摘要
乳腺癌作为全球范围内发病率较高的恶性肿瘤,对其分子分型的研究一直在进行,雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(C-erbB-2,HER2/neu)是已被广泛认可的乳腺癌的重要生物学标志物,对乳腺癌的分型诊断、治疗方案的制定及预后评价均具有重要意义。乳腺癌新辅助化疗(NAC)可有效控制肿瘤,针对新辅助化疗前后ER、PR及C-erbB-2的表达情况,国内外进行了大量的相关研究,但均未达成一致结论。
Breast cancer is a kind of malignant tumor with high incidence rate in all over the world and the studies of its molecular classifications have been always conducting. The estrogen receptor( ER),progesterone receptor( PR) and human epidermal growth factor receptor-2( C-erb B-2,HER2/neu) as important biological markers of breast cancer have been widely recognized,which are of great significance for classification,diagnosis,treatment and prognosis evaluation. The neoadjuvant chemotherapy( NAC) of breast cancer can effectively control the tumor. For the expression of ER,PR and C-erbB-2 before and after neoadjuvant chemotherapy of breast cancer,a large number of relevant researches have been studied at home and abroad,but all have failed to agree on same conclusions.
引文
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