外用类固醇治疗小儿包茎的研究进展
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摘要
目的综述近年来外用类固醇治疗小儿包茎的研究进展。方法查阅国内外有关外用类固醇治疗小儿包茎的期刊文献,进行归纳总结。结果近年大量实验研究和临床探索表明,发达国家行包皮环切术的比例正在下降,局部外用类固醇可通过抗炎及皮肤变薄效应来治疗小儿包茎,且并发症少。结论局部外用类固醇可治疗小儿包茎,为国内小儿包茎的治疗提供了新思路和参考。
Objective To summary the advances on topical steroids for treating phimosis in boys.Methods The domestic and overseas research literatures on topical steroids for treating phimosis in boys were consulted,reviewed and analyzed.Results Through the domestic and overseas research in recent years,the proportion of circumcision was descended in developed countries.The topical steroids for treating phimosis in boys was based on the anti inflammation and skin thinning effect of the steroids,and had fewer complication.Conclusion Topical steroids could be used in treating phimosis in boys.It provided new ideas and references for the treatment of phimosis in boys.
Objective To summary the advances on topical steroids for treating phimosis in boys.Methods The domestic and overseas research literatures on topical steroids for treating phimosis in boys were consulted,reviewed and analyzed.Results Through the domestic and overseas research in recent years,the proportion of circumcision was descended in developed countries.The topical steroids for treating phimosis in boys was based on the anti inflammation and skin thinning effect of the steroids,and had fewer complication.Conclusion Topical steroids could be used in treating phimosis in boys.It provided new ideas and references for the treatment of phimosis in boys.
引文
[1] Kikiros C S,Beasley S W,Woodward A A.The response of phimosis to local steroid application[J].Pediatr Surg Int,1993,(8):329-332.
[2] Nameless.Circumcision policy statement.American Academy of Pediatrics.Task Force on Circumcision[J].Pediatrics,1999,103(3):686-693.
[3] Jozsa T,Teiringer N,Csiszko A,et al.New recommendation on timing of preputial adhesiolysis[J].Eur Urol Suppl,2010,9(6):648.
[4] 邓小玲.上海市郊小儿包茎发生率及干预效果评估[J].中国社区医师,2013,15(5):178-179.
[5] Banwari M.Dangerous to mix:culture and politics in a traditional circumcision in South Africa[J].Afr Health,2015,15(1):283-287.
[6] Sch?fer H.Male circumcision from an infectiological point of view[J].Hautarzt,2015,66(1):30-37.
[7] 黄建权,许姜姜,高洁,等.2016年儿童医院清洁手术围术期预防用抗菌药物分析[J].西北药学杂志,2018,33(2):260-263.
[8] Gee W F,Ansell J S.Neonatal circumcision:a ten-year overview with comparison of the Gomco and the plastibell device[J].Paediatrics,1976,58:824-827.
[9] Gold G,Young S,O′Brien M,et al.Complications following circumcision:presentations to the emergency department[J].J Paediatr Child H,2015,51(12):1158-1163.
[10] Brook I.Infectious complications of circumcision and their prevention[J].Eur Urol Focus,2016,2(4):453-459.
[11] Srinivasan M,Hamvas C,Coplen D,et al.Rates of complications after newborn circumcision in a well-baby nursery,special care nursery,and neonatal intensive care unit[J].Clin Pediatr,2015,54(12):1185-1191.
[12] Lane V,Vajda P,Subramaniam R.Paediatric sutureless circumcision:a systematic literature review[J].Paediatr Surg Int,2010,26(2):141-144.
[13] Sookpotarom P,Porncharoenpong S,Vejchapipat P.Topical steroid is effective for the treatment of phimosis in young children[J].J Med Assoc Thai,2010,93(1):77-83.
[14] Ku W H,Chiu B S K,Huen K F.Outcome and recurrence in treatment of phimosis using topical betamethasone in children in Hong Kong[J].J Paediatr Child H,2007,43(1/2):74-79.
[15] Garcia R,Nobre Y D,Demarchi G T.Topical treatment for phimosis:time span and other factors behind treatment effectiveness[J].J Pediatr Urol,2006,2(4):380-385.
[16] Moreno G,Corbalán J,Peňaloza B,et al.Topical corticosteroids for treating phimosis in boys[J].Cochrane Database Syst Rev,2014,2(9):CD008973.
[17] Zeiai S,Wahlin N,Fossum M.Clobetasol primarily used for phimosis in children[J].Lakartidningen,2015,14:112.
