疏肝理气健脾活血法治疗慢性结石性胆囊炎的临床研究
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摘要
目的根据中医理论与临床观察,明确疏肝健脾活血法治疗慢性结石性胆囊炎肝郁脾虚气滞血瘀证的临床治疗效果,为临床治疗提供参考。方法收集慢性结石性胆囊炎肝郁脾虚气滞血瘀证患者120例,随机分为治疗组和对照组,每组60例(后来治疗组别除2例,对照组剔除3例)。治疗组予中医疏肝健脾活血法治疗,口服疏肝理气健脾活血汤;对照组服用胆舒胶囊,2粒/次,3次/d。两组患者均以45天为l个疗程,1个疗程结束后观察两组患者的肝功肾功血常规、心电图、主要症状体征积分及肝胆影像学结果,进行比较。结果治疗组与对照组中医证候总有效率分别为96.67%、70.00%,组间比较差异有统计学意义(P<0.05);治疗后两组的主要症状积分和影像学结果均有改善,治疗组优于对照组(P<0.05)。结论疏肝理气健脾活血法可明显减轻肝郁脾虚气滞血瘀证慢性结石性胆囊炎患者的临床症状及体征及显著改善超声影像表现,是一种使用方便、无毒副作用的治疗方法。
Objective according to the theory and clinical observation of traditional Chinese medicine, to clarify the clinical therapeutic effect of invigorating the liver and invigorating the spleen and activating the spleen in the treatment of chronic calculi cholecystitis. Methods 120 patients with chronic calculi cholecystitis, liver depression, spleen deficiency, qi stagnation and blood stasis were randomly divided into treatment group and control group, 60 patients in each group(2 patients were removed from the treatment group and 3 patients from the control group). The treatment group was treated by Chinese medicine dredging the liver, invigorating the spleen and activating the blood. The control group took dan-shu capsules 2 times and 3 times/d. After the end of one course of treatment, liver and kidney function blood routine, electrocardiogram, main symptoms and signs score and hepatobiliary imaging results of the two groups of patients were observed and compared. Results the total effective rates of TCM syndromes in the treatment group and the control group were 96.67% and 70.00% respectively, and the difference between the two groups was statistically significant(P< 0.05). The main symptom scores and imaging results of the two groups improved after chemotherapy, and the treatment group was superior to the control group(P< 0.05). Conclusion shugan liqi invigorates spleen and invigorates blood circulation can significantly reduce the clinical symptoms and physical signs of chronic calculi cholecystitis patients with qi stagnation and blood stasis of qi deficiency of liver qi and spleen and significantly improve the ultrasonographic manifestations.
Objective according to the theory and clinical observation of traditional Chinese medicine, to clarify the clinical therapeutic effect of invigorating the liver and invigorating the spleen and activating the spleen in the treatment of chronic calculi cholecystitis. Methods 120 patients with chronic calculi cholecystitis, liver depression, spleen deficiency, qi stagnation and blood stasis were randomly divided into treatment group and control group, 60 patients in each group(2 patients were removed from the treatment group and 3 patients from the control group). The treatment group was treated by Chinese medicine dredging the liver, invigorating the spleen and activating the blood. The control group took dan-shu capsules 2 times and 3 times/d. After the end of one course of treatment, liver and kidney function blood routine, electrocardiogram, main symptoms and signs score and hepatobiliary imaging results of the two groups of patients were observed and compared. Results the total effective rates of TCM syndromes in the treatment group and the control group were 96.67% and 70.00% respectively, and the difference between the two groups was statistically significant(P< 0.05). The main symptom scores and imaging results of the two groups improved after chemotherapy, and the treatment group was superior to the control group(P< 0.05). Conclusion shugan liqi invigorates spleen and invigorates blood circulation can significantly reduce the clinical symptoms and physical signs of chronic calculi cholecystitis patients with qi stagnation and blood stasis of qi deficiency of liver qi and spleen and significantly improve the ultrasonographic manifestations.
引文
[1]中华消化杂志编辑委员会.中国慢性胆囊炎、胆囊结石内科诊疗共识意见(2014年,上海)[J].中华消化杂志,2014(12):292-296.
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[3]孙政华,邵晶,郭玫.黄芪化学成分及药理作用研究进展[J].中医临床研究,2015(25):22-25.
[4]巩向丹,张叶,刘宏明.白芍的研究概况[J].药学研究,2014(9):531-534.
[5]田利鲜.柴胡的药理作用和临床运用[J].湖北中医杂志,2008,30(1):59-60.
[6]徐如英,童树洪.红花的化学成分及药理作用研究进展[J].中国药业,2010,19(20):86-87.
[7]严玮.佛手化学成分和药理作用研究进展[J].实用中医药杂志,2015(8):788-790.
[8]梁学清,李丹丹,黄忠威.茯苓药理作用研究进展[J].河南科技大学学报(医学版),2012,30(2):154-156.
[9]张建春,蔡雅明,周德斌,等.木香的研究进展[J].甘肃科技,2010,26(20):170-173.
[2]中华人民共和国卫生部.中药新药临床研究指导原则(第三辑)[M].中华人民共和国卫生部制定发布,1997.
[3]孙政华,邵晶,郭玫.黄芪化学成分及药理作用研究进展[J].中医临床研究,2015(25):22-25.
[4]巩向丹,张叶,刘宏明.白芍的研究概况[J].药学研究,2014(9):531-534.
[5]田利鲜.柴胡的药理作用和临床运用[J].湖北中医杂志,2008,30(1):59-60.
[6]徐如英,童树洪.红花的化学成分及药理作用研究进展[J].中国药业,2010,19(20):86-87.
[7]严玮.佛手化学成分和药理作用研究进展[J].实用中医药杂志,2015(8):788-790.
[8]梁学清,李丹丹,黄忠威.茯苓药理作用研究进展[J].河南科技大学学报(医学版),2012,30(2):154-156.
[9]张建春,蔡雅明,周德斌,等.木香的研究进展[J].甘肃科技,2010,26(20):170-173.