介孔硅材料在止血应用方面的研究进展
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摘要
介绍了介孔硅材料的类型以及合成方法,综述了以介孔硅材料为基材的止血材料的研究现状,主要包括介孔硅材料、介孔硅与有机材料的复合、介孔硅与金属离子材料的复合,介孔硅材料均显示了良好的止血和抗菌性能,最后展望了介孔硅与其他材料复合在止血应用方面的前景。
The types of mesoporous silica materials and synthetic methods were introduced and the research status of hemostatic materials based on mesoporous silica was reviewed. These hemostatic materials included mesoporous silica materials, the combination of mesoporous silica and organic materials, the combination of mesoporous silica and metal ion materials, and they demonstrated the good hemostatic and antibacterial properties due to the use of mesoporous silica. Finally, the prospect in the application of mesoporous silica combined with other materials for hemostasis applications was discussed.
The types of mesoporous silica materials and synthetic methods were introduced and the research status of hemostatic materials based on mesoporous silica was reviewed. These hemostatic materials included mesoporous silica materials, the combination of mesoporous silica and organic materials, the combination of mesoporous silica and metal ion materials, and they demonstrated the good hemostatic and antibacterial properties due to the use of mesoporous silica. Finally, the prospect in the application of mesoporous silica combined with other materials for hemostasis applications was discussed.
引文
[1] 黎檀实,潘菲,宋海楠.战术战伤救治指南的研究进展[J]. 中国急救复苏与灾害医学杂志,2015, 10(1):5-7. LI T S,PAN F,SONG H N. Research Progress on Tactical Combat Casualty Care Guidelines[J]. China Journal of Emergency Resuscitation and Disaster Medicine,2015, 10(1):5-7.
[2] LITTLEJOHN L, BENNETT B L, DREW B. Application of Current Hemorrhage Control Techniques for Backcountry Care: Part Two, Hemostatic Dressings and Other Adjuncts[J]. Wilderness Environ Med, 2015, 26(2):246-254.
[3] RHEE P, BROWN C, MARTIN M, et al. QuikClot Use in Trauma for Hemorrhage Control: Case Series of 103 Documented Uses [J]. Journal of Trauma & Acute Care Surgery, 2008, 64(4):1 093-1 099.
[4] MCMANUS J, HURTADO T, PUSATERI A, et al. A Case Series Describing Thermal Injury Resulting from Zeolite Use for Hemorrhage Control in Combat Operations[J]. Prehospital Emergency Care, 2007, 11(1):67-71.
[5] WRIGHT J K, KALNS J, WOLF E A, et al. Thermal Injury Resulting from Application of a Granular Mineral Hemostatic Agent[J]. Journal of Trauma, 2004, 57(2):224-30.
[6] PLURAD D, CHANDRASOMA S, BEST C, et al. A Complication of Intracorporeal Use of QuikClot for Pelvic Hemorrhage[J]. Journal of Trauma, 2009, 66(5):1 482.
[7] KHEIRABADI B S, MACE J E, TERRAZAS I B, et al. Safety Evaluation of New Hemostatic Agents, Smectite Granules, and Kaolin-coated Gauze in a Vascular Injury Wound Model in Swine[J]. Journal of Trauma, 2010, 68(2):269-278.
[8] KHEIRABADI B S, EDENS J W, TERRAZAS I B, et al. Comparison of New Hemostatic Granules/Powders with Currently Deployed Hemostatic Products in a Lethal Model of Extremity Arterial Hemorrhage in Swine[J]. Journal of Trauma & Acute Care Surgery, 2009, 66(2):316-326.
[9] 李钒, 田丰, 刘长军,等.急救止血材料的研究进展[J]. 材料导报, 2013, 27(3):70-73. LI F,TIAN F,LIUC J,et al. Advance in Emergengcy Hemostatic Materials[J].Materials Review, 2013, 27(3):70-73.
[10] 李晓生, 刘昌胜, 袁媛,等.介孔硅基干凝胶的制备及其止血性能的研究[J]. 无机材料学报, 2008, 23(2):327-331. LI X S,LIU C S,YUAN Y,et al. Preparation and Hemostatic Properties of Mesoporous Silica-based Xerogels[J].Journal of Inorganic Materials,2008, 23(2):327-331.
