灵芝生物活性成分及其药理作用研究进展
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摘要
灵芝中含有多糖类、三萜类、蛋白质、甾醇类、核苷类、微量元素等生物活性成分,具有免疫调节、抗癌、降血糖、抗氧化、抗纤维化、抗衰老等功效,药理作用广泛。从灵芝的生物活性物质、药理活性、毒性进行综述,旨在为灵芝的进一步研究和扩大应用范围提供依据。
引文
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[3]Hwang IW,Kim BM,Kim YC,et al.Improvement inβ-glucan extraction from Ganoderma lucidum with high-pressure steaming and enzymatic pretreatment[J].Appl.Biol.Chem,2018,61(2):235-242.
[4]Wasser SP.Current findings,future trends and unsolved problems in studies of medicinal mushrooms[J].Applied Microbiology and Biotechnology,2011,89(5):1323-1332.
[5]Baby S,Johnson AJ,Govindan B.Secondary metabolites from Ganoderma[J].Phytochemistry,2015,114:66-101.
[6]Luo J,Zhao YY,Li ZB.A new lanostane-type triterpene from the fruiting bodies of Ganoderma lucidum[J].J Asian Nat Prod Res,2002,4(2):129-134.
[7]Gill BS,Kumar S.Evaluating anti-oxidant potentia of ganoderic acid A in STAT 3 pathway in prostate cancer[J].Mol.Biol.Rep,2016,43(12):1411-1422.
[8]周帅,张晓昱,唐传红,等.沪农灵芝一号生长过程中子实体各部位糖醇和海藻糖积累及其代谢酶的表达变化[J].菌物学报,2018(8):1090-1099.
[9]刘艳芳,应一君,唐庆九,等.不同产地紫芝子实体中活性成分的测定分析[J].食用菌学报,2017(1):72-76.
[10]刘振东,李梁,罗章.等.西藏常见食药用真菌子实体脂肪酸组成研究[J].食品研究与开发2018(17):117-123.
[11]王长龙,祁秋霞.灵芝提取物与维生素E对高脂高糖饮食小鼠的协同保护作用研究[J].北京中医药2017(17):1121-1123.
[12]张瑞婷,周涛,宋潇潇,等.灵芝活性成分及其药理作用的研究进展[J].安徽农业科学,2018(3):18-19.
[13]Shamaki BU,Sandabe UK,Fanna IA,et al.Adamu Proximate composition,phytochemical and elementa analysis of some organic solvent extract of the wild mushroom Ganoderma lucidum[J].J.Nat.Sci Res,2012,2(4):24-35.
[14]林志斌.灵芝抗肿瘤作用的免疫学机制及其临床应用[J].中国药理学与毒理学杂志2015,29(6):865-876.
[15]李六文,赵刚.药用真菌多糖抗肿瘤免疫生物活性研究进展[J].中华肿瘤防治杂,2015(14):1156-1160.
[16]李宁,赵树立,徐贞俊,等.G L P对单核巨噬白血病细胞株的体外作用[J].现代生物医学进展,2014(27):5238-5241.
[17]Kao C,Jesuthasan AC,Bishop KS,et al.Anticancer activities of Ganoderma lucidum:active ingredients and pathways[J].Funct.Foods Health and Disease,2013,3(2):48-65.
[18]Krishna KV,Karuppuraj V,Perumal K.Antioxidan activity and Folic acid content in indigenous isolates of Ganoderma lucidum[J].Asian J.Pharm Anal,2016,6(4):213-215.
[19]Ishimoto Y,Ishibashi KI,Yamanaka D,et al Enhanced release of immunostimulatingβ-13-Glucan by autodigestion of the lingzhi medicina mushroom,ganoderma lingzhi(Agaricomycetes)[J]Int.J.Med.Mushrooms,2017,19(1):1-16.
[20]林志彬.灵芝的抗衰老与抗阿尔茨海默病的药理研究进展[J].神经药,2018(1):9-15.
[21]Zhang J,Tang Q,Zimmerman-Kordmann M,et al Activation of B lymphocytes by GLIS,a bioactive proteoglycan from Ganoderma lucidum[J].Life Sci,2002,71(6):623-638.
