鼓室注射甲泼尼龙琥珀酸钠治疗突发性耳聋的可行性
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摘要
目的:探讨鼓室注射甲泼尼龙琥珀酸钠治疗突发性耳聋的可行性。方法:选择2016年1月-2017年12月于本院确诊单侧突发性耳聋的患者60例,按照随机数字表法将所有患者分为治疗组(n=33)和对照组(n=27)。治疗组给予患耳鼓室注射甲泼尼龙琥珀酸钠,对照组给予静脉注射甲泼尼龙琥珀酸钠,对比两组患者治疗有效率、治疗前后听力阈值升高平均值及症状改善情况、血脂水平及治疗过程中不良反应之间的差异。结果:治疗组治疗总有效率显著高于对照组(P<0.05);治疗组患者治疗后各频率下的听力上升平均值明显高于对照组(P<0.05);治疗组治疗后三组主要症状改善率显著高于对照组(P<0.05);治疗组治疗后总胆固醇、甘油三酯及脂蛋白A均显著低于对照组(P<0.05);两组患者治疗过程中均未出现明显不良反应。结论:鼓室注射注甲泼尼龙琥珀酸钠能更有效提升突发性耳聋患者的治疗效果,同时对患者血脂水平变化影响较小,安全性也较高。
Objective:To investigate the feasibility of tympanosin injection of methylprednisolone sodium succinate in the treatment of sudden deafness.Method:Sixty patients with unilateral sudden deafness diagnosed in our hospital from January 2016 to December 2017 were enrolled.All patients were divided into treatment group(n=33) and control group(n=27) according to random number table.The treatment group was given Methylprednisolone Sodium Succinate Injection in the ear chamber.The control group received intravenous injection of Methylprednisolone Sodium Succinate.The effective rate of treatment,the mean value of hearing threshold before and after treatment,and the improvement of symptoms,blood lipid levels and adverse reactions during treatment of two groups were compared.Result:The total effective rate of treatment group was significantly higher than that of the control group(P<0.05).The average hearing increase of the treatment group was significantly higher than that of the control group(P<0.05).The improvement rate of the main symptoms in the treatment group was significantly higher than that in the control group(P<0.05).The total cholesterol,triglyceride and lipoprotein A in the treatment group were significantly lower than those in the control group(P<0.05).There were no significant adverse reactions during the treatment of the two groups of patients(P>0.05).Conclusion:Intratympanic injection of Methylprednisolone Sodium Succinate can effectively improve the therapeutic effect of patients with sudden deafness.At the same time,it has little effect on the changes of blood lipid levels and safety.
Objective:To investigate the feasibility of tympanosin injection of methylprednisolone sodium succinate in the treatment of sudden deafness.Method:Sixty patients with unilateral sudden deafness diagnosed in our hospital from January 2016 to December 2017 were enrolled.All patients were divided into treatment group(n=33) and control group(n=27) according to random number table.The treatment group was given Methylprednisolone Sodium Succinate Injection in the ear chamber.The control group received intravenous injection of Methylprednisolone Sodium Succinate.The effective rate of treatment,the mean value of hearing threshold before and after treatment,and the improvement of symptoms,blood lipid levels and adverse reactions during treatment of two groups were compared.Result:The total effective rate of treatment group was significantly higher than that of the control group(P<0.05).The average hearing increase of the treatment group was significantly higher than that of the control group(P<0.05).The improvement rate of the main symptoms in the treatment group was significantly higher than that in the control group(P<0.05).The total cholesterol,triglyceride and lipoprotein A in the treatment group were significantly lower than those in the control group(P<0.05).There were no significant adverse reactions during the treatment of the two groups of patients(P>0.05).Conclusion:Intratympanic injection of Methylprednisolone Sodium Succinate can effectively improve the therapeutic effect of patients with sudden deafness.At the same time,it has little effect on the changes of blood lipid levels and safety.
引文
[1]杨斌,王占强,朱建忠,等.高压氧联合地塞米松治疗突发性耳聋的疗效及对血液流变学的影响[J].现代生物医学进展,2016,16(17):3366-3369.
[2]舒博,叶胜难,林有辉,等.突发性耳聋患者眼肌前庭诱发肌源性电位特点[J].中华耳科学杂志,2016,14(1):75-78.
[3]张麦叶,尹桂茹,张洁,等.巴曲酶联合甲泼尼龙琥珀酸钠治疗高频下降型突发性耳聋的疗效分析[J].承德医学院学报,2018,35(2):111-113.
[4]班正锋.甲泼尼龙琥珀酸钠耳后注射治疗突发性耳聋的疗效观察[J].医学临床研究,2017,34(1):171-173.
[5]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋的诊断和治疗指南(2005,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41(8):569.
