山慈菇化学成分及其抗肿瘤作用机制研究进展
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摘要
中草药山慈菇具有清热解毒、化痰散结的功效,是临床常用的抗肿瘤中药之一,疗效肯定。通过查阅国内外公开发表的相关研究报道,从化学成分及抗肿瘤作用机制方面对山慈菇杜鹃兰品种进行分析、归纳和总结,以期为进一步研究提供思路,更好地指导临床应用。
The traditional Chinese herbal Pseudobulbus Cremastrae seu Pleiones has the efficacy of clearing away heat and toxic material,and reducing phlegm and resolving masses. It is a commonly-used antitumor drug clinically,which has the definite effect. Based on the latest domestic and foreign literature analysis and summary,this article discussed the chemical composition and antitumor mechanisms in order to provide ideas for further research and guide the clinical application.
The traditional Chinese herbal Pseudobulbus Cremastrae seu Pleiones has the efficacy of clearing away heat and toxic material,and reducing phlegm and resolving masses. It is a commonly-used antitumor drug clinically,which has the definite effect. Based on the latest domestic and foreign literature analysis and summary,this article discussed the chemical composition and antitumor mechanisms in order to provide ideas for further research and guide the clinical application.
引文
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[2]李琦,陈宇纵,辛海量.山慈菇的化学成分及药理作用研究进展[J].药学实践杂志,2014(4):250-253,260.
[3]郑伟达.国家级抗癌新药慈丹胶囊抗肿瘤作用研究概况[J].光明中医,2004,6:73.
[4]陈焕朝,贺兰湘,高小海,等.龙泉复方制剂的抑瘤作用及其作用机制[J].肿瘤防治研究,2006,4:255-257.
[5]吕林锋,蒋永海,朱希,等.山慈菇HPLC指纹图谱质量评价[J].中国现代应用药学,2016,33(10):1276-1280.
[6]董海玲,郭顺星,王春兰,等.山慈菇的化学成分和药理作用研究进展[J].中草药,2007(11):1734-1738.
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[12]Wang Y,Guan S,Meng Y,et al.Phenanthrenes,9,10-dihydro-phenanthrenes,bibenzyls with their derivatives,and malate or tartrate benzylester glucosides from tubers of Cremastra appendiculata[J].Phytochemistry,2013,94:268-276.
[13]林冰,周英.山慈菇化学成分研究(Ⅰ)[J].中国中医药资讯,2011,3(5):183.
[14]Li S,Xue Z,Wang S,et al.Terpenoids from the tuber of Cremastra appendiculata[J].Journal of Asian Natural Products Research,2008,10(7):677-683.
[15]Fujisawa Pharmaceutical Co,Ltd.Antihypertensive cremastosineⅠandⅡisolation[P].JP:57035518,1982-02-26.
[16]Yoshitaka I,Hikaru N,Tamotsu F,et al.Cremastrine,apyrrolizidine alkaloid from Cremastra appendiculata[J].J Nat Prod,2005,68(4):572.
[17]Joong S S,Jin H K,Jiyong L,et al.Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata[J].Plant Med,2004,70(2):171.
[18]张尧,黄波,赵致,等.山慈菇乙酸乙酯部位化学成分研究[J].中药材,2011,12:1882-1883.
[19]胡文娟.MMP-3多态性与乳腺癌关联分析及龙泉复方抗肿瘤机制研究[D].武汉:中南民族大学,2010.
[20]阮小丽,施大文.山慈菇的抗肿瘤及抑菌作用[J].中药材,2009,12:1886-1888.
[21]Liu L,Li J,Zeng KW,et al.Five New Biphenanthrenes from Cremastra appendiculata[J].Molecules,2016,21(8):1089-1098.
[22]田昌海,王世清.山慈菇的研究进展[J].现代医药卫生,2008,7:1009-1010.
[23]陈艳.中药多糖抗肿瘤机制研究进展[J].药学与临床研究,2010,2:123-126.
[24]谢好贵,陈美珍,张玉强.多糖抗肿瘤构效关系及其机制研究进展[J].食品科学,2011,11:329-333.
[25]任明.复合多糖抗辐射和抗肿瘤作用及其机制研究[D].长春:吉林大学,2014.
[26]吴俊林.中药山慈姑对甲状腺癌细胞的增殖及NIS基因的影响[D].南宁:广西医科大学,2014.
