维生素D缺乏与女性生殖关系的研究进展
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摘要
维生素D在体内不止作为维生素,也可以作为激素发挥作用。它是一种可以调节钙磷代谢的固醇类衍生物,在心血管疾病、免疫调节、抗炎、癌症、生殖等各方面都能发挥一定的生物学作用。该生物学作用通常通过可溶性蛋白维生素D受体(VDR)来实现。VDR是一种位于靶细胞核内的转录因子,分布在人类各种系统组织中,包括女性生殖系统。近年有关维生素D与女性生殖系统的关系引起人们关注。维生素D一定程度上影响卵巢生理功能及女性生育力,同时与一些女性生殖系统疾病有关,如多囊卵巢综合征、子痫前期、子宫内膜异位症、妊娠期糖尿病等。现就维生素D缺乏与女性生殖系统关系的相关研究进行综述。
Vitamin D acts not only as a vitamin but also as a hormone. It is a sterol derivative that regulates calcium and phosphorus metabolism. Vitamin D can play some biological roles in cardiovascular diseases, immune regulation, anti-inflammatory, cancer and reproduction. The biological effects of vitamin D are usually mediated by the soluble protein, vitamin D receptor(VDR). VDR is a transcription factor located in the nucleus of target cells distributed in various human systems and tissues, including the female reproductive system.Recently, the relationship between vitamin D and the female reproduction attracted more and more attention.Vitamin D affects ovarian physiological function and female fertility to a certain extent, and is associated with some female reproductive diseases, such as polycystic ovary syndrome, pre-eclampsia, endometriosis, and gestational diabetes. The relationship between vitamin D deficiency and female reproductive system is briefly discussed in this review.
Vitamin D acts not only as a vitamin but also as a hormone. It is a sterol derivative that regulates calcium and phosphorus metabolism. Vitamin D can play some biological roles in cardiovascular diseases, immune regulation, anti-inflammatory, cancer and reproduction. The biological effects of vitamin D are usually mediated by the soluble protein, vitamin D receptor(VDR). VDR is a transcription factor located in the nucleus of target cells distributed in various human systems and tissues, including the female reproductive system.Recently, the relationship between vitamin D and the female reproduction attracted more and more attention.Vitamin D affects ovarian physiological function and female fertility to a certain extent, and is associated with some female reproductive diseases, such as polycystic ovary syndrome, pre-eclampsia, endometriosis, and gestational diabetes. The relationship between vitamin D deficiency and female reproductive system is briefly discussed in this review.
引文
[1]Heyden EL,Wimalawansa SJ.Vitamin D:Effects on human reproduction,pregnancy,and fetal well-being[J].J Steroid Biochem Mol Biol,2018,180:41-50.
[2]Malloy PJ,Peng L,Wang J,et al.Interaction of the vitamin Dreceptor with a vitamin D response element in the Mullerianinhibiting substance(MIS)promoter:regulation of MIS expression by calcitriol in prostate cancer cells[J].Endocrinology,2009,150(4):1580-1587.
[3]Almeida FRCL,Costermans NGJ,Soede NM,et al.Presence of anti-Müllerian hormone(AMH)during follicular development in the porcine ovary[J].PLoS One,2018,13(7):e0197894.
[4]Lata I,Tiwari S,Gupta A,et al.To Study the Vitamin D Levels in Infertile Females and Correlation of Vitamin D Deficiency with AMH Levels in Comparison to Fertile Females[J].J Hum Reprod Sci,2017,10(2):86-90.
[5]冯营营.维生素D与不孕女性卵巢储备功能及辅助生殖助孕结局的相关性分析[D].郑州:郑州大学,2018.
[6]Fung JL,Hartman TJ,Schleicher RL,et al.Association of vitamin D intake and serum levels with fertility:results from the Lifestyle and Fertility Study[J].Fertil Steril,2017,108(2):302-311.
[7]Zhao J,Huang X,Xu B,et al.Whether vitamin D was associated with clinical outcome after IVF/ICSI:a systematic review and meta-analysis[J].Reprod Biol Endocrinol,2018,16(1):13.
[8]Polyzos NP,Anckaert E,Guzman L,et al.Vitamin D deficiency and pregnancy rates in women undergoing single embryo,blastocyst stage,transfer(SET)for IVF/ICSI[J].Hum Reprod,2014,29(9):2032-2040.
[9]Parikh G,Varadinova M,Suwandhi P,et al.Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1(IGFBP-1)production in human ovarian cells[J].Horm Metab Res,2010,42(10):754-757.
[10]Jiang R,Ding L,Zhou J,et al.Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure[J].Cell Death Discov,2017,3:17057.
