矮紫堇化学成分与生物活性研究进展
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摘要
矮紫堇为我国青藏高原地区民间常用藏药,主要含有生物碱、黄酮、三萜等化学成分,药理活性多样,具有解热、抗炎止痛、保护心脏、抗血小板聚集、抗乙酰胆碱酯酶、抗氧化等药理作用。作者综述了矮紫堇的化学成分及药理活性,以期为矮紫堇的进一步研究开发提供参考。
Corydalis hendersonii Hemsl.,one of the common folk medicine in Qinghai-Tibetan Plateau,has richchemical components and a variety of pharmacological activities. Phytochemical research shows that it mainlycontains alkaloids,flavonoids,triterpenes and other components. From the aspect of pharmacological activities,Corydalis hendersonii Hemsl. has antipyretic, analgesic and anti-inflammatory, cardio protective, inhibition ofplatelet aggregation, acetylcholinesterase inhibitory, antioxidant activity, and other pharmacological activities.Based on the domestic and foreign literatures,we reviewed the chemical components and pharmacological activitiesof Corydalis hendersonii Hemsl.,which is useful for further research and wider development of the plant.
Corydalis hendersonii Hemsl.,one of the common folk medicine in Qinghai-Tibetan Plateau,has richchemical components and a variety of pharmacological activities. Phytochemical research shows that it mainlycontains alkaloids,flavonoids,triterpenes and other components. From the aspect of pharmacological activities,Corydalis hendersonii Hemsl. has antipyretic, analgesic and anti-inflammatory, cardio protective, inhibition ofplatelet aggregation, acetylcholinesterase inhibitory, antioxidant activity, and other pharmacological activities.Based on the domestic and foreign literatures,we reviewed the chemical components and pharmacological activitiesof Corydalis hendersonii Hemsl.,which is useful for further research and wider development of the plant.
引文
[1]罗达尚.中华藏本草[M].北京:民族出版社,1997:165.
[2]罗达尚,冯赤华,夏光成.青藏高原藏药资源-紫堇属植物初探[J].中草药,1984,15(6):33-36.
[3]中国科学院西北高原生物研究所.藏药志[M].青海:青海人民出版社,1991:350.
[4]马世林,王振华,毛继祖.月王药诊[M].兰州:甘肃民族出版社,1993:159.
[5]王水潮.藏药丝哇类生药原植物考证[J].西北药学杂志,1998,13(5):204-205.
[6]淮虎银,杨生妹.紫堇属藏药的药用民族植物学研究[J].中国野生植物资源,2004,23(1):8-11.
[7]中国植物志编辑委员会.中国植物志(第32卷)[M].北京:科学出版社,1999:360-362.
[8]邢素立,王水潮.青海省紫堇属药用植物资源[J].中药材,1999,22(6):277-279.
[9]张秀峰,王水潮.青海紫堇属药用植物资源调查与开发利用[J].时珍国药研究,1997,8(6):547-548.
[10]范彩霞.紫堇属(Corydalis DC.)植物资源在藏药中的应用及其开发与保护[J].中国医学生物技术应用,2003,2(1):36-38.
[11]帝玛尔·丹增彭措.晶珠本草[M].上海:上海科学技术出版社,1986:110-111,135.
[12]杜品.青藏高原甘南藏药植物志[M].兰州:甘肃科学技术出版社,2006:113-114.
[13]中华人民共和国卫生部.中华人民共和国卫生部药品标准·藏药(第1册)[S].1995:156.
[14]吕芳,徐筱杰.紫堇属藏药中生物碱成分及生物活性研究进展[J].时珍国医国药,2007,18(4):779-780.
[15]FU Y,ZHOU Y,LIAO X,et al.A New Alkaloid from Corydalis hendersonii[J].Planta Med,2009,75(5):547-549.
[16]傅予,梁健,白央,等.尼泊尔黄堇中总生物碱的串联质谱分析[J].质谱学报,2010,31(2):98-102.
[17]高燕萍,吴强,梁健,等.矮紫堇生物碱成分[J].中国实验方剂学杂志,2016,22(17):67-70.
[18]魏春华,曾金祥,史亚夫,等.矮紫堇化学成分的UHPLC-Q-TOF-MS/MS分析[J].江西中医药大学学报,2018,30(2):65-68.
[19]赵学友.矮紫堇中紫堇灵和乙酰紫堇碱含量测定及体外抗氧化活性评价[J].中国医院药学杂志,2017,37(8):736-739.
[20]尹旭,张倩,张和新歌,等.藏药矮紫堇的化学成分研究[J].中国中药杂志,2018,43(9):1758-1763.
[21]YIN X,BAI F,GUO Q,et al.Hendersine A,a nove isoquinoline alkaloid from Corydalis hendersonii[J].Tetrahedron Lett,2016,57(43):4858-4862.
[22]林茂,刘欣,方起程.尼泊尔紫堇化学成分的研究[J].植物学报,1986,28(1):91.
[23]ZHANG J,ZHANG Q Y,TU P F,et al.Mucroniferanines A-G,Isoquinoline alkaloids from Corydalis mucronifera[J].J Nat Prod,2018,81(2):364-370.
[24]高燕萍,吴强,梁健,等.藏族药矮紫堇化学成分分离鉴定[J].中国实验方剂学杂志,2016,22(18):60-63.
