氦氖激光、补肾疏肝化瘀方联合川芎嗪静滴对黄褐斑血液流变学的影响分析
|
摘要
目的:探讨氦氖激光、补肾疏肝化瘀方联合川芎嗪静滴对黄褐斑患者血液流变学的影响,并分析其疗效。方法:选取2015年9月-2017年12月笔者科室就诊的147例女性黄褐斑患者为研究对象,按随机数字表法将其分为对照组和研究组。对照组:68例,采用氦氖激光联合川芎嗪注射液静滴治疗;研究组:79例,给予氦氖激光、补肾疏肝化瘀方联合川芎嗪注射液静滴治疗。对比两组患者治疗前后血浆黏度、全血黏度(高切)、全血黏度(低切)等血液流变学指标及临床疗效。结果:治疗前,两组患者血浆黏度、全血黏度(高切)、全血黏度(低切)等指标对比均无统计学差异(P>0.05),治疗后,研究组血浆黏度、高切、低切等指标均明显低于对照组,两组治疗后血液流变学指标均明显低于治疗前,且均有统计学意义(P<0.05)。对照组总有效率为57.35%,研究组81.01%,两组疗效比较有显著性差异,具有统计学意义(χ2=3.991,P<0.05)。结论:黄褐斑患者采用氦氖激光血管内照射、川芎嗪注射液联合补肾疏肝方治疗可改善血液流变学指标,提高临床治疗效果,可临床推广应用。
Objective Research the hemorheology and sex hormone of He-Ne laser, Bushenshuganhuayu Prescription combined with ligustrazine in the treatment of patients with chlosma. Methods Select 147 chlosma female patients between September2015 and December 2017 of our hospital, divided them into two groups called control group and research group randomly,the control group was taken He-Ne laser combined wtih ligustrazine,while research group was combined with Bushenshuganhuayu prescription,compared the hemorheology indexes such as plasma viscosity,high blood viscosity,low blood viscosity,and so on,and clinical efficacy of two groups. Results The hemorheology indexes such as plasma viscosity,high blood viscosity,low blood viscosity of two groups before treatment had no statistical difference(P>0.05),the plasma viscosity, high blood viscosity,low blood viscosity of research group after treatment were much lower than control group,the plasma viscosity,high blood viscosity,low blood viscosity of two groups after treatment were all much lower than pre-treatment respectively(P<0.05). The total effective rate was 57.35% in the control group and 81.01% in the research group,the effective rate of research group was much higher than control group,and had statistical difference(χ2=3.991,P<0.05). Conclusion Using He-Ne laser intravascular laser, ligustrazine injection combined with Bushenshugan prescription in patients with chloasma can improve the hemorheology and the treatment effect,worthy of clinical promotion.
Objective Research the hemorheology and sex hormone of He-Ne laser, Bushenshuganhuayu Prescription combined with ligustrazine in the treatment of patients with chlosma. Methods Select 147 chlosma female patients between September2015 and December 2017 of our hospital, divided them into two groups called control group and research group randomly,the control group was taken He-Ne laser combined wtih ligustrazine,while research group was combined with Bushenshuganhuayu prescription,compared the hemorheology indexes such as plasma viscosity,high blood viscosity,low blood viscosity,and so on,and clinical efficacy of two groups. Results The hemorheology indexes such as plasma viscosity,high blood viscosity,low blood viscosity of two groups before treatment had no statistical difference(P>0.05),the plasma viscosity, high blood viscosity,low blood viscosity of research group after treatment were much lower than control group,the plasma viscosity,high blood viscosity,low blood viscosity of two groups after treatment were all much lower than pre-treatment respectively(P<0.05). The total effective rate was 57.35% in the control group and 81.01% in the research group,the effective rate of research group was much higher than control group,and had statistical difference(χ2=3.991,P<0.05). Conclusion Using He-Ne laser intravascular laser, ligustrazine injection combined with Bushenshugan prescription in patients with chloasma can improve the hemorheology and the treatment effect,worthy of clinical promotion.
引文
[1]陈洁,何梅,谢洪霞,等.微针联合Q开关1 064nm激光治疗黄褐斑疗效观察[J].中国美容医学,2014,23(10):827-829.
[2]胡刘玉,叶明花.近十年黄褐斑中医研究进展及治疗方法总结[J].亚太传统医药,2015,11(12):66-67.
[3]胡博,张丰川,李楠,等.女性黄褐斑患者肝气虚证辨治探讨[J].环球中医药,2017,10(3):348-350.
[4]Sofen B,Prado G,Emer J.Melasma and post inflammatory hyperpigmentation:management update and expert opinion[J].Skin Therapy Lett,2016,21(1):1-7.
[5]徐永平,王志鹏,汤亚娥.Q开关1 064nm激光联合药物治疗黄褐斑疗效观察[J].浙江中西医结合杂志,2015,25(7):679-681.
