环境响应性载体材料在农药控释中的应用研究进展
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摘要
环境响应性载体材料是一种新兴的智能复合材料,能够响应酶、氧化还原、pH值、光、温度、电场、磁场和离子强度等环境刺激的变化,实现有效成分的靶向控制释放,在药物控释方面表现出突出的优越性,具有广阔的应用前景,已成为目前医药、食品和环境工程等领域的研究热点。文章综述了环境响应性载体材料的种类及其在农药领域的研究及应用状况,探讨了以环境响应性载体材料作为农药载体时存在的问题,并对其应用前景进行了展望。目前常见的环境响应性载体材料主要包括酶响应性载体材料、pH响应性载体材料、氧化还原响应性载体材料、光响应性载体材料及温度响应性载体材料等种类,已被广泛应用于药物传递、分离纯化、临床诊断以及酶和细胞的固定化等领域,其作为助剂在农药制剂加工中的应用尚处于基础阶段,在商业化与规模化应用等方面还有待进一步研究完善。
The stimuli-responsive carrier material is an emerging type of composite material, which can achieve self-regulated controlled-release in response to the change of enzyme, redox, p H,photoirradiation, temperature, electric field, magnetic field and ionic strength in external environment.Materials of this type exhibit excellent advantages for drug controlled-releasing and extensive application prospect. Therefore, they have attracted worldwide interest in the field of medicine, food and environmental engineering. The research progress in the field of stimuli-responsive carrier materials and their application as carrier of pesticides were discussed. Potential problems of employing stimuliresponsive carrier materials as pesticides controlled release carriers and its prospective were also discussed. Stimuli-responsive carrier materials, including enzyme-, p H-, redox-, photoirradiation-and temperature-responsive carrier materials, have been widely used in the field of drug delivery,purification, diagnostics, and immobilization of enzymes and cells. The application of stimuliresponsive carrier materials in pesticide formulation process is still in the basic stage, and need to be further studied in the aspects of commercialization and scale application.
The stimuli-responsive carrier material is an emerging type of composite material, which can achieve self-regulated controlled-release in response to the change of enzyme, redox, p H,photoirradiation, temperature, electric field, magnetic field and ionic strength in external environment.Materials of this type exhibit excellent advantages for drug controlled-releasing and extensive application prospect. Therefore, they have attracted worldwide interest in the field of medicine, food and environmental engineering. The research progress in the field of stimuli-responsive carrier materials and their application as carrier of pesticides were discussed. Potential problems of employing stimuliresponsive carrier materials as pesticides controlled release carriers and its prospective were also discussed. Stimuli-responsive carrier materials, including enzyme-, p H-, redox-, photoirradiation-and temperature-responsive carrier materials, have been widely used in the field of drug delivery,purification, diagnostics, and immobilization of enzymes and cells. The application of stimuliresponsive carrier materials in pesticide formulation process is still in the basic stage, and need to be further studied in the aspects of commercialization and scale application.
引文
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[38]KAZIEM A E,GAO Y H,HE S,et al.Synthesis and insecticidal activity of enzyme-triggered functionalized hollow mesoporous silica for controlled release[J].J Agric Food Chem,2017,65(36):7854-7864.
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[2]张一宾.农药制剂技术的开发与最近动向[J].农药译丛,1998,20(3):49-55.ZHANG Y B.Development and recent trend of pesticide formulation technology[J].Translated Collection of Pesticide,1998,20(3):49-55.
[3]冷阳.我国农药制剂的动态及发展趋势[J].世界农药,2010,32(1):19-21.LENG Y.Trends and development current of Chinese pesticide formulation[J].World Pestic,2010,32(1):19-21.
[4]华乃震.农药微胶囊剂的加工和进展(Ⅰ)[J].现代农药,2010,9(3):10-14.HUA N Z.Development and recent progress of pesticide microencapsulates(Ⅰ)[J].Modern Agrochem,2010,9(3):10-14.
[5]华乃震.农药微胶囊剂的加工和进展(Ⅱ)[J].现代农药,2010,9(4):6-10.HUA N Z.Development and recent progress of pesticide microencapsulates(Ⅱ)[J].Modern Agrochem,2010,9(4):6-10.
[6]BOEHM A L,MARTINON I,ZERROUK R,et al.Nanoprecipitation technique for the encapsulation of agrochemical active ingredients[J].J Microencapsul,2003,20(4):433-441.
[7]KNOWLES A.Recent developments of safer formulations of agrochemicals[J].Environmentalist,2008,28(1):35-44.
[8]MANATUNGA D C,DE SILVA R M,DE SILVA K M N,et al.p Hresponsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and hydroxyapatite bi-coated iron oxide nanoparticles[J].Eur J Pharm Biopharm,2017,117:29-38.