[27]刘银花,钟世军,曾涛,等.山慈菇提取液对小鼠4T1乳腺癌细胞抑制作用机制的研究[J].湖北农业科学,2016(1):134-137.
[28]林如辉,李钻芳,曾建伟,等.山慈姑醇提取液对SGC-7901细胞的抗肿瘤机制[J].福建中医药大学学报,2012(5):22-24.
[29]徐小娟,蔡懿鑫,毛宇,等.山慈菇多糖对荷H22肝癌小鼠的抗肿瘤机制研究[J].食品研究与开发,2015(7):23-25.
[30]徐小娟,周志涵,毛宇,等.山慈菇多糖对H22肝癌小鼠IL-2及p53蛋白表达的影响[J].食品研究与开发,2016,18:6-10.
[31]于林楠,翟宏颖.山慈菇提取物对结肠癌HT29细胞凋亡的影响[J].中国民族民间医药,2016,25(16):17-19.
[32]曾迪,李晓祥,边永钎,等.山慈菇含药血清对SMMC7-721细胞侵袭、黏附能力的影响[J].第四军医大学学报,2009(4):385.
[33]刘琦,程旭锋,张新峰,等.山慈菇-蜂房药对抑制人乳腺癌MDA-MB-231细胞体外侵袭转移的机理研究[J].中药新药与临床药理,2014(4):389-392.
[34]董缙,姚硕蔚,徐云根.肿瘤生成抑制剂[J].化学进展,2010,22(10):1993-2002.
[35]Shim JS,Kim JH,Lee J,et al.Anti-anglogenic activity of a homoisoflavanone from Cremastra appendiculata[J].Planta Med,2004,70(2):171-173.
[36]Kim JH,Kim KH.Homoisoflavanone inhibits retinal neovascularization thmush cell cycle arrest with decrease of cdc2 expression[J].Biochem and Biophs Res Commun,2007,362(4):848-852.
[37]Jeong Hun Kim,Jin Hyoung Kim,Young Suk Yu,etal.Inhibition of choroidal neovasularization by Homeisoflavanone,a new angiogenesis inhibitor[J].Mol Vis,2008(14):556-561.
[38]徐小娟.山慈菇多糖、牛膝多糖对H22小鼠肝癌抑制作用及其抗肿瘤机制研究[D].长沙:湖南农业大学,2015.
[2]李琦,陈宇纵,辛海量.山慈菇的化学成分及药理作用研究进展[J].药学实践杂志,2014(4):250-253,260.
[3]郑伟达.国家级抗癌新药慈丹胶囊抗肿瘤作用研究概况[J].光明中医,2004,6:73.
[4]陈焕朝,贺兰湘,高小海,等.龙泉复方制剂的抑瘤作用及其作用机制[J].肿瘤防治研究,2006,4:255-257.
[5]吕林锋,蒋永海,朱希,等.山慈菇HPLC指纹图谱质量评价[J].中国现代应用药学,2016,33(10):1276-1280.
[6]董海玲,郭顺星,王春兰,等.山慈菇的化学成分和药理作用研究进展[J].中草药,2007(11):1734-1738.
[7]Xue Z,Li S,Wang S J,et al.Mono-,bi-,and triphen-anthrenes from the tubers of Cremastra appendiculata[J].J Nat Prod,2006,69(6):907-913.
[8]朱毅.杜鹃兰的化学成分研究[D].武汉:湖北中医药大学,2014.
[9]申勇.杜鹃兰Cremastra appendiculata化学成分及抗肿瘤活性研究[D].保定:河北大学,2007.
[10]夏文斌,薛震,李帅,等.杜鹃兰化学成分及肿瘤细胞毒活性研究[J].中国中药杂志,2005,23:1827-1830.
[11]刘净,于志斌,叶蕴华,等.山慈菇的化学成分[J].药学学报,2008,2:181-184.
[12]Wang Y,Guan S,Meng Y,et al.Phenanthrenes,9,10-dihydro-phenanthrenes,bibenzyls with their derivatives,and malate or tartrate benzylester glucosides from tubers of Cremastra appendiculata[J].Phytochemistry,2013,94:268-276.
[13]林冰,周英.山慈菇化学成分研究(Ⅰ)[J].中国中医药资讯,2011,3(5):183.
