益生菌调节由抗生素导致肠道菌群失衡的研究进展
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摘要
就益生菌改善肠道菌群失衡、抑制有害菌生长及调节抗生素引起的肠道相关疾病及机理等方面进行了综述,包括益生菌调节由抗生素导致肠道菌群失衡问题,以及益生菌治疗由抗生素使用不当引起的疾病:包括抗生素相关腹泻、儿童肥胖、肠易激综合征。
The probiotics improve the intestinal flora imbalance, inhibit the growth of harmful bacteria and regulate the intestinal-related diseases and mechanisms caused by antibiotics, including probiotics regulating the imbalance of intestinal flora caused by antibiotics, and the treart ment of probiotics. Diseases caused by improper use of antibiotics: including antibiotic-associated diarrhea, childhood obesity, and irritable bowel syndrome.
The probiotics improve the intestinal flora imbalance, inhibit the growth of harmful bacteria and regulate the intestinal-related diseases and mechanisms caused by antibiotics, including probiotics regulating the imbalance of intestinal flora caused by antibiotics, and the treart ment of probiotics. Diseases caused by improper use of antibiotics: including antibiotic-associated diarrhea, childhood obesity, and irritable bowel syndrome.
引文
[1]杨兵,付雪琼,彭颂兴,等.益生菌预防抗生素相关性菌群失调的临床研究[J].临床医药实践,2014,23(9):658-660.
[2]郭抗萧,尹抗抗,王欢,等.抗生素对小鼠菌群失调腹泻肠道菌群多样性的影响[J].中国微生态学杂志,2014, 26(3):249-257.
[3]ZHANG L, QIAO M, LIANG Q H, et al. Protective effect of Lactobacillus rhamnosus GG on the damage of gut barrier function in SD rats with antibiotics induced diarrhea[J]. Chinese Journal of Microecology, 2011, 23(1):38-48.
[4]黄文献,王和平,王玉蕾,等.高通量测序检测肺炎婴幼儿抗生素治疗前后肠道菌群变化[J].中国微生态学杂志,2016, 28(5):497-500.
[5]孟艳鸽,李岩.不同剂量长双歧杆菌对抗生素诱导大鼠肠道菌群失调的疗效现察[J].中国微生态学杂志,2015, 27(3):280-283.
[6]杨兵,付雪琼,彭颂兴等.益生菌预防抗生素相关性菌群失调的临床研究[J].临床医药实践,2014,(9):658-660.
[7]TIAN P, XU B, AN G, et al. A new therapies for intestinal flora imbalance used ampicillin resistant probiotics.[J]. J Microbiol Biotechnol,2014.
[8]SHIEH M J, SHANG H, LIAO F H, et al. Lactobacillus fermenturm improved intestinal bacteria flora by reducing Clostridium perfringens[J]. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, 2011, 6(2):e59-e63.
[9]XIE C H, YUAN J, WANG P J, et al. Effect of lactobacillus acidophilus on disordered intestinal flora of mice introduced by antibiotics[J].Parenteral&Enteral Nutrition, 2007, 14(3):132-136.
[10]王瑾,刘静,杨丽杰.益生菌对抗生素性肠道菌群失衡的调节作用[J].中国乳品工业,2010, 38(11):15-17.
[11]谢强,李孟孟,王文策,等.益生菌对家禽肠道翅生态的调控及其应用[J].饲料研究,2017(2):30-36.
[12]郭芹,王安如,苏华荔.益生菌与肠黏膜互作的分子机制研究进展[J].中国微生态学杂志,2014, 26(3):351-353.
[13]吴利先,王国富,高峰.两歧双歧杆菌抗福氏痢疾杆菌感染的机制研究[J].大理大学学报,2010,09(6):16-18.
[14]翁志英,操寄望,罗和生.双歧杆菌对大鼠溃疡性结肠炎黏膜MMP-2、NF-κB激活的影响[J].武汉大学学报(医学版),2006, 27(6):699-702.
