畜禽粪便中氟喹诺酮类抗生素的生物转化与机制研究进展
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摘要
氟喹诺酮类抗生素(FQs)是广泛应用于畜牧养殖业的兽药之一,可随畜禽粪便进入环境,危害人类健康与环境安全。堆肥和外源添加高效降解菌剂是高效、绿色的抗生素处理方法,可有效降低FQs在环境中的生态风险。目前,国内相关研究主要集中于FQs生物去除效率方面,而对其生物转化机理与影响因素研究较少。本文概述了国内外FQs的降解条件、降解途径、降解产物及残留抗菌活性等生物转化研究,重点阐述了FQs的生物转化机制,并对FQs生物转化研究进行了展望,为FQs的高效生物降解与转化、畜禽粪便资源化安全利用提供理论基础和技术支撑。
Fluoroquinolone antibiotics(FQs)are veterinary drugs widely used in the livestock husbandry, which can enter the environment with livestock manure and increase the potential for adverse human health impacts and environmental safety. Composting and applying exog?enously with efficient degrading bacterium inoculation are considered efficient and green method to remove antibiotics, which reduce theecological risk of FQs to a minimum level in the environment. Although previous work provided focuses on the remove degradation of FQs,the mechanisms and effect factors of FQs biotransformation have not been studied. In this review article, we highlight the biotransformationof FQs, including degradation conditions, degradation pathways, degradation products and relative residual antibacterial activity. The bio?transformation mechanisms of FQs were discussed in detail, and the direction of biotransformation of FQs was also proposed. Overall, this re?view may provide theoretical basis and technical support for the efficient biodegradation and transformation of FQs and the safe application of livestock manure as resources.
Fluoroquinolone antibiotics(FQs)are veterinary drugs widely used in the livestock husbandry, which can enter the environment with livestock manure and increase the potential for adverse human health impacts and environmental safety. Composting and applying exog?enously with efficient degrading bacterium inoculation are considered efficient and green method to remove antibiotics, which reduce theecological risk of FQs to a minimum level in the environment. Although previous work provided focuses on the remove degradation of FQs,the mechanisms and effect factors of FQs biotransformation have not been studied. In this review article, we highlight the biotransformationof FQs, including degradation conditions, degradation pathways, degradation products and relative residual antibacterial activity. The bio?transformation mechanisms of FQs were discussed in detail, and the direction of biotransformation of FQs was also proposed. Overall, this re?view may provide theoretical basis and technical support for the efficient biodegradation and transformation of FQs and the safe application of livestock manure as resources.
引文
[1]Maia A S,Ribeiro A R,Amorim C L,et al.Degradation of fluoroquinolone antibiotics and identification of metabolites/transformation products by liquid chromatography-tandem mass spectrometry[J].Journal of Chromatography,2014,1333:87-98.
[2]Emmerson A M,Jones A M.The quinolones:Decades of development and use[J].Journal of Antimicrobial Chemotherapy,2003,51:13-20.
[3]GERMAP 2015-Antibiotika-Resistenz und-Verbrauch[EB/OL].Bundesamt für Verbrauche-rschutz und Lebensmittelsicherheit.2016.http://www.bvl.bund.de/SharedDocs/Downloads/05_Tierarzneimittel/germap2015.pdf?__blob=publicationFile&v=3
[4]Zhang Q Q,Ying G G,Pan C G,et al.Comprehensive evaluation of antibiotics emission and fate in the river basins of China:Source analysis,multimedia modeling,and linkage to bacterial resistance[J].Environmental Science&Technology,2015,49(11):6772-6782.
[5]Zhang Y L,Lin S S,Dai C M,et al.Sorption-desorption and transport of trimethoprim and sulfonamide antibiotics in agricultural soil:Effect of soil type,dissolved organic matter,and pH[J].Environmental Science and Pollution Research,2014,21(9):5827-5835.
[6]Liu F,Ying G G,Yang J F,et al.Dissipation of sulfamethoxazole,trimethoprim and tylosin in a soil under aerobic and anoxic conditions[J].Environmental Chemistry,2010,7(4):370-376.
[7]Barton M D.Impact of antibiotic use in the swine industry[J].Current Opinion in Microbiology,2014,19:9-15.
[8]Christou A,Aguera A,Bayona J M,et al.The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment:The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes:A review[J].Water Research,2017,123:448-467.
[9]Qiao M,Ying G G,Singer A C,et al.Review of antibiotic resistance in China and its environment[J].Environment International,2018,110:160-172.
[10]Speltini A,Sturini M,Maraschi F,et al.Analytical methods for the determination of fluoroquinolones in solid environmental matrices[J].Trac-Trends in Analytical Chemistry,2011,30(8):1337-1350.
[11]Almeida C M R,Santos F,Ferreira A C F,et al.Can veterinary antibiotics affect constructed wetlands performance during treatment of livestock wastewater?[J].Ecological Engineering,2017,102:583-588.
[12]Pan L J,Li J,Li C X,et al.Study of ciprofloxacin biodegradation by a Thermus sp.isolated from pharmaceutical sludge[J].Journal of Hazardous Materials,2018,343:59-67.
[13]Wang L,Qiang Z,Li Y,et al.An insight into the removal of fluoroquinolones in activated sludge process:Sorption and biodegradation characteristics[J].Journal of Environmental Sciences,2017,56:263-271.
[14]Chee-Sanford J C,Mackie R I,Koike S,et al.Fate and transport of antibiotic residues and antibiotic resistance genes following land application of manure waste[J].Journal of Environmental Quality,2009,38(3):1086-1108.