[18] Esposito C,Centonze A,Alicchio F,et al.Topical steroid application versus circumcision in pediatric patients with phimosis:a prospective randomized placebo controlled clinical trial[J].World J Urol,2008,26(2):187-190.
[19] Letendre J,Barrieras D,Franc-Guimond J,et al.Topical triamcinolone persistent phimosis[J].J Urology,2009,182(4):1759-1763.
[20] Sookpotarom P,Asawutmangkul C,Srinithiwat B,et al.Is half strength of 0.05% betamethasone valerate cream still effective in the treatment of phimosis in young children?[J].Pediatr Surg Int,2013,29(4):393-396.
[21] Kuehhas F E,Miernik A,Sevcenco S,et al.Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis[J].J Urology,2012,80(2):412-416.
[22] Nascimento F J,Pereira R F,Silva J L,et al.Topical betamethasone and hyaluronidase in the treatment of phimosis in boys:a double-blind,randomized,placebo-controlled trial[J].Int Braz J Urol,2011,37(3):314-319.
[23] Pileggi Fde O,Vicente Y A.Phimotic ring topical corticoid cream (0.1% mometasone furoate) treatment in children[J].J Pediatr Surg,2007,42(10):1749-1752.
[24] 陈伟中,凤仪萍.儿童包茎的内科治疗[J].男科学报,1999,5(4):207-208.
[25] 梁启宁,冯钢,吴坚,等.四环素可的松眼膏治疗儿童包茎疗效观察[J].中国航天工业医药,2001,3(4):71.
[26] Clark A R.Anti-inflammatory functions of glucocorticoid-induced genes[J].Mol Cell Endocrinol,2007,275(1/2):79-97.
[27] Jiang X,Dahlin A,Weiss S T,et al.A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor[J].Sci Rep,2017,7(1):7405.
[28] De Bosscher K,Vanden Berghe W,Haegeman G.Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids:negative interference of activated glucocorticoid receptor with transcription factors[J].J Neuroimmunol,2000,109(1):16-22.
[29] Barnes P J.Mechanisms and resistance in glucocorticoid control of inflammation[J].J Steroid Biochem,2010,120(2/3):76-85.
[30] 仇洪影.糖皮质激素类药物的作用机制和临床应用[J].中国中医药现代远程教育,2010,8(4):90-91.
[31] 杜臻雁,唐福林.糖皮质激素抗炎作用机制的研究进展[J].中华医学杂志,2006,86(35):2512-2515.
[32] Shlivko I L,Kamensky V A,Donchenko E V,et al.Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus[J].Skin Res Technol,2014,20(2):136-140.
[33] 孙程,盛新福,张立东,等.包茎局部狭窄环超微结构研究[J].新疆医科大学学报,2014,37(8):1044-1045.
[34] Van Howe R S.Cost-effective treatment of phimosis[J].Pediatrics,1998,102(4):E43.
[35] Klyver H,Mortensen S O,Klarskov O P,et al.Treatment of phimosis with a steroid creme in boys[J].Ugeskr Laeger,2001,163(7):922-924.
[2] Nameless.Circumcision policy statement.American Academy of Pediatrics.Task Force on Circumcision[J].Pediatrics,1999,103(3):686-693.
[3] Jozsa T,Teiringer N,Csiszko A,et al.New recommendation on timing of preputial adhesiolysis[J].Eur Urol Suppl,2010,9(6):648.
[4] 邓小玲.上海市郊小儿包茎发生率及干预效果评估[J].中国社区医师,2013,15(5):178-179.
[5] Banwari M.Dangerous to mix:culture and politics in a traditional circumcision in South Africa[J].Afr Health,2015,15(1):283-287.
[6] Sch?fer H.Male circumcision from an infectiological point of view[J].Hautarzt,2015,66(1):30-37.
[7] 黄建权,许姜姜,高洁,等.2016年儿童医院清洁手术围术期预防用抗菌药物分析[J].西北药学杂志,2018,33(2):260-263.
[8] Gee W F,Ansell J S.Neonatal circumcision:a ten-year overview with comparison of the Gomco and the plastibell device[J].Paediatrics,1976,58:824-827.
[9] Gold G,Young S,O′Brien M,et al.Complications following circumcision:presentations to the emergency department[J].J Paediatr Child H,2015,51(12):1158-1163.
[10] Brook I.Infectious complications of circumcision and their prevention[J].Eur Urol Focus,2016,2(4):453-459.