[11]Lagowska K,Bajerska J,Jamka M.The Role of Vitamin D Oral Supplementation in Insulin Resistance in Women with Polycystic Ovary Syndrome:A Systematic Review and Meta-Analysis of Randomized Controlled Trials[J].Nutrients,2018,10(11):E1637.
[12]Krul-Poel YHM,Koenders PP,Steegers-Theunissen RP,et al.Vitamin D and metabolic disturbances in polycystic ovary syndrome(PCOS):A cross-sectional study[J].PLoS One,2018,13(12):e0204748.
[13]Trummer C,Pilz S,Schwetz V,et al.Vitamin D,PCOS and androgens in men:a systematic review[J].Endocr Connect,2018,7(3):R95-R113.
[14]Esteghamati A,Aryan Z,Esteghamati A,et al.Vitamin Ddeficiency is associated with insulin resistance in nondiabetics and reduced insulin production in type 2 diabetics[J].Horm Metab Res,2015,47(4):273-279.
[15]Dabrowski FA,Grzechocinska B,Wielgos M,et al.The role of vitamin D in reproductive health--a Trojan Horse or the Golden Fleece?[J].Nutrients,2015,7(6):4139-4153.
[16]陈瑞利.维生素D对PCOS患者AMH、胰岛素代谢水平及促排卵的影响[D].郑州:郑州大学,2018.
[17]von Kanel R,Fardad N,Steurer N,et al.Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode:A Factor Analytic Study[J].PLoS One,2015,10(9):e0138550.
[18]Hypponen E.Vitamin D for the prevention of preeclampsia?Ahypothesis[J].Nutr Rev.2005,63(7):225-232.
[19]Mirzakhani H,Litonjua AA,McElrath TF,et al.Early pregnancy vitamin D status and risk of preeclampsia[J].J Clin Invest,2016,126(12):4702-4715.
[20]Sourial S,Tempest N,Hapangama DK.Theories on the pathogenesis of endometriosis[J].Int J Reprod Med,2014,2014:179515.
[21]Cermisoni GC,Alteri A,Corti L,et al.Vitamin D and Endometrium:A Systematic Review of a Neglected Area of Research[J].Int J Mol Sci,2018,19(8):E2320.
[22]Almassinokiani F,Khodaverdi S,Solaymani-Dodaran M,et al.Effects of Vitamin D on Endometriosis-Related Pain:A DoubleBlind Clinical Trial[J].Med Sci Monit,2016,22:4960-4966.
[23]Somigliana E,Panina-Bordignon P,Murone S,et al.Vitamin Dreserve is higher in women with endometriosis[J].Hum Reprod,2007,22(8):2273-2278.
[24]Harris HR,Chavarro JE,Malspeis S,et al.Dairy-food,calcium,magnesium,and vitamin D intake and endometriosis:a prospective cohort study[J].Am J Epidemiol,2013,177(5):420-430.
[25]Shahrokhi SZ,Ghaffari F,Kazerouni F,et al.Role of vitamin D in female reproduction[J].Clin Chim Acta,2016,455:33-38.
[26]Hao M,Lin L.Fasting plasma glucose and body mass index during the first trimester of pregnancy as predictors of gestational diabetes mellitus in a Chinese population[J].Endocr J,2017,64(5):561-569.
[27]Cho GJ,Hong SC,Oh MJ,et al.Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta[J].Am J Obstet Gynecol,2013,209(6):560.e1-e8.
[28]缪珺.维生素D缺乏与妊娠期糖尿病发病的相关性研究[J].实用临床医药杂志,2018,22(17):129-132.
[29]Soheilykhah S,Mojibian M,Moghadam MJ,et al.The effect of different doses of vitamin D supplementation on insulin resistance during pregnancy[J].Gynecol Endocrinol,2013,29(4):396-399.
[2]Malloy PJ,Peng L,Wang J,et al.Interaction of the vitamin Dreceptor with a vitamin D response element in the Mullerianinhibiting substance(MIS)promoter:regulation of MIS expression by calcitriol in prostate cancer cells[J].Endocrinology,2009,150(4):1580-1587.
[3]Almeida FRCL,Costermans NGJ,Soede NM,et al.Presence of anti-Müllerian hormone(AMH)during follicular development in the porcine ovary[J].PLoS One,2018,13(7):e0197894.
[4]Lata I,Tiwari S,Gupta A,et al.To Study the Vitamin D Levels in Infertile Females and Correlation of Vitamin D Deficiency with AMH Levels in Comparison to Fertile Females[J].J Hum Reprod Sci,2017,10(2):86-90.
[5]冯营营.维生素D与不孕女性卵巢储备功能及辅助生殖助孕结局的相关性分析[D].郑州:郑州大学,2018.