[25]魏春华,程虹毓,高燕萍,等.藏药矮紫堇解热镇痛抗炎作用的研究[J].中国新药杂志,2017,26(3):337-342.
[26]舒花,马学燕,李鑫,等.矮紫堇总生物碱的含量测定及其抗炎活性研究[J].西北药学杂志,2015,30(5):602-604.
[27]ZHAO F,BAI R,FENG X,et al.Traditional Tibetan medicine Corydalis hendersonii exerts antimyocardial ischemia effect by attenuating inflammation and fibrosis in acute myocardial infarction mice[J].J Am Coll Cardiol,2017,70(16):C13.
[28]BAI R,YIN X,FENG X,et al.Corydalis hendersonii Hemsl.protects against myocardial injury by attenuating inflammation and fibrosis via NF-kB and JAK2-STAT3 signaling pathways[J].JEthnopharmacol,2017,207:174-183.
[2]罗达尚,冯赤华,夏光成.青藏高原藏药资源-紫堇属植物初探[J].中草药,1984,15(6):33-36.
[3]中国科学院西北高原生物研究所.藏药志[M].青海:青海人民出版社,1991:350.
[4]马世林,王振华,毛继祖.月王药诊[M].兰州:甘肃民族出版社,1993:159.
[5]王水潮.藏药丝哇类生药原植物考证[J].西北药学杂志,1998,13(5):204-205.
[6]淮虎银,杨生妹.紫堇属藏药的药用民族植物学研究[J].中国野生植物资源,2004,23(1):8-11.
[7]中国植物志编辑委员会.中国植物志(第32卷)[M].北京:科学出版社,1999:360-362.
[8]邢素立,王水潮.青海省紫堇属药用植物资源[J].中药材,1999,22(6):277-279.
[9]张秀峰,王水潮.青海紫堇属药用植物资源调查与开发利用[J].时珍国药研究,1997,8(6):547-548.
[10]范彩霞.紫堇属(Corydalis DC.)植物资源在藏药中的应用及其开发与保护[J].中国医学生物技术应用,2003,2(1):36-38.
[11]帝玛尔·丹增彭措.晶珠本草[M].上海:上海科学技术出版社,1986:110-111,135.
[12]杜品.青藏高原甘南藏药植物志[M].兰州:甘肃科学技术出版社,2006:113-114.
[13]中华人民共和国卫生部.中华人民共和国卫生部药品标准·藏药(第1册)[S].1995:156.
[14]吕芳,徐筱杰.紫堇属藏药中生物碱成分及生物活性研究进展[J].时珍国医国药,2007,18(4):779-780.
[15]FU Y,ZHOU Y,LIAO X,et al.A New Alkaloid from Corydalis hendersonii[J].Planta Med,2009,75(5):547-549.
[16]傅予,梁健,白央,等.尼泊尔黄堇中总生物碱的串联质谱分析[J].质谱学报,2010,31(2):98-102.
[17]高燕萍,吴强,梁健,等.矮紫堇生物碱成分[J].中国实验方剂学杂志,2016,22(17):67-70.
[18]魏春华,曾金祥,史亚夫,等.矮紫堇化学成分的UHPLC-Q-TOF-MS/MS分析[J].江西中医药大学学报,2018,30(2):65-68.
[19]赵学友.矮紫堇中紫堇灵和乙酰紫堇碱含量测定及体外抗氧化活性评价[J].中国医院药学杂志,2017,37(8):736-739.
[20]尹旭,张倩,张和新歌,等.藏药矮紫堇的化学成分研究[J].中国中药杂志,2018,43(9):1758-1763.
[21]YIN X,BAI F,GUO Q,et al.Hendersine A,a nove isoquinoline alkaloid from Corydalis hendersonii[J].Tetrahedron Lett,2016,57(43):4858-4862.
[22]林茂,刘欣,方起程.尼泊尔紫堇化学成分的研究[J].植物学报,1986,28(1):91.
[23]ZHANG J,ZHANG Q Y,TU P F,et al.Mucroniferanines A-G,Isoquinoline alkaloids from Corydalis mucronifera[J].J Nat Prod,2018,81(2):364-370.
[24]高燕萍,吴强,梁健,等.藏族药矮紫堇化学成分分离鉴定[J].中国实验方剂学杂志,2016,22(18):60-63.
[25]魏春华,程虹毓,高燕萍,等.藏药矮紫堇解热镇痛抗炎作用的研究[J].中国新药杂志,2017,26(3):337-342.
[26]舒花,马学燕,李鑫,等.矮紫堇总生物碱的含量测定及其抗炎活性研究[J].西北药学杂志,2015,30(5):602-604.
[27]ZHAO F,BAI R,FENG X,et al.Traditional Tibetan medicine Corydalis hendersonii exerts antimyocardial ischemia effect by attenuating inflammation and fibrosis in acute myocardial infarction mice[J].J Am Coll Cardiol,2017,70(16):C13.
[28]BAI R,YIN X,FENG X,et al.Corydalis hendersonii Hemsl.protects against myocardial injury by attenuating inflammation and fibrosis via NF-kB and JAK2-STAT3 signaling pathways[J].JEthnopharmacol,2017,207:174-183.