薏苡仁多糖抗肿瘤作用及免疫作用研究进展
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摘要
薏苡仁中含有酯类、脂肪酸、多糖、甾体、三萜及蛋白质等化合物,目前已发现且分离鉴定出的活性成分多达41种。近几年关于薏苡仁多糖抗肿瘤作用方面的研究颇为活跃。该文主要综述近年来薏苡仁多糖在抗肿瘤作用方面的研究进展。为今后进一步探究薏苡仁多糖在抗肿瘤方面的作用提供理论性依据。
Coix seed contains esters,fatty acid,polysaccharide,steroid,terpene and chemical compounds such as proteins,has now found that separation and identify the active ingredients of up to 41.In recent years,research on coix seed polysaccharide antitumor effect is active. This article mainly reviews the coix seed polysaccharide in the progress of antitumor,to promote the coix seed polysaccharide in such aspects as antitumor provide theoretical basis for further research.
Coix seed contains esters,fatty acid,polysaccharide,steroid,terpene and chemical compounds such as proteins,has now found that separation and identify the active ingredients of up to 41.In recent years,research on coix seed polysaccharide antitumor effect is active. This article mainly reviews the coix seed polysaccharide in the progress of antitumor,to promote the coix seed polysaccharide in such aspects as antitumor provide theoretical basis for further research.
引文
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[4]姚小健.康莱特注射液联合化疗治疗老年胃癌临床观察[J].肿瘤基础与临床,2015,12(2):160-161.
[5]张智敏,谢刚.康莱特联合替吉奥治疗晚期胃癌的临床研究[J].现代中西医结合杂志,2013,22(15):1631-1632.
[6]Guibin Pang,Fujun Wang,Leshuai W. Dose matters:Directkilling or immunoregulatory effects of natural polysaccharidesin cancer treatment[J]. Carbohydrate Polymers,2018,195:243-256.
[7]何余堂,潘孝明.植物多糖的结构与活性研究进展[J].食品科学,2010,31(17):493-496.
[8]Meng-Hsueh Amanda Lin,Shin Lu,Jenshinn Lin. Glycemicindex,glycemic load and insulinemic index of Chinese starchyfoods[J]. World Journal of Gastroenterology,2010,16(39):4973-4979.
[9]Dan R Littman,Eric G Pamer. Role of the Commensal Microbiotain Normal and Pathogenic Host Immune Responses[J]. Cell Host&Microbe,2011,10(4):311-323.
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[13]徐梓辉,周世文,黄文权,等.薏苡仁多糖对实验性糖尿病大鼠红细胞免疫、T淋巴细胞亚群的影响[J].湖南中医学院学报,2001,21(1):17-19.
[14]李红燕,曹阳,陶小军,等.薏苡仁汤镇痛消炎作用的实验研究[J].亚太传统中医,2013,12(9):58-60.
[15]刘明健.疏水化半乳糖修饰的薏苡仁组分微乳增强肝肿瘤靶向研究[D].镇江:江苏大学,2016.
[16]Eirini I Rigopoulou,Dirk Roggenbuck,Daniel S Smyk,et al.Asialoglycoprotein receptor(ASGPR)as target autoantigen in liver autoimmunity:Lost and found[J]. Autoimmunity Reviews,2012,12(2):260-269.
[17]张盈,杨硕,李灵芝.肝靶向给药系统研究进展[J].中国新药杂志,2013,22(8):923-927.
[18]严红梅,贾晓斌,张振海,等.维生素E聚乙二醇1000琥珀酸酯对宝藿苷I抑制乳腺癌细胞MCF-7增殖的影响[J].中草药,2015,46(3):384-388.
[19]杨宪勇.应用环磷酰胺构建C57BL/6J小鼠免疫抑制模型[J].中国组织工程研究,2012(40):7486-7490.
[20]Xiangyi Lu,Wei Liu,Junhua Wu,et al. A polysaccharide fraction of adlay seed(Coix lachryma-jobi L.)induces apoptosis in human non-small cell lung cancer A549 cells[J].Biochemical and Biophysical Research Communications,2013,430(2):846-851.