[22]Kan Y,Chen T,Wu Y,et al.Antioxidant activity of polysaccharide extracted from Ganoderma lucidum using response surface methodology[J].Int.J.Biol Macromol,2015,72:151-157.
[23]Wachtel-Galor S,Tomlinson B,Benzie I FGanoderma lucidum(‘Lingzhi’),a Chinese medicinal mushroom:biomarker responses in a controlled human supplementation study[J].Br.JNutr,2004,91(2):263-269.
[24]Ferreira IC,Heleno SA,Reis FS,et al.Chemical features of Ganoderma polysaccharides with antioxidant,antitumor and antimicrobial activities[J]Phytochemistry,2015,114:38-55.
[25]Giavasis I.Bioactive fungal polysaccharides as potential functional ingredients in food and nutraceuticals[J].Current Opinion in Biotechnology2014,16:162-173.
[26]Siwulski M,Sobieralski K,Golak-Siwulska Iet al.Ganoderma lucidum(Curt.:Fr.)Karsthealth-promoting properties a review[J].Herba Pol,2015,61(3):105-118.
[27]Gao Y,Lan J,Dai X,et al.A phase I/II study of Ling Zhi mushroom Ganoderma lucidum(W.Curt.Fr.)Lloyd(Aphyllophoromycetideae)extract in patients with type II diabetes mellitus[J].Int.J.Med Mushrooms,2004,6(1):327-334.
[28]Seto S,Lam T,Tam H,et al.Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic(+db/+db)mice[J].Phytomedici ne,2009,16(5):426-436.
[29]刘亚萍,张泽生,李雨蒙,等.GLP降血糖机制的研究进展[J].食品研究与开发,2018(2):215-218.
[30]Xiao C.,WU Q.,ZHANG J.,et al.Antidiabetic activity of Ganoderma lucidum polysaccharides F31down-regulated hepatic glucose regulatory enzymes in diabetic mice[J].J Ethnopharmacol,2017,196:47-57.
[31]Naveenkumar C,Swathi S,Jayalakshmi G,et al Screening of antifungal activity of Ganoderma Lucidum extract against medically important Fungi[J]Indian J.Public Health Res,2018(1):269-272.
[32]赵成萍,冯翠萍,常晓敏.灵芝多糖抑菌作用的研究[J].食用菌,2012(2):63-64.
[33]徐繁,李潇,刘兰芳,等.灵芝多糖对阿霉素致心肌损伤保护作用的研究[J].中国地方病防治杂志,2017(4):372-375.
[34]Sheena N,Lakshmi B,Janardhanan KK.Therapeutic Potential of Ganoderma Lucidum(Fr.)P.Karst[J]Natural Product Padiance,2005,4(5):382-386.
[35]Xie YZ,Yang F,Tan W,et al.The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression[J].Oncoscience,2016,3(7):203.
[36]杨燕燕,谢金东,俞春英,等.GLP对动脉粥样硬化ApoE-/-小鼠血脂及LOX-1、TNF-α、ICAM-1的影响[J].山东医药,2018(1):33-36.
[37]Rajasekaran M,Kalaimagal C.Cardioprotective effect of a medicinal mushroom,Ganoderma lucidum against adriamycin induced toxicity[J].Int.JPharmacol,2012,8(4):252-258.
[38]Lasukova T,Maslov L,Arbuzov A,et al Cardioprotective activity of Ganoderma lucidum extract during total ischemia and reperfusion of isolated heart[J].Bull.Exp.Biol.Med,2015,158(6):739-741.
[39]毛慧慧,游育红.GLP肽对培养乳大鼠心肌细胞缺氧复氧损伤的保护作用[J].中国药理学与毒理学杂志,2015(3):398-403.
[40]Huang S,Mao J,Ding K,et al.Polysaccharides from ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of Alzheimer’s disease[J].Stem Cell Rep,2017,8(1):84-94.
