宫颈高危型人乳头状瘤病毒感染患者生殖道微生态检测状况分析
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摘要
目的探究宫颈高危型人乳头状瘤病毒(HR-HPV)感染患者生殖道微生态状况。方法从2015年3月至2017年9月在我院行生殖道感染筛查的妇女中随机抽取500例作为本次研究对象,所有研究对象均给予常规妇科检查及人乳头状瘤病毒(HPV)检测,分析HPV检测结果及HR-HPV基因分型、患者多重感染分布特征及年龄分布情况。结果 500例中共检出HR-HPV阳性90例,占18.00%,其中HPV52、HPV16、HPV58型所占比例最高;90例HR-HPV感染中多重感染64例,其中二重感染44例,占68.75%;三重感染16例,占25.00%;四重感染4例,占6.25%;在20～30岁及31～40岁单一感染和多重感染所占比例较高,高于其它年龄段,其中以20～30岁HR-HPV感染及多重感染的比例最高。结论 20～40岁为HR-HPV感染的高峰年龄段,并以HPV52、HPV16、HPV58为最为常见的感染亚型。
Objective To investigate the genital tract micro-ecology in patients with high-risk cervical papilloma virus(high-risk human papillomavirus, HR-HPV) infection.Methods A random sample of 500 women who were screened for genital tract infection in our hospital from March 2015 to September 2017 was selected as the study subjects of this study. The results of HPV detection and genotyping, the distribution characteristics and age distribution of multiple infections were analyzed.Results Among the 500 cases, 90 cases of HR-HPV positive were detected, accounting for 18.00%, of which HPV52, HPV16 and HPV58 accounted for the highest proportion. Among the 90 cases with HR-HPV infection, 64 were multiple infections, of which 44 were double infection with 68.75%, 16 cases were triple infection with 25.00%, and four cases were quadruple infection with 6.25%. The groups of 20 to 30 years old and 31 to 40 years old were the peak ages of single infection and multiple infections, with a higher proportion than that of other age groups, and HR-HPV infection and multiple infections of the group of 20 to 30 years old ranked the first.Conclusion The age group of 20 to 40 years old is the peak age of HR-HPV infection, and HPV52, HPV16, and HPV58 are the common subtypes of infection.
Objective To investigate the genital tract micro-ecology in patients with high-risk cervical papilloma virus(high-risk human papillomavirus, HR-HPV) infection.Methods A random sample of 500 women who were screened for genital tract infection in our hospital from March 2015 to September 2017 was selected as the study subjects of this study. The results of HPV detection and genotyping, the distribution characteristics and age distribution of multiple infections were analyzed.Results Among the 500 cases, 90 cases of HR-HPV positive were detected, accounting for 18.00%, of which HPV52, HPV16 and HPV58 accounted for the highest proportion. Among the 90 cases with HR-HPV infection, 64 were multiple infections, of which 44 were double infection with 68.75%, 16 cases were triple infection with 25.00%, and four cases were quadruple infection with 6.25%. The groups of 20 to 30 years old and 31 to 40 years old were the peak ages of single infection and multiple infections, with a higher proportion than that of other age groups, and HR-HPV infection and multiple infections of the group of 20 to 30 years old ranked the first.Conclusion The age group of 20 to 40 years old is the peak age of HR-HPV infection, and HPV52, HPV16, and HPV58 are the common subtypes of infection.
引文
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[11] 刘爱香,王鑫,郑红,等.泌尿外科患者发生医院感染的危险因素及护理对策分析[J].中国医院统计,2018,25(3):186-188.
[12] 赵学英,刘学伟,翁韶波,等.成年男性包皮高危型人乳头瘤病毒感染检测分析[J].河北医科大学学报,2016,37(5):592-594.
[13] 刘学伟,赵学英,张喜庄,等.高危型人乳头瘤病毒感染女性及其配偶病毒检测结果分析[J].现代中西医结合杂志,2016,25(8):802-809,864.
[14] 何海,徐建平,刘健玲,等.宫颈病变中心体异常扩增与高危人乳头状瘤病毒感染相关性[J].中华实用诊断与治疗杂志,2015,29(3):247-249.
