干姜及其提取物抗消化性溃疡的研究进展
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摘要
干姜属姜科类植物,其化学成分主要包括挥发油、姜辣素、二苯基庚烷等,目前研究发现具有抗氧化、解热抗炎、保肝利胆、抗肿瘤、抗消化性溃疡、改善局部血液循环等药理作用。消化系统中常见疾病消化性溃疡的发病率高达10%,其主要治疗药物包括抗酸药、抑酸剂、抗幽门螺杆菌药和胃黏膜保护剂。一直以来,中药在消化性溃疡治疗方面有不可或缺的地位。该文就中药干姜及其提取物对消化性溃疡的作用予以综述。
引文
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[24] MARSHALL B J,BARRETT L J,PRAKASH C,et al.Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid[J].Gastroenterology,1990,99(3):697-702.
[25] PERRAIS M,ROUSSEAUX C,DUCOUROUBLE M P,et al.Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells[J].Gastric Cancer,2014,17(2):235-246.
[26] OLIVERA-SEVERO D,UBERTI A F,MARQUES M S,et al.A new role for Helicobacter pylori urease:contributions to angiogenesis[J].Front Microbiol,2017,8:1883.
[27] 王美芬,黄永坤,李海林.幽门螺杆菌致病机制的研究进展[J].医学综述,2006,12(8):468-471.
[28] MAHADY G B,PENDLAND S L,YUN G S,et al.Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori[J].Anticancer Res,2003,23(5A):3699-3702.
[29] 陈碰玉,林蒙,陈艳,等.新鲜生姜对幽门螺杆菌抑菌杀菌作用的实验研究[J].中医药通报,2002,1(1):49-50.
[2] LAINE L,TAKEUCHI K,TARNAWSKI A.Gastric mucosal defense and cytoprotection:bench to bedside[J].Gastroenterology,2008,135(1):41-60.
[3] LEE M,FELDMAN M.Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats[J].Gastroenterology,1994,107(6):1746-1750.
[4] GRONBECH J E,LACY E R.Role of gastric blood flow in impaired defense and repair of aged rat stomachs[J].Am J Physiol,1995,269(5):G737-G744.
[5] 王萍.消化性溃疡的发病机制[J].咸宁学院学报(医学版),2008,22(5):457-459.
[6] 国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015:303.
[7] WATANABE T,HIGUCHI K,TOMINAGA K,et al.Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1β[J].Gut,2001,48(6):774-781.
[8] 王婷婷,钟凌云.不同姜汁制黄连抑制胃黏膜损伤方面的机制分析[J].中国实验方剂学杂志,2017,23(12):18-22.
[9] 蒋苏贞,廖康.干姜醇提取物对实验性胃溃疡的影响[J].中国民族民间医药,2010,19(8):79-80.
[10] KEEFER L,KESHAVARZIAN A,MUTLU E.Reconsidering the methodology of “stress” research in inflammatory bowel disease[J].J Crohns Colitis,2008,2(3):193-201.
[11] KONTUREK P C,BRZOZOWSKI T,KONTUREK S J.Stress and the gut:pathophysiology,clinical consequences,diagnostic approach and treatment options[J].J Physiol Pharmacol,2011,62(6):591-599.
[12] 朱崇嘉.消化性溃疡中医病理要素与SCL-90心理因子相关性研究[D].福州:福建中医药大学,2014.
[13] 付超明,牛新清,宋朝功.消化性溃疡的精神因素探讨及治疗[J].职业与健康,2000,16(6):111-112.
[14] MAWDSLEY J E,RAMPTON D S.Psychological stress in IBD:new insights into pathogenic and therapeutic implications [J].Gut,2005,54(10):1481-1491.
[15] 李艳玲,梁鹤.干姜的镇静作用研究[J].安徽农业科学,2008,36(32):14159-14160.
[16] 笠原义正,斋藤惠利子.半夏和干姜的药理作用[J].生药学杂志,1983,37(1):73-83.
[17] 侯家玉,方泰惠.中药药理学[M].2版.北京:中国中医药出版社,2007:114-116.
[18] 李春芳.负性情绪对消化性溃疡的患者的影响及护理干预效果[J].中外医疗,2013,32(22):140-142.
[19] 王梦,钱红美,苏简单.干姜乙醇提取物解热镇痛及体外抑菌作用研究[J].中药新药与临床药理,2003,14(5):299-301.
[20] OJEWOLE J A.Analgesic,antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats[J].Phytother Res,2006,20(9):764-772.
[21] 马晓茜,赵晓民.干姜水提物解热镇痛作用的实验研究[J].山东医学高等专科学校学报,2011,33(5):327-329.
[22] MUHAMMAD J S,ZAIDI S F,SUGIYAMA T.Epidemiological ins and outs of helicobacter pylori:a review[J].J Pak Med Assoc,2012,62(9):955-959.
[23] VILACHONE R K,MAHSCHSI V,TUMWASORN S,et al.Molecular epidemiology and outcome of Helicobacterpylori infection in Thailand:a cultural cross roads [J].Helicobacter,2004,9(5):453-459.
[24] MARSHALL B J,BARRETT L J,PRAKASH C,et al.Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid[J].Gastroenterology,1990,99(3):697-702.
[25] PERRAIS M,ROUSSEAUX C,DUCOUROUBLE M P,et al.Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells[J].Gastric Cancer,2014,17(2):235-246.
[26] OLIVERA-SEVERO D,UBERTI A F,MARQUES M S,et al.A new role for Helicobacter pylori urease:contributions to angiogenesis[J].Front Microbiol,2017,8:1883.
[27] 王美芬,黄永坤,李海林.幽门螺杆菌致病机制的研究进展[J].医学综述,2006,12(8):468-471.
[28] MAHADY G B,PENDLAND S L,YUN G S,et al.Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori[J].Anticancer Res,2003,23(5A):3699-3702.
[29] 陈碰玉,林蒙,陈艳,等.新鲜生姜对幽门螺杆菌抑菌杀菌作用的实验研究[J].中医药通报,2002,1(1):49-50.