[15]Girardi C,Greve J,Lamsh?ft M,et al.Biodegradation of ciprofloxacin in water and soil and its effects on the microbial communities[J].Journal of Hazardous Materials,2011,198:22-30.
[16]Park J Y,Huwe B.Effect of pH and soil structure on transport of sulfonamide antibiotics in agricultural soils[J].Environmental Pollution,2016,213:561-570.
[17]Wohde M,Berkner S,Junker T,et al.Occurrence and transformation of veterinary pharmaceuticals and biocides in manure:A literature review[J].Environmental Science Europe,2016,28(1):23.
[18]Ho Y B,Zakaria M P,Latif P A,et al.Degradation of veterinary antibiotics and hormone during broiler manure composting[J].Bioresource Technology,2013,131:476-484.
[19]孟磊,杨兵,薛南冬,等.高温堆肥对鸡粪中氟喹诺酮类抗生素的去除[J].农业环境科学学报,2015,34(2):377-383.MENG Lei,YANG Bing,XUE Nan-dong,et al.Effect of high temperature composting on removal of fluoroquinolones in chicken manures[J].Journal of Agro-Environment Science,2015,34(2):377-383.
[20]季秋洁.3种氟喹诺酮类抗生素在猪粪中的残留与降解[D].合肥:安徽农业大学,2012.JI Qiu-jie.The residues and degradation of three fluoroquinolone antibiotics in pig feces[D].Hefei:Anhui Agricultural University,2012.
[21]Karc?A,Balc?o?lu I A.Investigation of the tetracycline,sulfonamide,and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey[J].Science of the Total Environment,2009,407(16):4652-4664.
[22]Zhao L,Dong Y H,Wang H.Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China[J].Science of the Total Environment,2010,408(5):1069-1075.
[23]Sattelberger R,Oliver G,Martínez E.Veterin?rantibiotika in Wirtschaftsdünger und Boden[M].Wien:Reports BE-272,2005,Umweltbundesamt.
[24]Elena M C,Carmen G B,Sigrid S,et al.Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria[J].Environmental Pollution,2007,148(2):570-579.
[25]Guo X Y,Hao L J,Qiu P Z,et al.Pollution characteristics of 23 veterinary antibiotics in livestock manure and manure-amended soils in Jiangsu Province,China[J].Journal of Environmental Science and Health,2016,51(6):383-392.
[26]Huang Y,Cheng M,Li W,et al.Simultaneous extraction of four classes of antibiotics in soil,manure and sewage sludge and analysis by liquid chromatography-tandem mass spectrometry with the isotope-labelled internal standard method[J].Analytical Methods,2013,5(15):3721-3731.
[27]Janusch F,Scherz G,Mohring S A I,et al.Determination of fluoroquinolones in chicken feces:A new liquid-liquid extraction method combined with LC-MS/MS[J].Environmental Toxicology and Pharmacology,2014,38(3):792-799.
[28]Xie W Y,Yang X P,Li Q,et al.Changes in antibiotic concentrations and antibiotic resistome during commercial composting of animal manures[J].Environmental Pollution,2016,219:182-190.
[29]Pereira Leal R M,Figueira R F,Tornisielo V L,et al.Occurrence and sorption of fluoroquinolones in poultry litters and soils from Sao Paulo State,Brazil[J].Science of the Total Environment,2012,432:344-349.
[30]Wang N,Guo X,Xu J,et al.Pollution characteristics and environmental risk assessment of typical veterinary antibiotics in livestock farms in Southeastern China[J].J Environ Sci Health B,2014,49(7):468-479.
[31]Hu X,Zhou Q,Luo Y.Occurrence and source analysis of typical veterinary antibiotics in manure,soil,vegetables and groundwater from organic vegetable bases,northern China[J].Environmental Pollution,2010,158(9):2992-2998.
[32]Huang X,Liu C,Li K,et al.Occurrence and distribution of veterinary antibiotics and tetracycline resistance genes in farmland soils around swine feedlots in Fujian Province,China[J].Environmental Science and Pollution Research,2013,20(12):9066-9074.
[33]刘锋,廖德润,李可,等.畜禽养殖基地磺胺类喹诺酮类和大环内酯类抗生素污染特征[J].农业环境科学学报,2013,32(4):847-853.LIU Feng,LIAO De-run,LI Ke,et al.Pollution characteristics of the sulfonamides,quinolones and macrolides in the samples collected from livestock and poultry feedlots[J].Journal of Agro-Environment Science,2013,32(4):847-853.
[34]Hou J,Wan W,Mao D,et al.Occurrence and distribution of sulfonamides,tetracyclines,quinolones,macrolides,and nitrofurans in livestock manure and amended soils of northern China[J].Environmental Science and Pollution Research,2014,22(6):4545-4554.
[35]Zhang H,Zhou Y,Huang Y,et al.Residues and risks of veterinary antibiotics in protected vegetable soils following application of different manures[J].Chemosphere,2016,152:229-237.
[36]Dolliver H,Gupta S,Noll S.Antibiotic degradation during manure composting[J].Journal of Environmental Quality,2008,37(3):1245-1253.
[37]吴丹,韩梅琳,邹德勋,等.超高效液相色谱-串联质谱法检测鸡粪中16种残留抗生素[J].分析化学,2017,45(9):1389-1396.WU Dan,HAN Mei-lin,ZOU De-xun,et al.Detection of 16 residual antibiotics in chicken manure by ultra performance liquid chromatography-tandem mass spectrometry[J].Chinese Journal of Analytical Chemistry,2017,45(9):1389-1396.
