LASIK术后干眼与非干眼症状患者的影响因素比较研究
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摘要
目的:评价LASIK术后6个月干眼症状相关的影响因素。方法:随访LASIK手术后6个月,360例患者根据是否有干眼症状分成干眼症状组和非干眼症状组。比较两组间干眼症状和SPEED评分,χ2检验和t检验用于统计分析。结果:干眼症状组与非干眼症状组比较:长时间用眼阅读、睡眠差、紧张、认为干眼与手术有关的比例分别为(30.5%vs.12.5%,P=0.000)、(18.3%vs.9.6%,P=0.025)、(24.4%vs.9.9%,P=0.002)、(35.4%vs.1.5%,P=0.000);干眼症状组有、无相关影响因素SPEED评分分别为(3.22±1.72)vs.(1.92±1.57),P=0.001;(2.62±1.52)vs.(1.82±1.45),P=0.045;(2.72±1.57)vs.(1.98±1.39),P=0.043;(3.02±1.66)vs.(1.88±1.47),P=0.032。两组间饮酒和吸烟无统计学意义。结论:干眼症状组患者更容易发生长时间用眼阅读、睡眠差、紧张及认为干眼与手术有关等情况。本研究利于合理解释LASIK术后远期干眼的症状和提高相关治疗。
Objective: To evaluate the influencing factors associated with the symptoms of dry eye after laser-assisted in situ keratomileusis( LASIK) surgery at postoperative 6 months. Methods: At follow-up after postoperative 6 months,360 patients were divided into dry eye symptoms and no dry eye symptoms groups according to whether they had dry eye symptoms,dry eye symptoms and SPEED scores were compared between two groups. Chi-square and t test were performed for statistical analysis. Results: In the dry eye symptoms and no dry eye symptoms groups reading for long time,poor sleeping,stress,considering dry eye symptoms associated with operation occurred( 30. 5% vs. 12. 5%,P = 0. 000),( 18. 3% vs. 9. 6%,P = 0. 025),( 24. 4% vs. 9. 9%,P = 0. 002),( 35. 4% vs1. 5%,P = 0. 000),respectively. In the dry eye symptoms group patients with or without influencing factors SPEED scores were( 3. 22 ±1. 72 vs. 1. 92 ± 1. 57,P = 0. 001),( 2. 62 ± 1. 52 vs. 1. 82 ± 1. 45,P = 0. 045),( 2. 72 ± 1. 57 vs. 1. 98 ± 1. 39,P = 0. 043),( 3. 02± 1. 66 vs. 1. 88 ± 1. 47,P = 0. 032),respectively. No significant differences were observed in drinking,smoking habit between two groups. Conclusion: Reading for long time,poor sleeping,stress,considering dry eye symptoms associated with operation occurred more easily in dry eye symptoms group patients. These results may be helpful to explain further dry eye and improve related treatments after LASIK surgery.
Objective: To evaluate the influencing factors associated with the symptoms of dry eye after laser-assisted in situ keratomileusis( LASIK) surgery at postoperative 6 months. Methods: At follow-up after postoperative 6 months,360 patients were divided into dry eye symptoms and no dry eye symptoms groups according to whether they had dry eye symptoms,dry eye symptoms and SPEED scores were compared between two groups. Chi-square and t test were performed for statistical analysis. Results: In the dry eye symptoms and no dry eye symptoms groups reading for long time,poor sleeping,stress,considering dry eye symptoms associated with operation occurred( 30. 5% vs. 12. 5%,P = 0. 000),( 18. 3% vs. 9. 6%,P = 0. 025),( 24. 4% vs. 9. 9%,P = 0. 002),( 35. 4% vs1. 5%,P = 0. 000),respectively. In the dry eye symptoms group patients with or without influencing factors SPEED scores were( 3. 22 ±1. 72 vs. 1. 92 ± 1. 57,P = 0. 001),( 2. 62 ± 1. 52 vs. 1. 82 ± 1. 45,P = 0. 045),( 2. 72 ± 1. 57 vs. 1. 98 ± 1. 39,P = 0. 043),( 3. 02± 1. 66 vs. 1. 88 ± 1. 47,P = 0. 032),respectively. No significant differences were observed in drinking,smoking habit between two groups. Conclusion: Reading for long time,poor sleeping,stress,considering dry eye symptoms associated with operation occurred more easily in dry eye symptoms group patients. These results may be helpful to explain further dry eye and improve related treatments after LASIK surgery.
引文
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[2]赵小虎,田延原,马海鹰,等.飞秒激光和机械刀制瓣对中高度近视眼LASIK手术的对比研究[J].川北医学院学报,2010,25(4):328-330.
[3]Patel VD,Watanabe JH,Strauss JA,et al.Work productivity loss in patients with dry eye disease:an online survey[J].Curr Med Res Opin,2011,27(5):1041-1048.
[4]雍桂珍,兰长骏,甘宇业.三种人工泪液联合用药缓解LASIK术后重度干眼的疗效观察[J].川北医学院学报,2015,30(4):474-476.
[5]张佳楠,李海丽,晏晓明.两种干眼症状问卷评分与干眼临床检查的关联性研究[J].中华实验眼科杂志,2012,230(4):362-365.
[6]Bartlett JD,Keith MS,Sudharshan L,et al.Associations between signs and symptoms of dry eye disease:a systematic review[J].Clin Ophthalmol,2015,16(9):1719-1730.
[7]Tounaka K,Yuki K,Kouyama K,et al.Dry eye disease is associated with deterioration of mental health in male Japanese university staff[J].Tohoku J Exp Med,2014,233(3):215-220.
[2]赵小虎,田延原,马海鹰,等.飞秒激光和机械刀制瓣对中高度近视眼LASIK手术的对比研究[J].川北医学院学报,2010,25(4):328-330.
[3]Patel VD,Watanabe JH,Strauss JA,et al.Work productivity loss in patients with dry eye disease:an online survey[J].Curr Med Res Opin,2011,27(5):1041-1048.
[4]雍桂珍,兰长骏,甘宇业.三种人工泪液联合用药缓解LASIK术后重度干眼的疗效观察[J].川北医学院学报,2015,30(4):474-476.
[5]张佳楠,李海丽,晏晓明.两种干眼症状问卷评分与干眼临床检查的关联性研究[J].中华实验眼科杂志,2012,230(4):362-365.
[6]Bartlett JD,Keith MS,Sudharshan L,et al.Associations between signs and symptoms of dry eye disease:a systematic review[J].Clin Ophthalmol,2015,16(9):1719-1730.
[7]Tounaka K,Yuki K,Kouyama K,et al.Dry eye disease is associated with deterioration of mental health in male Japanese university staff[J].Tohoku J Exp Med,2014,233(3):215-220.