[11] 韦良, 赵燕熹, 向勇, 等.大孔径高比表面积介孔硅泡沫的制备和表征[J]. 武汉理工大学学报, 2013, 35(6):34-38. WEIL,ZHAO Y X,XIANG Y,et al. Preparation and Characterization of Mesocelluar Silia Foam with Large Pore Size znd High Surface Area[J].Journal of Wuhan University of Technology,2013, 35(6):34-38.
[12] NANDIYANTO A B D . Synthesis of Spherical Mesoporous Silica Nanoparticles with Nanometer-size Controllable Pores and Outer Diameters[J]. Microporous & Mesoporous Materials, 2009, 120(3):447-453.
[13] MILLER L, WINTER G, BAUR B, et al. Synthesis, Characterization, and Biodistribution of Multiple 89Zr-labeled Pore-expanded Mesoporous Silica Nanoparticles for PET [J]. Nanoscale, 2014, 6(9): 4 928-4 935.
[14] SUN J, ZHANG H, TIAN R, et al. Ultrafast Enzyme Immobilization over Large-pore Nanoscale Mesoporous Silica Nanoparticles [J]. Chemical Communications, 2006, 12(12): 1 322-1 324.
[15] YANG Y, KARMAKAR S, ZHANG J, et al. Synthesis of SBA-15 Rods with Small Sizes for Enhanced Cellular Uptake [J]. Journal of Materials Chemistry B, 2014, 2(30): 4 929-4 934.
[16] ANAND A, LALZAWMLIANA V, KUMAR V, et al. Preparation and in Vivo Biocompatibility Studies of Different Mesoporous Bioactive Glasses[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2019, 89:89-98.
[17] LI X, DONG S X. A Mesoporous Bioactive Glass/Polycaprolactone Composite Scaffold and Its Bioactivity Behavior[J]. Journal of Biomedical Materials Research Part A, 2010, 84A(1):84-91.
[18] CLAY J G, GRAYSON J K, ZIEROLD D. Comparative Testing of New Hemostatic Agents in a Swine Model of Extremity Arterial and Venous Hemorrhage[J]. Military Medicine, 2010, 175(4):280-4.
[19] KHEIRABADI B S, EDENS J W, TERRAZAS I B, et al. Comparison of New Hemostatic Granules/Powders with Currently Deployed Hemostatic Products in a Lethal Model of Extremity Arterial Hemorrhage in Swine[J]. Journal of Trauma & Acute Care Surgery, 2009, 66(2):316-326.
[20] LITTLEJOHN L F, DEVLIN J J, KIRCHER S S, et al. Comparison of Celox-A, ChitoFlex, WoundStat, and Combat Gauze Hemostatic Agents Versus Standard Gauze Dressing in Control of Hemorrhage in a Swine Model of Penetrating Trauma[J]. Wilderness & Environmental Medicine, 2011, 21(1):69-69.
[21] 王立群, 徐磊, 王树伟,等.介孔二氧化硅微球的淀粉复合止血敷料[J]. 中国组织工程研究, 2011, 15(29):5 379-5 383. WANG L Q, X L, WANG S W, et al. Mesoporous Silicon Dioxide Microsphere/Staech Composite Hemostatic Dressing[J]. Journal of Clinical Rehabilitative Tissue Engineering Research,2011, 15(29):5 379-5 383.
[22] DAI C, YUAN Y, LIU C, et al. Degradable, Antibacterial Silver Exchanged Mesoporous Silica Spheres for Hemorrhage Control[J]. Biomaterials, 2009, 30(29):5 364-5 375.
[23] PARK J U, JUNG H D, SONG E H, et al. The Accelerating Effect of Chitosan-silica Hybrid Dressing Materials on the Early Phase of Wound Healing[J]. Journal of Biome-dical Materials Research Part B Applied Biomaterials, 2016, 105(7):1 828-1 839.
