蒿属植物降糖活性成分及提取方法研究进展
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摘要
蒿属是菊科中分布最广的属之一,蒿属植物在我国民间被广泛使用。综述近年来蒿属植物降血糖的主要化学成分、降糖作用机制和提取方法等方面的研究进展,为蒿属植物降糖药效成分的进一步开发和利用提供参考。
The Artemisia species is one of the most broadly distributed genus of Compositae family, and Artemisia plants have been widely used as folk medicine. Research progress in the hypoglycemic constituents of Artemisia species, as well as their hypoglycemic mechanisms, extraction methods and quality analysis were reviewed, so as to provide reference for further exploration and utilization of hypoglycemic ingredients in Artemisia species.
The Artemisia species is one of the most broadly distributed genus of Compositae family, and Artemisia plants have been widely used as folk medicine. Research progress in the hypoglycemic constituents of Artemisia species, as well as their hypoglycemic mechanisms, extraction methods and quality analysis were reviewed, so as to provide reference for further exploration and utilization of hypoglycemic ingredients in Artemisia species.
引文
[1]刘爱文.中药治疗糖尿病的研究进展[J].内蒙古中医药,2017,36(12):154-155.
[2]Chan C C,Zhang H W,Chan K,et al.Xiaoke pill,and anti-diabetic drugs:a review on clinical evidence of possible herb-drug interactions[J/OL].Chin J Integr Med,2016:1-8[2018-05-04].https://link.springer.com/article/10.1007%2Fs11655-015-2106-5.
[3]杜悦凤,蔡青,王洪武.中医药治疗2型糖尿病的研究进展[J].湖南中医杂志,2017,33(3):169-172.
[4]Zhang L,Lv J.Phytochemistry and bioactivities of sesquiterpenoids from the Artemisia species[J].J Chin Pharm Sci,2017,26(5):317-334.
[5]刘玲艳.端午节,莫忘时令美食艾叶糕[J].医食参考,2017(5):48.
[6]汪李平,杨静.长江流域塑料大棚藜蒿栽培技术[J].长江蔬菜,2017,(22):20-23.
[7]龚莉.冬食三蔬,护心、抗癌、防老[J].健康指南:中老年,2017(2):41-42.
[8]侯小涛,何耀涛,杜正彩,等.降糖植物多糖来源及其降糖活性研究[J].中华中医药学刊,2017,35(2):358-360.
[9]孟祥云,郭树明,杨丽霞.中药植物多糖对2型糖尿病胰岛素抵抗的作用机制研究进展[J].中国实验方剂学杂志,2017,23(8):220-225.
[10]尹美珍,胡岗,苏振宏,等.艾叶多糖I型糖尿病小鼠的降血糖作用[J].时珍国医国药,2015,26(9):2072-2074.
[11]胡岗,尹美珍,喻昕,等.艾叶多糖体外抗氧化作用研究[J].时珍国医国药,2015,26(11):2650-2652.
[12]甘昌胜,尹彬彬,张靖华,等.艾叶精油蒸馏制取对相应水提液活性成分的影响及其抑菌性能比较[J].食品与生物技术学报,2015,34(12):1327-1331.
[13]罗旋,胡昌猛,沈远娟,等.艾叶多糖对小鼠免疫功能影响的研究[J].大理学院学报,2016,1(2):15-18.
[14]李华生,骆航,孙兴力,等.加压同步萃取艾叶挥发油、总黄酮和多糖的工艺研究[J].中国食品添加剂,2016(10):83-89.
[15]沈霞.艾叶多糖的提取、分离纯化及体外抗氧化活性研究[D].上海:华东理工大学,2010:16-60.
[16]薛燕芳,杨丽霞,范强,等.中药黄酮类化合物抗糖尿病作用机制研究述评[J].时珍国医国药,2017,28(8):1967-1970.
[17]Islam M N,Jung H A,Sohn H S,et al.Potentα-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris[J].Arch Pharm Res,2013,36(5):542-552.
