基于GLP-1的中药降糖作用研究进展
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摘要
胰高血糖素样肽-1(GLP-1)可从多种途径实现降糖作用,近些年来已成为糖尿病研究领域的热点之一。中药治疗糖尿病历史悠久,现代药理学研究证实其具有多途径、多靶点的降糖作用机制。基于GLP-1降糖作用的中药干预研究也日益增多,现对中药干预GLP-1实现降糖作用的相关研究进行综述,以期为从GLP-1角度阐明中药的降糖作用机制及筛选研制新的降糖中药提供参考。
Glucagon-like peptide-1(GLP-1) can achieve glucose-regulating effects in a variety of ways and it has become one of the hotspots in the field of diabetes research in recent years. Traditional Chinese medicine has a long history of treating diabetes, and modern pharmacological studies have confirmed its multi-pathway and multi-target mechanism. The research on the glucose-regulating effects of traditional Chinese medicine based on GLP-1 is increasing. This article reviews the related researches so as to provide a reference for the clarification of glucose-regulating mechanism and screening of traditional Chinese medicine based on GLP-1.
Glucagon-like peptide-1(GLP-1) can achieve glucose-regulating effects in a variety of ways and it has become one of the hotspots in the field of diabetes research in recent years. Traditional Chinese medicine has a long history of treating diabetes, and modern pharmacological studies have confirmed its multi-pathway and multi-target mechanism. The research on the glucose-regulating effects of traditional Chinese medicine based on GLP-1 is increasing. This article reviews the related researches so as to provide a reference for the clarification of glucose-regulating mechanism and screening of traditional Chinese medicine based on GLP-1.
引文
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[3]Yu Y,Hao G,Zhang Q,et al.Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways[J].Biochemical Pharmacology,2015,97(2):173-177.
[4]Zhang Q,Xiao X,Li M,et al.Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine[J].BMCComplementary&Alternative Medicine,2014,14(1):188.
[5]王春俊,鞠霖杰,温小花,等.葛根素激活GLP-1R通路改善高脂诱导的HFD小鼠高血糖水平[J].南京中医药大学学报,2017,33(6):587-590.
[6]Yang L,Yao D,Yang H,et al.Puerarin protects pancreaticβ-cells in obese diabetic mice via activation of GLP-1R signaling[J].Molecular Endocrinology,2016,30(3):me20151213.
[7]高钧,卢守四,张蕾,等.人参皂苷Re促进胰高血糖素样肽-1分泌的研究[J].中国药物与临床,2011,11(12):1383-1385.
[8]Liu C,Zhang M,Hu M Y,et al.Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides[J].Journal of Endocrinology,2013,217(2):185-196.
[9]周丽嫦,徐艳燕,陈伟标,等.大黄素通过激活PPARδ促进胰高血糖素样肽1分泌的研究[J].中国中医药现代远程教育,2011,09(21):142-144.
[10]Daoudi M,Hennuyer N,Borland M G,et al.PPAR?2/?′activation induces enteroendocrine L cell GLP-1 production[J].Gastroenterology,2011,140(5):1564-1574.
[11]郭莉霞.京尼平苷调节INS-1细胞胰岛素分泌的分子机制研究[D].重庆:重庆大学,2011.
[12]蔡春沉,王洪玺,王肃.地黄多糖对肥胖糖尿病大鼠模型的治疗作用及对血清中GLP-1、GIP水平的影响[J].中国老年学杂志,2013,33(18):4506-4507.
[13]Choi E K,Kim K S,Yang H J,et al.Hexane fraction of Citrus aurantium,L.stimulates glucagon-like peptide-1(GLP-1)secretion via membrane depolarization in NCI-H716 cells[J].Biochip Journal,2012,6(1):41-47.
[14]鞠霖杰,温小花,舒娈.红景天苷对胰岛β细胞保护作用研究及机制探讨[J].南京中医药大学学报,2016,32(5):456-460.
[15]刘健,喻凯,王明奎,等.知母中Officinalisinin I降糖机制及中枢神经保护研究[J].中华中医药杂志,2017(2):782-785.
[16]陶枫,姚政,陆灏,等.健胰方影响II型糖尿病患者肠促胰岛素GLP-1表达的临床观察[J].中国药房,2007,18(12):934-936.
[17]杨雪蓉,朱蕴华,陶枫,等.健胰方拆方对糖尿病大鼠胰高血糖素样肽-1的调节作用[J].上海中医药大学学报,2017(2):51-56.
[18]李俊燕,王静懿,徐杰,等.清化颗粒对db/db小鼠胰高血糖素样肽-1合成和分泌的影响[J].辽宁中医杂志,2017(6):1319-1322.