[24] DAI C, LIU C, WEI J, et al. Molecular Imprinted Macroporous Chitosan Coated Mesoporous Silica Xerogels for Hemorrhage Control[J]. Biomaterials, 2010, 31(30):7 620-7 630.
[25] 贾天保.介孔生物活性玻璃/壳聚糖止血材料的制备及研究[D]. 浙江理工大学, 2012.
[26] ARNAUD F, TERANISHI K, OKADA T, et al. Comparison of Combat Gauze and TraumaStat in Two Severe Groin Injury Models[J]. Journal of Surgical Research, 2011, 169(1):92-98.
[27] SAMBASIVAN C N, CHO S D , ZINK K A , et al. A Highly Porous Silica and Chitosan-based Hemostatic Dressing Is Superior in Controlling Hemorrhage in a Severe Groin Injury Model in Swine[J]. The American Journal of Surgery, 2009, 197(5):576-580.
[28] ENGLEHART M S , CHO S D , TIEU B H , et al. A Novel Highly Porous Silica and Chitosan-Based Hemostatic Dressing Is Superior to HemCon and Gauze Sponges[J]. The Journal of Trauma: Injury, Infection, and Critical Care, 2008, 65(4):884-892.
[29] CHEN Z H, HAN L,FAN L ,et al. A rapid Hemostatic Sponge Based on Large, Mesoporous Silica Nanoparticles and N-alkylated Chitosan[J]. Nanoscale, 2018, 10(43):20 234-20 245.
[30] HILLIS G R, YI C J, AMRANI D L, et al. Evaluation of NuStat, a Novel Nonimpregnated Hemostatic Dres-sing, Compared With Combat Gauze in Severe Traumatic Porcine Hemorrhage Model[J]. Journal of Special Operations Medicine A Peer Reviewed Journal for Sof Medical Professionals, 2014, 14(14):41-47.
[31] TANSAZ S, SCHULTE M, KNESER U, et al. Soy Protein Isolate/Bioactive Glass Composite Membranes: Processing and Properties[J]. European Polymer Journal, 2018:S0014305718305500-.
[32] 李静静, 朱海霖, 雷彩虹,等.介孔生物玻璃/丝素蛋白复合多孔海绵的结构及止血性能研究[J]. 功能材料, 2017, 48(2):2 096-2 101. LI J J,ZHU H L,LEI C H, et al. Study on Structure and Hemoststic Property of Mesoporous Bioglass/Silk Fibroin Composite Sponge[J].Journal of Functional Materials,2017, 48(2):2 096-2 101.
[33] ZHOU, H Y, WANG C W.A Novel Droplet-Fabricated Mesoporous Silica-Based Nanohybrid Granules for Hemorrhage Control[J].Journal of Biomedical Nanotechnology, 2018, 14(4): 649-661.
[34] LI D, NIE W, CHEN L, et al. Fabrication of Curcumin-loaded Mesoporous Silica Incorporated Polyvinyl Pyrrolidone Nanofibers for Rapid Hemostasis and Antibacterial Treatment[J]. RSC Adv, 2017, 7(13):7 973-7 982.
[35] WANG C W,ZHOU H Y, NIU H Y,et al. Tannic Acid-loaded Mesoporous Silica for Rapid Hemostasis and Antibacterial Activity[J].Biomater Sci, 2018,6(12): 3 318-3 331.
[36] AMBROGI V, DONNADIO A, PIETRELLA D .Chitosan Films Containing Mesoporous SBA-15 Supported Silver Nanoparticles for Wound Dressing[J].Journal of Materials,2014(2):6 054-6 063.
[37] NIE W, DAI X Y, LI D J, et al. One-Pot Synthesis of Silver Nanoparticle Incorporated Mesoporous Silica Granules for Hemorrhage Control and Antibacterial Treatment[J].ACS Biomater Sci Eng, 2018, 4 (10) :3 588-3 599.
[38] LU M M, BAI J, SHAO D, et al. Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure[J]. International Journal of Nanomedicine, 2018, Volume 13:5 849-5 863.
