眼底荧光血管造影在原发性开角型青光眼诊断中的应用
|
摘要
目的探讨眼底荧光血管造影在原发性开角型青光眼诊断中的诊断价值及其血液流变学状况。方法选取60例原发性开角型青光眼患者设为观察组,另选60例正常体检者设为对照组,比较2组眼底荧光血管造影相关指标(臂-脉络膜充盈时间、臂-视网膜动脉充盈时间、视网膜动-静脉充盈时间)以及血液流变学相关指标(高、中、低切变率下全血表观黏度值、血浆黏度值、红细胞压积)。结果观察组的高、中、低切变率下全血表观黏度值、红细胞压积显著高于对照组(P<0.05),但2组血浆黏度值无显著差异(P>0.05);观察组眼底荧光血管造影的臂-脉络膜充盈时间、臂-视网膜动脉充盈时间、视网膜动-静脉充盈时间均显著长于对照组(P<0.05)。结论眼底荧光血管造影对临床诊断原发性开角型青光眼有重要意义,而且可动态反映血液循环状况,了解原发性开角型青光眼患者血液黏度异常增高情况。
Objective To evaluate the value of fundus fluorescein angiography in primary open angle glaucoma and its hemorheological status.Methods A total of 60 patients with primary open angle glaucoma were selected as observation group,and 60 cases with healthy examinations were as control group.The indexes of fundus fluorescein angiography(brachial-choroidal filling time,brachial-retinal artery filling time,retinal-arteriovenous filling time) were compared and analyzed between the two groups.Hemorheological parameters(whole blood apparent viscosity at high,medium and low shear rates,value of plasma viscosity,hematocrit) in both groups were compared.Results The whole blood apparent viscosity at high,medium and low shear rates and hematocrit in the observation group were significantly higher than that in the control group(P<0.05),but there was no significant difference in plasma viscosity between the two groups(P>0.05).The brachial-choroidal filling time,brachial-retinal artery filling time,retinal-arteriovenous filling time in the observation group were longer than that in the control group(P<0.05).Conclusion Fundus fluorescein angiography is of great significance in diagnosis of primary open-angle glaucoma,and it can dynamically reflect blood circulation and the abnormal increase of blood viscosity in patients with primary open-angle glaucoma.
Objective To evaluate the value of fundus fluorescein angiography in primary open angle glaucoma and its hemorheological status.Methods A total of 60 patients with primary open angle glaucoma were selected as observation group,and 60 cases with healthy examinations were as control group.The indexes of fundus fluorescein angiography(brachial-choroidal filling time,brachial-retinal artery filling time,retinal-arteriovenous filling time) were compared and analyzed between the two groups.Hemorheological parameters(whole blood apparent viscosity at high,medium and low shear rates,value of plasma viscosity,hematocrit) in both groups were compared.Results The whole blood apparent viscosity at high,medium and low shear rates and hematocrit in the observation group were significantly higher than that in the control group(P<0.05),but there was no significant difference in plasma viscosity between the two groups(P>0.05).The brachial-choroidal filling time,brachial-retinal artery filling time,retinal-arteriovenous filling time in the observation group were longer than that in the control group(P<0.05).Conclusion Fundus fluorescein angiography is of great significance in diagnosis of primary open-angle glaucoma,and it can dynamically reflect blood circulation and the abnormal increase of blood viscosity in patients with primary open-angle glaucoma.
引文
[1]姚小磊,彭俊,李建超,等.原发性开角型青光眼患者眼底荧光血管造影及血液流变学改变与中医证型关系的研究[J].湖南中医药大学学报,2016,36(11):41-45.
[2]李建超,彭俊,曾志成,等.原发性开角型青光眼患者眼血流动力学的改变及与中医证型关系的研究[J].湖南中医药大学学报,2016,36(12):27-30.
[3]张永梅,于蒙,莫日根.原发性开角型青光眼发病机制的研究[J].内蒙古大学学报:自然科学版,2016,47(2):189-194.
[4]王灿,赵平.原发性开角型青光眼的早期诊断及研究进展[J].国际眼科杂志,2016,16(7):1287-1290.
[5]马丽琴.眼底荧光血管造影在糖尿病性视网膜病变中的具体应用[J].中国医药指南,2014,12(3):72-73.
[6]王霞,裴承华,丁爱东.眼底荧光血管造影对早期诊断糖尿病性视网膜病变的意义[J].中国医药科学,2014,4(16):211-212,216.
[7]杨迪亚,王宁利.重视原发性开角型青光眼的整合眼科学研究[J].中华眼科医学杂志:电子版,2016,6(1):1-6.
[8]任霞,贺经,冯延琴.原发性开角型青光眼治疗进展[J].国际眼科杂志,2016,16(3):458-461.
[9]张永梅,于蒙,莫日根.原发性开角型青光眼发病机制的研究[J].内蒙古大学学报:自然科学版,2016,47(2):189-194.
[10]王静,梁亮,莫纯坚.原发性开角型青光眼视神经损伤不同阶段血清细胞因子水平分析[J].眼科新进展,2015,35(11):1071-1072,1076.
[2]李建超,彭俊,曾志成,等.原发性开角型青光眼患者眼血流动力学的改变及与中医证型关系的研究[J].湖南中医药大学学报,2016,36(12):27-30.
[3]张永梅,于蒙,莫日根.原发性开角型青光眼发病机制的研究[J].内蒙古大学学报:自然科学版,2016,47(2):189-194.
[4]王灿,赵平.原发性开角型青光眼的早期诊断及研究进展[J].国际眼科杂志,2016,16(7):1287-1290.
[5]马丽琴.眼底荧光血管造影在糖尿病性视网膜病变中的具体应用[J].中国医药指南,2014,12(3):72-73.
[6]王霞,裴承华,丁爱东.眼底荧光血管造影对早期诊断糖尿病性视网膜病变的意义[J].中国医药科学,2014,4(16):211-212,216.
[7]杨迪亚,王宁利.重视原发性开角型青光眼的整合眼科学研究[J].中华眼科医学杂志:电子版,2016,6(1):1-6.
[8]任霞,贺经,冯延琴.原发性开角型青光眼治疗进展[J].国际眼科杂志,2016,16(3):458-461.
[9]张永梅,于蒙,莫日根.原发性开角型青光眼发病机制的研究[J].内蒙古大学学报:自然科学版,2016,47(2):189-194.
[10]王静,梁亮,莫纯坚.原发性开角型青光眼视神经损伤不同阶段血清细胞因子水平分析[J].眼科新进展,2015,35(11):1071-1072,1076.