甲基强的松龙联合丙种球蛋白治疗小儿急性特发性血小板减少性紫癜效果分析
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摘要
目的分析甲基强的松龙联合丙种球蛋白在小儿急性特发性血小板减少性紫癜(AITP)治疗中的应用效果。方法选择本院2015年2月至2017年3月收治的90例AITP患儿,随机分为对照组和观察组两组,各45例。对照组予以甲基强的松龙治疗,观察组予以甲基强的松龙联合丙种球蛋白治疗,比较两组临床应用效果。结果观察组患儿的总有效率93.33%显著高于对照组的71.11%,差异有统计学意义(P<0.05);观察组患儿出血症状控制时间(2.03±1.21)d及血小板恢复正常时间(3.86±1.35)d显著短于对照组的(5.01±2.10)d、(6.41±1.47)d,差异有统计学意义(P<0.05)。结论甲基强的松龙联合丙种球蛋白在小儿急性特发性血小板减少性紫癜治疗中的应用效果显著,优于单用甲基强的松龙治疗。
Objective Analyze the effect of methylprednisolone combined with gamma globulin in the treatment of AITP. Methods 90 cases of children with AITP in our hospital from February 2015 to March 2017 were randomly divided into control group and observation group, 45 cases ineach group. The control group was treated with methylprednisolone. The observation group was treated with methylprednisolone combined with gam-ma globulin, The clinical effects of the two groups were compared. Results The total effective rate of the observation group(93.33%) was higherthan that of the control group(71.11%), The difference was significant(P<0.05).The control time of bleeding symptoms and the recovery time ofplatelets in the observation group [(2.03±1.21)d、(3.86±1.35)d] were significantly shorter than the control group [(5.01±2.10)d、(6.41±1.47)d], Thedifference was significant(P<0.05). Conclusion Methylprednisolone combined with gamma globulin is effective in the treatment of acute idiopathic thrombocytopenic purpura in children. It is superior to methylprednisolone alone.
Objective Analyze the effect of methylprednisolone combined with gamma globulin in the treatment of AITP. Methods 90 cases of children with AITP in our hospital from February 2015 to March 2017 were randomly divided into control group and observation group, 45 cases ineach group. The control group was treated with methylprednisolone. The observation group was treated with methylprednisolone combined with gam-ma globulin, The clinical effects of the two groups were compared. Results The total effective rate of the observation group(93.33%) was higherthan that of the control group(71.11%), The difference was significant(P<0.05).The control time of bleeding symptoms and the recovery time ofplatelets in the observation group [(2.03±1.21)d、(3.86±1.35)d] were significantly shorter than the control group [(5.01±2.10)d、(6.41±1.47)d], Thedifference was significant(P<0.05). Conclusion Methylprednisolone combined with gamma globulin is effective in the treatment of acute idiopathic thrombocytopenic purpura in children. It is superior to methylprednisolone alone.
引文
[1]汤琳.小儿急性特发性血小板减少性紫癜应用甲基强的松龙联合丙种球蛋白治疗的效果与护理影响[J].中国医学工程,2016,24(3):3-6.
[2]王德文.重症血小板减少性紫癜35例临床分析[J].当代医学,2013,19(27):49-50.
[3]苏美云,侯正军,叶舒婷.不同剂量丙种球蛋白联合糖皮质激素治疗特发性血小板减少性紫癜的研究[J].现代实用医学,2017,29(2):222-224.
[4]方鹏.甲基强的松龙联合丙种球蛋白冲击治疗重症过敏性紫癜患儿的效果分析[J].河南医学研究,2017,26(22):4122-4123.
[5]黄清波.免疫球蛋白联合肾上腺皮质激素治疗儿童急性特发性血小板减少性紫癜效果观察[J].临床医学,2017,37(9):68-70.
[6]丁洪亮.甲基强的松龙联合丙种球蛋白冲击疗法对重症过敏性紫癜患儿症状改善及预后的影响[J].系统医学,2017,2(7):75-77.
[7]王香红,熊婷,程兰,等.人血丙种球蛋白冲击治疗小儿血小板减少性紫癜的护理配合[J].当代医学,2016,22(34):141-141,142.
[8]董存山.糖皮质激素联合丙种球蛋白治疗特发性血小板减少性紫癜患儿临床效果观察[J].河南医学研究,2017,26(2):258-259.
[2]王德文.重症血小板减少性紫癜35例临床分析[J].当代医学,2013,19(27):49-50.
[3]苏美云,侯正军,叶舒婷.不同剂量丙种球蛋白联合糖皮质激素治疗特发性血小板减少性紫癜的研究[J].现代实用医学,2017,29(2):222-224.
[4]方鹏.甲基强的松龙联合丙种球蛋白冲击治疗重症过敏性紫癜患儿的效果分析[J].河南医学研究,2017,26(22):4122-4123.
[5]黄清波.免疫球蛋白联合肾上腺皮质激素治疗儿童急性特发性血小板减少性紫癜效果观察[J].临床医学,2017,37(9):68-70.
[6]丁洪亮.甲基强的松龙联合丙种球蛋白冲击疗法对重症过敏性紫癜患儿症状改善及预后的影响[J].系统医学,2017,2(7):75-77.
[7]王香红,熊婷,程兰,等.人血丙种球蛋白冲击治疗小儿血小板减少性紫癜的护理配合[J].当代医学,2016,22(34):141-141,142.
[8]董存山.糖皮质激素联合丙种球蛋白治疗特发性血小板减少性紫癜患儿临床效果观察[J].河南医学研究,2017,26(2):258-259.