[11] Srinivasan M,Hamvas C,Coplen D,et al.Rates of complications after newborn circumcision in a well-baby nursery,special care nursery,and neonatal intensive care unit[J].Clin Pediatr,2015,54(12):1185-1191.
[12] Lane V,Vajda P,Subramaniam R.Paediatric sutureless circumcision:a systematic literature review[J].Paediatr Surg Int,2010,26(2):141-144.
[13] Sookpotarom P,Porncharoenpong S,Vejchapipat P.Topical steroid is effective for the treatment of phimosis in young children[J].J Med Assoc Thai,2010,93(1):77-83.
[14] Ku W H,Chiu B S K,Huen K F.Outcome and recurrence in treatment of phimosis using topical betamethasone in children in Hong Kong[J].J Paediatr Child H,2007,43(1/2):74-79.
[15] Garcia R,Nobre Y D,Demarchi G T.Topical treatment for phimosis:time span and other factors behind treatment effectiveness[J].J Pediatr Urol,2006,2(4):380-385.
[16] Moreno G,Corbalán J,Peňaloza B,et al.Topical corticosteroids for treating phimosis in boys[J].Cochrane Database Syst Rev,2014,2(9):CD008973.
[17] Zeiai S,Wahlin N,Fossum M.Clobetasol primarily used for phimosis in children[J].Lakartidningen,2015,14:112.
[18] Esposito C,Centonze A,Alicchio F,et al.Topical steroid application versus circumcision in pediatric patients with phimosis:a prospective randomized placebo controlled clinical trial[J].World J Urol,2008,26(2):187-190.
[19] Letendre J,Barrieras D,Franc-Guimond J,et al.Topical triamcinolone persistent phimosis[J].J Urology,2009,182(4):1759-1763.
[20] Sookpotarom P,Asawutmangkul C,Srinithiwat B,et al.Is half strength of 0.05% betamethasone valerate cream still effective in the treatment of phimosis in young children?[J].Pediatr Surg Int,2013,29(4):393-396.
[21] Kuehhas F E,Miernik A,Sevcenco S,et al.Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis[J].J Urology,2012,80(2):412-416.
[22] Nascimento F J,Pereira R F,Silva J L,et al.Topical betamethasone and hyaluronidase in the treatment of phimosis in boys:a double-blind,randomized,placebo-controlled trial[J].Int Braz J Urol,2011,37(3):314-319.
[23] Pileggi Fde O,Vicente Y A.Phimotic ring topical corticoid cream (0.1% mometasone furoate) treatment in children[J].J Pediatr Surg,2007,42(10):1749-1752.
[24] 陈伟中,凤仪萍.儿童包茎的内科治疗[J].男科学报,1999,5(4):207-208.
[25] 梁启宁,冯钢,吴坚,等.四环素可的松眼膏治疗儿童包茎疗效观察[J].中国航天工业医药,2001,3(4):71.
[26] Clark A R.Anti-inflammatory functions of glucocorticoid-induced genes[J].Mol Cell Endocrinol,2007,275(1/2):79-97.
[27] Jiang X,Dahlin A,Weiss S T,et al.A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor[J].Sci Rep,2017,7(1):7405.
[28] De Bosscher K,Vanden Berghe W,Haegeman G.Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids:negative interference of activated glucocorticoid receptor with transcription factors[J].J Neuroimmunol,2000,109(1):16-22.
[29] Barnes P J.Mechanisms and resistance in glucocorticoid control of inflammation[J].J Steroid Biochem,2010,120(2/3):76-85.
[30] 仇洪影.糖皮质激素类药物的作用机制和临床应用[J].中国中医药现代远程教育,2010,8(4):90-91.
[31] 杜臻雁,唐福林.糖皮质激素抗炎作用机制的研究进展[J].中华医学杂志,2006,86(35):2512-2515.
[32] Shlivko I L,Kamensky V A,Donchenko E V,et al.Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus[J].Skin Res Technol,2014,20(2):136-140.
[33] 孙程,盛新福,张立东,等.包茎局部狭窄环超微结构研究[J].新疆医科大学学报,2014,37(8):1044-1045.
[34] Van Howe R S.Cost-effective treatment of phimosis[J].Pediatrics,1998,102(4):E43.
[35] Klyver H,Mortensen S O,Klarskov O P,et al.Treatment of phimosis with a steroid creme in boys[J].Ugeskr Laeger,2001,163(7):922-924.