[38]冯瑶.鸡粪堆肥过程中诺氟沙星削减规律及微生物分子生态学机制[D].北京:中国农业科学院,2016.FENG Yao.Microbial ecological mechanism for degradation of norfloxacin during chicken manure composting[D].Beijing:Chinese Academy of Agricultural Sciences,2016.
[39]薛南冬.一种禽兽粪便中氟喳诺酮类抗生素的去除方法:中国,201510636598.8[P].2016-01-20.XUE Nan-dong.A method for removing fluoroquinolone antibiotics in animal excrement:China,201510636598.8[P].2016-01-20.
[40]Slana M,Zigon D,Sollner-Dolenc M.Enrofloxacin degradation in broiler chicken manure under field conditions and its residuals effects to the environment[J].Environmental Science and Pollution Research,2017,24(15):13722-13731.
[41]Selvam A,Zhao Z,Wong J W C.Composting of swine manure spiked with sulfadiazine,chlortetracycline and ciprofloxacin[J].Bioresource Technology,2012,126:412-417.
[42]Liao X,Li B,Zou R,et al.Biodegradation of antibiotic ciprofloxacin:Pathways,influential factors,and bacterial community structure[J].Environmental Science and Pollution Research,2016,23(8):7911-7918.
[43]Parshikov I A,Sutherland J B.Microbial transformations of antimicrobial quinolones and related drugs[J].Journal of Industrial Microbiology&Biotechnology,2012,39(12):1731-1740.
[44]Kim D W,Heinze T M,Kim B S,et al.Modification of norfloxacin by a Microbacterium sp.strain isolated from a wastewater treatment plant[J].Applied and Environmental Microbiology,2011,77:6100-6108.
[45]?van?arováM,Moeder M,FilipováA,et al.Biotransformation of fluoroquinolone antibiotics by ligninolytic fungi-Metabolites,enzymes and residual antibacterial activity[J].Chemosphere,2015,136:311-320.
[46]?van?arováM,Moeder M,FilipováA,et al.Biotransformation of the antibiotic agent flumequine by ligninolytic fungi and residual antibacterial activity of the transformation mixtures[J].Environmental Science&Technology,2013,47(24):14128-14136.
[47]Rusch M,Kauschat A,Spielmeyer A,et al.Biotransformation of the antibiotic danofloxacin by xylaria longipes leads to an efficient reduction of its antibacterial activity[J].Journal of Agricultural and Food Chemistry,2015,63(31):6897-6904.
[48]Rusch M,Spielmeyer A,Meissner J,et al.Efficient reduction of antibacterial activity and cytotoxicity of fluoroquinolones by fungal-mediated N-oxidation[J].Journal of Agricultural and Food Chemistry,2017,65(15):3118-3126.
[49]?van?arováM,Kresinova Z,FilipováA,et al.Biodegradation of PCBs by ligninolytic fungi and characterization of the degradation products[J].Chemosphere,2012,88(11):1317-1323.
[50]Muzikar M,Kresinova Z,Svobodova K,et al.Biodegradation of chlorobenzoic acids by ligninolytic fungi[J].Journal of Hazardous Materials,2011,196:386-394.
[51]Parshikov I A,Heinze T M,Moody J D,et al.The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin[J].Applied Microbiology and Biotechnology,2001,56(3/4):474-477.
[52]Marengo J R,Kok R A,Obrien K,et al.Aerobic biodegradation of(C-14)-sarafloxacin hydrochloride in soil[J].Environmental Toxicology and Chemistry,1997,16(3):462-471.
[53]Williams A J,Parshikov I A,Moody J D,et al.Fungal transformation of an antimicrobial fluoroquinolone drug during growth on poultry litter materials[J].Journal of Applied Poultry Research,2004,13(2):235-240.
[54]De Witte B,Dewulf J,Demeestere K,et al.Ozonation and advanced oxidation by the peroxone process of ciprofloxacin in water[J].Journal of Hazardous Materials,2009,161(2/3):701-708.
[55]Adjei M D,Heinze T M,Deck J,et al.Transformation of the antibacterial agent norfloxacin by environmental mycobacteria[J].Applied and Environmental Microbiology,2006,72(9):5790-5793.
[56]Wetzstein H G,Schneider J,Karl W.Patterns of metabolites produced from the fluoroquinolone enrofloxacin by basidiomycetes indigenous to agricultural sites[J].Applied Microbiology and Biotechnology,2006,71(1):90-100.
[57]Prieto A,Moeder M,Rodil R,et al.Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products[J].Bioresource Technology,2011,102(23):10987-10995.
[58]Fuentes S,Mendez V,Aguila P,et al.Bioremediation of petroleum hydrocarbons:catabolic genes,microbial communities,and applications[J].Applied Microbiology and Biotechnology,2014,98(11):4781-4794.
[59]Yang Y,Wang Z,Xie S.Aerobic biodegradation of bisphenol A in river sediment and associated bacterial community change[J].Science of the Total Environment,2014,470:1184-1188.
[60]戴琦.环丙沙星废水的膜生物反应器处理特性及污泥中抗性基因的变化研究[D].上海:上海师范大学,2017.DAI Qi.Research on the treatment characteristics of the membrane bioreactor and the change of resistance genes in the sludge[D].Shanghai:Shanghai Normal University,2017.
[61]Meng F,Gao G,Yang T T,et al.Effects of fluoroquinolone antibiotics on reactor performance and microbial community structure of a membrane bioreactor[J].Chemical Engineering Journal,2015,280:448-458.
