中药单体逆转大肠癌多药耐药的研究进展
摘要
多药耐药是大肠癌治疗的主要障碍之一,也是造成大肠癌高死亡率的重要因素。目前,中药逆转肿瘤多药耐药的作用被越来越多的人接受认可。本文对近年来中药单体逆转大肠癌多药耐药的研究进行总结,为中医药抗肿瘤的创新与发展提供新依据。
引文
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[3] Balaji S A,Udupa N,Chamallamudi M R,et al. Role of the drug transporter ABCC3 in breast cancer chemoresistance[J].PLoS One,2016,11(5):e0155013.
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[5] Kibria G,Hatakeyama H,Harsshima H. Cancer multidrug resistance:mechanisms involved and strategies for circumvention using a drug delivery system[J]. Arch Pharm Res,2014,37(1):4-15.
[6] Pramanik D,Campbel N R,Das S,et al. A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy[J]. Oncotarget,2012,3(6):640-650.
[7] Ward A B,Szewczyk P,Grimard V,et al. Structures of Pglycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain[J]. Proc Natl Acad Sci USA,2013,110(33):13386-13391.
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[9] Scheffer G L,Schroeijers A B,Izquierdo M A,et al. Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer[J]. Curr Opin Oncol,2000,12(6):550-556.
[10] Wang W J,Wang M Y,Wu N. Expression and research of Pgp and GST-πin breast Cancer[J]. Chin J Geronto,2008,28(9):893-894.
[11] Xie H Q,Xu X H,Ke M Y. A study on the expression of multidrug resistance-associated protein genes in lung cancer tissues and other malignant tumor[J]. Pract J Cancer,2010,25(2):150-152.
[12]安海莲,金仁顺. TopoⅡ及GST-π在胃癌和结直肠癌中的表达及其临床意义[J].现代肿瘤医学,2014,22(6):1369-1372.
[13] Cantero G,Campanella C,Mateos S,et al. TopoisomeraseⅡinhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin[J]. Mutagenesis,2006,21(5):321-325.
[14]檀碧波,李勇,韩杰,等.胃、大肠癌COX-2和多药耐药相关因子表达与体外化疗药敏性的关系及意义[J].四川大学学报(医学版),2010,41(1):128-131.
[15] Knauer S K, Unruhe B, Karczewski S, et al. Functional characterization of novel mutations affecting survivin(BIRC5)-mediated therapy resistance in head and neck cancer patients[J]. Hum Mutat,2013,34(2):395-404.
[16] Goldsmith K C,Gross M,Peirce S,et al. Mitochondrial Bcl-2family dynamics define therapy response and resistance in neuroblastoma[J]. Cancer Res,2012,72(10):2565-2577.
[17] Leeman-Neill R J,Cai Q,Joyce S C,et al. Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors[J].Clin Cancer Res,2010,16(9):2571-2579.
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[22]田文娴,李芳,岳银艳,等. HMGB1调节自噬诱导肿瘤细胞化疗耐药的研究进展[J].河南医学研究,2016,25(2):256-258.
[23]钟自强,黄桂柳,黄赞松,等.苦参素逆转结肠癌细胞多药耐药作用及机制研究[J].右江民族医学院学报,2017,39(1):17-21.
[24]张冬梅,张雅明.虎杖苷逆转人结肠癌细胞株HT-29奥沙利铂耐药性及机制[J].现代肿瘤医学,2016,24(16):2505-2508.
[25]靳祎祎,李琼瑜,赖子君,等.白花蛇舌草通过调控Hedgehog通路增加大肠癌耐药细胞的药物蓄积研究[J].康复学报,2016,26(3):34-39.
[26] Li Q Y,Wang X F,Shen A L,et al. Hedyotis diffusa willd overcomes 5-fluorouracil resistance in human colorectal cancer HCT-8/5-FU cells by downregulating the expression of P-glycoprotein and ATP-binding casette subfamily G member 2[J].Exp Ther Med,2015,10(5):1845-1850.
[27] Hu T,Cao Z X. The potential of therapeutic application of tanshinones in reversing multidrug resistance in colon cancer cells[J]. Chin J Pharmacol Toxicol,2015,29(Suppl 1):8.
[28]卢伟东,傅仲学,覃勇,等.姜黄素逆转结肠癌裸鼠移植瘤多药耐药的研究[J].第三军医大学学报,2011,33(4):376-380.
