养血平肝汤辨证治疗血虚肝旺型顽固性偏头痛效果观察
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摘要
目的:观察养血平肝汤辨证治疗血虚肝旺型顽固性偏头痛效果。方法:随机选取2015年12月-2017年12月笔者所在医院就诊的血虚肝旺型顽固性偏头痛患者100例,按随机数表法分为两组。两组均进行常规干预,对照组服用氟桂利嗪,5 mg/次,2次/d;观察组服用养血平肝汤,1剂/d;两组患者均治疗2个月。统计两组患者治疗前后中医症候积分,统计两组患者治疗前后1个月内每周头痛发作频率、头痛程度、1次头痛持续时间,采用生活质量综合评定问卷-74(GQOLI-74)统计两组患者治疗后3个月生活质量评分,统计两组患者治疗2个月内出现不良反应比例。结果:治疗后,观察组各项症状中医症候积分均低于对照组(P<0.05);治疗后,观察组头痛程度、每周头痛发作频率、1次头痛持续时间均低于对照组(P<0.05);治疗后3个月,观察组生活质量评分均高于对照组(P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论:养血平肝汤针对血虚肝旺型顽固性偏头痛具有养血滋阴、平肝祛风作用,治疗效果更好。
Objective:To observe the efficacy of Yangxue Pinggan Decoction in the treatment of refractory migraine(type of blood deficiency and hyperactive liver fire).Method:From December 2015 to December 2017,100 cases with refractory migraine with type of blood deficiency and hyperactive liver fire in our hospital were randomly selected and divided into two groups according to the random number table method.The two groups were given routine intervention,and the control group was given Flunarizine(5 mg/time,twice/d),and the observation group was given Yangxue Pinggan Decoction(1 dose/d),and the two groups were treated for 2 months.The TCM syndromes scores before and after treatment were counted in the two groups.The frequency of weekly headache attacks,degree of headache and duration of one headache were counted within 1 month before and after treatment.The general quality of life inventory-74(GQOLI-74)was used to count the quality of life score in the two groups at 3 months after treatment,and the proportion of adverse reactions was measured within 2 months of treatment in the two groups.Result:After treatment,the TCM syndromes scores in the observation group were lower than those in the control group(P<0.05).After treatment,the degree of headache,frequency of weekly headache attacks and duration of one headache in the observation group were lower than those in the control group(P<0.05).At 3 months after treatment,the quality of life score in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion:Yangxue Pinggan Decoction has the effects of nourishing blood and yin and calming liver and dispelling wind in the treatment of refractory migraine with type of blood deficiency and hyperactive liver fire,and it has good treatment effects.
Objective:To observe the efficacy of Yangxue Pinggan Decoction in the treatment of refractory migraine(type of blood deficiency and hyperactive liver fire).Method:From December 2015 to December 2017,100 cases with refractory migraine with type of blood deficiency and hyperactive liver fire in our hospital were randomly selected and divided into two groups according to the random number table method.The two groups were given routine intervention,and the control group was given Flunarizine(5 mg/time,twice/d),and the observation group was given Yangxue Pinggan Decoction(1 dose/d),and the two groups were treated for 2 months.The TCM syndromes scores before and after treatment were counted in the two groups.The frequency of weekly headache attacks,degree of headache and duration of one headache were counted within 1 month before and after treatment.The general quality of life inventory-74(GQOLI-74)was used to count the quality of life score in the two groups at 3 months after treatment,and the proportion of adverse reactions was measured within 2 months of treatment in the two groups.Result:After treatment,the TCM syndromes scores in the observation group were lower than those in the control group(P<0.05).After treatment,the degree of headache,frequency of weekly headache attacks and duration of one headache in the observation group were lower than those in the control group(P<0.05).At 3 months after treatment,the quality of life score in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion:Yangxue Pinggan Decoction has the effects of nourishing blood and yin and calming liver and dispelling wind in the treatment of refractory migraine with type of blood deficiency and hyperactive liver fire,and it has good treatment effects.
引文
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[14]崔春丽,王智强,顾锡镇.养血平肝方治疗偏头痛(肝阳上亢证)临床观察[J].中国中医急症,2015,24(8):1491-1493.
[15]刘金展,李佩珊,过伟峰.养血平肝方治疗血虚肝旺型偏头痛临床研究[J].山东中医杂志,2016,35(05):391-392,401.
[2]秦娜,李力,陈璇,等.舒马曲坦联合左乙拉西坦治疗顽固性偏头痛的疗效及对血浆5-羟色胺的影响[J].医学临床研究,2017,34(11):2255-2257.
[3]吴明华.偏头痛的中医药治疗[J].实用老年医学,2015,29(10):796-799.
[4]中华医学会疼痛分会头面痛学组.中国偏头痛诊断治疗指南[J].中国疼痛医学杂志,2011,17(2):65-86.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:105-109.
[6]李园媛,王德亮,吴会玲.偏头痛的中西医治疗研究进展[J].现代中西医结合杂志,2015,24(36):4099-4102.
[7]魏文亭,姜亚军.中西医治疗偏头痛研究进展[J].中西医结合心脑血管病杂志,2015,13(6):783-785.
[8]吴向东.补阳还五汤加减治疗偏头痛的临床疗效探究[J].中国医学创新,2013,10(19):127-129.
[9]王雷.针刺治疗偏头痛临床疗效观察[J].中国医学创新,2014,11(1):110-111.
[10]官国东,谭静,叶颖,等.半夏白术天麻汤加味治疗痰浊上扰证偏头痛临床疗效和治疗前后综合评分情况比较观察[J].中国医学创新,2016,13(7):80-83.
[11]李红月,孙志伟,王淑琴.天麻素在神经系统的药理作用研究概况[J].中国医院药学杂志,2015,35(11):1047-1050.
[12]张来宾,吕洁丽,陈红丽,等.当归中苯酞类成分及其药理作用研究进展[J].中国中药杂志,2016,41(2):167-176.
[13]王倩,刘子豪.白蒺藜的临床应用研究进展[J].中西医结合心脑血管病杂志,2016,14(16):1877-1879.
[14]崔春丽,王智强,顾锡镇.养血平肝方治疗偏头痛(肝阳上亢证)临床观察[J].中国中医急症,2015,24(8):1491-1493.
[15]刘金展,李佩珊,过伟峰.养血平肝方治疗血虚肝旺型偏头痛临床研究[J].山东中医杂志,2016,35(05):391-392,401.