[6]钟淑霞,周俊峰,姚蕾,等.脉冲激光联合氢醌乳膏、左旋微C治疗色素沉着12例临床观察[J].中国皮肤性病学杂志,2014,28(10):1075-1077.
[7]陈晓莉,蒋艳,皮超,等.Q开关激光辅助氨甲环酸治疗黄褐斑疗效观察[J].中国美容医学,2015,24(5):57-59.
[8]韦洁,黎冻,周翔,等.Q开关Nd:YAG 1 064nm激光联合口服氨甲环酸片治疗黄褐斑疗效观察[J].中国美容医学,2013,22(9):965-969.
[9]张晨光,许满萍,王晶,等.Q-开关Nd:YAG 1 064nm激光联合谷胱甘肽凝胶治疗黄褐斑的疗效观察[J].中国美容医学,2014,23(16):1359-1361.
[10]张艳丽.血府逐瘀汤联合外用复方维甲酸霜治疗黄褐斑伴月经不调临床观察[J].四川中医,2015,33(12):155-157.
[11]朱江婷,叶俊儒,唐蓉芳,等.点阵激光联合氨甲环酸、还原型谷胱甘肽以及微生素C治疗黄褐斑短期疗效观察[J].中国美容医学,2016,25(2):44-46.
[12]Rendon M,Dryer L.Investigator-blinded,single-center study to evaluate the efficacy and tolerability of a 4%hydroquinone skin care system plus 0.02%tretinoin cream in mild-to-moderate melasma and photodamage[J].J Drugs Dermatol,2016,15(4):466-475.
[13]Kwon HH,Ohn J,Suh DH,et al.A pilot study for triple combination therapy with a low-fluence 1 064 nm Q-switched Nd:YAGlase,hydroquinone cream and oral tranexaminc acid for recalcitrant Riehl’s Melanosis[J]J Dermatol Treat,2017,28(2):155-159.
[14]杨婷婷,杨国红,王曙光,等.黄褐斑发病机制及治疗药物的研究进展[J].中华中医药学刊,2013,31(3):604-606.
[2]胡刘玉,叶明花.近十年黄褐斑中医研究进展及治疗方法总结[J].亚太传统医药,2015,11(12):66-67.
[3]胡博,张丰川,李楠,等.女性黄褐斑患者肝气虚证辨治探讨[J].环球中医药,2017,10(3):348-350.
[4]Sofen B,Prado G,Emer J.Melasma and post inflammatory hyperpigmentation:management update and expert opinion[J].Skin Therapy Lett,2016,21(1):1-7.
[5]徐永平,王志鹏,汤亚娥.Q开关1 064nm激光联合药物治疗黄褐斑疗效观察[J].浙江中西医结合杂志,2015,25(7):679-681.
[6]钟淑霞,周俊峰,姚蕾,等.脉冲激光联合氢醌乳膏、左旋微C治疗色素沉着12例临床观察[J].中国皮肤性病学杂志,2014,28(10):1075-1077.
[7]陈晓莉,蒋艳,皮超,等.Q开关激光辅助氨甲环酸治疗黄褐斑疗效观察[J].中国美容医学,2015,24(5):57-59.
[8]韦洁,黎冻,周翔,等.Q开关Nd:YAG 1 064nm激光联合口服氨甲环酸片治疗黄褐斑疗效观察[J].中国美容医学,2013,22(9):965-969.
[9]张晨光,许满萍,王晶,等.Q-开关Nd:YAG 1 064nm激光联合谷胱甘肽凝胶治疗黄褐斑的疗效观察[J].中国美容医学,2014,23(16):1359-1361.
[10]张艳丽.血府逐瘀汤联合外用复方维甲酸霜治疗黄褐斑伴月经不调临床观察[J].四川中医,2015,33(12):155-157.
[11]朱江婷,叶俊儒,唐蓉芳,等.点阵激光联合氨甲环酸、还原型谷胱甘肽以及微生素C治疗黄褐斑短期疗效观察[J].中国美容医学,2016,25(2):44-46.
[12]Rendon M,Dryer L.Investigator-blinded,single-center study to evaluate the efficacy and tolerability of a 4%hydroquinone skin care system plus 0.02%tretinoin cream in mild-to-moderate melasma and photodamage[J].J Drugs Dermatol,2016,15(4):466-475.
[13]Kwon HH,Ohn J,Suh DH,et al.A pilot study for triple combination therapy with a low-fluence 1 064 nm Q-switched Nd:YAGlase,hydroquinone cream and oral tranexaminc acid for recalcitrant Riehl’s Melanosis[J]J Dermatol Treat,2017,28(2):155-159.
[14]杨婷婷,杨国红,王曙光,等.黄褐斑发病机制及治疗药物的研究进展[J].中华中医药学刊,2013,31(3):604-606.