LIM激酶2在高级别浆液性卵巢癌组织中的表达及意义
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摘要
目的探讨LIM激酶2 (LIMK2)在高级别浆液性卵巢癌(HGSOC)及正常卵巢组织中的表达情况,研究LIMK2在HGSOC发生发展过程中的作用。方法采用免疫组织化学法、实时荧光定量PCR (RT-PCT)方法检测LIMK2在41例HGSOC组织与30例正常卵巢组织中LIMK2蛋白的表达,分析其表达与临床病理参数的关系。结果 LIMK2在HGSOC中的表达较正常卵巢组织表达明显增高,且LIMK2表达与FIGO分期、血清CA125水平相关(P<0. 05),与年龄、淋巴结转移、肿瘤大小及腹水量无关(P>0. 05)。结论 LIMK2可能参与卵巢癌的发生发展,有可能成为卵巢癌诊断及治疗的新靶点。
引文
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[7]李冬霞,王永玲,蔡松旺.PAK4-LIMK1-Cofilin信号通路对非小细胞肺癌迁移及侵袭能力的影响[J].中国病理生理杂志,2015,31(12):2130-2135.
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[9]Mardilovich K,Gabrielsen M,Mcgarry L,et al.Elevated LIM kinase1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation[J].Mol Cancer Ther,2015,14(1):246-258.
[10]Acevedo K,Moussi N,Li R,et al.LIM kinase 2 is widely expressed in all tissues[J].J Histochem Cytochem,2006,54(5):487-501.
[11]Scott RW,Olson MF.LIM kinases:function,regulation and association with human disease[J].J Mol Med,2007,85(6):555-568.
[12]Qiu Y,Chen WY,Wang ZY.Simvastatin attenuates neuropathic pain by inhibiting the Rho A/LIMK/cofilin pathway[J],Neurochem Res,2016,41(9):2457-2469.
[13]Wang W,Townes-Anderson E.LIM Kinase,a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury[J].Invest Ophthalmol Vis Sci,2015,56(13):7847-7758.
[14]Wang W,Townes-Anderson E.Lim kinase,a bi-functional effector in injury-induced structural plasticity of synapses[J].Neural Regen Res,2016,11(7):1029-1032.
[15]陈燕,林莺莺,郑瑜宏,等.血清HE4、CA125和ROMA指数评估卵巢癌风险性的初步评价[J].中国免疫学杂志,2013,29(2):168-174.
[2]Scott RW,Olson MF.LIM kinases:function,regulation and association with human disease[J].J Mol Med,2007,85(6):555-568.
[3]耿力,王希涛,秦凤金,等.人宫颈癌细胞中RhoC、VAV2和LIMK2 mRNA的表达及临床意义[J].山东医药,2008,48(27):1-3.
[4]Wang A,Guo C,Sun Y,et al.Overexpression of CUEDC2 Predicts Poor Prognosis in Ovarian Serous Carcinomas[J].J Cancer,2015,6(6):542-547.
[5]Malpica A,Deavers MT,Lu K,et al.Grading ovarian serous carcinoma using a two-tier system[J].Am J Surg Pathol,2004,28(4):496-504.
[6]颜鸿飞,苏坚,廖前进,等.LIMK1在结肠癌组织中表达的临床病理意义[J].肿瘤防治研究,2013,40(6):576-579.
[7]李冬霞,王永玲,蔡松旺.PAK4-LIMK1-Cofilin信号通路对非小细胞肺癌迁移及侵袭能力的影响[J].中国病理生理杂志,2015,31(12):2130-2135.
[8]Chhavi,Saxena M,Singh S,et al.Expression profiling of G2/Mphase regulatory proteins in normal,premalignant and Malignant uterine cervix and their correlation with survival of patients[J].J Cancer Res Ther,2010,6(2):167-171.
[9]Mardilovich K,Gabrielsen M,Mcgarry L,et al.Elevated LIM kinase1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation[J].Mol Cancer Ther,2015,14(1):246-258.
[10]Acevedo K,Moussi N,Li R,et al.LIM kinase 2 is widely expressed in all tissues[J].J Histochem Cytochem,2006,54(5):487-501.
[11]Scott RW,Olson MF.LIM kinases:function,regulation and association with human disease[J].J Mol Med,2007,85(6):555-568.
[12]Qiu Y,Chen WY,Wang ZY.Simvastatin attenuates neuropathic pain by inhibiting the Rho A/LIMK/cofilin pathway[J],Neurochem Res,2016,41(9):2457-2469.
[13]Wang W,Townes-Anderson E.LIM Kinase,a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury[J].Invest Ophthalmol Vis Sci,2015,56(13):7847-7758.
[14]Wang W,Townes-Anderson E.Lim kinase,a bi-functional effector in injury-induced structural plasticity of synapses[J].Neural Regen Res,2016,11(7):1029-1032.
[15]陈燕,林莺莺,郑瑜宏,等.血清HE4、CA125和ROMA指数评估卵巢癌风险性的初步评价[J].中国免疫学杂志,2013,29(2):168-174.