摘要
目的:观察苍附导痰汤联合来曲唑治疗多囊卵巢综合征(PCOS)的临床疗效。方法:选取176例PCOS患者为研究对象,按随机数字表法分为观察组和对照组各88例。对照组给予来曲唑治疗,观察组在此基础上增加苍附导痰汤。对比2组临床疗效,观察2组治疗前后中医证候评分、生活质量评分、子宫内膜厚度、卵泡直径、激素水平的变化,记录不良反应发生情况。结果:观察组总有效率90.91%,对照组总有效率78.41%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组中医证候评分均较治疗前降低(P <0.05),生活质量评分均较治疗前升高(P <0.05);观察组中医证候评分低于对照组(P <0.05),生活质量评分高于对照组(P <0.05)。治疗后,2组子宫内膜厚度、卵泡直径均较治疗前增大(P <0.05),观察组子宫内膜厚度及卵泡直径均大于对照组(P <0.05)。治疗后,2组血清睾酮(T)、促黄体生成素(LH)、卵泡刺激素(FSH)水平均较治疗前下降(P <0.05),观察组T、LH及FSH水平均低于对照组(P <0.05)。观察组不良反应发生率17.05%,对照组不良反应发生率11.36%,2组比较,差异无统计学意义(P> 0.05)。结论:苍附导痰汤联合来曲唑治疗PCOS临床疗效显著,能有效改善患者的症状体征和激素水平,提高生活质量,用药安全性好,值得临床借鉴。
Objective:To observe the clinical effect of Cangfu Daotan tang combined with letrozole for polycystic ovary syndrome(PCOS). Methods:Selected 176 cases of patients with PCOS as study subjects,and divided them into the observation group and the control group randomly,88 cases in each group. The control group received letrozole,while the intervention group additionally received Cangfu Daotan tang. Compared the clinical effect in both groups,observed the changes of Chinese medicine syndrome scores,life quality scores,thickness of endometrium,follicular diameter and hormone levels in both groups before and after treatment,and recorded the occurrence of adverse reactions. Results:The total effective rate was 90.91% in the observation group and 78.41% in the control group,difference being significant(P <0.05). After treatment,Chinese medicine syndrome scores in both groups were lower than those before treatment(P < 0.05),and the life quality scores were higher than those before treatment(P < 0.05);Chinese medicine syndrome scores in the observation group were lower than those in the control group(P < 0.05),and the life quality scores were higher than those in the control group(P < 0.05). After treatment,the thickness of endometrium and follicular diameter in both groups were increased when comparing with those before treatment(P < 0.05),and the thickness of endometrium and follicular diameter in the observation group were higher than those in the control group(P < 0.05). After treatment,the levels of testosterone(T),luteinizing hormone(LH) and follicle stimulating hormone(FSH) in serum of both groups were all lower than thoe before treatment(P < 0.05),and the levels of T,LH and FSH in serum of the observation group were all lower than those of the control group(P < 0.05). The incidence of adverse reactions was 17.05% in the observation group and 11.36% in the control group,difference being insignificant(P > 0.05). Conclusion:Cangfu Daotan tang combined with letrozole has significant clinical effect in treating PCOS. It can effectively improve symptoms,physical signs and hormone levels of patients,and promote the quality of life with high safety of medication,which is worthy of clinical reference.
引文
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