[62]Grenni P,Ancona V,Barra Caracciolo A.Ecological effects of antibiotics on natural ecosystems:A review[J].Microchemical Journal,2018,136:25-39.
[63]Alexandrino D A M,Mucha A P,Almeida C M R,et al.Biodegradation of the veterinary antibiotics enrofloxacin and ceftiofur and associated microbial community dynamics[J].Science of the Total Environment,2017,581-582:359-368.
[64]Girardi C,Greve J,Lamsh?ft M,et al.Biodegradation of ciprofloxacin in water and soil and its effects on the microbial communities[J].Journal of Hazardous Materials,2011,198:22-30.
[65]Brandt K K,Amézquita A,Backhaus T,et al.Ecotoxicological assessment of antibiotics:A call for improved consideration of microorganisms[J].Environment International,2015,85:189-205.
[66]何势.曝气生物滤池中环丙沙星去除行为及其对降解菌群抗药性的诱导作用[D].上海:东华大学,2016.HE Shi.Removal behavior of ciprofloxacin in the biological aerated filter and its effect on the resistance of bacteria[D].Shanghai:Donghua University,2016.
[67]Asgher M,Bhatti H N,Ashraf M,et al.Recent developments in biodegradation of industrial pollutants by white rot fungi and their enzyme system[J].Biodegradation,2008,19(6):771-783.
[68]Michelini L,Reichel R,Werner W,et al.Sulfadiazine uptake and effects on Salix fragilis L.and Zea mays L.plants[J].Water Air and Soil Pollution,2012,223(8):5243-5257.
[69]Accinelli C,Sacca M L,Batisson I,et al.Removal of oseltamivir(Tamiflu)and other selected pharmaceuticals from wastewater using a granular bioplastic formulation entrapping propagules of Phanerochaete Chrysosporium[J].Chemosphere,2010,81(3):436-443.
[70]Rodriguez-Rodriguez C E,Marco-Urrea E,Caminal G.Degradation of naproxen and carbamazepine in spiked sludge by slurry and solidphase Trametes versicolor systems[J].Bioresource Technology,2010,101(7):2259-2266.
[71]Blanquez A,Guillen F,Rodriguez J,et al.The degradation of two fluoroquinolone based antimicrobials by SilA,an alkaline laccase from Streptomyces ipomoeae[J].World Journal of Microbiology&Biotechnology,2016,32(3):1-8.
[72]沈怡雯,黄智婷,谢冰.抗生素及其抗性基因在环境中的污染、降解和去除研究进展[J].应用与环境生物学报,2015,21(2):181-187.SHEN Yi-wen,HUANG Zhi-ting,XIE Bing.Advances in research of pollution,degradation and removal of antibiotics and antibiotic resistance genes in the environment[J].Chinese Journal of Applied&Environmental Biology,2015,21(2):181-187.
[73]Lucas D,Badia-Fabregat M,Vicent T,et al.Fungal treatment for the removal of antibiotics and antibiotic resistance genes in veterinary hospital wastewater[J].Chemosphere,2016,152:301-308.
[74]Rodriguez-Mozaz S,Chamorro S,Marti E,et al.Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river[J].Water Research,2015,69:234-242.
[75]赵祥.施用粪肥的设施菜地土壤中抗生素及抗性基因多样性及丰度的研究[D].泰安:山东农业大学,2017.ZHAO Xiang.Studies on the diversity and abundance of antibiotics and resistance genes in vegetable soils with facilities manure application[D].Tai′an:Shandong Agricultural University,2017.
[76]Knapp C W,Zhang W,Sturm B S M,et al.Differential fate of erythromycin and beta-lactam resistance genes from swine lagoon waste under different aquatic conditions[J].Environmental Pollution,2010,158(5):1506-1512.
[77]Zhu Y G,Johnson T A,Su J Q,et al.Diverse and abundant antibiotic resistance genes in Chinese swine farms[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(9):3435-3440.
[78]Mu Q H,Li J,Sun Y X,et al.Occurrence of sulfonamide-,tetracycline-,plasmid-mediated quinolone-and macrolide-resistance genes in livestock feedlots in northern China[J].Environmental Science and Pollution Research,2015,22(9):6932.
[79]Zhang Y J,Hu H W,Gou M,et al.Temporal succession of soil antibiotic resistance genes following application of swine,cattle and poultry manures spiked with or without antibiotics[J].Environmental Pollution,2017,231:1621-1632.
[80]Chen K,Zhou J L.Occurrence and behavior of antibiotics in water and sediments from the Huangpu River,Shanghai,China[J].Chemosphere,2014,95:604-612.
[81]Wang J,Guo X,Qin J,et al.Microstructure and mechanical properties of investment casted titanium matrix composites with B4C additions[J].Materials Science and Engineering:A,2015,628:366-373.
[82]Zhou X,Qiao M,Wang F H,et al.Use of commercial organic fertilizer increases the abundance of antibiotic resistance genes and antibiotics in soil[J].Environmental Science and Pollution Research,2017,24(1):701-710.
[83]Wang J,Ben W,Yang M,et al.Dissemination of veterinary antibiotics and corresponding resistance genes from a concentrated swine feedlot along the waste treatment paths[J].Environment International,2016,92-93:317-323.
[84]郑宁国,黄南,王卫卫,等.高温堆肥过程对猪粪来源抗生素抗性基因的影响[J].环境科学,2016,37(5):1986-1992.ZHENG Ning-guo,HUANG Nan,WANG Wei-wei,et al.Effects of high temperature composting on antibiotic resistance genes in pig manure[J].Environmental Science,2016,37(5):1986-1992.