[15] 王雁,苏莉,孔为民,等.二氧化碳激光联合保妇康栓治疗阴道上皮内瘤变合并高危型人乳头状瘤病毒感染的临床研究[J].癌症进展,2016,14(5):441-443,448.
[16] 刘成云,杜燕子,罗双梅,等.消疣汤联合宫颈环形电切术治疗宫颈上皮内瘤样病变伴高危型人乳头状瘤病毒感染疗效观察[J].现代中西医结合杂志,2017,26(26):2928-2930.
[2] 魏琳琳,杨波,赵欣.高危型人乳头状瘤病毒感染宫颈的病原学研究[J].中华医院感染学杂志,2014,24(24):6079-6081.
[3] REYES JC,SANCHE-DIAZ CT,TORTOLERO-LUNA G, et al. Demographic and high-risk behaviors associated with HPV and HPV vaccine awareness among persons aged 15-74 years in Puerto Rico[J].Puerto Rico Health Sciences Journal,2015,34(4):195-200.
[4] 徐红儿,饶慧,马美芬.宫颈高危型人乳头状瘤病毒感染保妇康栓治疗的临床研究[J].中华医院感染学杂志,2015,25(8):1887-1889.
[5] 罗思佳,李汉军,叶家欣,等.甲状腺乳头状癌中HER-2、CyclinD1的表达与颈部淋巴结转移的相关性[J].湖南师范大学学报(医学版),2015,11(6):74-77.
[6] 黄爱芳.重组人干扰素α-2b凝胶联合氯喹那多-普罗雌烯阴道片治疗慢性宫颈炎并阴道高危型人乳头状瘤病毒感染的疗效评价[J].中国药业,2015,24(2):23-25.
[7] 赵学英,刘学伟,刘京生,等.女性高危型人乳头瘤病毒感染者配偶病毒感染状况及危险因素[J].中国性科学,2017,26(10):69-72.
[8] 蒋珺瑛,黄莉,盛建丹,等.宫颈上皮内瘤变患者高危型人乳头状瘤病毒感染亚型分布与宫颈糜烂的关系研究[J].中华医院感染学杂志,2017,27(11):2580-2582.
[9] 朱阿强,何莲芝.宫颈环形电切术在治疗合并高危型人乳头瘤病毒感染的宫颈上皮内瘤变临床作用探讨[J].黑龙江医学,2016,40(3):210-211.
[10] PIYATHILAKE CJ, OLLBERDING NJ, KUMAR R, et al. Cervical microbiota associated with higher grade cervical intraepithelial neoplasia in women infected with high-risk human papillomaviruses [J]. Cancer Prev Res, 2016,9(5):357-366.
[11] 刘爱香,王鑫,郑红,等.泌尿外科患者发生医院感染的危险因素及护理对策分析[J].中国医院统计,2018,25(3):186-188.
[12] 赵学英,刘学伟,翁韶波,等.成年男性包皮高危型人乳头瘤病毒感染检测分析[J].河北医科大学学报,2016,37(5):592-594.
[13] 刘学伟,赵学英,张喜庄,等.高危型人乳头瘤病毒感染女性及其配偶病毒检测结果分析[J].现代中西医结合杂志,2016,25(8):802-809,864.
[14] 何海,徐建平,刘健玲,等.宫颈病变中心体异常扩增与高危人乳头状瘤病毒感染相关性[J].中华实用诊断与治疗杂志,2015,29(3):247-249.
[15] 王雁,苏莉,孔为民,等.二氧化碳激光联合保妇康栓治疗阴道上皮内瘤变合并高危型人乳头状瘤病毒感染的临床研究[J].癌症进展,2016,14(5):441-443,448.
[16] 刘成云,杜燕子,罗双梅,等.消疣汤联合宫颈环形电切术治疗宫颈上皮内瘤样病变伴高危型人乳头状瘤病毒感染疗效观察[J].现代中西医结合杂志,2017,26(26):2928-2930.