鸡坏死性肠炎模型构建和发病机理研究进展
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摘要
当前由于抗生素生长促进剂的限制和禁用,世界范围内鸡坏死性肠炎(Necrotic enteritis,NE)的发生率大幅上升,威胁着家禽产业及公众健康。了解NE的模型构建和发病机理对鸡NE的有效防控起着积极作用。文章综述了产气荚膜梭菌及其毒素、NE感染的组织生物学变化、NE诱导因素及试验模型建立方法和评价等的最新研究进展。
At this stage, due to the restriction and ban of antimicrobial growth promoters, the incidence of avian necrotic enteritis(NE) in the world has risen sharply, threatening the poultry industry and public health. Comprehension of the model establishment and pathogenesis of NE plays a positive role in developing a prevention and control of avian NE. Therefore, this article reviewed the latest advances in the Clostridium perfringens and its toxins, pathobiological changes of NE infection, NE induction factors and the establishment and evaluation of NE models.
At this stage, due to the restriction and ban of antimicrobial growth promoters, the incidence of avian necrotic enteritis(NE) in the world has risen sharply, threatening the poultry industry and public health. Comprehension of the model establishment and pathogenesis of NE plays a positive role in developing a prevention and control of avian NE. Therefore, this article reviewed the latest advances in the Clostridium perfringens and its toxins, pathobiological changes of NE infection, NE induction factors and the establishment and evaluation of NE models.
引文
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[2]MOORE R J.Necrotic enteritis predisposing factors in broiler chickens[J].Avian Pathology,2016,45(3):275-281.
[3]VAN I F,DE B J,PASMANS F,et al.Clostridium perfringens in poultry:an emerging threat for animal and public health[J].Avian Pathology,2004,33(6):537-549.
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[6]WADE B,KEYBURN A L.The true cost of necrotic enteritis[J].World Poultry,2015(31):7-16.
[7]王佰魁,徐歆,毛予龙,等.禽类坏死性肠炎发病机理的研究进展[J].中国畜牧杂志,2016,52(23):103-107.
[8]ENGSTR?M B E,FERM?R C,LINDBERG A,et al.Molecular typing of isolates of Clostridium perfringens from healthy and diseased poultry[J].Veterinary Microbiology,2003,94(3):225-235.
[9]DAHIYA J P,WILKIE D C,KESSEL A G V,et al.Potential strategies for controlling necrotic enteritis in broiler chickens in post-antibiotic era[J].Animal Feed Science&Technology,2006,129(1):60-88.
[2]MOORE R J.Necrotic enteritis predisposing factors in broiler chickens[J].Avian Pathology,2016,45(3):275-281.
[3]VAN I F,DE B J,PASMANS F,et al.Clostridium perfringens in poultry:an emerging threat for animal and public health[J].Avian Pathology,2004,33(6):537-549.
[4]TIMBERMONT L,HAESEBROUCK F,DUCATELLE R,et al.Necrotic enteritis in broilers:An updated review on the pathogenesis[J].Avian Pathology,2011,40(4):341-347.
[5]SLUIS W V D.Clostridial enteritis is an often underestimated problem[J].World Poultry,2000,16(7):42-43.
[6]WADE B,KEYBURN A L.The true cost of necrotic enteritis[J].World Poultry,2015(31):7-16.
[7]王佰魁,徐歆,毛予龙,等.禽类坏死性肠炎发病机理的研究进展[J].中国畜牧杂志,2016,52(23):103-107.
[8]ENGSTR?M B E,FERM?R C,LINDBERG A,et al.Molecular typing of isolates of Clostridium perfringens from healthy and diseased poultry[J].Veterinary Microbiology,2003,94(3):225-235.
[9]DAHIYA J P,WILKIE D C,KESSEL A G V,et al.Potential strategies for controlling necrotic enteritis in broiler chickens in post-antibiotic era[J].Animal Feed Science&Technology,2006,129(1):60-88.