10. 1016/j. mcn.2016. 10. 008.
[9]Carlsson T,Schindler FR,H9llerhage M,et al. Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson’s disease[J]. J Neurochem,2011,117(6):1066-1074. DOI:10. 1111/j. 1471-4159. 2011. 07284. x.
[10]Cui W,Tao J,Wang Z,et al. Neuregulin1 beta1 antagonizes apoptosis via ErbB4-dependent activation of PI3-kinase/Akt in APP/PS1 transgenic mice[J]. Neurochem Res,2013,38(11):2237-2246. DOI:10. 1007/s11064-013-1131-z.
[11]Jiang Q,Chen S,Hu C,et al. Neuregulin-1(Nrg1)signaling has a preventive role and is altered in the frontal cortex under the pathological conditions of Alzheimer’s disease[J]. Mol Med Rep,2016,14(3):2614-2624. DOI:10. 3892/mmr. 2016. 5542.
[12]Liu Y,Yu Y,Schachner M,et al. Neuregulin 1-βregulates cell adhesion molecule L1 expression in the cortex and hippocampus of mice[J]. Biochem Biophys Res Commun,2013,441(1):7-12. DOI:10. 1016/j. bbrc. 2013. 09. 102.
[13]Li Y,Lein PJ,Ford GD,et al. Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury[J]. J Neuroinflammation,2015,12:64. DOI:10. 1186/s12974-015-0283-y.
[14] Ledonne A,Mango D,Latagliata EC,et al. Neuregulin1/ErbB signalling modulates hippocampal m GluRI-dependent LTD and object recognition memory[J]. Pharmacol Res,2018(1),130:12-24. DOI:10. 1016/j. phrs. 2018. 02. 003.
[15] Hei Y,Chen R,Yi X,et al. The expression of hippocampal NRG1/ErbB4 correlates with neuronal apoptosis,but not with glial activation during chronic cerebral hypoperfusion[J]. Front Aging Neurosci. 2018,10:149. DOI:10. 3389/fnagi. 2018. 00149.
[16]吴丽珉. Neuregulin1在创伤性脑损伤中的保护作用及机制的研究[D].吉林大学,2015.
[17]Ortega MC,Bribián A,Peregrín S,et al. Neuregulin-1/ErbB4 signaling control the migration of o-ligodendrocyte precursor cells during development[J]. Exp Neurol,2012,235(2):610-620.DOI:10. 1016/j. expneurol. 2012. 03. 015.
[18]Gauthier MK,Kosciuczyk K,Tapley L,et al. Dysregulation of the neuregulin-1-ErbB network m-odulates endogenous oligodendrocyte differentiation and preservation after spinal cord injury[J]. Eur J Neurosci,2013,38(5):2693-2715. DOI:10. 1111/ejn.12268.
[19]Kataria H,Alizadeh A,Shahriary GM,et al. Neuregulin-1 promotes remyelination and fosters a proregenerative inflammatory response in focal demyelinating lesions of the spinal cord[J]. Glia,2018,66(3):538-561. DOI:10. 1002/glia. 23264.
[20]Chen PS,Peng GS,Li G,et al. Valproate protects dopa-minergic neurons in midbra-in neuron/gl-ia cultures by stimulating the release of neurotrophic factors from astrocytees[J]. Mol Psychiatry,2006,11(12):1116-1125. DOI:10. 1038/sj. mp. 4001893.
[21]Saito H,Sato T,Kaba H,et al. Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain[J]. Glia,2009,57(4):362-379. DOI:10. 1002/glia.20762.
[22]王智超,李冰,孙燕. Neuregulin-1β1对星形胶质细胞营养和氧气剥夺后分化抗原簇蛋白44,肿瘤坏死因子α和白细胞介素1β的影响[J].中华医学杂志,2012,92(5):3227-3231. DOI:10. 3760/cma. j. issn. 0376-2491. 2012. 45. 019.
[23]孙娇丽.神经调节蛋白1介导星形胶质细胞活化在慢性神经病理性疼痛发生发展中的作用研究[D].华中科技大学,2013.
[24]Xu J,Hu C,Chen S,et al. Neuregulin-1 protects mouse cerebellum against oxidative stress and neuroinflammation[J]. Brain Res,2017,1670(1):32-43. DOI:10. 1016/j. brainres. 2017. 06.012.