[19]李俊燕,王静懿,徐杰,等.清化颗粒对db/db糖尿病小鼠肠道环磷腺苷和三磷酸腺苷的影响[J].辽宁中医杂志,2016(11):2398-2400.
[20]Li J,Xu J,Hou R,et al.Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice[J].Biomedicine&Pharmacotherapy,2017,89:10-17.
[21]高长花,余文珍,施红,等.石斛合剂对糖尿病模型大鼠胰高血糖素样肽-1的影响[J].中医临床研究,2013(23):5-7.
[22]刘赟,施红,林心君,等.石斛合剂调控老年糖尿病大鼠GLP-1的研究[J].天津中医药大学学报,2015,34(6):346-348.
[23]林心君,刘言凤,高长花,等.石斛合剂通过GLP-1/β-Catenin信号通路促进胰岛细胞增殖的机制[J].中华中医药杂志,2016(8):3266-3269.
[24]袁名泽.从GLP-1探讨清热降浊方有效部位提取物对自发糖尿病大鼠的降糖机制[D].北京:北京中医药大学,2012.
[25]刘文科,仝小林,李君玲,等.中药清热降浊方对IEC-6细胞株增殖与凋亡的影响[J].中华中医药学刊,2016(11):2605-2608.
[26]马晖,谢春光.参芪复方降血糖实验研究[J].四川省卫生管理干部学院学报,2006,25(2):87-89.
[27]张新霞.参芪复方与胰岛素联用对II型糖尿病患者β细胞功能、氧化应激及血GLP-1水平影响的临床观察及机制研究[D].成都:成都中医药大学,2013.
[28]郑文雅.降糖三黄片对糖尿病大鼠肠道、胰腺GLP-1及PDX-1表达的影响[D].广州:广州中医药大学,2015.
[29]范佳琳.降糖三黄片对糖尿病心脏病变心肌保护作用及对GLP-1的影响[D].广州:广州中医药大学,2013.
[30]安宏,赵丹丹,于娜,等.降糖消渴颗粒联合二甲双胍对II型糖尿病小鼠糖脂代谢的影响[J].世界中医药,2016,11(3):486-489.
[31]安宏.降糖消渴颗粒联合二甲双胍对糖尿病小鼠糖脂代谢及GLP-1的影响[D].北京:北京中医药大学,2016.
[32]武志黔.葛根芩连汤对II型糖尿病大鼠的表征作用及其与GLP-1相关的生物学基础[D].北京:北京中医药大学,2014.
[33]Yu Y L,Lu S S,Yu S,et al.Huang-Lian-Jie-Du-Decoction modulates glucagon-like peptide-1 secretion in diabetic rats[J].Journal of Ethnopharmacology,2009,124(3):444-449.
[34]刘海逸,张欣荣,岳晓丹,等.黄连解毒汤对糖耐量减低大鼠的糖尿病延缓作用[J].国际内分泌代谢杂志,2017,37(3):149-154.
[2]Yu Y L,Li L,Wang X T,et al.Modulation of glucagon-like peptide-1 release by berberine:in vivo and in vitro studies[J].Biochemical Pharmacology,2010,79(7):1000-1006.
[3]Yu Y,Hao G,Zhang Q,et al.Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways[J].Biochemical Pharmacology,2015,97(2):173-177.
[4]Zhang Q,Xiao X,Li M,et al.Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine[J].BMCComplementary&Alternative Medicine,2014,14(1):188.
[5]王春俊,鞠霖杰,温小花,等.葛根素激活GLP-1R通路改善高脂诱导的HFD小鼠高血糖水平[J].南京中医药大学学报,2017,33(6):587-590.
[6]Yang L,Yao D,Yang H,et al.Puerarin protects pancreaticβ-cells in obese diabetic mice via activation of GLP-1R signaling[J].Molecular Endocrinology,2016,30(3):me20151213.
[7]高钧,卢守四,张蕾,等.人参皂苷Re促进胰高血糖素样肽-1分泌的研究[J].中国药物与临床,2011,11(12):1383-1385.
[8]Liu C,Zhang M,Hu M Y,et al.Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides[J].Journal of Endocrinology,2013,217(2):185-196.
[9]周丽嫦,徐艳燕,陈伟标,等.大黄素通过激活PPARδ促进胰高血糖素样肽1分泌的研究[J].中国中医药现代远程教育,2011,09(21):142-144.
[10]Daoudi M,Hennuyer N,Borland M G,et al.PPAR?2/?′activation induces enteroendocrine L cell GLP-1 production[J].Gastroenterology,2011,140(5):1564-1574.