[21]Luo Cheng,Wang Xin,An Can,et al. Molecular inhibition mechanismsofcellmigrationandinvasionbycoix polysaccharides in A549 NSCLC cells via targeting S100A4[J].Molecular Medicine Reports,2017,15(1):309-316.
[22]杨志云.递药系统创新“给力”抗肿瘤中药[N].中国中医药报,2015-08-13(006).
[23]刘明健,瞿鼎,陈彦,等.丁酰半乳糖酯修饰的薏苡仁组分微乳的制备及其体外抗肿瘤活性研究[J].中草药,2015,22(18):2696-2702.
[24]袁成甜,贺俊杰,陈彦,等.灵薏方多组分微乳的制备及其抗肺癌活性研究[J].中草药,2014,45(22):3284-3288.
[25]Nakatsura T. Era of cancer immunotherapy has come[J]. Nihon Rinsho Meneki Gakkai Kaishi,2016,39(3):164-171.
[26]Harrer DC,Dorrie J,Schaft N. Chimeric antigen receptors in different cell types:New vehicles join the race[J].Human Gene Therapy,2018,10:236-267.
[27]温晓蓉.薏苡仁化学成分及抗肿瘤活性研究进展[J].辽宁中医药大学报,2008,12(3):135-138.
[28]杨晓慧.薏苡仁为主治疗癌症术后及放疗、化疗后患者[J].中医杂志,2011,52(9):796.
[29]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002,30(5):49.
[30]吕峰,林勇毅,陈代园.薏苡仁活性多糖对小鼠的免疫调节作用[J].中国食品学报,2013,22(6):20-25.
[31]王彦芳,季旭明,赵海军,等.薏苡仁多糖不同组分对脾虚水湿不化大鼠模型免疫功能的影响[J].中华中医药杂志,2017,32(3):1303-1306.
[32]冯刚,孔庆志,黄冬生,等.薏苡仁注射液对小鼠移植性S180肉瘤血管形成抑制的作用[J].肿瘤防治研究,2004,31(4):229.
[33]肖志勇.薏苡仁多糖急性毒性及遗传毒性试验研究[J].中南药学,2009,11(9):678-681.
[2]李大鹏.康莱特注射液抗癌作用机理研究进展[J].中药新药与临床药理,2001,12(2):122.
[3]Fei Yu,Jun Zhang,Ya-zhuo Li,et al. Research and Applicationof Adlay in Medicinal Field[J]. Chinese Herbal Medicines,2017,9(2):126-133.
[4]姚小健.康莱特注射液联合化疗治疗老年胃癌临床观察[J].肿瘤基础与临床,2015,12(2):160-161.
[5]张智敏,谢刚.康莱特联合替吉奥治疗晚期胃癌的临床研究[J].现代中西医结合杂志,2013,22(15):1631-1632.
[6]Guibin Pang,Fujun Wang,Leshuai W. Dose matters:Directkilling or immunoregulatory effects of natural polysaccharidesin cancer treatment[J]. Carbohydrate Polymers,2018,195:243-256.
[7]何余堂,潘孝明.植物多糖的结构与活性研究进展[J].食品科学,2010,31(17):493-496.
[8]Meng-Hsueh Amanda Lin,Shin Lu,Jenshinn Lin. Glycemicindex,glycemic load and insulinemic index of Chinese starchyfoods[J]. World Journal of Gastroenterology,2010,16(39):4973-4979.
[9]Dan R Littman,Eric G Pamer. Role of the Commensal Microbiotain Normal and Pathogenic Host Immune Responses[J]. Cell Host&Microbe,2011,10(4):311-323.
[10]邓素芳,应朝阳,杨有泉,等.薏苡功能性成分研究进展[J].中国农学通报,2017,33(12):123-128.
[11]吴岩,原永芳.薏苡仁的化学成分和药理活性研究进展[J].华西药学杂志,2010,25(1):111-113.
