可卡因-安非他明转录调节肽的功能及抗应激调控机制的研究进展
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摘要
大多生产动物自出生后将面临补铁、断奶、环境及温度变化等应激源造成的威胁,这极大地增高动物的发病率和死亡率,严重地影响了畜牧经济的发展。神经肽具有多种生物学功能,尤其在动物机体抗应激调控过程中发挥重要的作用。本文将对可卡因-安非他明转录调节肽(CART)的功能以及参与抗氧化应激调控的相关机制进行综述。
Most producing animals would suffer from multiple stresses which are caused by iron supplementation,weaning,changes of surroundings and temperature after their birth,and that will increase the incidence of disease and the death rate,which seriously affects the development of animal husbandry.Neuropeptides have many important biological functions,especially,play an important role in the process of stress regulation.This article reviewed the functions of cocaine-and amphetamine-regulated transcript peptide(CART) as well as the mechanisms involved in anti-oxidative stress regulation.
Most producing animals would suffer from multiple stresses which are caused by iron supplementation,weaning,changes of surroundings and temperature after their birth,and that will increase the incidence of disease and the death rate,which seriously affects the development of animal husbandry.Neuropeptides have many important biological functions,especially,play an important role in the process of stress regulation.This article reviewed the functions of cocaine-and amphetamine-regulated transcript peptide(CART) as well as the mechanisms involved in anti-oxidative stress regulation.
引文
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[2]DOUGLASS J,MCKINZIE A A,COUCEYRO P.PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine[J].The Journal of Neuroscience,1995,15(3):2471-2481.
[3]HWANG Y G,LEE H S.Neuropeptide Y(NPY)or cocaine-and amphetamine-regulated transcript(CART)fiber innervation on central and medial amygdaloid neurons that project to the locus coeruleus and dorsal raphe in the rat[J].Brain Research,2018,1689:75-88.
[4]ZHU W L,WANG Z K.Effects of random food deprivation and refeeding on energy metabolism,behavior and hypothalamic neuropeptide expression in Apodemus chevrieri[J].Comparative Biochemistry and Physiology Part A:Molecular&Integrative Physiology,2016,201:71-78.
[5]SHA D J,WANG Z Y,QIAN L,et al.A cocaine-regulated and amphetamine-regulated transcript inhibits oxidative stress in neurons deprived of oxygen and glucose[J].Neuroreport,2013,24(13):698-703.
[6]OPONOWICZ A,KOZOWSKA A,GONKOWSKI S,et al.Changes in the distribution of cocaine-and amphetamine-regulated transcript-containing neural structures in the human colon affected by the neoplastic process[J].International Journal of Molecular Sciences,2018,19(2):414.
[7]DANDEKAR MP,SINGRU P S,KOKARE D M,et al.Cocaine-and amphetamine-regulated transcript peptide plays a role in the manifestation of depression:social isolation and olfactory bulbectomy models reveal unifying principles[J].Neuropsychopharmacology,2009,34(5):1288-1300.
[8]HUNTER R G,PHILPOT K,VICENTIC A,et al.CART in feeding and obesity[J].Trends in Endocrinology&Metabolism,2004,15(9):454-459.
[9]KRISTENSEN P,JUDGE ME,THIML,et al.Hypothalamic CART is a newanorectic peptide regulated by leptin[J].Nature,1998,393(6680):72-76.
[10]TACHIBANA T,TAKAGI T,TOMONAGA S,et al.Central administration of cocaine-and amphetamineregulated transcript inhibits food intake in chicks[J].Neuroscience Letters,2003,337(3):131-134.
[11]AJA S,SAHANDY S,LADENHEIME E,et al.Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2001,281(6):R1862-R1867.
[12]VRANG N,LARSEN P J,KRISTENSEN P,et al.Central administration of cocaine-amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat[J].Endocrinology,2000,141(2):794-801.
[13]KONG W Y,STANLEY S,GARDINER J,et al.A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia,thermogenesis,and cold adaptation[J].The FASEB Journal,2003,17(12):1688-1690.
[14]BLAIS A,DROUIN G,CHAUMONTET C,et al.Impact of orexin-A treatment on food intake,energy metabolism and body weight in mice[J].PLoS One,2017,12(1):e0169908.