[85]Selvam A,Xu D,Zhao Z,et al.Fate of tetracycline,sulfonamide and fluoroquinolone resistance genes and the changes in bacterial diversity during composting of swine manure[J].Bioresource Technology,2012,126:383-390.
[86]Qian X,Gu J,Sun W,et al.Diversity,abundance,and persistence of antibiotic resistance genes in various types of animal manure following industrial composting[J].Journal of Hazardous Materials,2018,344:716-722.
[87]Auerbach E A,Seyfried E E,McMahon K D.Tetracycline resistance genes in activated sludge wastewater treatment plants[J].Water Research,2007,41(5):1143-1151.
[88]Garcia-Galan M J,Diaz-Cruz M S,Barcelo D.Occurrence of sulfonamide residues along the Ebro river basin removal in wastewater treatment plants and environmental impact assessment[J].Environment International,2011,37(2):462-473.
[89]Su J Q,Wei B,OUYANG W Y,et al.Antibiotic resistome and its association with bacterial communities during sewage sludge composting[J].Environmental Science&Technology,2015,49(12):7356-7363.
[90]Qiao M,Ying G G,Singer A C,et al.Review of antibiotic resistance in China and its environment[J].Environmental International,2018,110:160-172.
[2]Emmerson A M,Jones A M.The quinolones:Decades of development and use[J].Journal of Antimicrobial Chemotherapy,2003,51:13-20.
[3]GERMAP 2015-Antibiotika-Resistenz und-Verbrauch[EB/OL].Bundesamt für Verbrauche-rschutz und Lebensmittelsicherheit.2016.http://www.bvl.bund.de/SharedDocs/Downloads/05_Tierarzneimittel/germap2015.pdf?__blob=publicationFile&v=3
[4]Zhang Q Q,Ying G G,Pan C G,et al.Comprehensive evaluation of antibiotics emission and fate in the river basins of China:Source analysis,multimedia modeling,and linkage to bacterial resistance[J].Environmental Science&Technology,2015,49(11):6772-6782.
[5]Zhang Y L,Lin S S,Dai C M,et al.Sorption-desorption and transport of trimethoprim and sulfonamide antibiotics in agricultural soil:Effect of soil type,dissolved organic matter,and pH[J].Environmental Science and Pollution Research,2014,21(9):5827-5835.
[6]Liu F,Ying G G,Yang J F,et al.Dissipation of sulfamethoxazole,trimethoprim and tylosin in a soil under aerobic and anoxic conditions[J].Environmental Chemistry,2010,7(4):370-376.
[7]Barton M D.Impact of antibiotic use in the swine industry[J].Current Opinion in Microbiology,2014,19:9-15.
[8]Christou A,Aguera A,Bayona J M,et al.The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment:The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes:A review[J].Water Research,2017,123:448-467.
[9]Qiao M,Ying G G,Singer A C,et al.Review of antibiotic resistance in China and its environment[J].Environment International,2018,110:160-172.
[10]Speltini A,Sturini M,Maraschi F,et al.Analytical methods for the determination of fluoroquinolones in solid environmental matrices[J].Trac-Trends in Analytical Chemistry,2011,30(8):1337-1350.
[11]Almeida C M R,Santos F,Ferreira A C F,et al.Can veterinary antibiotics affect constructed wetlands performance during treatment of livestock wastewater?[J].Ecological Engineering,2017,102:583-588.
[12]Pan L J,Li J,Li C X,et al.Study of ciprofloxacin biodegradation by a Thermus sp.isolated from pharmaceutical sludge[J].Journal of Hazardous Materials,2018,343:59-67.
[13]Wang L,Qiang Z,Li Y,et al.An insight into the removal of fluoroquinolones in activated sludge process:Sorption and biodegradation characteristics[J].Journal of Environmental Sciences,2017,56:263-271.
[14]Chee-Sanford J C,Mackie R I,Koike S,et al.Fate and transport of antibiotic residues and antibiotic resistance genes following land application of manure waste[J].Journal of Environmental Quality,2009,38(3):1086-1108.
[15]Girardi C,Greve J,Lamsh?ft M,et al.Biodegradation of ciprofloxacin in water and soil and its effects on the microbial communities[J].Journal of Hazardous Materials,2011,198:22-30.
[16]Park J Y,Huwe B.Effect of pH and soil structure on transport of sulfonamide antibiotics in agricultural soils[J].Environmental Pollution,2016,213:561-570.
[17]Wohde M,Berkner S,Junker T,et al.Occurrence and transformation of veterinary pharmaceuticals and biocides in manure:A literature review[J].Environmental Science Europe,2016,28(1):23.
[18]Ho Y B,Zakaria M P,Latif P A,et al.Degradation of veterinary antibiotics and hormone during broiler manure composting[J].Bioresource Technology,2013,131:476-484.
[19]孟磊,杨兵,薛南冬,等.高温堆肥对鸡粪中氟喹诺酮类抗生素的去除[J].农业环境科学学报,2015,34(2):377-383.MENG Lei,YANG Bing,XUE Nan-dong,et al.Effect of high temperature composting on removal of fluoroquinolones in chicken manures[J].Journal of Agro-Environment Science,2015,34(2):377-383.
[20]季秋洁.3种氟喹诺酮类抗生素在猪粪中的残留与降解[D].合肥:安徽农业大学,2012.JI Qiu-jie.The residues and degradation of three fluoroquinolone antibiotics in pig feces[D].Hefei:Anhui Agricultural University,2012.