[41]Chatterjee A,Acharya K.Include mushroom in daily diet--a strategy for better hepatic health[J].Food Rev.Int,2016,32(1):68-97.
[42]Yan R,Zhou Y,Liu J.Treatment of chronic hepatitis B with Wulingdan pill[J].J.Fourth Mil.Med.Coll1987,8:380-383.
[43]Dudhgaonkar S,Thyagarajan A,Sliva D.Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum[J].Int Immunopharmacol,2009,9(11):1272-1280.
[44]Cai Z,Wong CK,Dong J,et al.Anti-inflammatory activities of Ganoderma lucidum(Lingzhi)and SanMiao-San supplements in MRL/lpr mice for the treatment of systemic lupus erythematosus[J].Chin Med,2016,11(1):23.
[45]Polumuri SK,Toshchakov VY,Vogel SN.Role of phosphatidylinositol-3 kinase in transcriptiona regulation of TLR-induced IL-12 and IL-10 by Fcγreceptor ligation in murine macrophages[J].JImmunol,2007,179(1):236-246.
[46]《食药用菌》编辑部.灵芝有利于治疗类风湿性关节炎[J].食药用菌,2011(2):32.
[47]葛凡,葛孚章.泰山赤灵芝多糖提取物对骨质疏松大鼠骨量的影响[J].沈阳医学院学报,2016,18(1):21-22.
[48]Bishop KS,Kao CH,Xu Y,et al.From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals[J].Phytochemistry,2015,114:56-65.
[49]Dewi SC,Sargowo D,Widodo MA,et al.Ganoderma lucidum subchronic toxicity on the liver as antioxidant and anti-inflamatory agent for cardivascular disease[J].J.Hypertens,2015,33:30.
[50]Dulay R,Apolinar A,Tiniola R,et al.Aphrodisiac and diuretic activity of Philippine wild higher Basidiomycetes,ganoderma lucidum(W.Curt.:Fr.)PKarst.,extract in male mice(Mus musculus)[J].Adv Environ.Biol.,2016,10(1):144-149.
[51]Gurovic MSV,Viceconte FR,Pereyra MT,et al DNA damaging potential of Ganoderma lucidum extracts[J].J.Ethnopharmacol,2018,217:83-88.
[2]Sanodiya BS,Thakur GS,Baghel RK,et al Ganoderma lucidum:a potent pharmacological macrofungus[J].Curr.Pharm.Biotechnol,2009,10(8):717-742.
[3]Hwang IW,Kim BM,Kim YC,et al.Improvement inβ-glucan extraction from Ganoderma lucidum with high-pressure steaming and enzymatic pretreatment[J].Appl.Biol.Chem,2018,61(2):235-242.
[4]Wasser SP.Current findings,future trends and unsolved problems in studies of medicinal mushrooms[J].Applied Microbiology and Biotechnology,2011,89(5):1323-1332.
[5]Baby S,Johnson AJ,Govindan B.Secondary metabolites from Ganoderma[J].Phytochemistry,2015,114:66-101.
[6]Luo J,Zhao YY,Li ZB.A new lanostane-type triterpene from the fruiting bodies of Ganoderma lucidum[J].J Asian Nat Prod Res,2002,4(2):129-134.
[7]Gill BS,Kumar S.Evaluating anti-oxidant potentia of ganoderic acid A in STAT 3 pathway in prostate cancer[J].Mol.Biol.Rep,2016,43(12):1411-1422.
[8]周帅,张晓昱,唐传红,等.沪农灵芝一号生长过程中子实体各部位糖醇和海藻糖积累及其代谢酶的表达变化[J].菌物学报,2018(8):1090-1099.
[9]刘艳芳,应一君,唐庆九,等.不同产地紫芝子实体中活性成分的测定分析[J].食用菌学报,2017(1):72-76.
[10]刘振东,李梁,罗章.等.西藏常见食药用真菌子实体脂肪酸组成研究[J].食品研究与开发2018(17):117-123.
[11]王长龙,祁秋霞.灵芝提取物与维生素E对高脂高糖饮食小鼠的协同保护作用研究[J].北京中医药2017(17):1121-1123.