[39] 陈于, 李文锐, 徐灿,等.掺杂钙银介孔氧化硅凝胶抗菌止血材料的研究[J]. 无机材料学报, 2012, 27(5):513-518. CHEN YU,LI WEN-RUI,XU CAN,et al.Study on Hemostatic Materials of Mesoporous Silicon Dioxide Ca and Ag with Antibacterial Properties[J].Journal of inorganic materials,2012, 27(5):513-518.
[40] ZEIMARAN E, POURSHAHRESTANI S, DJORDJEVIC I, et al. Bioactive glass reinforced elastomer composites for skeletal regeneration: A review[J]. Materials Science & Engineering C, 2015, 53:175-188.
[41] ARNOLD C, LAWHON S D. Antimicrobial Activity of Gallium Maltolate Against Staphylococcus Aureus and Methicillin-resistant Saureus and Staphylococcus Pseudintermedius: An in Vitro Study[J]. Veterinary Microbiology,2012,155(2/4) :389-394.
[42] 吕毅华, 李昕, 刘周,等.镓在抗菌方面的研究进展[J]. 中国抗生素杂志, 2018, 43(4). LYU Y H,LI X, LIU Z,et al. Antimicrobial activity of gallium[J].Chinese Journal of Antibiotics,2018, 43(4).
[43] XU Z, ZHAO X, CHEN X, et al. Antimicrobial Effect of Gallium Nitrate Against Bacteria Encountered in Burn Wound Infections[J]. Rsc Advances, 2017, 7(82):52 266-52 273.
[44] GOODLEY P H, ROGOSNITZKY M. The Effect of Gallium Nitrate on Arresting Blood Flow from a Wound[J]. Case Reports in Medicine,2011,(2011-05-17), 2011, 2011(5):819710.
[45] ROGOSNITZKY M. Method of Wound Treatment Using Liquid Gallium Nitrate[J]. 2011.
[46] BAUTERS A, HOLT D J, ZERBIB P, et al. Gallium nitrate induces fibrinogen flocculation: an explanation for Its Hemostatic Effect?[J]. Biometals, 2013, 26(6):935-939.
[47] POURSHAHRESTANI S, ZEIMARAN E, KADRI N A, et al. Gallium-containing Mesoporous Bioactive Glass with Potent Hemostatic Activity and Antibacterial Efficacy[J]. Journal of Materials Chemistry B, 2015, 4(1):71-86.
[48] POURSHAHRESTANI S, KADRI N, ZEIMARAN E, et al. Comparative Efficacy of Hemorrhage Control of a Novel Mesoporous Bioactive Glass Versus Two Commercial Hemostats[J]. Biomedical Materials, 2017, 13(2).
[49] POURSHAHRESTANI S, ZEIMARAN E, KADRI N A, et al. Potency and Cytotoxicity of a Novel Gallium-containing Mesoporous Bioactive Glass/Chitosan Composite Scaffold as Hemostatic Agents[J]. Acs Applied Materials & Interfaces, 2017, 9(37).
[2] LITTLEJOHN L, BENNETT B L, DREW B. Application of Current Hemorrhage Control Techniques for Backcountry Care: Part Two, Hemostatic Dressings and Other Adjuncts[J]. Wilderness Environ Med, 2015, 26(2):246-254.
[3] RHEE P, BROWN C, MARTIN M, et al. QuikClot Use in Trauma for Hemorrhage Control: Case Series of 103 Documented Uses [J]. Journal of Trauma & Acute Care Surgery, 2008, 64(4):1 093-1 099.
[4] MCMANUS J, HURTADO T, PUSATERI A, et al. A Case Series Describing Thermal Injury Resulting from Zeolite Use for Hemorrhage Control in Combat Operations[J]. Prehospital Emergency Care, 2007, 11(1):67-71.
[5] WRIGHT J K, KALNS J, WOLF E A, et al. Thermal Injury Resulting from Application of a Granular Mineral Hemostatic Agent[J]. Journal of Trauma, 2004, 57(2):224-30.
[6] PLURAD D, CHANDRASOMA S, BEST C, et al. A Complication of Intracorporeal Use of QuikClot for Pelvic Hemorrhage[J]. Journal of Trauma, 2009, 66(5):1 482.