[6]Fung JL,Hartman TJ,Schleicher RL,et al.Association of vitamin D intake and serum levels with fertility:results from the Lifestyle and Fertility Study[J].Fertil Steril,2017,108(2):302-311.
[7]Zhao J,Huang X,Xu B,et al.Whether vitamin D was associated with clinical outcome after IVF/ICSI:a systematic review and meta-analysis[J].Reprod Biol Endocrinol,2018,16(1):13.
[8]Polyzos NP,Anckaert E,Guzman L,et al.Vitamin D deficiency and pregnancy rates in women undergoing single embryo,blastocyst stage,transfer(SET)for IVF/ICSI[J].Hum Reprod,2014,29(9):2032-2040.
[9]Parikh G,Varadinova M,Suwandhi P,et al.Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1(IGFBP-1)production in human ovarian cells[J].Horm Metab Res,2010,42(10):754-757.
[10]Jiang R,Ding L,Zhou J,et al.Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure[J].Cell Death Discov,2017,3:17057.
[11]Lagowska K,Bajerska J,Jamka M.The Role of Vitamin D Oral Supplementation in Insulin Resistance in Women with Polycystic Ovary Syndrome:A Systematic Review and Meta-Analysis of Randomized Controlled Trials[J].Nutrients,2018,10(11):E1637.
[12]Krul-Poel YHM,Koenders PP,Steegers-Theunissen RP,et al.Vitamin D and metabolic disturbances in polycystic ovary syndrome(PCOS):A cross-sectional study[J].PLoS One,2018,13(12):e0204748.
[13]Trummer C,Pilz S,Schwetz V,et al.Vitamin D,PCOS and androgens in men:a systematic review[J].Endocr Connect,2018,7(3):R95-R113.
[14]Esteghamati A,Aryan Z,Esteghamati A,et al.Vitamin Ddeficiency is associated with insulin resistance in nondiabetics and reduced insulin production in type 2 diabetics[J].Horm Metab Res,2015,47(4):273-279.
[15]Dabrowski FA,Grzechocinska B,Wielgos M,et al.The role of vitamin D in reproductive health--a Trojan Horse or the Golden Fleece?[J].Nutrients,2015,7(6):4139-4153.
[16]陈瑞利.维生素D对PCOS患者AMH、胰岛素代谢水平及促排卵的影响[D].郑州:郑州大学,2018.
[17]von Kanel R,Fardad N,Steurer N,et al.Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode:A Factor Analytic Study[J].PLoS One,2015,10(9):e0138550.
[18]Hypponen E.Vitamin D for the prevention of preeclampsia?Ahypothesis[J].Nutr Rev.2005,63(7):225-232.
[19]Mirzakhani H,Litonjua AA,McElrath TF,et al.Early pregnancy vitamin D status and risk of preeclampsia[J].J Clin Invest,2016,126(12):4702-4715.
[20]Sourial S,Tempest N,Hapangama DK.Theories on the pathogenesis of endometriosis[J].Int J Reprod Med,2014,2014:179515.
[21]Cermisoni GC,Alteri A,Corti L,et al.Vitamin D and Endometrium:A Systematic Review of a Neglected Area of Research[J].Int J Mol Sci,2018,19(8):E2320.
[22]Almassinokiani F,Khodaverdi S,Solaymani-Dodaran M,et al.Effects of Vitamin D on Endometriosis-Related Pain:A DoubleBlind Clinical Trial[J].Med Sci Monit,2016,22:4960-4966.
[23]Somigliana E,Panina-Bordignon P,Murone S,et al.Vitamin Dreserve is higher in women with endometriosis[J].Hum Reprod,2007,22(8):2273-2278.
[24]Harris HR,Chavarro JE,Malspeis S,et al.Dairy-food,calcium,magnesium,and vitamin D intake and endometriosis:a prospective cohort study[J].Am J Epidemiol,2013,177(5):420-430.
[25]Shahrokhi SZ,Ghaffari F,Kazerouni F,et al.Role of vitamin D in female reproduction[J].Clin Chim Acta,2016,455:33-38.
[26]Hao M,Lin L.Fasting plasma glucose and body mass index during the first trimester of pregnancy as predictors of gestational diabetes mellitus in a Chinese population[J].Endocr J,2017,64(5):561-569.
[27]Cho GJ,Hong SC,Oh MJ,et al.Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta[J].Am J Obstet Gynecol,2013,209(6):560.e1-e8.
[28]缪珺.维生素D缺乏与妊娠期糖尿病发病的相关性研究[J].实用临床医药杂志,2018,22(17):129-132.
[29]Soheilykhah S,Mojibian M,Moghadam MJ,et al.The effect of different doses of vitamin D supplementation on insulin resistance during pregnancy[J].Gynecol Endocrinol,2013,29(4):396-399.