S-腺苷甲硫氨酸联合还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症效果分析
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摘要
目的:研究S-腺苷甲硫氨酸联合还原型谷胱甘肽应用在妊娠期肝内胆汁淤积症的临床疗效。方法:选取笔者所在医院2015年1月-2016年12月收治的72例妊娠期肝内胆汁淤积症患者作为本次研究对象,按照随机数字表法将其分为研究组和对照组,每组36例,两组患者均应用S-腺苷甲硫氨酸常规治疗,研究组在此基础上加用还原型谷胱甘肽治疗,对比分析两组患者的治疗效果,谷丙转氨酶与血总胆汁酸及谷酸转氨酶水平,并比较两组的各项评分。结果:研究组剖宫产率(30.55%)显著低于对照组(63.89%),组间比较差异有统计学意义(P<0.05);两组在分娩孕周、Apgar评分与新生儿体质量和胎儿窘迫方面比较差异无统计学意义(P>0.05)。研究组治疗后的瘙痒程度评分为(0.42±0.16)分,对照组瘙痒评分为(0.76±0.19)分,组间比较差异有统计学意义(t=8.212 7,P<0.05)。研究组的血TBA、ALT与AST水平显著低于对照组,组间比较差异有统计学意义(P<0.05)。结论:S-腺苷甲硫氨酸联合还原型谷胱甘肽应用在妊娠期肝内胆汁淤积症的效果显著,能够有效提高患者的治疗总有效率,值得临床应用探索。
Objective:To study the clinical efficacy of S-adenosylmethionine combined with Reduced Glutathione in the treatment of intrahepatic cholestasis during pregnancy.Method:Seventy-two patients with intrahepatic cholestasis during pregnancy from January 2015 to December 2016 were selected as subjects of this study.They were divided into study group and control group according to the random number table method,each of 36 patients.Conventional therapy were used in both groups.The study group was treated with Reduced Glutathione,and the therapeutic effect of two groups of patients was compared.The alanine aminotransferase and blood were compared.Total bile acids and glutamic acid transaminase levels were compared and the scores of the two groups were compared.Result:Cesarean delivery rate(30.55%) of study group was significantly lower than the control group(63.89%),and there was statistical significance(P<0.05).Two groups of gestational age,Apgar score in labour quality and fetal distress and neonatal body wight had no statistical significance(P>0.05).The study group after treatment of itching degree score was(0.42±0.16)points and control group of pruritus score was(0.76±0.19)points,there was significant difference(t=8.212 7,P<0.05).The blood TBA,ALT and AST levels of the study group were significantly lower than those of the control group,and the difference between the groups was significant(P<0.05).Conclusion:S-adenosylmethionine combined with Reduced Glutathione has a significant effect on intrahepatic cholestasis during pregnancy,and can effectively improve the total treatment efficiency of patients.It is worthy of clinical application.
Objective:To study the clinical efficacy of S-adenosylmethionine combined with Reduced Glutathione in the treatment of intrahepatic cholestasis during pregnancy.Method:Seventy-two patients with intrahepatic cholestasis during pregnancy from January 2015 to December 2016 were selected as subjects of this study.They were divided into study group and control group according to the random number table method,each of 36 patients.Conventional therapy were used in both groups.The study group was treated with Reduced Glutathione,and the therapeutic effect of two groups of patients was compared.The alanine aminotransferase and blood were compared.Total bile acids and glutamic acid transaminase levels were compared and the scores of the two groups were compared.Result:Cesarean delivery rate(30.55%) of study group was significantly lower than the control group(63.89%),and there was statistical significance(P<0.05).Two groups of gestational age,Apgar score in labour quality and fetal distress and neonatal body wight had no statistical significance(P>0.05).The study group after treatment of itching degree score was(0.42±0.16)points and control group of pruritus score was(0.76±0.19)points,there was significant difference(t=8.212 7,P<0.05).The blood TBA,ALT and AST levels of the study group were significantly lower than those of the control group,and the difference between the groups was significant(P<0.05).Conclusion:S-adenosylmethionine combined with Reduced Glutathione has a significant effect on intrahepatic cholestasis during pregnancy,and can effectively improve the total treatment efficiency of patients.It is worthy of clinical application.