[29]王开雷,李乐平,靖昌庆,等.短发夹RNA干扰质粒与粉防己碱对结肠癌耐药细胞多药耐药性的逆转作用[J].中华消化外科杂志,2011,10(6):452-455.
[30]李彩丽,成丹,孙泽群,等.槲皮素逆转结肠癌耐药细胞SW480/OXP耐药性研究[J].胃肠病学和肝病学杂志,2017,26(5):551-554.
[31]金秀东,徐秋玲,王晓东,等.复方五味子素B逆转人结肠癌细胞THC-8307/OXA多药耐药性机制研究[J].中国现代医学杂志,2011,21(20):2384-2387,2391.
[32]李贺,李雷. GSTP1蛋白质低表达与姜黄素逆转结肠癌细胞多药耐药的关系[J].中华医学杂志,2015,95(30):2478-2482.
[33]吴汪泽,王卉,卢忠心.黄芩苷对结肠癌细胞迁移与侵袭能力的抑制作用及其机制研究[J].现代预防医学,2016,43(4):708-710,726.
[34] Liu Z,Duan Z J,Chang J Y,et al. Sinomenine sensitizes multidrug-resistant colon cancer cells(Caco-2)to doxorubicin by downregulation of MDR-1 expression[J]. PLoS One,2014,9(6):e98560.
[35]林久茂,彭军,魏丽慧,等.白花蛇舌草提取物诱导结肠癌HT-29细胞凋亡的机制研究[J].福建中医药,2010,41(5):49-51,64.
[36]林久茂,李琼瑜,严兆坤,等.白花蛇舌草对大肠癌耐药细胞microRNAs表达的影响[J].世界中医药,2017,12(11):2771-2774.
[37]吕红,苏子博,潘正,等.五味子乙素抗肿瘤及其他生物学作用研究进展[J].吉林医药学院学报,2015,36(2):138-141.
[38]姜恩平,李贺,于春艳,等.五味子乙素通过p38MAPK信号通路对结肠癌SW480细胞凋亡和侵袭的影响[J].吉林大学学报(医学版),2015,41(4):675-679,885.
[39]张铃,方翌,蔡巧燕,等.半枝莲氯仿极性部位提取物促进人结肠癌细胞凋亡及其逆转耐药的机制研究[J].福建中医药,2017,48(2):37-39.
[40]王子元,孙筱婷,吴丽莉,等.白藜芦醇对人大肠癌耐药细胞增殖及凋亡的影响[J].上海中医药大学学报,2017,31(3):51-56.
[41]壮雨雯,周锦勇,吴坚,等.澳洲茄胺诱导肠癌HCT-116细胞凋亡的实验研究[J].南京中医药大学学报,2017,33(1):69-73.
[42] Xie M J,Ma Y H,Miao L,et al. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway[J]. Asian Pac J Cancer Prev,2014,15(13):5201-5205.
[43] Liu L Y,Shen A L,Chen Y Q,et al. Patrinia scabiosaefolia induces mitochondrial-dependent apoptosis in a mouse model ofcolorectal cancer[J]. Oncol Rep,2013,30(2):897-903.
[44]杨鹏,张松,郭舜,等.苦参碱抑制Akt信号通路诱导结肠癌SW480细胞凋亡[J].中国实验方剂学杂志,2017,23(7):109-113.
[45]陶鹏宇,施明杰,黄永焯,等.双氢青蒿素逆转人结肠癌耐药细胞耐药性的研究[J].广州中医药大学学报,2016,33(5):698-703.
[46]苏建伟,蒋旗,黄桂柳,等.苦参碱对结肠癌耐药细胞化疗药物敏感性及自噬水平的影响[J].右江医学,2016,44(6):610-613.
[47]马强,常宗宏,邓尚新,等.自噬对苯丙素苷逆转耐药作用的影响[J].中草药,2014,45(2):238-243.
[2]李道娟,李倩,贺宇彤,等.结直肠癌流行病学趋势[J].肿瘤防治研究,2015,42(3):305-310.
[3] Balaji S A,Udupa N,Chamallamudi M R,et al. Role of the drug transporter ABCC3 in breast cancer chemoresistance[J].PLoS One,2016,11(5):e0155013.
