口腔生物膜在口腔扁平苔藓手术中的应用效果
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摘要
目的观察应用口腔生物膜手术治疗口腔扁平苔藓的效果,为临床治疗提供参考。方法选取2013年2月～2015年6月四川省自贡市第一人民医院口腔颌面外科经临床诊断为口腔扁平苔藓的26例患者作为研究对象,采用外科手术方式将病变组织切除,切除后使用口腔生物膜覆盖创面,行反包扎固定于创面,待生物膜与创面自然愈合。填写中文版《口腔黏膜疾病量表》(COMDQ),分析比较患者术前、术后1个月、半年、1年的量表得分。结果口腔生物膜与创面完全自然愈合,有效率>95%;患者术后1个月、半年、1年的COMDQ量表总分低于术前,差异有统计学意义(P<0.05)。结论口腔生物膜应用于口腔扁平苔藓切除术后,能够减轻患者术后疼痛和社会与情感因素的变化,值得临床推广应用。
Objective To observe the effect of Haiao Oral Biofilm in the operation of oral lichen planus(OLP),and provide reference for the clinical treatment. Methods A total of 26 cases of OLP diagnosed clinically in Oral and Maxillofacial Surgery of Zigong First People′ s Hospital in Sichuan From February 2013 to June 2015 were selected as the subjects. The diseased tissues were excised surgically and covered with Haiao Oral Biofilm, and then fixed to the wound by reverse bandage, finally biofilm and the wound were healed naturally. The Chinese version of chronic oral mucosal diseases questionnaire(COMDQ) were filled in the 26 cases, then the scale score of preoperative, one month after the operation, 6 months after the operation, one year after the operation were analysed and compared. Results Haiao Oral Biofilm and wound completely healed naturally, the effective percentage was over 95%. The total scores of the COMDQ 1 and 6 months after the operation, one year after the operation were lower than those preoperative, the differences were statistically significant(P<0.05). Conclusion Haiao Oral Biofilm can relieve postoperative pain and the changes of social and emotional factors. So it is worthy of clinical application.
Objective To observe the effect of Haiao Oral Biofilm in the operation of oral lichen planus(OLP),and provide reference for the clinical treatment. Methods A total of 26 cases of OLP diagnosed clinically in Oral and Maxillofacial Surgery of Zigong First People′ s Hospital in Sichuan From February 2013 to June 2015 were selected as the subjects. The diseased tissues were excised surgically and covered with Haiao Oral Biofilm, and then fixed to the wound by reverse bandage, finally biofilm and the wound were healed naturally. The Chinese version of chronic oral mucosal diseases questionnaire(COMDQ) were filled in the 26 cases, then the scale score of preoperative, one month after the operation, 6 months after the operation, one year after the operation were analysed and compared. Results Haiao Oral Biofilm and wound completely healed naturally, the effective percentage was over 95%. The total scores of the COMDQ 1 and 6 months after the operation, one year after the operation were lower than those preoperative, the differences were statistically significant(P<0.05). Conclusion Haiao Oral Biofilm can relieve postoperative pain and the changes of social and emotional factors. So it is worthy of clinical application.
引文
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[12]刘鸿伟,李晟磊.扁平苔藓100例的病理分析[J].医药论坛杂志,2016,48(12):109-110.
[13]齐静,张沙沙.精神神经因素在扁平苔藓治疗中的考量[J].内蒙古医学杂志,2016,48(12):1480-1481.
[14]李晓静,刘宝珍,蔡杨.激光在口腔扁平苔藓中的治疗进展[J].临床口腔医学杂志,2017,33(10):635-637.
[15]薛媛,但年华,但卫华,等.口腔修复膜的研究进展及其应用[J].生物医学工程与临床,2016,20(1):103-107.
[16]Wei PC,Laurell L,Lingen MW,et al.Acellular dermal matrix allografts to achieve increased attached gingiva.Part2.A histologycal comparative study[J].J Periodontol,2002,73(3):257-265.
[17]Li M,He SL.Reliability and validity of the Chinese version of the chronic mucosa disease questionnaire[J].J oral Pathol Med,2013,42(2):194-199.
[18]周婷婷,华红.口腔扁平苔藓与系统性疾病的关系[J].中国实用口腔科杂志,2015,8(12):709-712.
[2]G Du,J Chen,Wang Y.Differential expression of STAT-3 in subtypes of oral lichen planus:a preliminary study[J].Oral Surg Oral Med Oral Pathol Oral Radiol,2018,125(3):236.
[3]卢锐.口腔扁平苔藓的目标治疗:观点和展望[J].口腔医学研究,2016,32(11):1213-1216.
[4]陈平,高平.口腔扁平苔藓局部治疗进展[J].医学综述,2015,21(7):1227-1229.
[5]杨建光,韩建国,刘宗响.中西药联合治疗糜烂型口腔扁平苔藓的疗效研究[J].徐州医学院学报,2010,30(10):683-684.
[6]Rajan B,Ahmed J,Shenoy N,et al.Assessment of quality of life in patients with chronic oral mucosal diseases:a questionnaire-based study[J].Penn J,2014,18(1):e123-e127.
[7]刘东娟,陈谦明.口腔扁平苔藓的诊断及治疗[J].中华实用口腔科杂志,2017,10(9):518-521.
[8]李相如,朱奎成,乔彬.口腔扁平苔藓患者口腔黏膜超微结构特征和细胞凋亡检测?[J].郑州大学学报(医学版),2015,50(4):485-487.
[9]高岩.从病理学角度看关于口腔扁平苔藓潜在恶性性质的争论[J].中华口腔医学杂志,2015,50(10):577-580.
[10]Kragelund C,Hansen C,Reibel J,et al.Polymorphic drug metabolizing CYP-enzymesa pathogenic factor in oral lichen planus[J].J Oral Pathol Med,2009,38(1):63-71.
[11]Casparis S,Borm JM,Tektas S,et al.Oral lichen planus(OLP),oral lichenoid lesions(OLL),oral dysplasia,and oral cancer:retrospective analysis of clinicopathological data from 2002-2011[J].Oral Maxillofac Surg,2015,19(2):149-156.
[12]刘鸿伟,李晟磊.扁平苔藓100例的病理分析[J].医药论坛杂志,2016,48(12):109-110.
[13]齐静,张沙沙.精神神经因素在扁平苔藓治疗中的考量[J].内蒙古医学杂志,2016,48(12):1480-1481.
[14]李晓静,刘宝珍,蔡杨.激光在口腔扁平苔藓中的治疗进展[J].临床口腔医学杂志,2017,33(10):635-637.
[15]薛媛,但年华,但卫华,等.口腔修复膜的研究进展及其应用[J].生物医学工程与临床,2016,20(1):103-107.
[16]Wei PC,Laurell L,Lingen MW,et al.Acellular dermal matrix allografts to achieve increased attached gingiva.Part2.A histologycal comparative study[J].J Periodontol,2002,73(3):257-265.
[17]Li M,He SL.Reliability and validity of the Chinese version of the chronic mucosa disease questionnaire[J].J oral Pathol Med,2013,42(2):194-199.
[18]周婷婷,华红.口腔扁平苔藓与系统性疾病的关系[J].中国实用口腔科杂志,2015,8(12):709-712.