[21]Karc?A,Balc?o?lu I A.Investigation of the tetracycline,sulfonamide,and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey[J].Science of the Total Environment,2009,407(16):4652-4664.
[22]Zhao L,Dong Y H,Wang H.Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China[J].Science of the Total Environment,2010,408(5):1069-1075.
[23]Sattelberger R,Oliver G,Martínez E.Veterin?rantibiotika in Wirtschaftsdünger und Boden[M].Wien:Reports BE-272,2005,Umweltbundesamt.
[24]Elena M C,Carmen G B,Sigrid S,et al.Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria[J].Environmental Pollution,2007,148(2):570-579.
[25]Guo X Y,Hao L J,Qiu P Z,et al.Pollution characteristics of 23 veterinary antibiotics in livestock manure and manure-amended soils in Jiangsu Province,China[J].Journal of Environmental Science and Health,2016,51(6):383-392.
[26]Huang Y,Cheng M,Li W,et al.Simultaneous extraction of four classes of antibiotics in soil,manure and sewage sludge and analysis by liquid chromatography-tandem mass spectrometry with the isotope-labelled internal standard method[J].Analytical Methods,2013,5(15):3721-3731.
[27]Janusch F,Scherz G,Mohring S A I,et al.Determination of fluoroquinolones in chicken feces:A new liquid-liquid extraction method combined with LC-MS/MS[J].Environmental Toxicology and Pharmacology,2014,38(3):792-799.
[28]Xie W Y,Yang X P,Li Q,et al.Changes in antibiotic concentrations and antibiotic resistome during commercial composting of animal manures[J].Environmental Pollution,2016,219:182-190.
[29]Pereira Leal R M,Figueira R F,Tornisielo V L,et al.Occurrence and sorption of fluoroquinolones in poultry litters and soils from Sao Paulo State,Brazil[J].Science of the Total Environment,2012,432:344-349.
[30]Wang N,Guo X,Xu J,et al.Pollution characteristics and environmental risk assessment of typical veterinary antibiotics in livestock farms in Southeastern China[J].J Environ Sci Health B,2014,49(7):468-479.
[31]Hu X,Zhou Q,Luo Y.Occurrence and source analysis of typical veterinary antibiotics in manure,soil,vegetables and groundwater from organic vegetable bases,northern China[J].Environmental Pollution,2010,158(9):2992-2998.
[32]Huang X,Liu C,Li K,et al.Occurrence and distribution of veterinary antibiotics and tetracycline resistance genes in farmland soils around swine feedlots in Fujian Province,China[J].Environmental Science and Pollution Research,2013,20(12):9066-9074.
[33]刘锋,廖德润,李可,等.畜禽养殖基地磺胺类喹诺酮类和大环内酯类抗生素污染特征[J].农业环境科学学报,2013,32(4):847-853.LIU Feng,LIAO De-run,LI Ke,et al.Pollution characteristics of the sulfonamides,quinolones and macrolides in the samples collected from livestock and poultry feedlots[J].Journal of Agro-Environment Science,2013,32(4):847-853.
[34]Hou J,Wan W,Mao D,et al.Occurrence and distribution of sulfonamides,tetracyclines,quinolones,macrolides,and nitrofurans in livestock manure and amended soils of northern China[J].Environmental Science and Pollution Research,2014,22(6):4545-4554.
[35]Zhang H,Zhou Y,Huang Y,et al.Residues and risks of veterinary antibiotics in protected vegetable soils following application of different manures[J].Chemosphere,2016,152:229-237.
[36]Dolliver H,Gupta S,Noll S.Antibiotic degradation during manure composting[J].Journal of Environmental Quality,2008,37(3):1245-1253.
[37]吴丹,韩梅琳,邹德勋,等.超高效液相色谱-串联质谱法检测鸡粪中16种残留抗生素[J].分析化学,2017,45(9):1389-1396.WU Dan,HAN Mei-lin,ZOU De-xun,et al.Detection of 16 residual antibiotics in chicken manure by ultra performance liquid chromatography-tandem mass spectrometry[J].Chinese Journal of Analytical Chemistry,2017,45(9):1389-1396.
[38]冯瑶.鸡粪堆肥过程中诺氟沙星削减规律及微生物分子生态学机制[D].北京:中国农业科学院,2016.FENG Yao.Microbial ecological mechanism for degradation of norfloxacin during chicken manure composting[D].Beijing:Chinese Academy of Agricultural Sciences,2016.
[39]薛南冬.一种禽兽粪便中氟喳诺酮类抗生素的去除方法:中国,201510636598.8[P].2016-01-20.XUE Nan-dong.A method for removing fluoroquinolone antibiotics in animal excrement:China,201510636598.8[P].2016-01-20.
[40]Slana M,Zigon D,Sollner-Dolenc M.Enrofloxacin degradation in broiler chicken manure under field conditions and its residuals effects to the environment[J].Environmental Science and Pollution Research,2017,24(15):13722-13731.
[41]Selvam A,Zhao Z,Wong J W C.Composting of swine manure spiked with sulfadiazine,chlortetracycline and ciprofloxacin[J].Bioresource Technology,2012,126:412-417.
[42]Liao X,Li B,Zou R,et al.Biodegradation of antibiotic ciprofloxacin:Pathways,influential factors,and bacterial community structure[J].Environmental Science and Pollution Research,2016,23(8):7911-7918.