[18]文荣,周成江,贾彦彬,等.野艾蒿中4种黄酮类化合物对HepG2细胞AMPK和LPIN1表达的影响[J].药物分析杂志,2017,37(1):74-82.
[19]Anaya-Eugenio G D,Riverocruz I,Riverachávez J,et al.Hypoglycemic properties of some preparations and compounds from Artemisia ludoviciana Nutt.[J].J Ethnopharmacol,2014,155(1):416-25.
[20]Huang D,Jiang Y,Chen W,et al.Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense[J/OL].JEthnopharmacol,2015,163:256-263[2018-05-04].https://www.sciencedirect.com/science/article/pii/S037887411500029X?via%3Dihub.Doi:10.1016/j.jep.2015.01.014.
[21]Ota A,Ulrih N P.An overview of herbal products and secondary metabolites used for management of type two diabetes[J/OL].Front Pharmacol,2017:8[2018-05-04].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499308/pdf/fphar-08-00436.pdf.Doi:10.3389/fphar.2017.00436.
[22]Santana A,Santamarina A,Souza G,et al.Decaffeinated green tea extract rich in epigallocatechin-3-gallate improves insulin resistance and metabolic profiles in normolipidic diet-but not high-fat diet-fed mice[J].J Nutr Biochem,2015,26(9):893-902.
[23]陈瑶,吴龙月,向福,等.泥蒿叶总黄酮的酶法提取及其抗氧化活性评价[J].中国酿造,2017,36(6):142-146.
[24]卫星星,曹琛,高慧,等.正交试验优选艾叶总黄酮索氏提取工艺[J].氨基酸和生物资源,2016,38(3):45-47.
[25]姚华,刘燕,杨巧丽,等.滨蒿总黄酮体内外抗甲型流感病毒作用的研究[J].西北药学杂志.2018,33(2):193-195.
[26]何健民,刘忆明,王丽月.茄叶一枝蒿中总黄酮的超声辅助提取工艺研究[J].中国化工贸易,2017,9(9):104-105.
[27]胡吉清,夏恒建,郭双喜,等.蕲艾挥发油、总黄酮和鞣质含量测定及最佳采收期确定[J].中华中医药杂志,2016,31(8):3013-3016.
[28]焦美,刘蕊,郝迪,等柳蒿化学成分的分离与鉴定[J].山东化工,2018,47(9):16-18.
[29]向海燕,黄艳菲,李伯超,等.藏药材全缘叶绿绒蒿总黄酮的富集纯化工艺研究[J].中华中医药杂志,2017,32(9):4269-4272.
[30]张浩超,郝宝燕,孙皓熠,等.绿原酸研究进展[J].食品与药品,2017,19(3):222-227.
[31]李珊珊,刘琳,李猛,等.茼蒿中绿原酸抑制西瓜枯萎病菌活性研究[J].核农学报,2018,32(1):104-111.
[32]马援杰,江蔚新,李志雄,等.茵陈中绿原酸的提取工艺研究进展[J].北京联合大学学报,2015,29(2):57-60.
[33]李熹,邱细敏,任达兵,等.高速逆流色谱法分离纯化艾叶中的异绿原酸A[J].食品工业科技,2016,37(10):295-297.
[34]Wang Y,Wang M,Chen B,et al.Scoparone attenuates high glucoseinduced extracellular matrix accumulation in rat mesangial cells[J/OL].Eur J Pharmacol,2017,815:376-380[2018-05-04].https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(17)30625-8.Doi:10.1016/j.ejphar.2017.09.039.
[35]Zengin G,Mollica A,Aktumsek A,et al.In vitro,and in silico insights of Cupressus sempervirens,Artemisia absinthium,and Lippia triphylla:bridging traditional knowledge and scientific validation[J/OL].Eur JIntegr Med,2017,12:135-141[2018-05-04].https://www.sciencedirect.com/science/article/abs/pii/S1876382017301087.Doi:10.1016/j.eujim.2017.05.010.
