基于“真实世界”HIS数据探析未成年人群脉血康胶囊中西药合并用药规律
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摘要
目的基于医院信息管理系统(hospital information system,HIS)数据,研究未成年人群脉血康胶囊中西药合并用药规律,为临床用药提供参考。方法基于全国25家医院11446例使用脉血康胶囊患者,从中遴选出使用过脉血康胶囊的216例未成年患者的用药信息,用频数统计的方法找出使用频次较高药物进行评价,基于Apriori算法的用药特征关联规则分析未成年人群脉血康胶囊中西药合并用药规律。结果真实世界HIS数据库中,脉血康胶囊治疗未成年患者常常与活血化瘀剂、抗生素类、抗病毒药、抗消化性溃疡药、抗肿瘤药等药品联合应用。结论脉血康胶囊在治疗未成年患者时常与药理作用相似的化学药物联合使用,请临床医生注意患者的获益与风险。
Objective To analyze the rules of Mai Xue Kang Capsule in combination of Chinese and Western medicine in treating juveniles based on Hospital Information System(HIS). Methods The data of this study was based on electrical medical records in real world clinical situations extracted from hospital information system of 25 Grade ⅢA hospitals in China.The cases of 216 juveniles using Mai Xuekang capsule were selected. Descriptive analysis and association rules were used to research the characteristics of combination of drugs.Results In the real world HIS database, Mai Xuekang capsule is often used in combination with blood activating and stasis removing agents, antibiotics, antiviral drugs, anti-peptic ulcer drugs, antitumor drugs and other drugs. Conclusion Mai Xuekang capsule was used at treatment of juveniles is often combination with similar pharmacological effects chemical drugs. Doctors should balance the benefits and the risks.
Objective To analyze the rules of Mai Xue Kang Capsule in combination of Chinese and Western medicine in treating juveniles based on Hospital Information System(HIS). Methods The data of this study was based on electrical medical records in real world clinical situations extracted from hospital information system of 25 Grade ⅢA hospitals in China.The cases of 216 juveniles using Mai Xuekang capsule were selected. Descriptive analysis and association rules were used to research the characteristics of combination of drugs.Results In the real world HIS database, Mai Xuekang capsule is often used in combination with blood activating and stasis removing agents, antibiotics, antiviral drugs, anti-peptic ulcer drugs, antitumor drugs and other drugs. Conclusion Mai Xuekang capsule was used at treatment of juveniles is often combination with similar pharmacological effects chemical drugs. Doctors should balance the benefits and the risks.
引文
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[2] 葛长江,吕树铮,柳弘,等.脉血康胶囊对经皮冠状动脉介入治疗急性冠脉综合征患者血小板聚集率及其长期预后的影响[J].中国中西医结合杂志,2012,32(7):906.
[3] 王倩,刘小瑜,胡东生,等.深圳市中学生药物滥用危险因素分析[J].中国学校卫生,2013,34(3):275.
[4] Wang J,Deng JX,Guo L,et al.Non-medical use of psychoactive drugs in relation to suicide tendencies among Chinese adolescents[J].Addict Behav,2015,51.
[5] 刘智.关联规则挖掘方法及其在冠心病中医诊疗中的应用研究[D].大连海事大学博士学位论文,2012.
[6] 杜婧,杨薇,易丹辉,等.基于HIS“真实世界”的丹红注射液治疗冠心病患者合并用药分析[J].中国中药杂志,2011,36(20):2821.
[7] 李茜,李晓阳,黄伟.基于关联规则和复杂系统熵聚类的刘持年教授治疗慢性胃炎的用药规律[J].中国实验方剂学杂志,2016,22(20):183.
[8] 李立,廖星,谢雁鸣等.中国小儿急性上呼吸道感染相关临床指南的解读[J].中国中药杂志,2017,42(8):1510.
[9] 齐建光,杜军保.美国儿童青少年高血压最新诊治指南[J].实用儿科临床杂志,2006(1):57.
[10] 任树风.肾功能不全患者的临床用药指导[J].中国社区医师,2009,25(19):8.
[11] 李兰,王乃博,余超等.青少年药物滥用现状及影响因素分析[J].中国学校卫生,2017,38(3):478.
[12] 陆权,陈慧中,杨永弘.制定与推广抗生素合理使用指南控制细菌耐药[J].中华儿科杂志,2002(8):13.