[43]Parshikov I A,Sutherland J B.Microbial transformations of antimicrobial quinolones and related drugs[J].Journal of Industrial Microbiology&Biotechnology,2012,39(12):1731-1740.
[44]Kim D W,Heinze T M,Kim B S,et al.Modification of norfloxacin by a Microbacterium sp.strain isolated from a wastewater treatment plant[J].Applied and Environmental Microbiology,2011,77:6100-6108.
[45]?van?arováM,Moeder M,FilipováA,et al.Biotransformation of fluoroquinolone antibiotics by ligninolytic fungi-Metabolites,enzymes and residual antibacterial activity[J].Chemosphere,2015,136:311-320.
[46]?van?arováM,Moeder M,FilipováA,et al.Biotransformation of the antibiotic agent flumequine by ligninolytic fungi and residual antibacterial activity of the transformation mixtures[J].Environmental Science&Technology,2013,47(24):14128-14136.
[47]Rusch M,Kauschat A,Spielmeyer A,et al.Biotransformation of the antibiotic danofloxacin by xylaria longipes leads to an efficient reduction of its antibacterial activity[J].Journal of Agricultural and Food Chemistry,2015,63(31):6897-6904.
[48]Rusch M,Spielmeyer A,Meissner J,et al.Efficient reduction of antibacterial activity and cytotoxicity of fluoroquinolones by fungal-mediated N-oxidation[J].Journal of Agricultural and Food Chemistry,2017,65(15):3118-3126.
[49]?van?arováM,Kresinova Z,FilipováA,et al.Biodegradation of PCBs by ligninolytic fungi and characterization of the degradation products[J].Chemosphere,2012,88(11):1317-1323.
[50]Muzikar M,Kresinova Z,Svobodova K,et al.Biodegradation of chlorobenzoic acids by ligninolytic fungi[J].Journal of Hazardous Materials,2011,196:386-394.
[51]Parshikov I A,Heinze T M,Moody J D,et al.The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin[J].Applied Microbiology and Biotechnology,2001,56(3/4):474-477.
[52]Marengo J R,Kok R A,Obrien K,et al.Aerobic biodegradation of(C-14)-sarafloxacin hydrochloride in soil[J].Environmental Toxicology and Chemistry,1997,16(3):462-471.
[53]Williams A J,Parshikov I A,Moody J D,et al.Fungal transformation of an antimicrobial fluoroquinolone drug during growth on poultry litter materials[J].Journal of Applied Poultry Research,2004,13(2):235-240.
[54]De Witte B,Dewulf J,Demeestere K,et al.Ozonation and advanced oxidation by the peroxone process of ciprofloxacin in water[J].Journal of Hazardous Materials,2009,161(2/3):701-708.
[55]Adjei M D,Heinze T M,Deck J,et al.Transformation of the antibacterial agent norfloxacin by environmental mycobacteria[J].Applied and Environmental Microbiology,2006,72(9):5790-5793.
[56]Wetzstein H G,Schneider J,Karl W.Patterns of metabolites produced from the fluoroquinolone enrofloxacin by basidiomycetes indigenous to agricultural sites[J].Applied Microbiology and Biotechnology,2006,71(1):90-100.
[57]Prieto A,Moeder M,Rodil R,et al.Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products[J].Bioresource Technology,2011,102(23):10987-10995.
[58]Fuentes S,Mendez V,Aguila P,et al.Bioremediation of petroleum hydrocarbons:catabolic genes,microbial communities,and applications[J].Applied Microbiology and Biotechnology,2014,98(11):4781-4794.
[59]Yang Y,Wang Z,Xie S.Aerobic biodegradation of bisphenol A in river sediment and associated bacterial community change[J].Science of the Total Environment,2014,470:1184-1188.
[60]戴琦.环丙沙星废水的膜生物反应器处理特性及污泥中抗性基因的变化研究[D].上海:上海师范大学,2017.DAI Qi.Research on the treatment characteristics of the membrane bioreactor and the change of resistance genes in the sludge[D].Shanghai:Shanghai Normal University,2017.
[61]Meng F,Gao G,Yang T T,et al.Effects of fluoroquinolone antibiotics on reactor performance and microbial community structure of a membrane bioreactor[J].Chemical Engineering Journal,2015,280:448-458.
[62]Grenni P,Ancona V,Barra Caracciolo A.Ecological effects of antibiotics on natural ecosystems:A review[J].Microchemical Journal,2018,136:25-39.
[63]Alexandrino D A M,Mucha A P,Almeida C M R,et al.Biodegradation of the veterinary antibiotics enrofloxacin and ceftiofur and associated microbial community dynamics[J].Science of the Total Environment,2017,581-582:359-368.
[64]Girardi C,Greve J,Lamsh?ft M,et al.Biodegradation of ciprofloxacin in water and soil and its effects on the microbial communities[J].Journal of Hazardous Materials,2011,198:22-30.
[65]Brandt K K,Amézquita A,Backhaus T,et al.Ecotoxicological assessment of antibiotics:A call for improved consideration of microorganisms[J].Environment International,2015,85:189-205.
[66]何势.曝气生物滤池中环丙沙星去除行为及其对降解菌群抗药性的诱导作用[D].上海:东华大学,2016.HE Shi.Removal behavior of ciprofloxacin in the biological aerated filter and its effect on the resistance of bacteria[D].Shanghai:Donghua University,2016.
[67]Asgher M,Bhatti H N,Ashraf M,et al.Recent developments in biodegradation of industrial pollutants by white rot fungi and their enzyme system[J].Biodegradation,2008,19(6):771-783.