[12]张洋婷,马洪波,宋春梅,等.薏苡仁多糖的提取及其对油脂的抗氧化作用研究[J].食品研究与开发,2015,23(18):58-61.
[13]徐梓辉,周世文,黄文权,等.薏苡仁多糖对实验性糖尿病大鼠红细胞免疫、T淋巴细胞亚群的影响[J].湖南中医学院学报,2001,21(1):17-19.
[14]李红燕,曹阳,陶小军,等.薏苡仁汤镇痛消炎作用的实验研究[J].亚太传统中医,2013,12(9):58-60.
[15]刘明健.疏水化半乳糖修饰的薏苡仁组分微乳增强肝肿瘤靶向研究[D].镇江:江苏大学,2016.
[16]Eirini I Rigopoulou,Dirk Roggenbuck,Daniel S Smyk,et al.Asialoglycoprotein receptor(ASGPR)as target autoantigen in liver autoimmunity:Lost and found[J]. Autoimmunity Reviews,2012,12(2):260-269.
[17]张盈,杨硕,李灵芝.肝靶向给药系统研究进展[J].中国新药杂志,2013,22(8):923-927.
[18]严红梅,贾晓斌,张振海,等.维生素E聚乙二醇1000琥珀酸酯对宝藿苷I抑制乳腺癌细胞MCF-7增殖的影响[J].中草药,2015,46(3):384-388.
[19]杨宪勇.应用环磷酰胺构建C57BL/6J小鼠免疫抑制模型[J].中国组织工程研究,2012(40):7486-7490.
[20]Xiangyi Lu,Wei Liu,Junhua Wu,et al. A polysaccharide fraction of adlay seed(Coix lachryma-jobi L.)induces apoptosis in human non-small cell lung cancer A549 cells[J].Biochemical and Biophysical Research Communications,2013,430(2):846-851.
[21]Luo Cheng,Wang Xin,An Can,et al. Molecular inhibition mechanismsofcellmigrationandinvasionbycoix polysaccharides in A549 NSCLC cells via targeting S100A4[J].Molecular Medicine Reports,2017,15(1):309-316.
[22]杨志云.递药系统创新“给力”抗肿瘤中药[N].中国中医药报,2015-08-13(006).
[23]刘明健,瞿鼎,陈彦,等.丁酰半乳糖酯修饰的薏苡仁组分微乳的制备及其体外抗肿瘤活性研究[J].中草药,2015,22(18):2696-2702.
[24]袁成甜,贺俊杰,陈彦,等.灵薏方多组分微乳的制备及其抗肺癌活性研究[J].中草药,2014,45(22):3284-3288.
[25]Nakatsura T. Era of cancer immunotherapy has come[J]. Nihon Rinsho Meneki Gakkai Kaishi,2016,39(3):164-171.
[26]Harrer DC,Dorrie J,Schaft N. Chimeric antigen receptors in different cell types:New vehicles join the race[J].Human Gene Therapy,2018,10:236-267.
[27]温晓蓉.薏苡仁化学成分及抗肿瘤活性研究进展[J].辽宁中医药大学报,2008,12(3):135-138.
[28]杨晓慧.薏苡仁为主治疗癌症术后及放疗、化疗后患者[J].中医杂志,2011,52(9):796.
[29]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002,30(5):49.
[30]吕峰,林勇毅,陈代园.薏苡仁活性多糖对小鼠的免疫调节作用[J].中国食品学报,2013,22(6):20-25.
[31]王彦芳,季旭明,赵海军,等.薏苡仁多糖不同组分对脾虚水湿不化大鼠模型免疫功能的影响[J].中华中医药杂志,2017,32(3):1303-1306.
[32]冯刚,孔庆志,黄冬生,等.薏苡仁注射液对小鼠移植性S180肉瘤血管形成抑制的作用[J].肿瘤防治研究,2004,31(4):229.
[33]肖志勇.薏苡仁多糖急性毒性及遗传毒性试验研究[J].中南药学,2009,11(9):678-681.