[15]YANG X, GAO X C, LIU J, et al. Effect of SPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll like receptor 2 and toll like receptor 4 expression in intestinal epithelial cell-18[J]. world Journal of Gastroenterology, 2017, 23(26):4744 4751.
[16]JINLAN L. Effects of Changlekang on intestinal microbiota and intestinal mucosal barrier function it patients with HBV-induced cirrhosis[J]. Chinese Journal of Microecology, 2017.
[17]ZAMFIP. M, GROSUTUDOP S. Impact of stress conditions on the growth of Lactobacillus acidophilus IBB 801 and production of acidophilin 801.[J]. Journal of General&Applied Microbiology, 2009,55(4):277-282.
[18]RERKSUPPAPHOL S, RERKSUPPAPHOL L. Lactobacillus acidoplilis and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea[J]. Annals of Tropical Paediatrics, 2010, 30(4):299-304.
[19]METSALA J, LUNDQVIST A, VIRTA L J, et al. Prenatal and post-natal exposure to antibiotics and risk of asthma in childhood.[J]. Clinical&Experimental Allergy Journal of the British Society for Allergy&Clinical Immunology, 2015, 45(1):137-145.
[20]SAARI A, VIRTA L J, SANKILAMPI U, et al. Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life[J]. Pediatrics, 2015, 135(4):617-626.
[21]UNGAIRO R, BERNSTEIN C N, GEARRY R, et al. Antibiotics Associated With Increased Risk of New-Onset Crohn|[rsquo]|s Disease But Not Ulcerative Colitis:A Meta-Analysis[J]. American Journal of Gastroenterology, 2014, 109(11):1728-1738.
[22]ETTORRE G D, ROSSI G, SCAGNOLARI C. Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitorhondrial morphology in ART-treated HIV-1-positive patients.[J]. Immunity, Inflammation and Disease,5,3(2017-04-20),2017, 5(3):244-260.
[23]李宁,田宏亮,马春联,等.菌群移植治疗肠道疾病406例疗效分析[J].中华胃肠外科杂志,2017, 20(1):40-46.
[24]DAI C, JIANG M, SUN M J. Probiotics in gastrointestinal tract and related diseases[J]. Monatsschrift Kinderheilkunde, 2014, 121(2):76-78.
[25]高怀信.抗生素相关性结肠炎伴发溃疡性结肠炎临床分析[J].中国保健营养,2016, 26(22):193-19.
[26]周雪艳.抗生素相关件腹泻的发病机制[J].中国微生态学杂志,2004, 16(6):376-377.
[27]BARTLETT JG. Antibiotic-associated diarrhea. N Engl J Med.2002; 346(5):334-339.
[28]SUARDI E, CRIPPA F, MONFORTE A D. Probiotics in the prevention of antibiotic-Associated diarrhea in adults[J]. International Journal of Probiotics&Prebiotics, 2013, 8(1):41-44.
[29]李玓嬗,王惠吉,谭漫红,等.益生菌制剂预防老年患者抗生素相关性腹泻[J].胃肠病学,2010, 15(3):154-156,
[30]JOHNSTON B C, SUPLNA A L, VOHRA S. Probiotics for pediatric antibiotic-associated diarrhea:a rmeta-analysis of randomized placebo-controlled trials[J].Cmaj Canadian Medical Association Journal, 2006, 175(175):377-383.
[31]FRIEDMAN G. The Role of Probiotics in the Prevention and Treatment of Antibiotic-Associated Diarrhea and Clostridium Difficile Colitis[J]. Gastroenterology Clinics of North America, 2012, 41(4):763-779.
[32]PATTANI R, PALDA V A, HWANG S W, et al. Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients:systematic review and metaanalysis.[J]. Open Medicine, 2013, 7(2):e56-e67.
[33]MORROW LE, GOGINENI V, MALESKER MA. Probiotics in the intensive care unit. Nutr Clin Pract. 2012;27(2):235-241.