[15]HSIEH Y S,CHEN P N,YU C H,et al.Both CART and POMC neurotransmission participate in neuropeptide Y-mediated appetite control in rats treated with amphetamine[J].Chung Shan Medical Journal,2014,25(2):79-89.
[16]STANLEY S A,MURPHY K G,BEWICK G A,et al.Regulation of rat pituitary cocaine-and amphetamineregulated transcript(CART)by CRH and glucocorticoids[J].American Journal of Physiology:Endocrinology and Metabolism,2004,287(3):E583-E590.
[17]周璇,王雪琦.谷氨酸能和γ氨基丁酸能系统与情感障碍[J].中国神经科学杂志,2003,19(2):130-133.
[18]ZHANG MJ,HAN L J,XU Y.Roles of cocaine-and amphetamine-regulated transcript in the central nervous system[J].Clinical and Experimental Pharmacology and Physiology,2012,39(6):586-592.
[19]XU Y,ZHANG W,KLAUS J,et al.Role of cocaineand amphetamine-regulated transcript in estradiol-mediated neuroprotection[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(39):14489-14494.
[20]BONACIC K,MARTNEZ A,MARTN-ROBLESJ,et al.Characterization of seven cocaine-and amphetamine-regulated transcripts(CARTs)differentially expressed in the brain and peripheral tissues of Solea senegalensis(Kaup)[J].General and Comparative Endocrinology,2015,224:260-272.
[21]QIU B,HU S D,LIU L B,et al.CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion[J].Biochemical and Biophysical Research Communications,2013,436(4):655-659.
[22]BHARNE A P,UPADHYA MA,SHELKAR G P,et al.Neuroprotective effect of cocaine-and amphetamineregulated transcript peptide in spinal cord injury in mice[J].Neuropharmacology,2013,67:126-135.
[23]BALKAN B.Cocaine-and amphetamine-regulated transcript:a possible regulator of the stress response[J].OA Neurosciences,2013,1(1):4.
[24]VICENTIC A,HUNTER R G,KUHAR MJ.Effect of corticosterone on CART peptide levels in rat blood[J].Peptides,2005,26(3):531-533.
[25]吴彬,胡胜娣,邱彬,等.CART肽抑制NMDA诱导海马神经元凋亡的机制[J].中国病理生理杂志,2009,25(7):1325-1330.
[26]YANG B Y,MEI H Y,GAN L Y,et al.Expression of microRNAs associated with oxidative stress in the hippocampus of piglets[J].Genes&Genomics,2017,39(7):701-712.
[27]朱震寒.可卡因-苯丙胺调节转录肽对缺血性脑损伤的保护作用及其机制探讨[D].硕士学位论文.南京:南京医科大学,2012:51-53.
[28]JIN J L,LIOU A K F,SHI Y J,et al.CART treatment improves memory and synaptic structure in APP/PS1mice[J].Scientific Reports,2015,5:10224.
[29]JEˇEK P,HOLENDOVB,GARLID K D,et al.Mitochondrial uncoupling proteins:subtle regulators of cellular redox signaling[J].Antioxidants&Redox Signaling,2018,29(7):667-714.
[30]ZHANG J,KHVOROSTOV I,HONG J S,et al.UCP2regulates energy metabolism and differentiation potential of human pluripotent stem cells[J].The EMBO Journal,2011,30(24):4860-4873.
[31]MAO P Z,MESHUL C K,THUILLIER P,et al.CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria[J].PLoS One,2012,7(1):e29343.
[32]GOGVADZE V,ORRENIUS S,ZHIVOTOVSKY B.Mitochondria as targets for cancer chemotherapy[J].Seminars in Cancer Biology,2009,19(1):57-66.
[33]JIAO W Y,WANG Y C,KONG L H,et al.CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease[J].Biochemical and Biophysical Research Communications,2018,501(4):1016-1022.
[34]TSUDA M,SUGIURA T,ISHII T,et al.A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila[J].Biochemical and Biophysical Research Communications,2007,363(2):342-346.
