血浆脑钠素和同型半胱氨酸在急性冠状动脉综合征中的临床应用价值
|
摘要
目的探讨血浆脑钠素(BNP)和同型半胱氨酸(HCY)在急性冠状动脉综合征(ACS)中的临床应用价值。方法选择2009年12月至2011年4月该院住院的ACS患者85例为ACS组,同期体检健康者72例为对照组,比较两组的血浆BNP和HCY水平。结果 ACS组患者BNP和HCY值均高于对照组(P<0.05),ACS组血浆BNP水平和血浆HCY水平呈正相关,相关系数(r)=0.421。结论血浆BNP和HCY水平与ACS病情显著相关,可作为ACS的危险分层和预后评估。
Objective To explore the clinical application value of plasma brain natriuretic peptide(BNP) level and homocysteine(HCY) in the patients with acute coronary syndrome(ACS).Methods 85 patients with ACS hospitalized in this hospital from December 2009 to April 2011 were selected as the ACS group and contemporaneous 72 individuals of healthy examination as the control group.The plasma level of BNP and HCY were compared between the two groups.Results The plasma level of BNP and HCY in the ACS group was significantly higher than that in the control group(P<0.05).The plasma levels of BNP and HCY in the ACS group showed positive correlation,the correlation coefficient r=0.421,P<0.05.Conclusion The plasma level of BNP and HCY is significantly correlated with ACS and can be used as the risk stratification and prognosis evaluation of ACS.
Objective To explore the clinical application value of plasma brain natriuretic peptide(BNP) level and homocysteine(HCY) in the patients with acute coronary syndrome(ACS).Methods 85 patients with ACS hospitalized in this hospital from December 2009 to April 2011 were selected as the ACS group and contemporaneous 72 individuals of healthy examination as the control group.The plasma level of BNP and HCY were compared between the two groups.Results The plasma level of BNP and HCY in the ACS group was significantly higher than that in the control group(P<0.05).The plasma levels of BNP and HCY in the ACS group showed positive correlation,the correlation coefficient r=0.421,P<0.05.Conclusion The plasma level of BNP and HCY is significantly correlated with ACS and can be used as the risk stratification and prognosis evaluation of ACS.
引文
[1]Morrow DA,Delemons JA,Sabatine MS,et al.Evaluationof B-type natriuretic peptide for risk assessment inunsta-ble angina/non-ST-elevation myocardial infarction;B-typenatriuretic peptide and prognosis in TACTICS TIMI18[J].J Am Coll Cardiol,2003,41(8):1264-1272.
[2]蔡瑾,李雅君,朱红梅.2型糖尿病合并脂肪肝患者血清同型半胱氨酸水平的临床研究[J].心肺血管病杂志,2009,28(1):29-31.
[3]王鸿珍.脑钠素在急性心肌梗死中的应用[J].国外医学心血管疾病分册,2005,32(3):176-178.
[4]de Lemos JA,McGuire DK,Drazner MH.B-type natri-uretic peptide in cardiovascular disease[J].Lancet,2003,362(9380):316-322.
[5]Hama N,Itoh H,Shirakami G,et al.Rapid ventricular in-duction of brain natriuretic peptide gene expression in ex-perimental acute myocardial infarction[J].Circulation,1995,92(6):1558-1564.
[6]刘发军.血浆B型钠尿肽,超敏C-反应蛋白在急性心肌梗死中的临床应用价值[J].临床内科杂志,2008,25(5):314-315.
[7]Bassan R,Potsch A,Maisel A,et al.B-type natriureticpeptide:a novel early blood marker of acute myocardialinfarction in patients with chest pain and no ST-segmentelevation[J].Eur Heart J,2005,26(3):234-240.
[8]崔琪琼,张薇.声学定量技术对高血压左心室不同构型舒张功能的评价[J].中华影像学杂志,2005,11(12):716-719.