[4] Chen Z L,Shi T L,Zhang L,et al. Mammalian drug efflux transporters of the ATP binding cassette(ABC)family in multidrug resistance:A review of the past decade[J]. Cancer Lett,2016,370(1):153-164.
[5] Kibria G,Hatakeyama H,Harsshima H. Cancer multidrug resistance:mechanisms involved and strategies for circumvention using a drug delivery system[J]. Arch Pharm Res,2014,37(1):4-15.
[6] Pramanik D,Campbel N R,Das S,et al. A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy[J]. Oncotarget,2012,3(6):640-650.
[7] Ward A B,Szewczyk P,Grimard V,et al. Structures of Pglycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain[J]. Proc Natl Acad Sci USA,2013,110(33):13386-13391.
[8] Calatoz zolo C,Gelati M,Ciusani E,et al. Expression of drug resistance proteins P-gp, MRP1, MRP3, MRP5 and GST-pi in human glioma[J]. J Neurooncol,2005,74(2):113-121.
[9] Scheffer G L,Schroeijers A B,Izquierdo M A,et al. Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer[J]. Curr Opin Oncol,2000,12(6):550-556.
[10] Wang W J,Wang M Y,Wu N. Expression and research of Pgp and GST-πin breast Cancer[J]. Chin J Geronto,2008,28(9):893-894.
[11] Xie H Q,Xu X H,Ke M Y. A study on the expression of multidrug resistance-associated protein genes in lung cancer tissues and other malignant tumor[J]. Pract J Cancer,2010,25(2):150-152.
[12]安海莲,金仁顺. TopoⅡ及GST-π在胃癌和结直肠癌中的表达及其临床意义[J].现代肿瘤医学,2014,22(6):1369-1372.
[13] Cantero G,Campanella C,Mateos S,et al. TopoisomeraseⅡinhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin[J]. Mutagenesis,2006,21(5):321-325.
[14]檀碧波,李勇,韩杰,等.胃、大肠癌COX-2和多药耐药相关因子表达与体外化疗药敏性的关系及意义[J].四川大学学报(医学版),2010,41(1):128-131.
[15] Knauer S K, Unruhe B, Karczewski S, et al. Functional characterization of novel mutations affecting survivin(BIRC5)-mediated therapy resistance in head and neck cancer patients[J]. Hum Mutat,2013,34(2):395-404.
[16] Goldsmith K C,Gross M,Peirce S,et al. Mitochondrial Bcl-2family dynamics define therapy response and resistance in neuroblastoma[J]. Cancer Res,2012,72(10):2565-2577.
[17] Leeman-Neill R J,Cai Q,Joyce S C,et al. Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors[J].Clin Cancer Res,2010,16(9):2571-2579.
[18] Klionsky D J,Abdalla F C,Abeliovich H,et al. Guidelines for the use and interpretation of assays for monitoring autophagy[J]. Autophagy,2012,8(4):445-544.
[19] Cao Y,Zhang A H,Cai J Y,et al. Autophagy regulates the cell cycle of murine HSPCs in a nutrient-dependent manner[J].Exp Hematol,2015,43(3):229-242.
[20] Chen S N,Rehman S K,Zhang W,et al. Autophagy is a therapeutic target in anticancer drug resistance[J]. Biochim Biophys Acta,2010,1806(2):220-229.
[21] Du H L,Yang W P,Chen L,et al. Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells[J].Oncol Rep,2012,27(1):143-150.
[22]田文娴,李芳,岳银艳,等. HMGB1调节自噬诱导肿瘤细胞化疗耐药的研究进展[J].河南医学研究,2016,25(2):256-258.
[23]钟自强,黄桂柳,黄赞松,等.苦参素逆转结肠癌细胞多药耐药作用及机制研究[J].右江民族医学院学报,2017,39(1):17-21.
[24]张冬梅,张雅明.虎杖苷逆转人结肠癌细胞株HT-29奥沙利铂耐药性及机制[J].现代肿瘤医学,2016,24(16):2505-2508.
[25]靳祎祎,李琼瑜,赖子君,等.白花蛇舌草通过调控Hedgehog通路增加大肠癌耐药细胞的药物蓄积研究[J].康复学报,2016,26(3):34-39.
[26] Li Q Y,Wang X F,Shen A L,et al. Hedyotis diffusa willd overcomes 5-fluorouracil resistance in human colorectal cancer HCT-8/5-FU cells by downregulating the expression of P-glycoprotein and ATP-binding casette subfamily G member 2[J].Exp Ther Med,2015,10(5):1845-1850.