[36]Khan I,Ahmad W,Karim N,et al.Antidiabetic activity and histopathological analysis of carnosol isolated from Artemisia indica linn,in streptozotocin-induced diabetic rats[J].Med Chem Res,2016,26(2):1-9.
[37]Islam M N,Choi R J,Jung H A,et al.Promising anti-diabetic potential of capillin and capillinol isolated from Artemisia capillaris[J].Arch Pharmacal Res,2016,39(3):340-349.
[2]Chan C C,Zhang H W,Chan K,et al.Xiaoke pill,and anti-diabetic drugs:a review on clinical evidence of possible herb-drug interactions[J/OL].Chin J Integr Med,2016:1-8[2018-05-04].https://link.springer.com/article/10.1007%2Fs11655-015-2106-5.
[3]杜悦凤,蔡青,王洪武.中医药治疗2型糖尿病的研究进展[J].湖南中医杂志,2017,33(3):169-172.
[4]Zhang L,Lv J.Phytochemistry and bioactivities of sesquiterpenoids from the Artemisia species[J].J Chin Pharm Sci,2017,26(5):317-334.
[5]刘玲艳.端午节,莫忘时令美食艾叶糕[J].医食参考,2017(5):48.
[6]汪李平,杨静.长江流域塑料大棚藜蒿栽培技术[J].长江蔬菜,2017,(22):20-23.
[7]龚莉.冬食三蔬,护心、抗癌、防老[J].健康指南:中老年,2017(2):41-42.
[8]侯小涛,何耀涛,杜正彩,等.降糖植物多糖来源及其降糖活性研究[J].中华中医药学刊,2017,35(2):358-360.
[9]孟祥云,郭树明,杨丽霞.中药植物多糖对2型糖尿病胰岛素抵抗的作用机制研究进展[J].中国实验方剂学杂志,2017,23(8):220-225.
[10]尹美珍,胡岗,苏振宏,等.艾叶多糖I型糖尿病小鼠的降血糖作用[J].时珍国医国药,2015,26(9):2072-2074.
[11]胡岗,尹美珍,喻昕,等.艾叶多糖体外抗氧化作用研究[J].时珍国医国药,2015,26(11):2650-2652.
[12]甘昌胜,尹彬彬,张靖华,等.艾叶精油蒸馏制取对相应水提液活性成分的影响及其抑菌性能比较[J].食品与生物技术学报,2015,34(12):1327-1331.
[13]罗旋,胡昌猛,沈远娟,等.艾叶多糖对小鼠免疫功能影响的研究[J].大理学院学报,2016,1(2):15-18.
[14]李华生,骆航,孙兴力,等.加压同步萃取艾叶挥发油、总黄酮和多糖的工艺研究[J].中国食品添加剂,2016(10):83-89.
[15]沈霞.艾叶多糖的提取、分离纯化及体外抗氧化活性研究[D].上海:华东理工大学,2010:16-60.
[16]薛燕芳,杨丽霞,范强,等.中药黄酮类化合物抗糖尿病作用机制研究述评[J].时珍国医国药,2017,28(8):1967-1970.
[17]Islam M N,Jung H A,Sohn H S,et al.Potentα-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris[J].Arch Pharm Res,2013,36(5):542-552.
[18]文荣,周成江,贾彦彬,等.野艾蒿中4种黄酮类化合物对HepG2细胞AMPK和LPIN1表达的影响[J].药物分析杂志,2017,37(1):74-82.
[19]Anaya-Eugenio G D,Riverocruz I,Riverachávez J,et al.Hypoglycemic properties of some preparations and compounds from Artemisia ludoviciana Nutt.[J].J Ethnopharmacol,2014,155(1):416-25.