[11]郭莉霞.京尼平苷调节INS-1细胞胰岛素分泌的分子机制研究[D].重庆:重庆大学,2011.
[12]蔡春沉,王洪玺,王肃.地黄多糖对肥胖糖尿病大鼠模型的治疗作用及对血清中GLP-1、GIP水平的影响[J].中国老年学杂志,2013,33(18):4506-4507.
[13]Choi E K,Kim K S,Yang H J,et al.Hexane fraction of Citrus aurantium,L.stimulates glucagon-like peptide-1(GLP-1)secretion via membrane depolarization in NCI-H716 cells[J].Biochip Journal,2012,6(1):41-47.
[14]鞠霖杰,温小花,舒娈.红景天苷对胰岛β细胞保护作用研究及机制探讨[J].南京中医药大学学报,2016,32(5):456-460.
[15]刘健,喻凯,王明奎,等.知母中Officinalisinin I降糖机制及中枢神经保护研究[J].中华中医药杂志,2017(2):782-785.
[16]陶枫,姚政,陆灏,等.健胰方影响II型糖尿病患者肠促胰岛素GLP-1表达的临床观察[J].中国药房,2007,18(12):934-936.
[17]杨雪蓉,朱蕴华,陶枫,等.健胰方拆方对糖尿病大鼠胰高血糖素样肽-1的调节作用[J].上海中医药大学学报,2017(2):51-56.
[18]李俊燕,王静懿,徐杰,等.清化颗粒对db/db小鼠胰高血糖素样肽-1合成和分泌的影响[J].辽宁中医杂志,2017(6):1319-1322.
[19]李俊燕,王静懿,徐杰,等.清化颗粒对db/db糖尿病小鼠肠道环磷腺苷和三磷酸腺苷的影响[J].辽宁中医杂志,2016(11):2398-2400.
[20]Li J,Xu J,Hou R,et al.Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice[J].Biomedicine&Pharmacotherapy,2017,89:10-17.
[21]高长花,余文珍,施红,等.石斛合剂对糖尿病模型大鼠胰高血糖素样肽-1的影响[J].中医临床研究,2013(23):5-7.
[22]刘赟,施红,林心君,等.石斛合剂调控老年糖尿病大鼠GLP-1的研究[J].天津中医药大学学报,2015,34(6):346-348.
[23]林心君,刘言凤,高长花,等.石斛合剂通过GLP-1/β-Catenin信号通路促进胰岛细胞增殖的机制[J].中华中医药杂志,2016(8):3266-3269.
[24]袁名泽.从GLP-1探讨清热降浊方有效部位提取物对自发糖尿病大鼠的降糖机制[D].北京:北京中医药大学,2012.
[25]刘文科,仝小林,李君玲,等.中药清热降浊方对IEC-6细胞株增殖与凋亡的影响[J].中华中医药学刊,2016(11):2605-2608.
[26]马晖,谢春光.参芪复方降血糖实验研究[J].四川省卫生管理干部学院学报,2006,25(2):87-89.
[27]张新霞.参芪复方与胰岛素联用对II型糖尿病患者β细胞功能、氧化应激及血GLP-1水平影响的临床观察及机制研究[D].成都:成都中医药大学,2013.
[28]郑文雅.降糖三黄片对糖尿病大鼠肠道、胰腺GLP-1及PDX-1表达的影响[D].广州:广州中医药大学,2015.
[29]范佳琳.降糖三黄片对糖尿病心脏病变心肌保护作用及对GLP-1的影响[D].广州:广州中医药大学,2013.
[30]安宏,赵丹丹,于娜,等.降糖消渴颗粒联合二甲双胍对II型糖尿病小鼠糖脂代谢的影响[J].世界中医药,2016,11(3):486-489.
[31]安宏.降糖消渴颗粒联合二甲双胍对糖尿病小鼠糖脂代谢及GLP-1的影响[D].北京:北京中医药大学,2016.
[32]武志黔.葛根芩连汤对II型糖尿病大鼠的表征作用及其与GLP-1相关的生物学基础[D].北京:北京中医药大学,2014.
[33]Yu Y L,Lu S S,Yu S,et al.Huang-Lian-Jie-Du-Decoction modulates glucagon-like peptide-1 secretion in diabetic rats[J].Journal of Ethnopharmacology,2009,124(3):444-449.
[34]刘海逸,张欣荣,岳晓丹,等.黄连解毒汤对糖耐量减低大鼠的糖尿病延缓作用[J].国际内分泌代谢杂志,2017,37(3):149-154.