[7] KHEIRABADI B S, MACE J E, TERRAZAS I B, et al. Safety Evaluation of New Hemostatic Agents, Smectite Granules, and Kaolin-coated Gauze in a Vascular Injury Wound Model in Swine[J]. Journal of Trauma, 2010, 68(2):269-278.
[8] KHEIRABADI B S, EDENS J W, TERRAZAS I B, et al. Comparison of New Hemostatic Granules/Powders with Currently Deployed Hemostatic Products in a Lethal Model of Extremity Arterial Hemorrhage in Swine[J]. Journal of Trauma & Acute Care Surgery, 2009, 66(2):316-326.
[9] 李钒, 田丰, 刘长军,等.急救止血材料的研究进展[J]. 材料导报, 2013, 27(3):70-73. LI F,TIAN F,LIUC J,et al. Advance in Emergengcy Hemostatic Materials[J].Materials Review, 2013, 27(3):70-73.
[10] 李晓生, 刘昌胜, 袁媛,等.介孔硅基干凝胶的制备及其止血性能的研究[J]. 无机材料学报, 2008, 23(2):327-331. LI X S,LIU C S,YUAN Y,et al. Preparation and Hemostatic Properties of Mesoporous Silica-based Xerogels[J].Journal of Inorganic Materials,2008, 23(2):327-331.
[11] 韦良, 赵燕熹, 向勇, 等.大孔径高比表面积介孔硅泡沫的制备和表征[J]. 武汉理工大学学报, 2013, 35(6):34-38. WEIL,ZHAO Y X,XIANG Y,et al. Preparation and Characterization of Mesocelluar Silia Foam with Large Pore Size znd High Surface Area[J].Journal of Wuhan University of Technology,2013, 35(6):34-38.
[12] NANDIYANTO A B D . Synthesis of Spherical Mesoporous Silica Nanoparticles with Nanometer-size Controllable Pores and Outer Diameters[J]. Microporous & Mesoporous Materials, 2009, 120(3):447-453.
[13] MILLER L, WINTER G, BAUR B, et al. Synthesis, Characterization, and Biodistribution of Multiple 89Zr-labeled Pore-expanded Mesoporous Silica Nanoparticles for PET [J]. Nanoscale, 2014, 6(9): 4 928-4 935.
[14] SUN J, ZHANG H, TIAN R, et al. Ultrafast Enzyme Immobilization over Large-pore Nanoscale Mesoporous Silica Nanoparticles [J]. Chemical Communications, 2006, 12(12): 1 322-1 324.
[15] YANG Y, KARMAKAR S, ZHANG J, et al. Synthesis of SBA-15 Rods with Small Sizes for Enhanced Cellular Uptake [J]. Journal of Materials Chemistry B, 2014, 2(30): 4 929-4 934.
[16] ANAND A, LALZAWMLIANA V, KUMAR V, et al. Preparation and in Vivo Biocompatibility Studies of Different Mesoporous Bioactive Glasses[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2019, 89:89-98.
[17] LI X, DONG S X. A Mesoporous Bioactive Glass/Polycaprolactone Composite Scaffold and Its Bioactivity Behavior[J]. Journal of Biomedical Materials Research Part A, 2010, 84A(1):84-91.
[18] CLAY J G, GRAYSON J K, ZIEROLD D. Comparative Testing of New Hemostatic Agents in a Swine Model of Extremity Arterial and Venous Hemorrhage[J]. Military Medicine, 2010, 175(4):280-4.
[19] KHEIRABADI B S, EDENS J W, TERRAZAS I B, et al. Comparison of New Hemostatic Granules/Powders with Currently Deployed Hemostatic Products in a Lethal Model of Extremity Arterial Hemorrhage in Swine[J]. Journal of Trauma & Acute Care Surgery, 2009, 66(2):316-326.
[20] LITTLEJOHN L F, DEVLIN J J, KIRCHER S S, et al. Comparison of Celox-A, ChitoFlex, WoundStat, and Combat Gauze Hemostatic Agents Versus Standard Gauze Dressing in Control of Hemorrhage in a Swine Model of Penetrating Trauma[J]. Wilderness & Environmental Medicine, 2011, 21(1):69-69.
