姜黄素类似物的合成及其抗氧化活性
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摘要
姜黄素具有抗氧化、抗肿瘤、抗炎、神经保护等多种生物活性,但其自身结构使得其生物利用度低。通过对其双羰基结构的改造合成了系列姜黄素类似物,并研究了所合成的化合物对DPPH自由基和ABTS+自由基的清除能力,结果表明,一些姜黄素类似物具有很好的抗氧化能力。
Curcumin has a variety of biological activities,including antioxidant,antitumor,antiinflammation,and neuroprotection,but its bioavailability is low because of its structure. A series of curcumin analogues were synthesized by reforming the double carbonyl moiety of curcumin. And their abilities to scavenge DPPH free radical and ABTS free radical were evaluated. The results revealed that some curcumin analogues exhibited strong antioxidant activities.
Curcumin has a variety of biological activities,including antioxidant,antitumor,antiinflammation,and neuroprotection,but its bioavailability is low because of its structure. A series of curcumin analogues were synthesized by reforming the double carbonyl moiety of curcumin. And their abilities to scavenge DPPH free radical and ABTS free radical were evaluated. The results revealed that some curcumin analogues exhibited strong antioxidant activities.
引文
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[2]Rice-Evans CA,Diplock AT.Current Status of Antioxidant Therapy[J].Free Radical Biology and Medicine,1993,15(1):77-96.
[3]鲍华英,陈荣华.姜黄素的研究进展[J].国外医学:儿科学分册,2003,30(5):254-256.
[4]Agrawal D K,Mishra PK.Curcumin and Its Analogues::Potential Anticancer Agents[J].Med Res Rev,2010,30:818-860.
[5]Anand P,Kunnumakkara AB,Newman RA,et al.Bioavailability of Curcumin:Problems and Promises[J].Molecular Pharmaceutics,2007,4(6):807-818.
[6]王永成,李玉山,杨瀚泽,等.新型姜黄素类似物的合成及初步抗肿瘤活性研究[J].药学学报,2014,49(7):78-84.
[7]Zhu N,Wang M,Wei GJ,et al.Identification of Reaction Products of(-)-epigallocatechin,(-)-epigallocatechin Gallate and Pyrogallol with 2,2-diphenyl-1-picrylhydrazyl Radical[J].Food Chemistry,2001,73(3):345-349.
[8]白海娜,王振宇,刘瑞海,等.白藜芦醇与黑木耳多糖协同清除ABTS自由基活性的研究[J].现代食品科技,2014,30(3):64-68.