[9]杨婉花,汪自龙,欧阳平.血浆脑钠素和超敏C反应蛋白联合监测对急性冠状动脉综合征的评估价值[J].中国临床医学,2007,14(6):767-769.
[10]Blom HJ,Smulders Y.Overview of homocysteine and fo-late metabolism with special referen-ces to cardiovasculardisease and neural tube defects[J].J Inherited MetabolicDis,2011,34(1):75-81.
[11]Sharma P,Senthilkumar RD,Brahmachari V,et al.Miningliterature for a comprehensive pathway analysis:a casestudy for retrieval of homocysteine related genes for ge-netic and epigenetic studies[J].Lipids Health Dis,2006,5:1.
[12]Geisel J,Hennen B,Hübner U,et al.The impact of hy-perhomocysteinemia as a cardiovascular risk factor in theprediction of coronary heart disease[J].Clin Chem LabMed,2003,41(11):1513-1517.
[13]Beltowski J.Protein homocysteinylation:a new mecha-nism of atherogenesis[J].Postepy Hig Med Dosw(On-line),2005,59:392-404.
[14]刘梅,丁晓梅.急性冠状动脉综合征患者血清同型半胱氨酸和hs-CRP的相关性[J].心血管康复医学杂志,2007,16(5):455-457.
[2]蔡瑾,李雅君,朱红梅.2型糖尿病合并脂肪肝患者血清同型半胱氨酸水平的临床研究[J].心肺血管病杂志,2009,28(1):29-31.
[3]王鸿珍.脑钠素在急性心肌梗死中的应用[J].国外医学心血管疾病分册,2005,32(3):176-178.
[4]de Lemos JA,McGuire DK,Drazner MH.B-type natri-uretic peptide in cardiovascular disease[J].Lancet,2003,362(9380):316-322.
[5]Hama N,Itoh H,Shirakami G,et al.Rapid ventricular in-duction of brain natriuretic peptide gene expression in ex-perimental acute myocardial infarction[J].Circulation,1995,92(6):1558-1564.
[6]刘发军.血浆B型钠尿肽,超敏C-反应蛋白在急性心肌梗死中的临床应用价值[J].临床内科杂志,2008,25(5):314-315.
[7]Bassan R,Potsch A,Maisel A,et al.B-type natriureticpeptide:a novel early blood marker of acute myocardialinfarction in patients with chest pain and no ST-segmentelevation[J].Eur Heart J,2005,26(3):234-240.
[8]崔琪琼,张薇.声学定量技术对高血压左心室不同构型舒张功能的评价[J].中华影像学杂志,2005,11(12):716-719.
[9]杨婉花,汪自龙,欧阳平.血浆脑钠素和超敏C反应蛋白联合监测对急性冠状动脉综合征的评估价值[J].中国临床医学,2007,14(6):767-769.
[10]Blom HJ,Smulders Y.Overview of homocysteine and fo-late metabolism with special referen-ces to cardiovasculardisease and neural tube defects[J].J Inherited MetabolicDis,2011,34(1):75-81.
[11]Sharma P,Senthilkumar RD,Brahmachari V,et al.Miningliterature for a comprehensive pathway analysis:a casestudy for retrieval of homocysteine related genes for ge-netic and epigenetic studies[J].Lipids Health Dis,2006,5:1.
[12]Geisel J,Hennen B,Hübner U,et al.The impact of hy-perhomocysteinemia as a cardiovascular risk factor in theprediction of coronary heart disease[J].Clin Chem LabMed,2003,41(11):1513-1517.
[13]Beltowski J.Protein homocysteinylation:a new mecha-nism of atherogenesis[J].Postepy Hig Med Dosw(On-line),2005,59:392-404.
[14]刘梅,丁晓梅.急性冠状动脉综合征患者血清同型半胱氨酸和hs-CRP的相关性[J].心血管康复医学杂志,2007,16(5):455-457.