胃肠道间质瘤42例临床病理分析
摘要
目的探讨胃肠道间质瘤的临床病理特征及免疫组化特点。方法复习42例胃肠道间质瘤临床病理资料,观察肿瘤组织形态学及其免疫表型。结果 42例胃肠道间质瘤中,男23例,女19例,平均年龄53.4岁,临床多表现腹痛,腹胀,反复黑便等消化道症状,肿块边界清楚,肿瘤细胞由梭形细胞和上皮样细胞组成。免疫组化表型:CD117阳性37例,CD34阳性35例,Vim阳性41例,Ki-67阳性7例,HHF阳性8例,S-100阳性2例,EMA阳性0例。结论胃肠道间质瘤是消化道常见的间叶源性肿瘤,好发于胃、小肠,其次是直肠、结肠、食管,极少数可发生于肠系膜、腹膜后。CD117和CD34阳性表达是确诊GIST最有价值依据。GIST的恶性程度与肿瘤大小,核分裂象数密切相关。
引文
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[3]中国胃肠道间质瘤专家组.中国胃肠道间质瘤诊断治疗共识[J].中华病理学杂志,2009,38(10):697.
[4]Lux ML,Rubin BP,Biase TL,et al.KIT extracellular and Kinase domain murations in gastrointestinal tumous[J].Am J Parho,2000,156:791.
[5]Heinrich MC,Corless CL,Duensing A,et al.PDGFRA activating mutations in gastrointestinal stromal tumors[J].Science,2003,299:708.
[6]梁玉梅,李向红,吕有勇,等.胃肠道间质瘤15例的临床病理学特征与预后分析[J].中华病理学杂志,2007,36(4):233.
[7]Van Koggen JF,Van Velthuysen ML,Hogendoom.The histopathological differential diagnosis of gastrointest inalstromal tumors[J].Clinpathol,2001,54(2):96.
[8]Joensuu H.Risk stratification of patients diagnosed with gastrointestinal stromal tumor[J].Hum Pathol,2008,39(10):1411-9.
[9]张兴义,孙梅,王荣有.22例胃肠道间质瘤临床病理及免疫组化分析[J].中国实验诊断学,2005,9:94.