妇科恶性肿瘤化疗患者卵巢功能保护
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摘要
得益于肿瘤普查及诊断方法的进展,更多的妇科恶性肿瘤可在早期被发现。对于年轻患者,如何保留其卵巢功能及减轻后续的化疗对卵巢功能的损害,从而改善患者生存质量,提高生育能力显得尤为重要。文章针对妇科恶性肿瘤治疗过程中卵巢功能的保护,特别是化疗对卵巢的影响及其保护措施进行阐述。
Improvement in diagnosis has made it possible to have the early detection of gynecologic malignancies.Among premenopausal women,the loss of future fertility or ovarian function is considered among the most dreadful long-term side effects of treatments.Therefore,the preservation of fertility and ovarian function during chemotherapy treatment is of great important.This article will summarize the effect of chemotherapy on ovarian function and protective measures for chemotherapy-induced ovarian damage.
Improvement in diagnosis has made it possible to have the early detection of gynecologic malignancies.Among premenopausal women,the loss of future fertility or ovarian function is considered among the most dreadful long-term side effects of treatments.Therefore,the preservation of fertility and ovarian function during chemotherapy treatment is of great important.This article will summarize the effect of chemotherapy on ovarian function and protective measures for chemotherapy-induced ovarian damage.
引文
[1]Koh WJ,Abu-Rustum NR,Bean S,et al.Cervical Cancer,Version 3.2019,NCCN Clinical Practice Guidelines in Oncology[J].J Natl Compr Canc Netw,2019,17(1):64-84.
[2]Shimada M,Kigawa J,Nishimura R,et al.Ovarian metastasis in carcinoma of the uterine cervix[J].Gynecol Oncol,2006,101(2):234-237.
[3]Ronnett BM,Yemelyanova AV,Vang R,et al.Endocervical adenocarcinomas with ovarian metastases:analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms[J].Am J Surg Pathol,2008,32(12):1835-1853.
[4]Zhou J,Chen Y,Zhang P,et al.Ovarian preservation in adenocarcinoma of the uterine cervix[J].J Ovarian Res,2017,10(1):48.
[5]Jiangtao L,Tingting S,Xianjie T.Ovarian preservation in young patients with stage I cervical adenocarcinoma:a surveillance,epidemiology,and end results study[J].Int J Gynecol Cancer,2014,24(8):1513-1520.
[6]Karuna G,Soslow RA.Endometrial carcinoma in women aged 40years and younger[J].Arch Pathol Lab Med,2014,138(3):335-342.
[7]Ignatov T,Eggemann H,Burger E,et al.Ovarian metastasis in patients with endometrial cancer:risk factors and impact on survival[J].J Cancer Res Clin Oncol,2018,144(6):1103-1107.
[8]Codacci-Pisanelli G,Del Pup L,Del Grande M,et al.Mechanisms of chemotherapy-induced ovarian damage in breast cancer patients[J].Crit Rev Oncol Hematol,2017,113:90-96.
[9]Morgan S,Anderson RA,Gourley C,et al.How do chemotherapeutic agents damage the ovary?[J].Hum Reprod Update,2012,18(5):525-535.
[10]Kropp J,Roti Roti EC,Ringelstetter A,et al.Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice[J].PLoSOne,2015,10(11):e0142588.
[11]Roti Roti EC,Leisman SK,Abbott DH,et al.Acute doxorubicin insult in the mouse ovary is cell-and follicle-type dependent[J].PLoS One,2012,7(8):e42293.
[12]Falcone T,Bedaiwy MA.Fertility preservation and pregnancy outcome after malignancy[J].Curr Opin Obstet Gynecol,2005,17(1):21-26.
[13]付子洁,李晓冬.化疗药物对卵巢功能的损伤机制及生育力保护[J].中华生殖与避孕杂志,2018,38(9):737-740.
[14]Stephanie M,Federica L,Charlie G,et al.Cisplatin and doxorubicin induce distinct mechanisms of ovarian follicle loss;imatinib provides selective protection only against cisplatin[J].PloS One,2013,8(7):e70117.
[15]Kim SY,Cordeiro MH,Serna VA,et al.Rescue of platinumdamaged oocytes from programmed cell death through inactivation of the p53 family signaling network[J].Cell Death Differ,2013,20(8):987-997.
[16]Lopes F,Smith R,Anderson RA,et al.Docetaxel induces moderate ovarian toxicity in mice,primarily affecting granulosa cells of early growing follicles[J].Mol Hum Reprod,2014,20(10):948-959.
[17]Bower M,Rustin GJ,Newlands ES,et al.Chemotherapy for gestational trophoblastic tumours hastens menopause by 3years[J].Eur J Cancer,1998,34(8):1204-1207.