[34]D'SOUZA A L. Probiotics in prevention of antibiotic associated diarrhoea:meta-analysis.[J]. Bmj British Medical Journal, 2003, 324(7350):1361.
[35]周庆民,李桂伟,冯万宇等.猪肠道益生菌的种类及生理功能[J].中国猪业,2010,07:57.
[36]SHERMAN PM, JOHNSON-HENRY KC, YEUNG HP, et al.Probiotics reduce enterohemorrhagic escherichia coli 0157:H7 and enteropathogenic E.coli 0127:H6-induced changes in polarized T84 epithelial cell monolayers by reducing bacterial adhesion and cytoskeletal rearrangements. Infect Immun. 2005;73(8):5183-5188.
[37]单丽沈,侯萍,王植嘉等.布拉氏酵母菌散剂防治小儿急性支气管肺炎抗生素相关性腹泻的疗效分析[J].中国医科大学学报,2014,(01):55-58.
[38]HE J, CHEN W, WU H, et al, et al. Downregulation of BCSG1may correlate with better outcome of neoadjuvant chemotherapy for triple-negative breast cancer[J]. Oncology letters, 2012, 4(6):1209-1212.
[39]EHRHARDT S, GUO N, HINZ R, et al. Saccharomyces boulardii to prevent antibiotic-associated diarrhea:randomized, doublemasked, placebo-controlled trial[J]. Open Forum Infectious Diseases,2016, 3(1):ofw011.
[40]BAILEY L C, FORREST C B, ZHANG P, et al. Association of antibiotics in infancy with early childhood obesity[J]. Jama Pediatrics,2014, 168(11):1063.
[41]MUELLER N T, WHY ATT R, HOEPNER L, et al. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity[J].Int J Obes,2015, 39(4):665-670.
[42]PRINCIPI N, ESPOSITO S. Antibiotic administration and the development of obesity in children[J]. Int J Antimicrob Agents, 2016,47(3):171-177.
[43]MEKKES M C, WEENEN T C, BRUMMER R J, et al. The development of probiotic treatment in obesity:a review[J]. Beneficial Microbes, 2014, 5(1):19-28.
[44]LUOTO R, KALLIOMKI M, LAITINEN K, et al. The impact ofperinatal probiotic intervention on the development of overweight and obesity:follow-up study from birth to 10 years.[J]. International Journal of Obesity, 2010, 34(10):1531.
[45]KAJANDER K, HATAKKA K, POUSSA T, et al. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients:a controlled 6-month intervention.[J]. Alimentary Pharmacology&Therapeutics, 2005, 22(5):387-394.
[46]KULSTAD E, KELLEY K, RZECHULA K. Clinical trial:multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota[J]. Alimentary Pharmacology&Therapeutics,2008, 27(1):48-57.
[2]郭抗萧,尹抗抗,王欢,等.抗生素对小鼠菌群失调腹泻肠道菌群多样性的影响[J].中国微生态学杂志,2014, 26(3):249-257.
[3]ZHANG L, QIAO M, LIANG Q H, et al. Protective effect of Lactobacillus rhamnosus GG on the damage of gut barrier function in SD rats with antibiotics induced diarrhea[J]. Chinese Journal of Microecology, 2011, 23(1):38-48.
[4]黄文献,王和平,王玉蕾,等.高通量测序检测肺炎婴幼儿抗生素治疗前后肠道菌群变化[J].中国微生态学杂志,2016, 28(5):497-500.
[5]孟艳鸽,李岩.不同剂量长双歧杆菌对抗生素诱导大鼠肠道菌群失调的疗效现察[J].中国微生态学杂志,2015, 27(3):280-283.
[6]杨兵,付雪琼,彭颂兴等.益生菌预防抗生素相关性菌群失调的临床研究[J].临床医药实践,2014,(9):658-660.
[7]TIAN P, XU B, AN G, et al. A new therapies for intestinal flora imbalance used ampicillin resistant probiotics.[J]. J Microbiol Biotechnol,2014.