[6]黄智强,李洁,喇新军,等.甲泼尼龙琥珀酸钠对突发性耳聋患者听力康复及血脂水平的影响[J].中国听力语言康复科学杂志,2017,15(6):414-417.
[7]李娜,秦振龙,袁蓉,等.超声引导下小剂量利多卡因颈交感神经阻滞治疗突发性耳聋的短期疗效及安全性分析[J].中国康复医学杂志,2017,32(4):461-463.
[8]郑逸品,张建华.突发性耳聋患者治疗中出现听力损失加重的病因分析[J].临床和实验医学杂志,2016,15(20):2034-2037.
[9]付建梅.鼓室注射类固醇激素联合改善微循环药物治疗突发性耳聋疗效观察[J].山西医药杂志,2018,47(1):71-72.
[10]耿萍,陈亚权.鼓室注射与静脉滴注甲泼尼龙琥珀酸钠治疗突发性耳聋的疗效对比研究[J].现代药物与临床,2017,32(6):1105-1108.
[11]张慧平,屈永涛,赵冬华,等.鼓室注射类固醇激素治疗中老年突发性耳聋患者的临床疗效观察[J].现代生物医学进展,2016,16(22):4286-4288.
[12]周长华,桂明才,徐丹,等.地塞米松耳后注射治疗突发性聋的临床观察[J].中国中西医结合耳鼻咽喉科杂志,2016,24(2):99-100.
[13]张宇,高中,刘亚军,等.早期联合鼓室注射糖皮质激素治疗突发性聋效果分析[J].中国耳鼻咽喉头颈外科,2016,23(2):73-77.
[14]吴晓蓓,郭嘉隆,刘波,等.60例成人原发性肾病综合征患者血脂异常的对比分析[J].中国实验诊断学,2017,21(4):671-672.
[15]刘麟,胡蓉杰,肖社平.血脂代谢及凝血功能与突发性耳聋相关性研究[J].血栓与止血学,2015,21(6):393-394.
[16]陈玉卿,朱婕,张磊.突发性耳聋患者血脂代谢及凝血功能的临床分析[J].山西医药杂志,2017,46(17):2095-2096.
[2]舒博,叶胜难,林有辉,等.突发性耳聋患者眼肌前庭诱发肌源性电位特点[J].中华耳科学杂志,2016,14(1):75-78.
[3]张麦叶,尹桂茹,张洁,等.巴曲酶联合甲泼尼龙琥珀酸钠治疗高频下降型突发性耳聋的疗效分析[J].承德医学院学报,2018,35(2):111-113.
[4]班正锋.甲泼尼龙琥珀酸钠耳后注射治疗突发性耳聋的疗效观察[J].医学临床研究,2017,34(1):171-173.
[5]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋的诊断和治疗指南(2005,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41(8):569.
[6]黄智强,李洁,喇新军,等.甲泼尼龙琥珀酸钠对突发性耳聋患者听力康复及血脂水平的影响[J].中国听力语言康复科学杂志,2017,15(6):414-417.
[7]李娜,秦振龙,袁蓉,等.超声引导下小剂量利多卡因颈交感神经阻滞治疗突发性耳聋的短期疗效及安全性分析[J].中国康复医学杂志,2017,32(4):461-463.
[8]郑逸品,张建华.突发性耳聋患者治疗中出现听力损失加重的病因分析[J].临床和实验医学杂志,2016,15(20):2034-2037.
[9]付建梅.鼓室注射类固醇激素联合改善微循环药物治疗突发性耳聋疗效观察[J].山西医药杂志,2018,47(1):71-72.
[10]耿萍,陈亚权.鼓室注射与静脉滴注甲泼尼龙琥珀酸钠治疗突发性耳聋的疗效对比研究[J].现代药物与临床,2017,32(6):1105-1108.
[11]张慧平,屈永涛,赵冬华,等.鼓室注射类固醇激素治疗中老年突发性耳聋患者的临床疗效观察[J].现代生物医学进展,2016,16(22):4286-4288.
[12]周长华,桂明才,徐丹,等.地塞米松耳后注射治疗突发性聋的临床观察[J].中国中西医结合耳鼻咽喉科杂志,2016,24(2):99-100.
[13]张宇,高中,刘亚军,等.早期联合鼓室注射糖皮质激素治疗突发性聋效果分析[J].中国耳鼻咽喉头颈外科,2016,23(2):73-77.
[14]吴晓蓓,郭嘉隆,刘波,等.60例成人原发性肾病综合征患者血脂异常的对比分析[J].中国实验诊断学,2017,21(4):671-672.
[15]刘麟,胡蓉杰,肖社平.血脂代谢及凝血功能与突发性耳聋相关性研究[J].血栓与止血学,2015,21(6):393-394.
[16]陈玉卿,朱婕,张磊.突发性耳聋患者血脂代谢及凝血功能的临床分析[J].山西医药杂志,2017,46(17):2095-2096.