[35]MORELLI L,PERRY G,TAGLIAVINI F.The contribution of the amyloid hypothesis to the understanding of Alzheimer's disease:a critical overview[J].International Journal of Alzheimers Disease,2012,2012:709613.
[36]殷凯林.CART通过调节MAPK和AKT通路抑制β淀粉样蛋白沉积改善阿尔茨海默病认知功能的相关研究[D].硕士学位论文.南京:南京大学,2014:67-78.
[37]YUFUNE S,SATOH Y,AKAI R,et al.Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain[J].Scientific Reports,2016,6:21859.
[38]JIA J,CHEN X M,ZHU W J,et al.CART protects brain from damage through ERK activation in ischemic stroke[J].Neuropeptides,2008,42(5/6):653-661.
[2]DOUGLASS J,MCKINZIE A A,COUCEYRO P.PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine[J].The Journal of Neuroscience,1995,15(3):2471-2481.
[3]HWANG Y G,LEE H S.Neuropeptide Y(NPY)or cocaine-and amphetamine-regulated transcript(CART)fiber innervation on central and medial amygdaloid neurons that project to the locus coeruleus and dorsal raphe in the rat[J].Brain Research,2018,1689:75-88.
[4]ZHU W L,WANG Z K.Effects of random food deprivation and refeeding on energy metabolism,behavior and hypothalamic neuropeptide expression in Apodemus chevrieri[J].Comparative Biochemistry and Physiology Part A:Molecular&Integrative Physiology,2016,201:71-78.
[5]SHA D J,WANG Z Y,QIAN L,et al.A cocaine-regulated and amphetamine-regulated transcript inhibits oxidative stress in neurons deprived of oxygen and glucose[J].Neuroreport,2013,24(13):698-703.
[6]OPONOWICZ A,KOZOWSKA A,GONKOWSKI S,et al.Changes in the distribution of cocaine-and amphetamine-regulated transcript-containing neural structures in the human colon affected by the neoplastic process[J].International Journal of Molecular Sciences,2018,19(2):414.
[7]DANDEKAR MP,SINGRU P S,KOKARE D M,et al.Cocaine-and amphetamine-regulated transcript peptide plays a role in the manifestation of depression:social isolation and olfactory bulbectomy models reveal unifying principles[J].Neuropsychopharmacology,2009,34(5):1288-1300.
[8]HUNTER R G,PHILPOT K,VICENTIC A,et al.CART in feeding and obesity[J].Trends in Endocrinology&Metabolism,2004,15(9):454-459.
[9]KRISTENSEN P,JUDGE ME,THIML,et al.Hypothalamic CART is a newanorectic peptide regulated by leptin[J].Nature,1998,393(6680):72-76.
[10]TACHIBANA T,TAKAGI T,TOMONAGA S,et al.Central administration of cocaine-and amphetamineregulated transcript inhibits food intake in chicks[J].Neuroscience Letters,2003,337(3):131-134.
[11]AJA S,SAHANDY S,LADENHEIME E,et al.Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2001,281(6):R1862-R1867.
[12]VRANG N,LARSEN P J,KRISTENSEN P,et al.Central administration of cocaine-amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat[J].Endocrinology,2000,141(2):794-801.
[13]KONG W Y,STANLEY S,GARDINER J,et al.A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia,thermogenesis,and cold adaptation[J].The FASEB Journal,2003,17(12):1688-1690.
[14]BLAIS A,DROUIN G,CHAUMONTET C,et al.Impact of orexin-A treatment on food intake,energy metabolism and body weight in mice[J].PLoS One,2017,12(1):e0169908.
[15]HSIEH Y S,CHEN P N,YU C H,et al.Both CART and POMC neurotransmission participate in neuropeptide Y-mediated appetite control in rats treated with amphetamine[J].Chung Shan Medical Journal,2014,25(2):79-89.
[16]STANLEY S A,MURPHY K G,BEWICK G A,et al.Regulation of rat pituitary cocaine-and amphetamineregulated transcript(CART)by CRH and glucocorticoids[J].American Journal of Physiology:Endocrinology and Metabolism,2004,287(3):E583-E590.
[17]周璇,王雪琦.谷氨酸能和γ氨基丁酸能系统与情感障碍[J].中国神经科学杂志,2003,19(2):130-133.