[25]Zhao X,Liao Y,Morgan S,et al. Noninflammatory changes of microglia are sufficient to cause epilepsy[J]. Cell Rep,2018,22(8):2080-2093. DOI:10. 1016/j. celrep. 2018. 02. 004.
[26]Xiang Y,Liu T,Yang H,et al. NRG-1‐ErbB signalling promotes microglia activation contributing to incision‐induced mechanical allodynia[J]. Eur J Pain,2015,19(5):686-694.DOI:10. 1002/ejp. 590.
[27]Calvo M,Zhu N,Tsantoulas C,et al. Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury[J]. J Neurosci,2010,30(15):5437-5450. DOI:10. 1523/JNEUROSCI. 5169-09. 2010.
[28]Ikawa D,Makinodan M,Iwata K,et al. Microglia-derived neuregulin expression in psychiatric disorders[J]. Brain Behav Immun,2017,61:375-385. DOI:10. 1016/j. bbi. 2017. 01. 003.
[29]Alizadeh A,Santhosh KT,Kataria H,et al. Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury[J]. J Neuroinflammation,2018,15(1):53. DOI:10. 1186/s12974-018-1093-9.
[30]Lok J,Zhao S,Leung W,et al. Neuregulin-1 effects on endothelial and blood-brain barrier perme-ability after experimental injury[J].Transl Stroke Res,2012,3(suppl 1):S119-124. DOI:10.1007/s12975-012-0157-x.
[31]Liu M,Solomon W,Cespedes JC,et al. Neuregulin-1 attenuates experimental cerebral malaria(ECM)pathogenesis by regulating ErbB4/AKT/STAT3 signaling[J]. J Neuroinflammation,2018,15(1):104. DOI:10. 1186/s12974-018-1147-z.
[32]Bartus K,Galino J,James ND,et al. Neuregulin-1 controls an endogenous repair mechanism aft-er spinal cord injury[J]. Brain,2016,139(Pt):1394-1416. DOI:10. 1093/brain/aww039.
[33] Alizadeh A,Dyck SM,Kataria H,et al. Neuregulin-1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury[J]. Glia,2017,65(7):1152-1175. DOI:10. 1002/glia. 23150.
[34]Puntambekar SS,Hinton DR,Yin X,et al. Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination[J]. Glia,2015,63(11):2106-2120.DOI:10. 1002/glia. 22880.
[35]Santhosh KT,Alizadeh A,Karimi-Abdolrezaee S. Design and optimization of PLGA microparticle-s for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury[J]. J Control Release,2017,261:147-162. DOI:10. 1016/j. jconrel. 2017. 06.030.
[36]Guan YF,Wu CY,Fang YY,et al. Neuregulin1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission[J]. Neuroscience,2015,307:151-159. DOI:10. 1016/j. neuroscience. 2015. 08. 047.
[37]Wang S,Li Y,Paudyal R,et al. Evaluation of neuregulin-1’s neuroprotection against ischemic injury in rats using diffusion tensor imaging[J]. Magn Reson Imaging,2018,53(1):63-70. DOI:10. 1016/j. mri. 2018. 07. 002.
[38]Surles-zeigler MC,Li Y,Distel TJ,et al. Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites:A role for the ETS-1 transcription factor[J]. PLo S One,2018,13(6):e0197092.DOI:10. 1371/journal. pone. 0197092.
[39]Li Q,Zhang R,Ge YL,et al. Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat[J]. J Mol Neurosci,2009,38(2):207-215. DOI:10. 1007/s12031-008-9150-y.
[40]Gu N,Ge K,Hao C,et al. Neuregulin1βeffects on brain tissue via ERK5-dependent MAPK pathway in a rat model of cerebral ischemia-reperfusion injury[J]. J Mol Neurosci,2017,61(4):607-616. DOI:10. 1007/s12031-017-0902-4.
[41] Ji Y,Teng L,Zhang R,et al. NRG-1βexerts neuroprotective effects against ischemia reperfusion-induced injury in rats through the JNK signaling pathway[J]. Neuroscience,2017,362(1):13-24. DOI:10. 1016/j. neuroscience. 2017. 08. 032.