[21] 王立群, 徐磊, 王树伟,等.介孔二氧化硅微球的淀粉复合止血敷料[J]. 中国组织工程研究, 2011, 15(29):5 379-5 383. WANG L Q, X L, WANG S W, et al. Mesoporous Silicon Dioxide Microsphere/Staech Composite Hemostatic Dressing[J]. Journal of Clinical Rehabilitative Tissue Engineering Research,2011, 15(29):5 379-5 383.
[22] DAI C, YUAN Y, LIU C, et al. Degradable, Antibacterial Silver Exchanged Mesoporous Silica Spheres for Hemorrhage Control[J]. Biomaterials, 2009, 30(29):5 364-5 375.
[23] PARK J U, JUNG H D, SONG E H, et al. The Accelerating Effect of Chitosan-silica Hybrid Dressing Materials on the Early Phase of Wound Healing[J]. Journal of Biome-dical Materials Research Part B Applied Biomaterials, 2016, 105(7):1 828-1 839.
[24] DAI C, LIU C, WEI J, et al. Molecular Imprinted Macroporous Chitosan Coated Mesoporous Silica Xerogels for Hemorrhage Control[J]. Biomaterials, 2010, 31(30):7 620-7 630.
[25] 贾天保.介孔生物活性玻璃/壳聚糖止血材料的制备及研究[D]. 浙江理工大学, 2012.
[26] ARNAUD F, TERANISHI K, OKADA T, et al. Comparison of Combat Gauze and TraumaStat in Two Severe Groin Injury Models[J]. Journal of Surgical Research, 2011, 169(1):92-98.
[27] SAMBASIVAN C N, CHO S D , ZINK K A , et al. A Highly Porous Silica and Chitosan-based Hemostatic Dressing Is Superior in Controlling Hemorrhage in a Severe Groin Injury Model in Swine[J]. The American Journal of Surgery, 2009, 197(5):576-580.
[28] ENGLEHART M S , CHO S D , TIEU B H , et al. A Novel Highly Porous Silica and Chitosan-Based Hemostatic Dressing Is Superior to HemCon and Gauze Sponges[J]. The Journal of Trauma: Injury, Infection, and Critical Care, 2008, 65(4):884-892.
[29] CHEN Z H, HAN L,FAN L ,et al. A rapid Hemostatic Sponge Based on Large, Mesoporous Silica Nanoparticles and N-alkylated Chitosan[J]. Nanoscale, 2018, 10(43):20 234-20 245.
[30] HILLIS G R, YI C J, AMRANI D L, et al. Evaluation of NuStat, a Novel Nonimpregnated Hemostatic Dres-sing, Compared With Combat Gauze in Severe Traumatic Porcine Hemorrhage Model[J]. Journal of Special Operations Medicine A Peer Reviewed Journal for Sof Medical Professionals, 2014, 14(14):41-47.
[31] TANSAZ S, SCHULTE M, KNESER U, et al. Soy Protein Isolate/Bioactive Glass Composite Membranes: Processing and Properties[J]. European Polymer Journal, 2018:S0014305718305500-.
[32] 李静静, 朱海霖, 雷彩虹,等.介孔生物玻璃/丝素蛋白复合多孔海绵的结构及止血性能研究[J]. 功能材料, 2017, 48(2):2 096-2 101. LI J J,ZHU H L,LEI C H, et al. Study on Structure and Hemoststic Property of Mesoporous Bioglass/Silk Fibroin Composite Sponge[J].Journal of Functional Materials,2017, 48(2):2 096-2 101.
[33] ZHOU, H Y, WANG C W.A Novel Droplet-Fabricated Mesoporous Silica-Based Nanohybrid Granules for Hemorrhage Control[J].Journal of Biomedical Nanotechnology, 2018, 14(4): 649-661.
[34] LI D, NIE W, CHEN L, et al. Fabrication of Curcumin-loaded Mesoporous Silica Incorporated Polyvinyl Pyrrolidone Nanofibers for Rapid Hemostasis and Antibacterial Treatment[J]. RSC Adv, 2017, 7(13):7 973-7 982.