[18]ZHANG MJ,HAN L J,XU Y.Roles of cocaine-and amphetamine-regulated transcript in the central nervous system[J].Clinical and Experimental Pharmacology and Physiology,2012,39(6):586-592.
[19]XU Y,ZHANG W,KLAUS J,et al.Role of cocaineand amphetamine-regulated transcript in estradiol-mediated neuroprotection[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(39):14489-14494.
[20]BONACIC K,MARTNEZ A,MARTN-ROBLESJ,et al.Characterization of seven cocaine-and amphetamine-regulated transcripts(CARTs)differentially expressed in the brain and peripheral tissues of Solea senegalensis(Kaup)[J].General and Comparative Endocrinology,2015,224:260-272.
[21]QIU B,HU S D,LIU L B,et al.CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion[J].Biochemical and Biophysical Research Communications,2013,436(4):655-659.
[22]BHARNE A P,UPADHYA MA,SHELKAR G P,et al.Neuroprotective effect of cocaine-and amphetamineregulated transcript peptide in spinal cord injury in mice[J].Neuropharmacology,2013,67:126-135.
[23]BALKAN B.Cocaine-and amphetamine-regulated transcript:a possible regulator of the stress response[J].OA Neurosciences,2013,1(1):4.
[24]VICENTIC A,HUNTER R G,KUHAR MJ.Effect of corticosterone on CART peptide levels in rat blood[J].Peptides,2005,26(3):531-533.
[25]吴彬,胡胜娣,邱彬,等.CART肽抑制NMDA诱导海马神经元凋亡的机制[J].中国病理生理杂志,2009,25(7):1325-1330.
[26]YANG B Y,MEI H Y,GAN L Y,et al.Expression of microRNAs associated with oxidative stress in the hippocampus of piglets[J].Genes&Genomics,2017,39(7):701-712.
[27]朱震寒.可卡因-苯丙胺调节转录肽对缺血性脑损伤的保护作用及其机制探讨[D].硕士学位论文.南京:南京医科大学,2012:51-53.
[28]JIN J L,LIOU A K F,SHI Y J,et al.CART treatment improves memory and synaptic structure in APP/PS1mice[J].Scientific Reports,2015,5:10224.
[29]JEˇEK P,HOLENDOVB,GARLID K D,et al.Mitochondrial uncoupling proteins:subtle regulators of cellular redox signaling[J].Antioxidants&Redox Signaling,2018,29(7):667-714.
[30]ZHANG J,KHVOROSTOV I,HONG J S,et al.UCP2regulates energy metabolism and differentiation potential of human pluripotent stem cells[J].The EMBO Journal,2011,30(24):4860-4873.
[31]MAO P Z,MESHUL C K,THUILLIER P,et al.CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria[J].PLoS One,2012,7(1):e29343.
[32]GOGVADZE V,ORRENIUS S,ZHIVOTOVSKY B.Mitochondria as targets for cancer chemotherapy[J].Seminars in Cancer Biology,2009,19(1):57-66.
[33]JIAO W Y,WANG Y C,KONG L H,et al.CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease[J].Biochemical and Biophysical Research Communications,2018,501(4):1016-1022.
[34]TSUDA M,SUGIURA T,ISHII T,et al.A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila[J].Biochemical and Biophysical Research Communications,2007,363(2):342-346.
[35]MORELLI L,PERRY G,TAGLIAVINI F.The contribution of the amyloid hypothesis to the understanding of Alzheimer's disease:a critical overview[J].International Journal of Alzheimers Disease,2012,2012:709613.
[36]殷凯林.CART通过调节MAPK和AKT通路抑制β淀粉样蛋白沉积改善阿尔茨海默病认知功能的相关研究[D].硕士学位论文.南京:南京大学,2014:67-78.
[37]YUFUNE S,SATOH Y,AKAI R,et al.Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain[J].Scientific Reports,2016,6:21859.
[38]JIA J,CHEN X M,ZHU W J,et al.CART protects brain from damage through ERK activation in ischemic stroke[J].Neuropeptides,2008,42(5/6):653-661.