[8]SHIEH M J, SHANG H, LIAO F H, et al. Lactobacillus fermenturm improved intestinal bacteria flora by reducing Clostridium perfringens[J]. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, 2011, 6(2):e59-e63.
[9]XIE C H, YUAN J, WANG P J, et al. Effect of lactobacillus acidophilus on disordered intestinal flora of mice introduced by antibiotics[J].Parenteral&Enteral Nutrition, 2007, 14(3):132-136.
[10]王瑾,刘静,杨丽杰.益生菌对抗生素性肠道菌群失衡的调节作用[J].中国乳品工业,2010, 38(11):15-17.
[11]谢强,李孟孟,王文策,等.益生菌对家禽肠道翅生态的调控及其应用[J].饲料研究,2017(2):30-36.
[12]郭芹,王安如,苏华荔.益生菌与肠黏膜互作的分子机制研究进展[J].中国微生态学杂志,2014, 26(3):351-353.
[13]吴利先,王国富,高峰.两歧双歧杆菌抗福氏痢疾杆菌感染的机制研究[J].大理大学学报,2010,09(6):16-18.
[14]翁志英,操寄望,罗和生.双歧杆菌对大鼠溃疡性结肠炎黏膜MMP-2、NF-κB激活的影响[J].武汉大学学报(医学版),2006, 27(6):699-702.
[15]YANG X, GAO X C, LIU J, et al. Effect of SPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll like receptor 2 and toll like receptor 4 expression in intestinal epithelial cell-18[J]. world Journal of Gastroenterology, 2017, 23(26):4744 4751.
[16]JINLAN L. Effects of Changlekang on intestinal microbiota and intestinal mucosal barrier function it patients with HBV-induced cirrhosis[J]. Chinese Journal of Microecology, 2017.
[17]ZAMFIP. M, GROSUTUDOP S. Impact of stress conditions on the growth of Lactobacillus acidophilus IBB 801 and production of acidophilin 801.[J]. Journal of General&Applied Microbiology, 2009,55(4):277-282.
[18]RERKSUPPAPHOL S, RERKSUPPAPHOL L. Lactobacillus acidoplilis and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea[J]. Annals of Tropical Paediatrics, 2010, 30(4):299-304.
[19]METSALA J, LUNDQVIST A, VIRTA L J, et al. Prenatal and post-natal exposure to antibiotics and risk of asthma in childhood.[J]. Clinical&Experimental Allergy Journal of the British Society for Allergy&Clinical Immunology, 2015, 45(1):137-145.
[20]SAARI A, VIRTA L J, SANKILAMPI U, et al. Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life[J]. Pediatrics, 2015, 135(4):617-626.
[21]UNGAIRO R, BERNSTEIN C N, GEARRY R, et al. Antibiotics Associated With Increased Risk of New-Onset Crohn|[rsquo]|s Disease But Not Ulcerative Colitis:A Meta-Analysis[J]. American Journal of Gastroenterology, 2014, 109(11):1728-1738.
[22]ETTORRE G D, ROSSI G, SCAGNOLARI C. Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitorhondrial morphology in ART-treated HIV-1-positive patients.[J]. Immunity, Inflammation and Disease,5,3(2017-04-20),2017, 5(3):244-260.
[23]李宁,田宏亮,马春联,等.菌群移植治疗肠道疾病406例疗效分析[J].中华胃肠外科杂志,2017, 20(1):40-46.
[24]DAI C, JIANG M, SUN M J. Probiotics in gastrointestinal tract and related diseases[J]. Monatsschrift Kinderheilkunde, 2014, 121(2):76-78.
[25]高怀信.抗生素相关性结肠炎伴发溃疡性结肠炎临床分析[J].中国保健营养,2016, 26(22):193-19.
[26]周雪艳.抗生素相关件腹泻的发病机制[J].中国微生态学杂志,2004, 16(6):376-377.
[27]BARTLETT JG. Antibiotic-associated diarrhea. N Engl J Med.2002; 346(5):334-339.
