经肝动脉EAP栓塞化疗在胃癌肝转移患者中的临床效果及对毒副反应发生率的影响研究
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摘要
目的探讨经肝动脉EAP栓塞化疗在胃癌肝转移患者中的临床效果及对毒副反应发生率的影响。方法选择我院2016年5月至2017年2月收治的胃癌肝转移患者72例,随机分为对照组(n=36)和观察组(n=36)。对照组给予单纯放疗治疗,观察组采用经肝动脉EAP栓塞化疗。比较两组的近期疗效、 KPS评分及毒副反应发生率。结果观察组治疗4个疗程后的总有效率为61.11%,高于对照组的30.56%(P <0.05)。观察组治疗1个疗程、 2个疗程、 3个疗程及4个疗程后的KPS评分均高于对照组(P <0.05)。治疗过程中,两组的毒副反应发生率比较差异均无统计学意义(P>0.05)。结论经肝动脉EAP栓塞化疗应用于胃癌肝转移患者中能够获得较好的近期疗效,提高患者的生活质量,未增加毒副反应。
Objective To explore the clinical effect of transhepatic arterial EAP chemoembolization in patients with gastric cancer liver metastasis and the influence on incidence of toxic side effects. Methods 72 cases of patients with gastric cancer liver metastasis admitted to our hospital from May 2016 to February 2017 were selected and randomly divided into control group(n = 36) and observation group(n = 36). The control group only received radiotherapy, while the observation group received transhepatic arterial EAP chemoembolization. The short-term efficacy, KPS score and incidence of toxic side effects were compared between two groups. Results The total effective rate after 4 courses of treatment in the observation group was 61.11%, higher than 30.56% in the control group(P <0.05). The KPS scores after 1 course, 2 courses, 3 courses and 4 courses of treatment in the observation group were higher than those in the control group(P <0.05). No statistical difference was found in the incidence of toxic side effects during treatment between the two groups(P >0.05).Conclusions Transhepatic arterial EAP chemoembolization in the application of patients with gastric cancer liver metastasis can obtain better short-term efficacy, improve patients' quality of life, and not increase toxic side effects.
Objective To explore the clinical effect of transhepatic arterial EAP chemoembolization in patients with gastric cancer liver metastasis and the influence on incidence of toxic side effects. Methods 72 cases of patients with gastric cancer liver metastasis admitted to our hospital from May 2016 to February 2017 were selected and randomly divided into control group(n = 36) and observation group(n = 36). The control group only received radiotherapy, while the observation group received transhepatic arterial EAP chemoembolization. The short-term efficacy, KPS score and incidence of toxic side effects were compared between two groups. Results The total effective rate after 4 courses of treatment in the observation group was 61.11%, higher than 30.56% in the control group(P <0.05). The KPS scores after 1 course, 2 courses, 3 courses and 4 courses of treatment in the observation group were higher than those in the control group(P <0.05). No statistical difference was found in the incidence of toxic side effects during treatment between the two groups(P >0.05).Conclusions Transhepatic arterial EAP chemoembolization in the application of patients with gastric cancer liver metastasis can obtain better short-term efficacy, improve patients' quality of life, and not increase toxic side effects.
引文
[1]克尤木·阿不来提,周应恩,布瓦扎尔·沙吾提.鸦胆子油乳剂辅助经导管肝动脉化疗栓塞术治疗肝癌患者临床疗效及对血浆内毒素、血管内皮生长因子水平影响[J].临床军医杂志, 2017, 45(8):851-853, 856.
[2] Prince JF, van den Bosch MAAJ, Nijsen JFW, et al. Efficacy of radioembolization with166Ho-microspheres in salvage patients with liver metastases:a phase 2 study[J]. J Nucl Med, 2018, 59(4):582-588.
[3]徐兰英,杨国春,王艳丽,等.脾多肽注射液对原发性肝癌患者超声学改变及AFP水平的影响[J].现代生物医学进展, 2017, 17(18):3574-3578.
[4]刘晓鹏,王国兴,张文超.经肝动脉栓塞化疗治疗结直肠癌肝转移的CT影像学评估及疗效观察[J].医学临床研究, 2017, 34(5):974-976.
[5]李博,谷铁树,张毅博,等.经导管肝动脉灌注化疗栓塞术联合三维适形放疗治疗中晚期肝癌的临床疗效研究[J].中国全科医学,2017, 20(33):4121-4124, 4129.
[2] Prince JF, van den Bosch MAAJ, Nijsen JFW, et al. Efficacy of radioembolization with166Ho-microspheres in salvage patients with liver metastases:a phase 2 study[J]. J Nucl Med, 2018, 59(4):582-588.
[3]徐兰英,杨国春,王艳丽,等.脾多肽注射液对原发性肝癌患者超声学改变及AFP水平的影响[J].现代生物医学进展, 2017, 17(18):3574-3578.
[4]刘晓鹏,王国兴,张文超.经肝动脉栓塞化疗治疗结直肠癌肝转移的CT影像学评估及疗效观察[J].医学临床研究, 2017, 34(5):974-976.
[5]李博,谷铁树,张毅博,等.经导管肝动脉灌注化疗栓塞术联合三维适形放疗治疗中晚期肝癌的临床疗效研究[J].中国全科医学,2017, 20(33):4121-4124, 4129.