[12]张瑞婷,周涛,宋潇潇,等.灵芝活性成分及其药理作用的研究进展[J].安徽农业科学,2018(3):18-19.
[13]Shamaki BU,Sandabe UK,Fanna IA,et al.Adamu Proximate composition,phytochemical and elementa analysis of some organic solvent extract of the wild mushroom Ganoderma lucidum[J].J.Nat.Sci Res,2012,2(4):24-35.
[14]林志斌.灵芝抗肿瘤作用的免疫学机制及其临床应用[J].中国药理学与毒理学杂志2015,29(6):865-876.
[15]李六文,赵刚.药用真菌多糖抗肿瘤免疫生物活性研究进展[J].中华肿瘤防治杂,2015(14):1156-1160.
[16]李宁,赵树立,徐贞俊,等.G L P对单核巨噬白血病细胞株的体外作用[J].现代生物医学进展,2014(27):5238-5241.
[17]Kao C,Jesuthasan AC,Bishop KS,et al.Anticancer activities of Ganoderma lucidum:active ingredients and pathways[J].Funct.Foods Health and Disease,2013,3(2):48-65.
[18]Krishna KV,Karuppuraj V,Perumal K.Antioxidan activity and Folic acid content in indigenous isolates of Ganoderma lucidum[J].Asian J.Pharm Anal,2016,6(4):213-215.
[19]Ishimoto Y,Ishibashi KI,Yamanaka D,et al Enhanced release of immunostimulatingβ-13-Glucan by autodigestion of the lingzhi medicina mushroom,ganoderma lingzhi(Agaricomycetes)[J]Int.J.Med.Mushrooms,2017,19(1):1-16.
[20]林志彬.灵芝的抗衰老与抗阿尔茨海默病的药理研究进展[J].神经药,2018(1):9-15.
[21]Zhang J,Tang Q,Zimmerman-Kordmann M,et al Activation of B lymphocytes by GLIS,a bioactive proteoglycan from Ganoderma lucidum[J].Life Sci,2002,71(6):623-638.
[22]Kan Y,Chen T,Wu Y,et al.Antioxidant activity of polysaccharide extracted from Ganoderma lucidum using response surface methodology[J].Int.J.Biol Macromol,2015,72:151-157.
[23]Wachtel-Galor S,Tomlinson B,Benzie I FGanoderma lucidum(‘Lingzhi’),a Chinese medicinal mushroom:biomarker responses in a controlled human supplementation study[J].Br.JNutr,2004,91(2):263-269.
[24]Ferreira IC,Heleno SA,Reis FS,et al.Chemical features of Ganoderma polysaccharides with antioxidant,antitumor and antimicrobial activities[J]Phytochemistry,2015,114:38-55.
[25]Giavasis I.Bioactive fungal polysaccharides as potential functional ingredients in food and nutraceuticals[J].Current Opinion in Biotechnology2014,16:162-173.
[26]Siwulski M,Sobieralski K,Golak-Siwulska Iet al.Ganoderma lucidum(Curt.:Fr.)Karsthealth-promoting properties a review[J].Herba Pol,2015,61(3):105-118.
[27]Gao Y,Lan J,Dai X,et al.A phase I/II study of Ling Zhi mushroom Ganoderma lucidum(W.Curt.Fr.)Lloyd(Aphyllophoromycetideae)extract in patients with type II diabetes mellitus[J].Int.J.Med Mushrooms,2004,6(1):327-334.
[28]Seto S,Lam T,Tam H,et al.Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic(+db/+db)mice[J].Phytomedici ne,2009,16(5):426-436.
[29]刘亚萍,张泽生,李雨蒙,等.GLP降血糖机制的研究进展[J].食品研究与开发,2018(2):215-218.
[30]Xiao C.,WU Q.,ZHANG J.,et al.Antidiabetic activity of Ganoderma lucidum polysaccharides F31down-regulated hepatic glucose regulatory enzymes in diabetic mice[J].J Ethnopharmacol,2017,196:47-57.
