苍附导痰汤联合来曲唑治疗多囊卵巢综合征临床研究
|
摘要
目的:观察苍附导痰汤联合来曲唑治疗多囊卵巢综合征(PCOS)的临床疗效。方法:选取176例PCOS患者为研究对象,按随机数字表法分为观察组和对照组各88例。对照组给予来曲唑治疗,观察组在此基础上增加苍附导痰汤。对比2组临床疗效,观察2组治疗前后中医证候评分、生活质量评分、子宫内膜厚度、卵泡直径、激素水平的变化,记录不良反应发生情况。结果:观察组总有效率90.91%,对照组总有效率78.41%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组中医证候评分均较治疗前降低(P <0.05),生活质量评分均较治疗前升高(P <0.05);观察组中医证候评分低于对照组(P <0.05),生活质量评分高于对照组(P <0.05)。治疗后,2组子宫内膜厚度、卵泡直径均较治疗前增大(P <0.05),观察组子宫内膜厚度及卵泡直径均大于对照组(P <0.05)。治疗后,2组血清睾酮(T)、促黄体生成素(LH)、卵泡刺激素(FSH)水平均较治疗前下降(P <0.05),观察组T、LH及FSH水平均低于对照组(P <0.05)。观察组不良反应发生率17.05%,对照组不良反应发生率11.36%,2组比较,差异无统计学意义(P> 0.05)。结论:苍附导痰汤联合来曲唑治疗PCOS临床疗效显著,能有效改善患者的症状体征和激素水平,提高生活质量,用药安全性好,值得临床借鉴。
Objective:To observe the clinical effect of Cangfu Daotan tang combined with letrozole for polycystic ovary syndrome(PCOS). Methods:Selected 176 cases of patients with PCOS as study subjects,and divided them into the observation group and the control group randomly,88 cases in each group. The control group received letrozole,while the intervention group additionally received Cangfu Daotan tang. Compared the clinical effect in both groups,observed the changes of Chinese medicine syndrome scores,life quality scores,thickness of endometrium,follicular diameter and hormone levels in both groups before and after treatment,and recorded the occurrence of adverse reactions. Results:The total effective rate was 90.91% in the observation group and 78.41% in the control group,difference being significant(P <0.05). After treatment,Chinese medicine syndrome scores in both groups were lower than those before treatment(P < 0.05),and the life quality scores were higher than those before treatment(P < 0.05);Chinese medicine syndrome scores in the observation group were lower than those in the control group(P < 0.05),and the life quality scores were higher than those in the control group(P < 0.05). After treatment,the thickness of endometrium and follicular diameter in both groups were increased when comparing with those before treatment(P < 0.05),and the thickness of endometrium and follicular diameter in the observation group were higher than those in the control group(P < 0.05). After treatment,the levels of testosterone(T),luteinizing hormone(LH) and follicle stimulating hormone(FSH) in serum of both groups were all lower than thoe before treatment(P < 0.05),and the levels of T,LH and FSH in serum of the observation group were all lower than those of the control group(P < 0.05). The incidence of adverse reactions was 17.05% in the observation group and 11.36% in the control group,difference being insignificant(P > 0.05). Conclusion:Cangfu Daotan tang combined with letrozole has significant clinical effect in treating PCOS. It can effectively improve symptoms,physical signs and hormone levels of patients,and promote the quality of life with high safety of medication,which is worthy of clinical reference.
Objective:To observe the clinical effect of Cangfu Daotan tang combined with letrozole for polycystic ovary syndrome(PCOS). Methods:Selected 176 cases of patients with PCOS as study subjects,and divided them into the observation group and the control group randomly,88 cases in each group. The control group received letrozole,while the intervention group additionally received Cangfu Daotan tang. Compared the clinical effect in both groups,observed the changes of Chinese medicine syndrome scores,life quality scores,thickness of endometrium,follicular diameter and hormone levels in both groups before and after treatment,and recorded the occurrence of adverse reactions. Results:The total effective rate was 90.91% in the observation group and 78.41% in the control group,difference being significant(P <0.05). After treatment,Chinese medicine syndrome scores in both groups were lower than those before treatment(P < 0.05),and the life quality scores were higher than those before treatment(P < 0.05);Chinese medicine syndrome scores in the observation group were lower than those in the control group(P < 0.05),and the life quality scores were higher than those in the control group(P < 0.05). After treatment,the thickness of endometrium and follicular diameter in both groups were increased when comparing with those before treatment(P < 0.05),and the thickness of endometrium and follicular diameter in the observation group were higher than those in the control group(P < 0.05). After treatment,the levels of testosterone(T),luteinizing hormone(LH) and follicle stimulating hormone(FSH) in serum of both groups were all lower than thoe before treatment(P < 0.05),and the levels of T,LH and FSH in serum of the observation group were all lower than those of the control group(P < 0.05). The incidence of adverse reactions was 17.05% in the observation group and 11.36% in the control group,difference being insignificant(P > 0.05). Conclusion:Cangfu Daotan tang combined with letrozole has significant clinical effect in treating PCOS. It can effectively improve symptoms,physical signs and hormone levels of patients,and promote the quality of life with high safety of medication,which is worthy of clinical reference.