[20]Huang D,Jiang Y,Chen W,et al.Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense[J/OL].JEthnopharmacol,2015,163:256-263[2018-05-04].https://www.sciencedirect.com/science/article/pii/S037887411500029X?via%3Dihub.Doi:10.1016/j.jep.2015.01.014.
[21]Ota A,Ulrih N P.An overview of herbal products and secondary metabolites used for management of type two diabetes[J/OL].Front Pharmacol,2017:8[2018-05-04].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499308/pdf/fphar-08-00436.pdf.Doi:10.3389/fphar.2017.00436.
[22]Santana A,Santamarina A,Souza G,et al.Decaffeinated green tea extract rich in epigallocatechin-3-gallate improves insulin resistance and metabolic profiles in normolipidic diet-but not high-fat diet-fed mice[J].J Nutr Biochem,2015,26(9):893-902.
[23]陈瑶,吴龙月,向福,等.泥蒿叶总黄酮的酶法提取及其抗氧化活性评价[J].中国酿造,2017,36(6):142-146.
[24]卫星星,曹琛,高慧,等.正交试验优选艾叶总黄酮索氏提取工艺[J].氨基酸和生物资源,2016,38(3):45-47.
[25]姚华,刘燕,杨巧丽,等.滨蒿总黄酮体内外抗甲型流感病毒作用的研究[J].西北药学杂志.2018,33(2):193-195.
[26]何健民,刘忆明,王丽月.茄叶一枝蒿中总黄酮的超声辅助提取工艺研究[J].中国化工贸易,2017,9(9):104-105.
[27]胡吉清,夏恒建,郭双喜,等.蕲艾挥发油、总黄酮和鞣质含量测定及最佳采收期确定[J].中华中医药杂志,2016,31(8):3013-3016.
[28]焦美,刘蕊,郝迪,等柳蒿化学成分的分离与鉴定[J].山东化工,2018,47(9):16-18.
[29]向海燕,黄艳菲,李伯超,等.藏药材全缘叶绿绒蒿总黄酮的富集纯化工艺研究[J].中华中医药杂志,2017,32(9):4269-4272.
[30]张浩超,郝宝燕,孙皓熠,等.绿原酸研究进展[J].食品与药品,2017,19(3):222-227.
[31]李珊珊,刘琳,李猛,等.茼蒿中绿原酸抑制西瓜枯萎病菌活性研究[J].核农学报,2018,32(1):104-111.
[32]马援杰,江蔚新,李志雄,等.茵陈中绿原酸的提取工艺研究进展[J].北京联合大学学报,2015,29(2):57-60.
[33]李熹,邱细敏,任达兵,等.高速逆流色谱法分离纯化艾叶中的异绿原酸A[J].食品工业科技,2016,37(10):295-297.
[34]Wang Y,Wang M,Chen B,et al.Scoparone attenuates high glucoseinduced extracellular matrix accumulation in rat mesangial cells[J/OL].Eur J Pharmacol,2017,815:376-380[2018-05-04].https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(17)30625-8.Doi:10.1016/j.ejphar.2017.09.039.
[35]Zengin G,Mollica A,Aktumsek A,et al.In vitro,and in silico insights of Cupressus sempervirens,Artemisia absinthium,and Lippia triphylla:bridging traditional knowledge and scientific validation[J/OL].Eur JIntegr Med,2017,12:135-141[2018-05-04].https://www.sciencedirect.com/science/article/abs/pii/S1876382017301087.Doi:10.1016/j.eujim.2017.05.010.
[36]Khan I,Ahmad W,Karim N,et al.Antidiabetic activity and histopathological analysis of carnosol isolated from Artemisia indica linn,in streptozotocin-induced diabetic rats[J].Med Chem Res,2016,26(2):1-9.
[37]Islam M N,Choi R J,Jung H A,et al.Promising anti-diabetic potential of capillin and capillinol isolated from Artemisia capillaris[J].Arch Pharmacal Res,2016,39(3):340-349.