[31]Naveenkumar C,Swathi S,Jayalakshmi G,et al Screening of antifungal activity of Ganoderma Lucidum extract against medically important Fungi[J]Indian J.Public Health Res,2018(1):269-272.
[32]赵成萍,冯翠萍,常晓敏.灵芝多糖抑菌作用的研究[J].食用菌,2012(2):63-64.
[33]徐繁,李潇,刘兰芳,等.灵芝多糖对阿霉素致心肌损伤保护作用的研究[J].中国地方病防治杂志,2017(4):372-375.
[34]Sheena N,Lakshmi B,Janardhanan KK.Therapeutic Potential of Ganoderma Lucidum(Fr.)P.Karst[J]Natural Product Padiance,2005,4(5):382-386.
[35]Xie YZ,Yang F,Tan W,et al.The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression[J].Oncoscience,2016,3(7):203.
[36]杨燕燕,谢金东,俞春英,等.GLP对动脉粥样硬化ApoE-/-小鼠血脂及LOX-1、TNF-α、ICAM-1的影响[J].山东医药,2018(1):33-36.
[37]Rajasekaran M,Kalaimagal C.Cardioprotective effect of a medicinal mushroom,Ganoderma lucidum against adriamycin induced toxicity[J].Int.JPharmacol,2012,8(4):252-258.
[38]Lasukova T,Maslov L,Arbuzov A,et al Cardioprotective activity of Ganoderma lucidum extract during total ischemia and reperfusion of isolated heart[J].Bull.Exp.Biol.Med,2015,158(6):739-741.
[39]毛慧慧,游育红.GLP肽对培养乳大鼠心肌细胞缺氧复氧损伤的保护作用[J].中国药理学与毒理学杂志,2015(3):398-403.
[40]Huang S,Mao J,Ding K,et al.Polysaccharides from ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of Alzheimer’s disease[J].Stem Cell Rep,2017,8(1):84-94.
[41]Chatterjee A,Acharya K.Include mushroom in daily diet--a strategy for better hepatic health[J].Food Rev.Int,2016,32(1):68-97.
[42]Yan R,Zhou Y,Liu J.Treatment of chronic hepatitis B with Wulingdan pill[J].J.Fourth Mil.Med.Coll1987,8:380-383.
[43]Dudhgaonkar S,Thyagarajan A,Sliva D.Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum[J].Int Immunopharmacol,2009,9(11):1272-1280.
[44]Cai Z,Wong CK,Dong J,et al.Anti-inflammatory activities of Ganoderma lucidum(Lingzhi)and SanMiao-San supplements in MRL/lpr mice for the treatment of systemic lupus erythematosus[J].Chin Med,2016,11(1):23.
[45]Polumuri SK,Toshchakov VY,Vogel SN.Role of phosphatidylinositol-3 kinase in transcriptiona regulation of TLR-induced IL-12 and IL-10 by Fcγreceptor ligation in murine macrophages[J].JImmunol,2007,179(1):236-246.
[46]《食药用菌》编辑部.灵芝有利于治疗类风湿性关节炎[J].食药用菌,2011(2):32.
[47]葛凡,葛孚章.泰山赤灵芝多糖提取物对骨质疏松大鼠骨量的影响[J].沈阳医学院学报,2016,18(1):21-22.
[48]Bishop KS,Kao CH,Xu Y,et al.From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals[J].Phytochemistry,2015,114:56-65.
[49]Dewi SC,Sargowo D,Widodo MA,et al.Ganoderma lucidum subchronic toxicity on the liver as antioxidant and anti-inflamatory agent for cardivascular disease[J].J.Hypertens,2015,33:30.
[50]Dulay R,Apolinar A,Tiniola R,et al.Aphrodisiac and diuretic activity of Philippine wild higher Basidiomycetes,ganoderma lucidum(W.Curt.:Fr.)PKarst.,extract in male mice(Mus musculus)[J].Adv Environ.Biol.,2016,10(1):144-149.
[51]Gurovic MSV,Viceconte FR,Pereyra MT,et al DNA damaging potential of Ganoderma lucidum extracts[J].J.Ethnopharmacol,2018,217:83-88.