引文
[1]谢萍,王莹,尹燕平.S-腺苷甲硫氨酸联合还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症[J].国际妇产科学杂志,2017,44(2):222-224,240.
[2]周学梅.还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症的效果观察[J].中国妇幼保健,2017,30(9):1885-1887.
[3]余万洪.还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症疗效观察[J].深圳中西医结合杂志,2017,27(20):164-165.
[4]张凌云.思美泰联合还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症30例疗效观察[J].河南外科学杂志,2011,27(3):102-104.
[5]李伟,沈连强,何慧.妊娠期高血压疾病合并妊娠期肝内胆汁淤积症35例临床分析[J].中国妇产科临床杂志,2012,13(3):167-169.
[6]陈晓玲.低分子肝素对妊娠期肝内胆汁淤积症患者预后的影响[J].医学信息,2015,29(38):48.
[7]韦懿芸,庞丽红.妊娠期肝内胆汁淤积症90例临床分析[J].广东医学,2017,38(z1):167-169.
[8]邵勇.妊娠期肝内胆汁淤积症转诊常见问题及注意事项[J].中国计划生育和妇产科,2018,10(3):1-3,9.
[9]林少芳.妊娠期肝内胆汁淤积症的护理经验总结[J].基层医学论坛,2017,21(33):4744-4745.
[10]段秀群,尹良琼.胆汁酸测定在妊娠期肝内胆汁淤积症早筛中的临床应用[J].中国生育健康杂志,2017,28(1):70-72.
[11]谢萍,王莹,尹燕平.S-腺苷甲硫氨酸联合还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症[J].国际妇产科学杂志,2017,44(2):222-224.
[12]谭白菊,李玉梅,冯小平,等.丁二磺酸腺苷蛋氨酸联合地塞米松对妊娠期肝内胆汁淤积症患者免疫功能及疗效的影响[J].国际妇产科学杂志,2016,43(5):563-566.
[2]周学梅.还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症的效果观察[J].中国妇幼保健,2017,30(9):1885-1887.
[3]余万洪.还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症疗效观察[J].深圳中西医结合杂志,2017,27(20):164-165.
[4]张凌云.思美泰联合还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症30例疗效观察[J].河南外科学杂志,2011,27(3):102-104.
[5]李伟,沈连强,何慧.妊娠期高血压疾病合并妊娠期肝内胆汁淤积症35例临床分析[J].中国妇产科临床杂志,2012,13(3):167-169.
[6]陈晓玲.低分子肝素对妊娠期肝内胆汁淤积症患者预后的影响[J].医学信息,2015,29(38):48.
[7]韦懿芸,庞丽红.妊娠期肝内胆汁淤积症90例临床分析[J].广东医学,2017,38(z1):167-169.
[8]邵勇.妊娠期肝内胆汁淤积症转诊常见问题及注意事项[J].中国计划生育和妇产科,2018,10(3):1-3,9.
[9]林少芳.妊娠期肝内胆汁淤积症的护理经验总结[J].基层医学论坛,2017,21(33):4744-4745.
[10]段秀群,尹良琼.胆汁酸测定在妊娠期肝内胆汁淤积症早筛中的临床应用[J].中国生育健康杂志,2017,28(1):70-72.
[11]谢萍,王莹,尹燕平.S-腺苷甲硫氨酸联合还原型谷胱甘肽治疗妊娠期肝内胆汁淤积症[J].国际妇产科学杂志,2017,44(2):222-224.
[12]谭白菊,李玉梅,冯小平,等.丁二磺酸腺苷蛋氨酸联合地塞米松对妊娠期肝内胆汁淤积症患者免疫功能及疗效的影响[J].国际妇产科学杂志,2016,43(5):563-566.