引文
[1]Merz NB,Shaw LJ,Azziz R,et al.Cardiovascular Disease and 10-Year Mortality in Postmenopausal Women with Clinical Features of Polycystic Ovary Syndrome[J].Womens Health(Larchmt),2016,25(9):875-881.
[2]马素侠.养精汤合来曲唑治疗多囊卵巢综合征肾气虚证临床观察[J].中医药临床杂志,2017,29(11):1881-1883.
[3]崔琳琳,陈子江.多囊卵巢综合征诊断标准和诊疗指南介绍[J].国际生殖健康/计划生育杂志,2011,30(5):405-408.
[4]刘敏如,欧阳惠卿.实用中医妇科学[M].2版.上海:上海科学技术出版社,2010.
[5]郝元涛,方积乾.世界卫生组织生存质量测定量表中文版介绍及其使用说明[J].中国组织工程研究,2000,4(8):1127-1129.
[6]陈丽英.达英-35联合来曲唑治疗难治性多囊卵巢综合征患者的疗效观察[J].临床合理用药杂志,2017,10(10):18-20.
[7]孟丹.疏肝补肾汤联合来曲唑治疗多囊卵巢综合征不孕不育症临床观察及对血清孕酮的影响[J].中华中医药学刊,2018,36(2):507-509.
[8]李蓉.疏肝补肾汤联合来曲唑治疗多囊卵巢综合征不孕不育症临床观察[J].深圳中西医结合杂志,2017,27(3):30-31.
[9]帅奕.针灸联合中药与来曲唑治疗多囊卵巢综合征不孕症(肾虚痰湿型)的疗效观察[J].实用妇科内分泌杂志(电子版),2017,4(20):98-99.
[10]胡艳军,杨永妮.多囊卵巢综合征患者血清FSH、LH、睾酮检测的临床意义[J].包头医学院学报,2016,32(7):92-93.
[11]巫伟芳,朱桂清,张永红.经阴道超声监测卵泡发育在多囊卵巢综合征不孕患者的临床价值[J].现代诊断与治疗,2017,28(19):3543-3544.
[2]马素侠.养精汤合来曲唑治疗多囊卵巢综合征肾气虚证临床观察[J].中医药临床杂志,2017,29(11):1881-1883.
[3]崔琳琳,陈子江.多囊卵巢综合征诊断标准和诊疗指南介绍[J].国际生殖健康/计划生育杂志,2011,30(5):405-408.
[4]刘敏如,欧阳惠卿.实用中医妇科学[M].2版.上海:上海科学技术出版社,2010.
[5]郝元涛,方积乾.世界卫生组织生存质量测定量表中文版介绍及其使用说明[J].中国组织工程研究,2000,4(8):1127-1129.
[6]陈丽英.达英-35联合来曲唑治疗难治性多囊卵巢综合征患者的疗效观察[J].临床合理用药杂志,2017,10(10):18-20.
[7]孟丹.疏肝补肾汤联合来曲唑治疗多囊卵巢综合征不孕不育症临床观察及对血清孕酮的影响[J].中华中医药学刊,2018,36(2):507-509.
[8]李蓉.疏肝补肾汤联合来曲唑治疗多囊卵巢综合征不孕不育症临床观察[J].深圳中西医结合杂志,2017,27(3):30-31.
[9]帅奕.针灸联合中药与来曲唑治疗多囊卵巢综合征不孕症(肾虚痰湿型)的疗效观察[J].实用妇科内分泌杂志(电子版),2017,4(20):98-99.
[10]胡艳军,杨永妮.多囊卵巢综合征患者血清FSH、LH、睾酮检测的临床意义[J].包头医学院学报,2016,32(7):92-93.
[11]巫伟芳,朱桂清,张永红.经阴道超声监测卵泡发育在多囊卵巢综合征不孕患者的临床价值[J].现代诊断与治疗,2017,28(19):3543-3544.