[18]Bedoschi G,Navarro PA,Oktay K.Chemotherapy-induced damage to ovary:mechanisms and clinical impact[J].Future Oncol,2016,12(20):2333-2344.
[19]Bar-Joseph H,Ben-Aharon I,Tzabari M,et al.In vivo bioimaging as a novel strategy to detect doxorubicin-induced damage to gonadal blood vessels[J].PLoS One,2011,6(9):e23492.
[20]Soleimani R,Heytens E,Darzynkiewicz Z,et al.Mechanisms of chemotherapy-induced human ovarian aging:double strand DNA breaks and microvascular compromise[J].Aging,2011,3(8):782-793.
[21]Nishi K,Gunasekaran VP,Arunachalam J,et al.Doxorubicininduced female reproductive toxicity:an assessment of ovarian follicular apoptosis,cyclicity and reproductive tissue histology in Wistar rats[J].Drug Chem Toxicol,2018,41(1):72-81.
[22]Ataya K,Rao LV,Lawrence E,et al.Luteinizing hormone-releasing hormone agonist inhibits cyclophosphamide-induced ovarian follicular depletion in rhesus monkeys[J].Biol Reprod,1995,52(2):365-372.
[23]Blumenfeld Z.Fertility Preservation by Endocrine Suppression of Ovarian Function Using Gonadotropin-Releasing Hormone Agonists:The End of the Controversy?[J].J Clin Oncol,2018,36(19):1895-1897.
[24]Blumenfeld Z,Katz G,Evron A.'An ounce of prevention is worth a pound of cure':the case for and against GnRH-agonist for fertility preservation[J].Ann Oncol,2014,25(9):1719-1728.
[25]Oktay K,Harvey BE,Partridge AH,et al.Fertility Preservation in Patients With Cancer:ASCO Clinical Practice Guideline Update[J].J Clin Oncol,2018,36(19):1994-2001.
[26]Donnez J,Dolmans MM.Fertility Preservation in Women[J].NEngl J Med,2017,377(17):1657-1665.
[27]国际妇科内分泌学会中国妇科内分泌学分会及共识专家.卵巢组织冻存与移植中国专家共识[J].中国临床医生杂志,2018,46(4):496-500.
[28]狄文,宋柯琦.化疗对年轻恶性肿瘤患者卵巢功能的影响[J].中国实用妇科与产科杂志,2016,32(9):908-910.
[29]Hancke K,Strauch OC,Gobel H,et al.Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo[J].Fertil Steril,2007,87(1):172-177.
[30]Meng Y,Xu Z,Wu F,et al.Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice[J].Fertil Steril,2014,102(3):871-877.
[31]Kerr JB,Hutt KJ,Cook M,et al.Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib[J].Nat Med,2012,18(8):1170-1172.
[32]Francesco R,Gaetano S,Giovanna A,et al.Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma[J].Cancer,2006,106(3):514-523.
[33]Coelho NMA,Ludwin A.Counting ovarian antral follicles by ultrasound:a practical guide[J].Ultrasound Obstet Gynecol,2018,51(1):10-20.
[2]Shimada M,Kigawa J,Nishimura R,et al.Ovarian metastasis in carcinoma of the uterine cervix[J].Gynecol Oncol,2006,101(2):234-237.
[3]Ronnett BM,Yemelyanova AV,Vang R,et al.Endocervical adenocarcinomas with ovarian metastases:analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms[J].Am J Surg Pathol,2008,32(12):1835-1853.
[4]Zhou J,Chen Y,Zhang P,et al.Ovarian preservation in adenocarcinoma of the uterine cervix[J].J Ovarian Res,2017,10(1):48.
[5]Jiangtao L,Tingting S,Xianjie T.Ovarian preservation in young patients with stage I cervical adenocarcinoma:a surveillance,epidemiology,and end results study[J].Int J Gynecol Cancer,2014,24(8):1513-1520.
[6]Karuna G,Soslow RA.Endometrial carcinoma in women aged 40years and younger[J].Arch Pathol Lab Med,2014,138(3):335-342.
[7]Ignatov T,Eggemann H,Burger E,et al.Ovarian metastasis in patients with endometrial cancer:risk factors and impact on survival[J].J Cancer Res Clin Oncol,2018,144(6):1103-1107.
[8]Codacci-Pisanelli G,Del Pup L,Del Grande M,et al.Mechanisms of chemotherapy-induced ovarian damage in breast cancer patients[J].Crit Rev Oncol Hematol,2017,113:90-96.
[9]Morgan S,Anderson RA,Gourley C,et al.How do chemotherapeutic agents damage the ovary?[J].Hum Reprod Update,2012,18(5):525-535.