[28]SUARDI E, CRIPPA F, MONFORTE A D. Probiotics in the prevention of antibiotic-Associated diarrhea in adults[J]. International Journal of Probiotics&Prebiotics, 2013, 8(1):41-44.
[29]李玓嬗,王惠吉,谭漫红,等.益生菌制剂预防老年患者抗生素相关性腹泻[J].胃肠病学,2010, 15(3):154-156,
[30]JOHNSTON B C, SUPLNA A L, VOHRA S. Probiotics for pediatric antibiotic-associated diarrhea:a rmeta-analysis of randomized placebo-controlled trials[J].Cmaj Canadian Medical Association Journal, 2006, 175(175):377-383.
[31]FRIEDMAN G. The Role of Probiotics in the Prevention and Treatment of Antibiotic-Associated Diarrhea and Clostridium Difficile Colitis[J]. Gastroenterology Clinics of North America, 2012, 41(4):763-779.
[32]PATTANI R, PALDA V A, HWANG S W, et al. Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients:systematic review and metaanalysis.[J]. Open Medicine, 2013, 7(2):e56-e67.
[33]MORROW LE, GOGINENI V, MALESKER MA. Probiotics in the intensive care unit. Nutr Clin Pract. 2012;27(2):235-241.
[34]D'SOUZA A L. Probiotics in prevention of antibiotic associated diarrhoea:meta-analysis.[J]. Bmj British Medical Journal, 2003, 324(7350):1361.
[35]周庆民,李桂伟,冯万宇等.猪肠道益生菌的种类及生理功能[J].中国猪业,2010,07:57.
[36]SHERMAN PM, JOHNSON-HENRY KC, YEUNG HP, et al.Probiotics reduce enterohemorrhagic escherichia coli 0157:H7 and enteropathogenic E.coli 0127:H6-induced changes in polarized T84 epithelial cell monolayers by reducing bacterial adhesion and cytoskeletal rearrangements. Infect Immun. 2005;73(8):5183-5188.
[37]单丽沈,侯萍,王植嘉等.布拉氏酵母菌散剂防治小儿急性支气管肺炎抗生素相关性腹泻的疗效分析[J].中国医科大学学报,2014,(01):55-58.
[38]HE J, CHEN W, WU H, et al, et al. Downregulation of BCSG1may correlate with better outcome of neoadjuvant chemotherapy for triple-negative breast cancer[J]. Oncology letters, 2012, 4(6):1209-1212.
[39]EHRHARDT S, GUO N, HINZ R, et al. Saccharomyces boulardii to prevent antibiotic-associated diarrhea:randomized, doublemasked, placebo-controlled trial[J]. Open Forum Infectious Diseases,2016, 3(1):ofw011.
[40]BAILEY L C, FORREST C B, ZHANG P, et al. Association of antibiotics in infancy with early childhood obesity[J]. Jama Pediatrics,2014, 168(11):1063.
[41]MUELLER N T, WHY ATT R, HOEPNER L, et al. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity[J].Int J Obes,2015, 39(4):665-670.
[42]PRINCIPI N, ESPOSITO S. Antibiotic administration and the development of obesity in children[J]. Int J Antimicrob Agents, 2016,47(3):171-177.
[43]MEKKES M C, WEENEN T C, BRUMMER R J, et al. The development of probiotic treatment in obesity:a review[J]. Beneficial Microbes, 2014, 5(1):19-28.
[44]LUOTO R, KALLIOMKI M, LAITINEN K, et al. The impact ofperinatal probiotic intervention on the development of overweight and obesity:follow-up study from birth to 10 years.[J]. International Journal of Obesity, 2010, 34(10):1531.
[45]KAJANDER K, HATAKKA K, POUSSA T, et al. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients:a controlled 6-month intervention.[J]. Alimentary Pharmacology&Therapeutics, 2005, 22(5):387-394.
[46]KULSTAD E, KELLEY K, RZECHULA K. Clinical trial:multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota[J]. Alimentary Pharmacology&Therapeutics,2008, 27(1):48-57.