[68]Michelini L,Reichel R,Werner W,et al.Sulfadiazine uptake and effects on Salix fragilis L.and Zea mays L.plants[J].Water Air and Soil Pollution,2012,223(8):5243-5257.
[69]Accinelli C,Sacca M L,Batisson I,et al.Removal of oseltamivir(Tamiflu)and other selected pharmaceuticals from wastewater using a granular bioplastic formulation entrapping propagules of Phanerochaete Chrysosporium[J].Chemosphere,2010,81(3):436-443.
[70]Rodriguez-Rodriguez C E,Marco-Urrea E,Caminal G.Degradation of naproxen and carbamazepine in spiked sludge by slurry and solidphase Trametes versicolor systems[J].Bioresource Technology,2010,101(7):2259-2266.
[71]Blanquez A,Guillen F,Rodriguez J,et al.The degradation of two fluoroquinolone based antimicrobials by SilA,an alkaline laccase from Streptomyces ipomoeae[J].World Journal of Microbiology&Biotechnology,2016,32(3):1-8.
[72]沈怡雯,黄智婷,谢冰.抗生素及其抗性基因在环境中的污染、降解和去除研究进展[J].应用与环境生物学报,2015,21(2):181-187.SHEN Yi-wen,HUANG Zhi-ting,XIE Bing.Advances in research of pollution,degradation and removal of antibiotics and antibiotic resistance genes in the environment[J].Chinese Journal of Applied&Environmental Biology,2015,21(2):181-187.
[73]Lucas D,Badia-Fabregat M,Vicent T,et al.Fungal treatment for the removal of antibiotics and antibiotic resistance genes in veterinary hospital wastewater[J].Chemosphere,2016,152:301-308.
[74]Rodriguez-Mozaz S,Chamorro S,Marti E,et al.Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river[J].Water Research,2015,69:234-242.
[75]赵祥.施用粪肥的设施菜地土壤中抗生素及抗性基因多样性及丰度的研究[D].泰安:山东农业大学,2017.ZHAO Xiang.Studies on the diversity and abundance of antibiotics and resistance genes in vegetable soils with facilities manure application[D].Tai′an:Shandong Agricultural University,2017.
[76]Knapp C W,Zhang W,Sturm B S M,et al.Differential fate of erythromycin and beta-lactam resistance genes from swine lagoon waste under different aquatic conditions[J].Environmental Pollution,2010,158(5):1506-1512.
[77]Zhu Y G,Johnson T A,Su J Q,et al.Diverse and abundant antibiotic resistance genes in Chinese swine farms[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(9):3435-3440.
[78]Mu Q H,Li J,Sun Y X,et al.Occurrence of sulfonamide-,tetracycline-,plasmid-mediated quinolone-and macrolide-resistance genes in livestock feedlots in northern China[J].Environmental Science and Pollution Research,2015,22(9):6932.
[79]Zhang Y J,Hu H W,Gou M,et al.Temporal succession of soil antibiotic resistance genes following application of swine,cattle and poultry manures spiked with or without antibiotics[J].Environmental Pollution,2017,231:1621-1632.
[80]Chen K,Zhou J L.Occurrence and behavior of antibiotics in water and sediments from the Huangpu River,Shanghai,China[J].Chemosphere,2014,95:604-612.
[81]Wang J,Guo X,Qin J,et al.Microstructure and mechanical properties of investment casted titanium matrix composites with B4C additions[J].Materials Science and Engineering:A,2015,628:366-373.
[82]Zhou X,Qiao M,Wang F H,et al.Use of commercial organic fertilizer increases the abundance of antibiotic resistance genes and antibiotics in soil[J].Environmental Science and Pollution Research,2017,24(1):701-710.
[83]Wang J,Ben W,Yang M,et al.Dissemination of veterinary antibiotics and corresponding resistance genes from a concentrated swine feedlot along the waste treatment paths[J].Environment International,2016,92-93:317-323.
[84]郑宁国,黄南,王卫卫,等.高温堆肥过程对猪粪来源抗生素抗性基因的影响[J].环境科学,2016,37(5):1986-1992.ZHENG Ning-guo,HUANG Nan,WANG Wei-wei,et al.Effects of high temperature composting on antibiotic resistance genes in pig manure[J].Environmental Science,2016,37(5):1986-1992.
[85]Selvam A,Xu D,Zhao Z,et al.Fate of tetracycline,sulfonamide and fluoroquinolone resistance genes and the changes in bacterial diversity during composting of swine manure[J].Bioresource Technology,2012,126:383-390.
[86]Qian X,Gu J,Sun W,et al.Diversity,abundance,and persistence of antibiotic resistance genes in various types of animal manure following industrial composting[J].Journal of Hazardous Materials,2018,344:716-722.
[87]Auerbach E A,Seyfried E E,McMahon K D.Tetracycline resistance genes in activated sludge wastewater treatment plants[J].Water Research,2007,41(5):1143-1151.
[88]Garcia-Galan M J,Diaz-Cruz M S,Barcelo D.Occurrence of sulfonamide residues along the Ebro river basin removal in wastewater treatment plants and environmental impact assessment[J].Environment International,2011,37(2):462-473.
[89]Su J Q,Wei B,OUYANG W Y,et al.Antibiotic resistome and its association with bacterial communities during sewage sludge composting[J].Environmental Science&Technology,2015,49(12):7356-7363.
[90]Qiao M,Ying G G,Singer A C,et al.Review of antibiotic resistance in China and its environment[J].Environmental International,2018,110:160-172.