中药菩人丹对糖尿病视网膜病变视网膜血流动力学的影响
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摘要
目的:观察中药菩人丹对单纯型糖尿病视网膜病变(simple diabetic retinopathy,SDR)视网膜血流动力学的变化影响。方法:选择正常人20例,应用彩色多普勒血流成像(color doppler flow imaging,CDFI)技术检测视网膜中央动脉(central retinal artery,CRA)和视网膜中央静脉(central retinal vein,CRV)的收缩期血流峰值速度(Vs),舒张末期血流速度(Vd),阻力指数(RI),同时选择糖尿病患者20例,经眼底荧光血管造影(fluorescence fundus angiography,FFA)检查,为糖尿病视网膜病变Ⅰ期和Ⅱ期患者,给中药菩人丹治疗6个月,治疗前后应用彩色多普勒血流成像(CDFI)技术行视网膜中央动脉(CRA)和视网膜中央静脉(CRV)收缩期血流峰值速度(Vs),舒张末期血流速度(Vd),阻力指数(RI)检测。结果:治疗前糖尿病患者视网膜中央动脉和视网膜中央静脉的血流速度较正常人明显下降,阻力指数较正常人升高(P<0.05)。治疗后视网膜中央动脉血流参数基本恢复正常,视网膜中央静脉血流速度较治疗前显著改善,但仍低于正常,视网膜中央动脉,中央静脉阻力指数治疗前后发生明显的变化(P<0.05)。结论:中药菩人丹治疗糖尿病视网膜病变患者,其视网膜血流动力学明显得到改善,从而证实了中药菩人丹对DR治疗的有效。
Objective: To observe the effect of traditional Chinese medicine " Purendan" on retinal hemodynamics in patients with simple diabetic retinopathy. Methods: The peak systolic velocity(Vs),end diastolic velocity(Vd),and obstruction of central retinal artery(CRA) and central retinal vein(CRV) were measured by color Doppler flow imaging(CDFI) in 20 normal subjects. Force index(RI) was measured by fundus fluorescence angiography(FFA) in 20 patients with diabetes mellitus. Patients with stage I and stage II diabetic retinopathy were treated with Borendan for 6 months. The central retinal artery was performed by color Doppler flow imaging(CDFI) before and after treatment. The peak systolic velocity(Vs),end diastolic velocity(Vd) and resistance index(RI) of CRA and CRV were measured. Results: Before treatment,the blood flow velocity of central retinal artery and central retinal vein in diabetic patients was significantly lower than that of normal people,and the resistance index was higher than that of normal people(P <0.05). After treatment,the parameters of central retinal artery blood flow basically returned to normal,and the velocity of central retinal vein blood flow was significantly improved,but still lower than normal. The resistance index of central retinal artery and central vein changed significantly before and after treatment(P < 0. 05). Conclusion:Retinal hemodynamics of diabetic retinopathy patients treated with traditional Chinese medicine Bo Ren Dan has been significantly improved,thus confirming the effectiveness of traditional Chinese medicine Bo Ren Dan on DR treatment.
Objective: To observe the effect of traditional Chinese medicine " Purendan" on retinal hemodynamics in patients with simple diabetic retinopathy. Methods: The peak systolic velocity(Vs),end diastolic velocity(Vd),and obstruction of central retinal artery(CRA) and central retinal vein(CRV) were measured by color Doppler flow imaging(CDFI) in 20 normal subjects. Force index(RI) was measured by fundus fluorescence angiography(FFA) in 20 patients with diabetes mellitus. Patients with stage I and stage II diabetic retinopathy were treated with Borendan for 6 months. The central retinal artery was performed by color Doppler flow imaging(CDFI) before and after treatment. The peak systolic velocity(Vs),end diastolic velocity(Vd) and resistance index(RI) of CRA and CRV were measured. Results: Before treatment,the blood flow velocity of central retinal artery and central retinal vein in diabetic patients was significantly lower than that of normal people,and the resistance index was higher than that of normal people(P <0.05). After treatment,the parameters of central retinal artery blood flow basically returned to normal,and the velocity of central retinal vein blood flow was significantly improved,but still lower than normal. The resistance index of central retinal artery and central vein changed significantly before and after treatment(P < 0. 05). Conclusion:Retinal hemodynamics of diabetic retinopathy patients treated with traditional Chinese medicine Bo Ren Dan has been significantly improved,thus confirming the effectiveness of traditional Chinese medicine Bo Ren Dan on DR treatment.
引文
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[10]张垒,董志军,张铁民,等.菩人丹超微粉对糖尿病大鼠视网膜血管生成素-2表达的影响[J].中国老年学杂志,2012,32(9):1888~1889.
[2]刘祖涵,张梓倩.菩人丹对T2DM胰腺微血管损伤大鼠胰岛β细胞功能及胰岛素抵抗的影响[J].天津中医药,2016,33(7):414~418.
[3]张耀丹,陈书,苏冷高娃,等.菩人丹对ob/ob小鼠糖脂代谢及胰岛素抵抗的影响[J].天津中医药,2017,34(3):175~180.
[4]李婧.糖尿病眼部病变的影像学诊断研究进展[J].医学影像学杂志,2018,28(5):852~854.
[5]王俊霞,张丽,杨泽,等.人参醇提物对糖尿病小鼠模型的治疗机理研究[J].北京中医药,2011,30(2):146~149.
[6]何文凤,吕湛,张全波.丹参酮在心血管保护中的药理作用机制研究进展[J].中国医药导报,2013,10(29):34~38.
[7]李文平,石京山,陈修平.葛根素对糖尿病及其并发症的治疗作用和机制研究进展[J].山东医药,2015,(15):90~92.
[8]高丽娟,高娟,胡耀红,等.水蛭粉对高脂血症大鼠动脉粥样硬化形成过程的干预机制[J].中成药,2014,36(9):1962~1965.
[9]庞宗然,刘祖涵,苏晓慧,等.菩人丹超微粉对肥胖型T2DM大血管损伤大鼠ET-1、NO、FFAs含量的影响[J].中国老年学杂志,2011,31(10):1779~1780.
[10]张垒,董志军,张铁民,等.菩人丹超微粉对糖尿病大鼠视网膜血管生成素-2表达的影响[J].中国老年学杂志,2012,32(9):1888~1889.