[10]Kropp J,Roti Roti EC,Ringelstetter A,et al.Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice[J].PLoSOne,2015,10(11):e0142588.
[11]Roti Roti EC,Leisman SK,Abbott DH,et al.Acute doxorubicin insult in the mouse ovary is cell-and follicle-type dependent[J].PLoS One,2012,7(8):e42293.
[12]Falcone T,Bedaiwy MA.Fertility preservation and pregnancy outcome after malignancy[J].Curr Opin Obstet Gynecol,2005,17(1):21-26.
[13]付子洁,李晓冬.化疗药物对卵巢功能的损伤机制及生育力保护[J].中华生殖与避孕杂志,2018,38(9):737-740.
[14]Stephanie M,Federica L,Charlie G,et al.Cisplatin and doxorubicin induce distinct mechanisms of ovarian follicle loss;imatinib provides selective protection only against cisplatin[J].PloS One,2013,8(7):e70117.
[15]Kim SY,Cordeiro MH,Serna VA,et al.Rescue of platinumdamaged oocytes from programmed cell death through inactivation of the p53 family signaling network[J].Cell Death Differ,2013,20(8):987-997.
[16]Lopes F,Smith R,Anderson RA,et al.Docetaxel induces moderate ovarian toxicity in mice,primarily affecting granulosa cells of early growing follicles[J].Mol Hum Reprod,2014,20(10):948-959.
[17]Bower M,Rustin GJ,Newlands ES,et al.Chemotherapy for gestational trophoblastic tumours hastens menopause by 3years[J].Eur J Cancer,1998,34(8):1204-1207.
[18]Bedoschi G,Navarro PA,Oktay K.Chemotherapy-induced damage to ovary:mechanisms and clinical impact[J].Future Oncol,2016,12(20):2333-2344.
[19]Bar-Joseph H,Ben-Aharon I,Tzabari M,et al.In vivo bioimaging as a novel strategy to detect doxorubicin-induced damage to gonadal blood vessels[J].PLoS One,2011,6(9):e23492.
[20]Soleimani R,Heytens E,Darzynkiewicz Z,et al.Mechanisms of chemotherapy-induced human ovarian aging:double strand DNA breaks and microvascular compromise[J].Aging,2011,3(8):782-793.
[21]Nishi K,Gunasekaran VP,Arunachalam J,et al.Doxorubicininduced female reproductive toxicity:an assessment of ovarian follicular apoptosis,cyclicity and reproductive tissue histology in Wistar rats[J].Drug Chem Toxicol,2018,41(1):72-81.
[22]Ataya K,Rao LV,Lawrence E,et al.Luteinizing hormone-releasing hormone agonist inhibits cyclophosphamide-induced ovarian follicular depletion in rhesus monkeys[J].Biol Reprod,1995,52(2):365-372.
[23]Blumenfeld Z.Fertility Preservation by Endocrine Suppression of Ovarian Function Using Gonadotropin-Releasing Hormone Agonists:The End of the Controversy?[J].J Clin Oncol,2018,36(19):1895-1897.
[24]Blumenfeld Z,Katz G,Evron A.'An ounce of prevention is worth a pound of cure':the case for and against GnRH-agonist for fertility preservation[J].Ann Oncol,2014,25(9):1719-1728.
[25]Oktay K,Harvey BE,Partridge AH,et al.Fertility Preservation in Patients With Cancer:ASCO Clinical Practice Guideline Update[J].J Clin Oncol,2018,36(19):1994-2001.
[26]Donnez J,Dolmans MM.Fertility Preservation in Women[J].NEngl J Med,2017,377(17):1657-1665.
[27]国际妇科内分泌学会中国妇科内分泌学分会及共识专家.卵巢组织冻存与移植中国专家共识[J].中国临床医生杂志,2018,46(4):496-500.
[28]狄文,宋柯琦.化疗对年轻恶性肿瘤患者卵巢功能的影响[J].中国实用妇科与产科杂志,2016,32(9):908-910.
[29]Hancke K,Strauch OC,Gobel H,et al.Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo[J].Fertil Steril,2007,87(1):172-177.
[30]Meng Y,Xu Z,Wu F,et al.Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice[J].Fertil Steril,2014,102(3):871-877.
[31]Kerr JB,Hutt KJ,Cook M,et al.Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib[J].Nat Med,2012,18(8):1170-1172.
[32]Francesco R,Gaetano S,Giovanna A,et al.Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma[J].Cancer,2006,106(3):514-523.
[33]Coelho NMA,Ludwin A.Counting ovarian antral follicles by ultrasound:a practical guide[J].Ultrasound Obstet Gynecol,2018,51(1):10-20.