[27] Hu T,Cao Z X. The potential of therapeutic application of tanshinones in reversing multidrug resistance in colon cancer cells[J]. Chin J Pharmacol Toxicol,2015,29(Suppl 1):8.
[28]卢伟东,傅仲学,覃勇,等.姜黄素逆转结肠癌裸鼠移植瘤多药耐药的研究[J].第三军医大学学报,2011,33(4):376-380.
[29]王开雷,李乐平,靖昌庆,等.短发夹RNA干扰质粒与粉防己碱对结肠癌耐药细胞多药耐药性的逆转作用[J].中华消化外科杂志,2011,10(6):452-455.
[30]李彩丽,成丹,孙泽群,等.槲皮素逆转结肠癌耐药细胞SW480/OXP耐药性研究[J].胃肠病学和肝病学杂志,2017,26(5):551-554.
[31]金秀东,徐秋玲,王晓东,等.复方五味子素B逆转人结肠癌细胞THC-8307/OXA多药耐药性机制研究[J].中国现代医学杂志,2011,21(20):2384-2387,2391.
[32]李贺,李雷. GSTP1蛋白质低表达与姜黄素逆转结肠癌细胞多药耐药的关系[J].中华医学杂志,2015,95(30):2478-2482.
[33]吴汪泽,王卉,卢忠心.黄芩苷对结肠癌细胞迁移与侵袭能力的抑制作用及其机制研究[J].现代预防医学,2016,43(4):708-710,726.
[34] Liu Z,Duan Z J,Chang J Y,et al. Sinomenine sensitizes multidrug-resistant colon cancer cells(Caco-2)to doxorubicin by downregulation of MDR-1 expression[J]. PLoS One,2014,9(6):e98560.
[35]林久茂,彭军,魏丽慧,等.白花蛇舌草提取物诱导结肠癌HT-29细胞凋亡的机制研究[J].福建中医药,2010,41(5):49-51,64.
[36]林久茂,李琼瑜,严兆坤,等.白花蛇舌草对大肠癌耐药细胞microRNAs表达的影响[J].世界中医药,2017,12(11):2771-2774.
[37]吕红,苏子博,潘正,等.五味子乙素抗肿瘤及其他生物学作用研究进展[J].吉林医药学院学报,2015,36(2):138-141.
[38]姜恩平,李贺,于春艳,等.五味子乙素通过p38MAPK信号通路对结肠癌SW480细胞凋亡和侵袭的影响[J].吉林大学学报(医学版),2015,41(4):675-679,885.
[39]张铃,方翌,蔡巧燕,等.半枝莲氯仿极性部位提取物促进人结肠癌细胞凋亡及其逆转耐药的机制研究[J].福建中医药,2017,48(2):37-39.
[40]王子元,孙筱婷,吴丽莉,等.白藜芦醇对人大肠癌耐药细胞增殖及凋亡的影响[J].上海中医药大学学报,2017,31(3):51-56.
[41]壮雨雯,周锦勇,吴坚,等.澳洲茄胺诱导肠癌HCT-116细胞凋亡的实验研究[J].南京中医药大学学报,2017,33(1):69-73.
[42] Xie M J,Ma Y H,Miao L,et al. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway[J]. Asian Pac J Cancer Prev,2014,15(13):5201-5205.
[43] Liu L Y,Shen A L,Chen Y Q,et al. Patrinia scabiosaefolia induces mitochondrial-dependent apoptosis in a mouse model ofcolorectal cancer[J]. Oncol Rep,2013,30(2):897-903.
[44]杨鹏,张松,郭舜,等.苦参碱抑制Akt信号通路诱导结肠癌SW480细胞凋亡[J].中国实验方剂学杂志,2017,23(7):109-113.
[45]陶鹏宇,施明杰,黄永焯,等.双氢青蒿素逆转人结肠癌耐药细胞耐药性的研究[J].广州中医药大学学报,2016,33(5):698-703.
[46]苏建伟,蒋旗,黄桂柳,等.苦参碱对结肠癌耐药细胞化疗药物敏感性及自噬水平的影响[J].右江医学,2016,44(6):610-613.
[47]马强,常宗宏,邓尚新,等.自噬对苯丙素苷逆转耐药作用的影响[J].中草药,2014,45(2):238-243.