[35] WANG C W,ZHOU H Y, NIU H Y,et al. Tannic Acid-loaded Mesoporous Silica for Rapid Hemostasis and Antibacterial Activity[J].Biomater Sci, 2018,6(12): 3 318-3 331.
[36] AMBROGI V, DONNADIO A, PIETRELLA D .Chitosan Films Containing Mesoporous SBA-15 Supported Silver Nanoparticles for Wound Dressing[J].Journal of Materials,2014(2):6 054-6 063.
[37] NIE W, DAI X Y, LI D J, et al. One-Pot Synthesis of Silver Nanoparticle Incorporated Mesoporous Silica Granules for Hemorrhage Control and Antibacterial Treatment[J].ACS Biomater Sci Eng, 2018, 4 (10) :3 588-3 599.
[38] LU M M, BAI J, SHAO D, et al. Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure[J]. International Journal of Nanomedicine, 2018, Volume 13:5 849-5 863.
[39] 陈于, 李文锐, 徐灿,等.掺杂钙银介孔氧化硅凝胶抗菌止血材料的研究[J]. 无机材料学报, 2012, 27(5):513-518. CHEN YU,LI WEN-RUI,XU CAN,et al.Study on Hemostatic Materials of Mesoporous Silicon Dioxide Ca and Ag with Antibacterial Properties[J].Journal of inorganic materials,2012, 27(5):513-518.
[40] ZEIMARAN E, POURSHAHRESTANI S, DJORDJEVIC I, et al. Bioactive glass reinforced elastomer composites for skeletal regeneration: A review[J]. Materials Science & Engineering C, 2015, 53:175-188.
[41] ARNOLD C, LAWHON S D. Antimicrobial Activity of Gallium Maltolate Against Staphylococcus Aureus and Methicillin-resistant Saureus and Staphylococcus Pseudintermedius: An in Vitro Study[J]. Veterinary Microbiology,2012,155(2/4) :389-394.
[42] 吕毅华, 李昕, 刘周,等.镓在抗菌方面的研究进展[J]. 中国抗生素杂志, 2018, 43(4). LYU Y H,LI X, LIU Z,et al. Antimicrobial activity of gallium[J].Chinese Journal of Antibiotics,2018, 43(4).
[43] XU Z, ZHAO X, CHEN X, et al. Antimicrobial Effect of Gallium Nitrate Against Bacteria Encountered in Burn Wound Infections[J]. Rsc Advances, 2017, 7(82):52 266-52 273.
[44] GOODLEY P H, ROGOSNITZKY M. The Effect of Gallium Nitrate on Arresting Blood Flow from a Wound[J]. Case Reports in Medicine,2011,(2011-05-17), 2011, 2011(5):819710.
[45] ROGOSNITZKY M. Method of Wound Treatment Using Liquid Gallium Nitrate[J]. 2011.
[46] BAUTERS A, HOLT D J, ZERBIB P, et al. Gallium nitrate induces fibrinogen flocculation: an explanation for Its Hemostatic Effect?[J]. Biometals, 2013, 26(6):935-939.
[47] POURSHAHRESTANI S, ZEIMARAN E, KADRI N A, et al. Gallium-containing Mesoporous Bioactive Glass with Potent Hemostatic Activity and Antibacterial Efficacy[J]. Journal of Materials Chemistry B, 2015, 4(1):71-86.
[48] POURSHAHRESTANI S, KADRI N, ZEIMARAN E, et al. Comparative Efficacy of Hemorrhage Control of a Novel Mesoporous Bioactive Glass Versus Two Commercial Hemostats[J]. Biomedical Materials, 2017, 13(2).
[49] POURSHAHRESTANI S, ZEIMARAN E, KADRI N A, et al. Potency and Cytotoxicity of a Novel Gallium-containing Mesoporous Bioactive Glass/Chitosan Composite Scaffold as Hemostatic Agents[J]. Acs Applied Materials & Interfaces, 2017, 9(37).