[9]ZHANG C Y,PAN D Y,LI J,et al.Enzyme-responsive peptide dendrimer-gemcitabine conjugate as a controlled-release drug delivery vehicle with enhanced antitumor efficacy[J].Acta Biomaterialia,2017,55:153-162.
[10]ESWARAMMA S,RAO K S V K.Synthesis of dual responsive carbohydrate polymer based IPN microbeads for controlled release of anti-HIV drug[J].Carbohydr Polym,2017,156:125-134.
[11]SHAO L,HUA B,SUN J F,et al.A cucurbit[J].Tetrahedron Lett,2017,58(19):1863-1867.
[12]ZHOU Y J,JIE K C,HUANG F H.A redox-responsive seleniumcontaining pillar[J].Chem Commun,2017,53(59):8364-8367.
[13]SUKHORUKOV G,FERY A,M?HWALD H.Intelligent micro-and nanocapsules[J].Prog Polym Sci,2005,30(8-9):885-897.
[14]ESSER-KAHN A P,ODOM S A,SOTTOS N R,et al.Triggered release from polymer capsules[J].Macromolecules,2011,44(14):5539-5553.
[15]KOST J,LANGER R.Responsive polymeric delivery systems[J].Adv Drug Delivery Rev,2012,64(Suppl.1):327-341.
[16]WANG C,CHEN Q S,WANG Z Q,et al.An enzyme-responsive polymeric superamphiphile[J].Angew Chem,2010,122(46):8794-8797.
[17]NGUYEN M M,CARLINI A S,CHIEN M P,et al.Enzymeresponsive nanoparticles for targeted accumulation and prolonged retention in heart tissue after myocardial infarction[J].Adv Mater,2015,27(37):5547-5552.
[18]HU J M,ZHANG G Q,LIU S Y.Enzyme-responsive polymeric assemblies,nanoparticles and hydrogels[J].Chem Soc Rev,2012,41(18):5933-5949.
[19]LI X,BURGER S,O'CONNOR A J,et al.An enzyme-responsive controlled release system based on a dual-functional peptide[J].Chem Commun,2016,52(29):5112-5115.
[20]ZHA ZB,ZHANG S H,DENG Z J,et al.Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging,tumorselective chemotherapy and photothermal therapy[J].Chem Commun,2013,49(33):3455-3457.
[21]TOKAREV I,GOPISHETTY V,ZHOU J,et al.Stimuli-responsive hydrogel membranes coupled with biocatalytic processes[J].ACSAppl Mater Interfaces,2009,1(3):532-536.
[22]TEIXEIRA L S M,FEIJEN J,VAN BLITTERSWIJK C A,et al.Enzyme-catalyzed crosslinkable hydrogels:emerging strategies for tissue engineering[J].Biomaterials,2012,33(5):1281-1290.
[23]DE LA RICA R,AILI D,STEVENS M M.Enzyme-responsive nanoparticles for drug release and diagnostics[J].Adv Drug Delivery Rev,2012,64(11):967-978.
[24]ANDRESEN T L,THOMPSON D H,KAASGAARD T.Enzymetriggered nanomedicine:drug release strategies in cancer therapy(invited review)[J].Mol Membr Biol,2010,27(7):353-363.
[25]WATANABE H,TOKUDA G.Cellulolytic systems in insects[J].Annu Rev Entomol,2010,55(1):609-632.
[26]MAISURIA V B,PATEL V A,NERURKAR A S.Biochemical and thermal stabilization parameters of polygalacturonase from Erwinia carotovora subsp.carotovora BR1[J].J Microbiol Biotechnol,2010,20(7):1077-1085.
[27]AGUSTíN,COHEN A C.Lygus hesperus and L.lineolaris(Hemiptera:Miridae),phytophages,zoophages,or omnivores:evidence of feeding adaptations suggested by the salivary and midgut digestive enzymes[J].J Entomol Sci,2000,35(2):176-186.
[28]BAE Y,FUKUSHIMA S,HARADA A,et al.Design of environment-sensitive supramolecular assemblies for intracellular drug delivery:polymeric micelles that are responsive to intracellular p H change[J].Angew Chem Int Ed Engl,2003,42(38):4640-4643.
[29]SCHMALJOHANN D.Thermo-and p H-responsive polymers in drug delivery[J].Adv Drug Delivery Rev,2006,58(15):1655-1670.
[30]ZHAO S,XU M M,CAO C W,et al.A redox-responsive strategy using mesoporous silica nanoparticles for co-delivery of si RNA and doxorubicin[J].J Mater Chem B,2017,5(33):6908-6919.
[31]WANG D L,JIN Y,ZHU X Y,et al.Synthesis and applications of stimuli-responsive hyperbranched polymers[J].Prog Polym Sci,2017,64:114-153.
[32]BROMBERG L E,RON E S.Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery[J].Adv Drug Delivery Rev,1998,31(3):197-221.