[14]Li S,Xue Z,Wang S,et al.Terpenoids from the tuber of Cremastra appendiculata[J].Journal of Asian Natural Products Research,2008,10(7):677-683.
[15]Fujisawa Pharmaceutical Co,Ltd.Antihypertensive cremastosineⅠandⅡisolation[P].JP:57035518,1982-02-26.
[16]Yoshitaka I,Hikaru N,Tamotsu F,et al.Cremastrine,apyrrolizidine alkaloid from Cremastra appendiculata[J].J Nat Prod,2005,68(4):572.
[17]Joong S S,Jin H K,Jiyong L,et al.Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata[J].Plant Med,2004,70(2):171.
[18]张尧,黄波,赵致,等.山慈菇乙酸乙酯部位化学成分研究[J].中药材,2011,12:1882-1883.
[19]胡文娟.MMP-3多态性与乳腺癌关联分析及龙泉复方抗肿瘤机制研究[D].武汉:中南民族大学,2010.
[20]阮小丽,施大文.山慈菇的抗肿瘤及抑菌作用[J].中药材,2009,12:1886-1888.
[21]Liu L,Li J,Zeng KW,et al.Five New Biphenanthrenes from Cremastra appendiculata[J].Molecules,2016,21(8):1089-1098.
[22]田昌海,王世清.山慈菇的研究进展[J].现代医药卫生,2008,7:1009-1010.
[23]陈艳.中药多糖抗肿瘤机制研究进展[J].药学与临床研究,2010,2:123-126.
[24]谢好贵,陈美珍,张玉强.多糖抗肿瘤构效关系及其机制研究进展[J].食品科学,2011,11:329-333.
[25]任明.复合多糖抗辐射和抗肿瘤作用及其机制研究[D].长春:吉林大学,2014.
[26]吴俊林.中药山慈姑对甲状腺癌细胞的增殖及NIS基因的影响[D].南宁:广西医科大学,2014.
[27]刘银花,钟世军,曾涛,等.山慈菇提取液对小鼠4T1乳腺癌细胞抑制作用机制的研究[J].湖北农业科学,2016(1):134-137.
[28]林如辉,李钻芳,曾建伟,等.山慈姑醇提取液对SGC-7901细胞的抗肿瘤机制[J].福建中医药大学学报,2012(5):22-24.
[29]徐小娟,蔡懿鑫,毛宇,等.山慈菇多糖对荷H22肝癌小鼠的抗肿瘤机制研究[J].食品研究与开发,2015(7):23-25.
[30]徐小娟,周志涵,毛宇,等.山慈菇多糖对H22肝癌小鼠IL-2及p53蛋白表达的影响[J].食品研究与开发,2016,18:6-10.
[31]于林楠,翟宏颖.山慈菇提取物对结肠癌HT29细胞凋亡的影响[J].中国民族民间医药,2016,25(16):17-19.
[32]曾迪,李晓祥,边永钎,等.山慈菇含药血清对SMMC7-721细胞侵袭、黏附能力的影响[J].第四军医大学学报,2009(4):385.
[33]刘琦,程旭锋,张新峰,等.山慈菇-蜂房药对抑制人乳腺癌MDA-MB-231细胞体外侵袭转移的机理研究[J].中药新药与临床药理,2014(4):389-392.
[34]董缙,姚硕蔚,徐云根.肿瘤生成抑制剂[J].化学进展,2010,22(10):1993-2002.
[35]Shim JS,Kim JH,Lee J,et al.Anti-anglogenic activity of a homoisoflavanone from Cremastra appendiculata[J].Planta Med,2004,70(2):171-173.
[36]Kim JH,Kim KH.Homoisoflavanone inhibits retinal neovascularization thmush cell cycle arrest with decrease of cdc2 expression[J].Biochem and Biophs Res Commun,2007,362(4):848-852.
[37]Jeong Hun Kim,Jin Hyoung Kim,Young Suk Yu,etal.Inhibition of choroidal neovasularization by Homeisoflavanone,a new angiogenesis inhibitor[J].Mol Vis,2008(14):556-561.
[38]徐小娟.山慈菇多糖、牛膝多糖对H22小鼠肝癌抑制作用及其抗肿瘤机制研究[D].长沙:湖南农业大学,2015.