[33]CHUNG J E,YOKOYAMA M,YAMATO M,et al.Thermoresponsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide)and poly(butylmethacrylate)[J].J Controlled Release,1999,62(1/2):115-127.
[34]GANTA S,DEVALAPALLY H,SHAHIWALA A,et al.A review of stimuli-responsive nanocarriers for drug and gene delivery[J].JControlled Release,2008,126(3):187-204.
[35]DING G L,LI D G,LIU Y,et al.Preparation and characterization of kasuga-silica-conjugated nanospheres for sustained antimicrobial activity[J].J Nanopart Res,2014,16:2671.
[36]LIU Y,SUN Y,DING G L,et al.Synthesis,characterization,and application of microbe-triggered controlled-release kasugamycinpectin conjugate[J].J Agric Food Chem,2015,63(17):4263-4268.
[37]GUO M C,ZHANG W B,DING G L,et al.Preparation and characterization of enzyme-responsive emamectin benzoate microcapsules based on a copolymer matrix of silica-epichlorohydrincarboxymethylcellulose[J].RSC Adv,2015,5(113):93170-93179.
[38]KAZIEM A E,GAO Y H,HE S,et al.Synthesis and insecticidal activity of enzyme-triggered functionalized hollow mesoporous silica for controlled release[J].J Agric Food Chem,2017,65(36):7854-7864.
[39]RUDZINSKI W E,CHIPUK T,DAVE A M,et al.p H-sensitive acrylic-based copolymeric hydrogels for the controlled release of a pesticide and a micronutrient[J].J Appl Polym Sci,2003,87(3):394-403.
[40]CHEN M S,JENSEN S P,HILL M R,et al.Synthesis of amphiphilic polysuccinimide star copolymers for responsive delivery in plants[J].Chem Commun,2015,51(47):9694-9697.
[41]HILL M R,MACKRELL E J,FORSTHOEFEL C P,et al.Biodegradable and p H-responsive nanoparticles designed for sitespecific delivery in agriculture[J].Biomacromolecules,2015,16(4):1276-1282.
[42]林粤顺,周红军,周新华,等.p H响应性PAA/毒死蜱/氨基化介孔硅缓释体系的制备与性能[J].化工学报,2016,67(10):4500-4507.LIN Y S,ZHOU H J,ZHOU X H,et al.Preparation and properties of p H-responsive control release system of PAA/chlorpyrifos/amino functionalized mesoporous silica[J].CIESC J,2016,67(10):4500-4507.
[43]XIANG Y B,ZHANG G L,CHEN C W,et al.Fabrication of a p H-responsively controlled-release pesticide using an attapulgite-based hydrogel[J].ACS Sustainable Chem Eng,2018,6(1):1192-1201.
[44]YU Z Y,SUN X,SONG H X,et al.Glutathione-responsive carboxymethyl chitosan nanoparticles for controlled release of herbicides[J].Mater Sci Appl,2015,6(6):591-604.
[45]YI Z F,HUSSAIN H I,FENG C F,et al.Functionalized mesoporous silica nanoparticles with redox-responsive short-chain gatekeepers for agrochemical delivery[J].ACS Appl Mater Interfaces,2015,7(18):9937-9946.
[46]郭明程.环境响应性农药控释剂的制备及生物效应研究[D].北京:中国农业大学,2016:39-51.GUO M C.Preparation and biological efficacy evaluation of stimuliresponsive controlled release formulation of pesticide[D].Beijing:China Agricultural University,2016:39-51.
[47]SUN D Q,HUSSAIN H I,YI Z F,et al.Delivery of abscisic acid to plants using glutathione responsive mesoporous silica nanoparticles[J].J Nanosci Nanotechnol,2018,18(3):1615-1625.
[48]ATTA S,BERA M,CHATTOPADHYAY T,et al.Nano-pesticide formulation based on fluorescent organic photoresponsive nanoparticles:for controlled release of 2,4-D and real time monitoring of morphological changes induced by 2,4-D in plant systems[J].RSCAdv,2015,5(106):86990-86996.
[49]ATTA S,PAUL A,BANERJEE R,et al.Photoresponsive polymers based on a coumarin moiety for the controlled release of pesticide2,4-D[J].RSC Adv,2015,5(121):99968-99975.
[50]YE Z,GUO J J,WU D W,et al.Photo-responsive shell cross-linked micelles based on carboxymethyl chitosan and their application in controlled release of pesticide[J].Carbohydr Polym,2015,132:520-528.
[51]DING K K,SHI L Y,ZHANG L,et al.Synthesis of photoresponsive polymeric propesticide micelles based on PEG for the controlled release of a herbicide[J].Polym Chem,2016,7(4):899-904.
[52]XU Z P,GAO Z H,SHAO X S.Light-triggered release of insecticidally active spirotetramat-enol[J/OL].Chin Chem Lett,2018[2018-02-10].https://doi.org/10.1016/j.cclet.2018.01.025.
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